Herb & supplement monograph

Chuchuhuasi Drug Interactions, Uses, Safety & More

Check Chuchuhuasi against your medication

Add one medication
Chuchuhuasi
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Chuchuhuasi

0 medications have a known interaction with Chuchuhuasi, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Chuchuhuasi. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Chuchuhuasi combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Chuchuhuasi: Uses, Safety & Side Effects

The bottom line

Chuchuhuasi is an Amazonian tree bark traditionally used for joint pain, inflammation, and as a general tonic. Solid human studies are lacking, so its benefits remain unproven, and you should talk to your pharmacist or doctor before trying it—especially if you are pregnant, breastfeeding, or taking other medicines.

Scientific name
Maytenus krukovii
Family
Celastraceae
Part used
Bark (mainly the inner bark) and roots
Common forms
Tinctures, capsules, dried bark for tea/decoction, liquid extracts, and bark soaked in aguardiente (local rum)
People commonly use it for
  • Arthritis and joint pain
  • Back pain and muscle aches
  • Inflammation
  • Menstrual cramps
  • General tonic and energy
  • Digestive complaints

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

It has a long history of traditional use but very little modern safety or quality testing, so use cautiously.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Chuchuhuasi (often spelled chuchuhuasha or chuchuwasi) comes from a tall rainforest tree that grows in the Amazon basin, including parts of Peru, Ecuador, Brazil, and Colombia. The part most often used is the bark, and sometimes the roots.

In traditional Amazonian medicine, the bark is usually soaked in alcohol (often a local rum) or boiled into a tea. People have long used it as a remedy for aches, joint pain, and as an overall "strengthening" tonic. Today you can also find it sold as tinctures, capsules, and dried bark in health stores and online.

It is important to know that most of what we hear about chuchuhuasi comes from folk tradition rather than from carefully designed human studies.

Uses & effectiveness

People most commonly take chuchuhuasi for arthritis, joint and muscle pain, back pain, inflammation, and menstrual cramps. It is also used as a general tonic believed to boost energy and well-being.

The honest answer about effectiveness is that the evidence is very limited. Some laboratory and animal studies suggest the bark contains compounds with possible anti-inflammatory or antioxidant activity. However, lab and animal findings often do not carry over to real benefits in people.

There are no large, high-quality human clinical trials proving that chuchuhuasi treats arthritis, pain, or any other condition. Because of this, it should not be relied on to replace proven treatments for any medical problem.

How it works

Chuchuhuasi bark contains a mix of natural compounds, including substances such as triterpenes, sesquiterpenes, and alkaloids. Some of these have shown anti-inflammatory and antioxidant effects in test-tube and animal research.

Researchers think these compounds may calm certain chemical signals involved in inflammation and pain. This is the proposed reason behind its traditional use for arthritis and aches.

Keep in mind that these mechanisms are based mostly on early laboratory studies. We do not yet have good evidence showing exactly how—or whether—chuchuhuasi works in the human body when taken as a supplement.

Safety & precautions

Chuchuhuasi has a long history of traditional use, but it has not been well studied for safety in modern research. Quality and strength can vary a lot from product to product, and supplements are not tightly regulated, so you cannot always be sure what is in the bottle.

People with existing health conditions, those taking prescription medicines, and older adults should be especially careful and check with a healthcare professional first. Many traditional preparations are made with alcohol, which adds its own risks.

Pregnancy and breastfeeding: Because there is not enough reliable safety information, chuchuhuasi should be avoided during pregnancy and while breastfeeding. Always speak with your pharmacist or doctor before using it.

Side effects

Because chuchuhuasi has not been studied carefully in people, its full side effect profile is not known. With herbal bark products, possible effects can include stomach upset, nausea, or digestive discomfort.

Allergic reactions are always possible with any plant product. Stop using it and seek medical care if you notice a rash, itching, swelling, or trouble breathing.

Tinctures made with alcohol carry the usual risks linked to alcohol. If you experience any unusual or severe symptoms, stop taking it and contact a healthcare professional.

Dosing

There is no established or standardized dose for chuchuhuasi. Because human studies are lacking, no one has determined a safe and effective amount.

If you choose to try it, the safest approach is to follow the directions on the product label and not exceed them. Doses vary widely between tinctures, capsules, and teas.

Before starting, talk with your pharmacist or doctor, especially if you take other medicines or have a health condition. Choose products from reputable companies that test for quality and purity.

Pregnancy & Breastfeeding

Chuchuhuasi & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Chuchuhuasi & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 3 sources that drive our Chuchuhuasi monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health (NCCIH) Source
  2. Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source
  3. About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Brand directory

Brands that make products with Chuchuhuasi

1 brand in our database make a supplement containing Chuchuhuasi.

Pharmacist Counseling Corner

Chuchuhuasi: Common Questions

Does Chuchuhuasi interact with prescription medications?
We do not currently list any known drug interactions for Chuchuhuasi. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Chuchuhuasi interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Chuchuhuasi with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Chuchuhuasi interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Chuchuhuasi used for?
It is traditionally used in the Amazon for joint and muscle pain, arthritis, inflammation, menstrual cramps, and as a general energy tonic. These uses come mainly from folk tradition, and good human studies are lacking.
Is Chuchuhuasi safe to take?
It has a long history of traditional use, but it has not been well tested in modern safety studies, so it should be used with caution. Check with your pharmacist or doctor first, especially if you take other medicines or have health conditions.
Can I take Chuchuhuasi while pregnant or breastfeeding?
No—there is not enough reliable safety information, so it is best to avoid Chuchuhuasi during pregnancy and breastfeeding.
How is Chuchuhuasi usually taken?
It is commonly taken as a tincture, in capsules, or as a tea or decoction made from the dried bark. Since there is no standard dose, follow the product label and ask a healthcare professional for guidance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Chuchuhuasi

A rotating sample of real supplements in our database that list Chuchuhuasi — open any to see its full ingredients and every drug interaction we check.

Have a question about Chuchuhuasi?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist