Drug & supplement interaction

Cucumber + Sitagliptin

Sitagliptin brand names: Januvia, Zituvio.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Cucumber has a moderate interaction with Sitagliptin. Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cucumber and Sitagliptin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Sitagliptin

Sitagliptin falls under ANTIDIABETES DRUGS — the group Cucumber interacts with.

Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Animal research shows that cucumber seed extract can decrease blood glucose levels. Monitor blood glucose levels closely.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with sitagliptin (Januvia) and cucumber: this is really about concentrated cucumber seed extract, not the cucumber slices in your salad. In animal studies, cucumber seed extract nudged blood sugar a little lower on its own. Since sitagliptin already works to bring high blood sugar down, the theory is that the two together could push your numbers a bit too low.

I want to be honest that this is theoretical and based only on animal research, so it's not a strong concern. Eating cucumber as food is unlikely to cause any trouble. If you take a concentrated seed extract, just keep an eye out for low blood sugar signs (shakiness, sweating, dizziness, feeling foggy) and check your glucose. Chat with your pharmacist or doctor before starting any cucumber supplement.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Minaiyan M, Zolfaghari B, Kamal A. Effect of hydroalcoholic and buthanolic extract of Cucumis sativus seeds on blood glucose level of normal and streptozotocin-induced diabetic rats. Iran J Basic Med Sci. 2011;14(5):436-42.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cucumber Also Interacts With Other Medications

Cucumber has 85 moderate known drug interactions in our database — the Sitagliptin one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Sitagliptin)
Taking anything else?

Check Another of Your Medications Against Cucumber

Covers the 2,830 medications we’ve checked against Cucumber. Pick one to open its full report.

From our Q&A

Questions About Cucumber or Sitagliptin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cucumber or Sitagliptin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sitagliptin

This page covers Cucumber only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sitagliptin page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

Open the Sitagliptin interaction page

One more smart check

Taking Cucumber as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,026 real supplement products containing Cucumber, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cucumber. Your product may carry other ingredients that interact with Sitagliptin too, on top of Cucumber — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cucumber and Sitagliptin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cucumber
Top 25%

#248 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sitagliptin
Top half

#866 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cucumber

What is Cucumber?

  • Hydration and skin care
  • Cooling and soothing puffy eyes
  • Mild diuretic effect
  • Antioxidant support
  • Digestive comfort

Cucumber is a common food vegetable that is mostly water and is generally safe to eat. As a supplement or skincare ingredient it is popular for hydration and soothing the skin, but solid human research showing health benefits beyond basic nutrition is limited.

Read the full Cucumber monograph & all interactions
Medication

About Sitagliptin

What Is Sitagliptin Used For?

Brand names: Januvia, Zituvio

Sitagliptin is used alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It is available as tablets (Januvia, Zituvio, and generic sitagliptin products) and as an oral solution (Brynovin), all approved for this same use.

Sitagliptin is not for type 1 diabetes. It has not been studied in people with a history of pancreatitis, so its safety in that group is unknown.

See full Sitagliptin drug information
Keep checking

Other Drugs & Cucumber

Browse every other medication we’ve checked against Cucumber — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Cucumber page.

No interaction 2,744 drugs checked — show the list

We also checked Cucumber against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Cucumber list.

See the full Cucumber interactions page
See every supplement checked against Sitagliptin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cucumber monograph › Uses, safety, and every drug interaction in one place Sitagliptin supplement interactions › Every supplement checked against Sitagliptin, ranked by severity Sitagliptin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cucumber and Sitagliptin Together: Common Questions

Can you take Cucumber with Sitagliptin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cucumber and Sitagliptin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Sitagliptin and Cucumber?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.