Drug & supplement interaction

Rupturewort + Lusutrombopag

Lusutrombopag brand name: Mulpleta.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Rupturewort and Lusutrombopag in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Rupturewort and Lusutrombopag

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lusutrombopag and Rupturewort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rupturewort safety at a glance

Rupturewort overall Use caution Limited safety data exist, so use carefully and under professional guidance.
Pregnancy Avoid Not enough safety information; traditional diuretic use makes it best avoided in pregnancy.
Breastfeeding Avoid No reliable safety data, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lusutrombopag and Rupturewort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lusutrombopag

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lusutrombopag is filed under 2 classifications — p-glycoprotein substrates, oral drugs. Rupturewort has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Lusutrombopag’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rupturewort Does Interact With Other Medications

Rupturewort has 1 moderate known drug interaction in our database — Lusutrombopag isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Lusutrombopag)
Taking anything else?

Check Another of Your Medications Against Rupturewort

Covers the 2,830 medications we’ve checked against Rupturewort. Pick one to open its full report.

What to actually watch for

What Lusutrombopag’s Own FDA Label Lists

This is not an interaction — none of it involves Rupturewort. These are the most notable effects listed in the ADVERSE REACTIONS section of Lusutrombopag’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • A low platelet count Worth acting on
  • Headache

From the ADVERSE REACTIONS section of the FDA label for Lusutrombopag. Read the label on DailyMed › Rupturewort’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Rupturewort side to compare — that is a limit of the record, not a statement that Rupturewort has no side effects.

Everything else you take

See Every Supplement That Interacts With Lusutrombopag

This page covers Rupturewort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lusutrombopag page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 35 moderate · 17 minor.

From our pharmacist’s overview on the Lusutrombopag page

“If you take lusutrombopag (Mulpleta), it is probably a short course meant to raise your platelet count before a procedure, and that narrow window is exactly why these 54 interactions deserve real respect. The two rated major, St.”

Reviewed by 2 · Jul 18, 2026

Open the Lusutrombopag interaction page

One more smart check

Taking Rupturewort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 19 real supplement products containing Rupturewort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rupturewort. Even though Rupturewort itself has no known interaction with Lusutrombopag, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rupturewort and Lusutrombopag Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rupturewort
Steady interest

#877 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lusutrombopag
Steady interest

#1,935 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rupturewort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rupturewort and Lusutrombopag records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rupturewort

What is Rupturewort?

  • Urinary tract complaints
  • Mild fluid retention (as a diuretic)
  • Kidney and bladder support
  • Wound healing and inflammation (topical, traditional)
  • Spasms or cramping (traditional)

Rupturewort is a traditional European herb mainly used as a mild diuretic and for urinary complaints. Solid human research is very limited, so its true benefits and long-term safety are not well established. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Herniaria glabra · Caryophyllaceae · Aerial parts (the above-ground flowering herb) · Tea, dried herb, tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Rupturewort is a good idea for someone in your situation. Here is what our Rupturewort record says about it on its own.

Rupturewort: dosing

There is no well-established or standardized dose for rupturewort. Traditional use involves brewing the dried herb as a tea, but reliable dosing guidance from clinical research does not exist.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Rupturewort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rupturewort monograph & all interactions
Medication

About Lusutrombopag

What Is Lusutrombopag Used For?

Brand name: Mulpleta

Mulpleta (lusutrombopag) is used to treat thrombocytopenia — a low platelet count — in adults who have chronic liver disease and are scheduled to have a procedure. Raising the platelet count before the procedure helps reduce the risk of bleeding.

Mulpleta is taken for a short, fixed course before the procedure. It is not meant to be used to bring platelet counts all the way to normal, or for long-term management of chronic liver disease.

See full Lusutrombopag drug information
Keep checking

Other Drugs & Rupturewort

Browse every other medication we’ve checked against Rupturewort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Rupturewort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Rupturewort list.

See the full Rupturewort interactions page
See every supplement checked against Lusutrombopag, ranked by severity
Evidence & sources

Rupturewort References

The 1 references that drive our Rupturewort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hakim EM, Sivak KV, Kaukhova IE. Evaluation of the diuretic effect of crude ethanol and saponin-rich extracts of Herniaria glabra L. in rats. J Ethnopharmacol. 2021 Jun 12;273:113942. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rupturewort and Lusutrombopag Together: Common Questions

Is it safe to take Rupturewort with Lusutrombopag?
We do not list a known interaction between Rupturewort and Lusutrombopag. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Rupturewort and Lusutrombopag combination checked?
Interactions in our licensed database are recorded against drug classes. Lusutrombopag is filed under 2 classifications, and Rupturewort has documented interactions with 1 drug class — none of Lusutrombopag's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rupturewort interact with any other medications?
Yes. Rupturewort has 1 documented drug interaction in our database — Lusutrombopag is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lusutrombopag interact with any supplements?
Yes. Lusutrombopag has documented interactions with 54 supplements in our database — Rupturewort is not one of them. The Lusutrombopag interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rupturewort monograph Uses, safety profile, and every drug interaction in one place Lusutrombopag drug information The full plain-English guide to this medication Lusutrombopag supplement interactions Every supplement checked against Lusutrombopag, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lusutrombopag and Rupturewort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.