Sitagliptin

45 interactions 2 explained in plain English

Also sold as: Brynovin Januvia Januvia® Zituvio

About Sitagliptin

Sitagliptin is a DPP-4 inhibitor medication used to lower blood sugar levels in adults with type 2 diabetes. Read the full Sitagliptin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Moxifloxacin Chloroquine Octreotide Insulin Glulisine (Rdna Origin) Injection Levofloxacin Injection Ofloxacin Otic

22 Major 22 Moderate 1 Minor

All (45) Major (22) Moderate (22) Minor (1)

Major

Sitagliptin Abiraterone Abirtega An increased risk of severe hypoglycemia Details Sitagliptin Chloroquine Aralen® Hypoglycemia Details Sitagliptin Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sitagliptin Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sitagliptin Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Sitagliptin Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sitagliptin Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sitagliptin Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Sitagliptin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Sitagliptin Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Sitagliptin Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Sitagliptin Lanreotide Injection Somatuline An increased risk of hypoglycemia and impaired glucose regulation Details Sitagliptin Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sitagliptin Levofloxacin Injection Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sitagliptin Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sitagliptin Moxifloxacin Injection Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sitagliptin Moxifloxacin Ophthalmic Moxeza® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sitagliptin Octreotide Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Sitagliptin Octreotide Injection Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Sitagliptin Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sitagliptin Ofloxacin Ophthalmic Ocuflox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sitagliptin Ofloxacin Otic Floxin® Otic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

Moderate

Sitagliptin Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Sitagliptin Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Benazepril Lotensin An increased risk of hypoglycemia Details Sitagliptin Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Captopril Capoten® An increased risk of hypoglycemia Details Sitagliptin Enalapril Epaned An increased risk of hypoglycemia Details Sitagliptin Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Fosinopril Monopril® An increased risk of hypoglycemia Details Sitagliptin Glimepiride Amaryl An increased risk of hypoglycemia Details Sitagliptin Glipizide Glucotrol An increased risk of hypoglycemia Details Sitagliptin Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sitagliptin Levothyroxine Ermeza Worsening of glycemic control Details Sitagliptin Moexipril Univasc® An increased risk of hypoglycemia Details Sitagliptin Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.