Medication interaction hub

What Supplements Interact with Lusutrombopag?

Lusutrombopag brand name: Mulpleta. Every interaction below applies to the brands too.

54 Interactions 2 Major 35 Moderate 17 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lusutrombopag? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lusutrombopag against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take lusutrombopag (Mulpleta), it is probably a short course meant to raise your platelet count before a procedure, and that narrow window is exactly why these 54 interactions deserve real respect. The two rated major, St. John's wort and activated charcoal, can both drag the drug's level down, one by speeding up the transporter (P-glycoprotein) that clears it from the body, the other by binding it in the gut before it absorbs. A dose that falls short can mean going into your procedure with fewer platelets than planned.

The remaining 35 moderate and 17 minor entries mostly repeat those two themes at lower stakes, herbs that push that same transporter one way or the other, green tea among them, and fiber products that can blunt what an oral dose delivers. Take fiber well apart from your pill, and with a treatment this brief, pausing doubtful supplements until after the procedure is often the simpler call.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 35 Minor 17 No known interaction 1,398

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Lusutrombopag: Top Interactions at a Glance

The most significant Lusutrombopag supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 54 interacting ingredients — plus 1,398 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Lusutrombopag + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Lusutrombopagi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable St. John's Wort + Lusutrombopagi

St.

Read the full interaction
The complete list

Every Supplement Checked Against Lusutrombopag

All 1,452 ingredients in our database, ranked by severity — 54 with a Lusutrombopag interaction on file and 1,398 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lusutrombopag?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Agar with Lusutrombopag?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Lusutrombopag answer

Can you take Diosmin with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might increase levels of drugs that are substrates of P-glycoprotein (P-gp).

Full Diosmin + Lusutrombopag answer

Can you take Xanthan Gum with Lusutrombopag?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Lusutrombopag answer

Can you take Milk Thistle with Lusutrombopag?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, milk thistle might increase the absorption of P-glycoprotein substrates.

Full Milk Thistle + Lusutrombopag answer

Can you take Activated Charcoal with Lusutrombopag?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Lusutrombopag answer

Can you take St. John's Wort with Lusutrombopag?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Lusutrombopag answer

Can you take Coffee Charcoal with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Lusutrombopag answer

Can you take European Mandrake with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Lusutrombopag answer

Can you take Glucomannan with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Lusutrombopag answer

Can you take Goldenseal with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase or decrease serum levels of P-glycoprotein (P-gp) substrates.

Full Goldenseal + Lusutrombopag answer

Can you take Bitter Melon with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Full Bitter Melon + Lusutrombopag answer

Can you take Black Pepper with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of P-glycoprotein substrates.

Full Black Pepper + Lusutrombopag answer

Can you take Bulbine Natalensis with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might increase the levels and clinical effects of p-glycoprotein substrates.

Full Bulbine Natalensis + Lusutrombopag answer

Can you take Cannabis with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might alter levels of drugs that are substrates of P-glycoprotein (P-gp).

Full Cannabis + Lusutrombopag answer

Can you take Danshen with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels of drugs cleared by p-glycoprotein.

Full Danshen + Lusutrombopag answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might alter levels of drugs that are substrates of P-glycoprotein (P-gp).

Full Delta-9-tetrahydrocannabinol (thc) + Lusutrombopag answer

Can you take Eleuthero with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of P-glycoprotein substrates.

Full Eleuthero + Lusutrombopag answer

Can you take Ginger with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.

Full Ginger + Lusutrombopag answer

Can you take Ginkgo with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with P-glycoprotein substrates might increase the levels and adverse effects of these substrates.

Full Ginkgo + Lusutrombopag answer

Can you take Green Tea with Lusutrombopag?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Green tea might increase the levels and adverse effects of P-glycoprotein (P-gp) substrates.

Full Green Tea + Lusutrombopag answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lusutrombopag is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lusutrombopag, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lusutrombopag sits in 2 interaction categories. Open any one to see what the group means:

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Lusutrombopag through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lusutrombopag through this category.

About Lusutrombopag

Lusutrombopag is an oral thrombopoietin receptor agonist used to treat low platelet counts (thrombocytopenia) in adults with chronic liver disease who are preparing for a medical procedure.

Generic name: Lusutrombopag  ·  Brand name: Mulpleta.

See the full Lusutrombopag drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lusutrombopag

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lusutrombopag.

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Products that contain Lusutrombopag-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Lusutrombopag.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort
Pharmacist Counseling Corner

Lusutrombopag & Supplements: Common Questions

What supplements interact with Lusutrombopag?
Our database currently documents 54 ingredients with a known Lusutrombopag interaction (2 major, 35 moderate, 17 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 54. The highest-ranked right now: Activated Charcoal, St. John's Wort, Coffee Charcoal.
Which Lusutrombopag supplement interactions are the most serious?
The 2 major-rated combinations — led by Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Lusutrombopag?
Plenty of supplements coexist fine with Lusutrombopag; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Mulpleta have the same supplement interactions as Lusutrombopag?
Yes — Mulpleta all contain Lusutrombopag, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Lusutrombopag and my other medications?
This page covers Lusutrombopag against supplements and herbal ingredients. Checking Lusutrombopag against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lusutrombopag drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.