Herb & supplement monograph

Rupturewort Drug Interactions, Uses, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated June 2026

What is this page for?

First and foremost: how Rupturewort interacts with medications. The heart of this page is the interaction list — every drug Rupturewort is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Rupturewort is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Rupturewort Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Rupturewort drug interaction appears low for most people. Only a single interaction has been identified, it is rated moderate rather than major, and no other medications are known to be affected.

Interactions deserving the most attention

The one interaction worth knowing about involves lithium, a mood-stabilizing medicine with a narrow safety margin where even small changes in blood levels can matter. Animal research suggests rupturewort may act as a diuretic, changing how the body handles salt and water. Because lithium leaves the body along with sodium, this effect could in theory cause lithium levels to rise. Anyone taking lithium should treat this combination with caution.

What the rest of the list means

This concern comes from animal research and reasoning about how the herb might work, not from documented problems in people taking both together. A very short interaction list like this one also means rupturewort has not been linked to problems with common medicine groups such as blood thinners, blood pressure drugs, or diabetes treatments, though it has not been studied as thoroughly as many herbs.

Check your medications against Rupturewort

Based on HelloPharmacist’s Rupturewort interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Rupturewort

1 medication has a known interaction with Rupturewort, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Rupturewort using our pharmacist-reviewed interaction data.

AI summaries are generated from our Rupturewort interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

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What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Rupturewort combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Rupturewort affects

Every type of medication (drug category) Rupturewort is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Rupturewort interacts with

Lithium

Theoretically, rupturewort might increase the levels and clinical effects of lithium.
Animal research shows that rupturewort may have diuretic effects, increasing the excretion of sodium, potassium, and chloride. Theoretically, due to these effects, rupturewort might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D

Monograph

Rupturewort: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed June 2026 ·

The bottom line

Rupturewort is a traditional European herb mainly used as a mild diuretic and for urinary complaints. Solid human research is very limited, so its true benefits and long-term safety are not well established. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Scientific name: Herniaria glabra
Family: Caryophyllaceae
Part used: Aerial parts (the above-ground flowering herb)
Common forms: Tea, dried herb, tincture, capsules

People commonly use it for

Urinary tract complaints
Mild fluid retention (as a diuretic)
Kidney and bladder support
Wound healing and inflammation (topical, traditional)
Spasms or cramping (traditional)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Limited safety data exist, so use carefully and under professional guidance.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail

BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Rupturewort (Herniaria glabra) is a low-growing herb in the carnation family. It spreads close to the ground and produces tiny greenish flowers. It grows in sandy, dry soils across Europe, parts of Asia, and North Africa.

The name "rupturewort" comes from its old folk use for hernias ("ruptures"). Today, people mostly know it as a traditional remedy taken as a tea or tincture for urinary and kidney complaints. The dried above-ground parts of the plant are the parts usually used.

It is considered a folk or traditional medicine rather than a mainstream supplement, and you are most likely to find it in herbal blends marketed for urinary or "water balance" support.

Uses & effectiveness

Rupturewort has been used in traditional European herbal medicine, but high-quality human studies are lacking for nearly all of its uses. Most claims rest on tradition, laboratory tests, or a small number of older animal studies.

People commonly use it for:

Urinary tract complaints — used traditionally to help "flush" the urinary system; human evidence is weak.
Mild fluid retention — used as a gentle diuretic, but this effect has not been well proven in people.
Kidney and bladder support — traditional use only, without strong clinical backing.
Inflammation and wound healing — based mostly on tradition and limited lab work.

In short, there is not enough reliable evidence to say that rupturewort works for any specific health condition. It should not replace proven treatments, especially for urinary or kidney problems that need medical care.

How it works

Rupturewort contains plant compounds such as saponins, flavonoids, and coumarins. Saponins are thought to contribute to its supposed diuretic and mild irritant effects on the urinary tract, while flavonoids may have antioxidant and anti-inflammatory activity.

These ideas come mostly from laboratory and animal research, not from well-controlled human trials. Because of this, we cannot be sure how—or whether—these compounds produce meaningful effects in people at the amounts found in teas or supplements.

Safety & precautions

There is limited modern safety data on rupturewort, so caution is wise. The saponins it contains can irritate tissues, and high or prolonged use may not be safe.

People who should be especially careful or avoid it include:

Anyone with kidney disease or reduced kidney function.
People taking diuretics or who are prone to dehydration.
Those with known plant allergies.
Pregnant or breastfeeding people — because safety is unknown and its traditional diuretic use raises concern, it is best avoided.

Always tell your pharmacist or doctor about any herb you are taking, especially if you have a medical condition or take prescription medicines.

Side effects

Because rupturewort has not been studied carefully in people, its full side-effect profile is unclear. Based on its saponin content, possible effects include stomach upset, nausea, or digestive irritation, especially at higher doses.

Allergic reactions are possible with any plant product. Stop use and seek medical care if you notice rash, swelling, or trouble breathing. If you have any unusual or lasting symptoms, stop using it and check with a healthcare professional.

Dosing

There is no well-established or standardized dose for rupturewort. Traditional use involves brewing the dried herb as a tea, but reliable dosing guidance from clinical research does not exist.

If you choose to use a product, follow the directions on the label and do not exceed them. Because strength varies between products and safety data are limited, it is best to check with a pharmacist or doctor first and use it only for short periods.

Pregnancy & Breastfeeding

Rupturewort & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Rupturewort & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Rupturewort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Hakim EM, Sivak KV, Kaukhova IE. Evaluation of the diuretic effect of crude ethanol and saponin-rich extracts of Herniaria glabra L. in rats. J Ethnopharmacol. 2021 Jun 12;273:113942. PubMed

Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

Brand directory

Brands that make products with Rupturewort

7 brands in our database make a supplement containing Rupturewort.

Flora 215 products Hawaii Pharm 4,726 products Herbal Terra 3,138 products Nestmann 28 products Pure Herbs 634 products TerraVita 2,475 products TerraVita Premium Collection 4,019 products

Product directory

Supplement products with Rupturewort

19 products in our database contain Rupturewort. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Rupturewort: Common Questions

Does Rupturewort interact with prescription medications?

Yes. We list 1 medication with a known interaction with Rupturewort. Use the checker above to see how Rupturewort interacts with a specific drug.

How are Rupturewort interactions rated?

Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.

Is it safe to take Rupturewort with my medications?

It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.

Where does this Rupturewort interaction information come from?

Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.

What is Rupturewort used for?

It is traditionally used as a mild diuretic and for urinary and kidney complaints, and sometimes for inflammation. However, there is little strong scientific evidence that it works for any of these.

Is Rupturewort safe to take?

Safety data are limited. It may cause stomach upset and is best used cautiously, for short periods, and after checking with a healthcare professional—especially if you have kidney problems.

Can I take Rupturewort while pregnant or breastfeeding?

No reliable safety information exists, and its traditional diuretic use raises concern. It is best to avoid Rupturewort during pregnancy and breastfeeding.

How is Rupturewort usually taken?

It is most often taken as a tea made from the dried herb, and is also sold as tinctures or capsules. There is no standardized dose, so follow the product label and ask a pharmacist for guidance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Rupturewort

A rotating sample of real supplements in our database that list Rupturewort — open any to see its full ingredients and every drug interaction we check.

See all 19 products with Rupturewort →

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Rupturewort Drug Interactions, Uses, Safety & More

Your Choice:

Rupturewort Drug Interactions: The Bottom Line

Drugs that interact with Rupturewort

Don’t want to scroll the list? Just ask.

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Likelihood — How Well It’s Documented

Where This Data Comes From

The kinds of drugs Rupturewort affects

Rupturewort: Uses, Safety & Side Effects

Overview

Uses & effectiveness

How it works

Safety & precautions

Side effects

Dosing

Rupturewort & Pregnancy

Rupturewort & Breastfeeding

References & further reading

Brands that make products with Rupturewort

Supplement products with Rupturewort

Rupturewort: Common Questions

Related supplements & herbs

Products that contain Rupturewort

Have a question about Rupturewort?