Calcium D-glucarate + Lusutrombopag
Lusutrombopag brand name: Mulpleta.
We found no known interaction between Calcium D-glucarate and Lusutrombopag in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Calcium D-glucarate and Lusutrombopag
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Lusutrombopag and Calcium D-glucarate in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Calcium D-glucarate safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Lusutrombopag
Interactions in our licensed database are recorded against drug classes, not just single drug names. Lusutrombopag is filed under 2 classifications — p-glycoprotein substrates, oral drugs. Calcium D-glucarate has documented interactions with 3 drug classes — the most serious being alcohol (ethanol) (moderate), glucuronidated drugs (moderate) and kanamycin (minor) — and none of Lusutrombopag’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Calcium D-glucarate Does Interact With Other Medications
Calcium D-glucarate has 125 moderate, 1 minor known drug interactions in our database — Lusutrombopag isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Calcium D-glucarate
We haven’t checked that one against Calcium D-glucarate yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Calcium D-glucarate. Pick one to open its full report.
See Every Supplement That Interacts With Lusutrombopag
This page covers Calcium D-glucarate only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lusutrombopag page lists 54 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).
By severity: 2 major · 35 moderate · 17 minor.
From our pharmacist’s overview on the Lusutrombopag page
“If you take lusutrombopag (Mulpleta), it is probably a short course meant to raise your platelet count before a procedure, and that narrow window is exactly why these 54 interactions deserve real respect. The two rated major, St.”
Reviewed by 2 · Jul 18, 2026
Taking Calcium D-glucarate as Part of a Dietary Supplement Product? Check It for Interactions
We hold 369 real supplement products containing Calcium D-glucarate, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Calcium D-glucarate. Even though Calcium D-glucarate itself has no known interaction with Lusutrombopag, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Calcium D-glucarate and Lusutrombopag Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#486 of 1,452 supplements looked up here in the last 7 days
#1,708 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calcium D-glucarate reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Calcium D-glucarate and Lusutrombopag records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Calcium D-glucarate
What is Calcium D-glucarate?
- Detoxification support
- Hormone balance
- Estrogen metabolism
- Liver support
- General wellness
Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence for these benefits is very limited, and most research comes from laboratory or animal studies. Talk to your pharmacist or doctor before using it, especially if you have a hormone-related condition.
Not applicable (a calcium salt of D-glucaric acid) · Tablets, capsules
An interaction check asks whether these two react with each other — it does not ask whether Calcium D-glucarate is a good idea for someone in your situation. Here is what our Calcium D-glucarate record says about it on its own.
Calcium D-glucarate: dosing
There is no official or standardized dose for calcium D-glucarate, and the best dose for any health goal has not been established in humans. Amounts used in supplements vary widely from product to product.The safest approach is to follow the directions on the product label and not exceed the recommended amount.
From our Calcium D-glucarate monograph — the full record covers uses, side effects and every documented interaction.
About Lusutrombopag
What Is Lusutrombopag Used For?
Brand name: Mulpleta
Mulpleta (lusutrombopag) is used to treat thrombocytopenia — a low platelet count — in adults who have chronic liver disease and are scheduled to have a procedure. Raising the platelet count before the procedure helps reduce the risk of bleeding.
Mulpleta is taken for a short, fixed course before the procedure. It is not meant to be used to bring platelet counts all the way to normal, or for long-term management of chronic liver disease.
Other Drugs & Calcium D-glucarate
Browse every other medication we’ve checked against Calcium D-glucarate — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
125 interactions
- Apomorphine ›
- Doxorubicin ›
- Morphine Sulfate ›
- Acetaminophen ›
- Conjugated Estrogens ›
- Diazepam ›
- Meprobamate ›
- Digoxin ›
- Deferasirox ›
- Esterified Estrogens ›
- Irinotecan ›
- Lovastatin ›
- Pitavastatin ›
- Tamoxifen Citrate ›
- Apomorphine Hydrochloride ›
- Atorvastatin ›
- Atorvastatin Calcium ›
- Belinostat ›
- Belzutifan ›
- Cabotegravir ›
- Cabotegravir Sodium ›
- Dolutegravir ›
- Enasidenib ›
- Entacapone ›
- Ethanol ›
- Ezogabine ›
- Lamotrigine ›
- Lorazepam ›
- Oxazepam ›
- Paracetamol ›
- Pexidartinib Hydrochloride ›
- Raltegravir ›
- Sacituzumab Govitecan-hziy ›
- Simvastatin ›
- Simvastatin/ezetimibe ›
- Sorafenib ›
- Sotagliflozin ›
- Toremifene Citrate ›
- Irinotecan Hydrochloride ›
- Acetaminophen, Hydrocodone ›
- Acetaminophen, Butalbital ›
- Acetaminophen, Pseudoephedrine ›
- Acetaminophen, Chlorpheniramine, Pseudoephedrine ›
- Acetaminophen, Butalbital, Caffeine ›
- Acetaminophen, Caffeine, Codeine ›
- Acetaminophen, Dextromethorphan, Pseudoephedrine ›
- Acetaminophen, Chlorpheniramine, Phenylpropanolamine ›
- Acetaminophen, Dichloralantipyrine, Isometheptene ›
- Acetaminophen, Oxycodone ›
- Acetaminophen, Propoxyphene ›
- Acetaminophen, Aspirin, Caffeine ›
- Acetaminophen, Caffeine, Codeine, Salicylamide ›
- Acetaminophen, Caffeine, Dihydrocodeine ›
- Acetaminophen, Chlorpheniramine, Phenylephrine ›
- Acetaminophen, Chlorzoxazone ›
- Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine ›
- Acetaminophen, Diphenhydramine, Pseudoephedrine ›
- Acetaminophen, Pamabrom, Pyrilamine ›
- Acetaminophen, Butalbital, Caffeine, Codeine ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine ›
Showing 60 of 125 moderate interactions — see all 125 on the Calcium D-glucarate page.
1 interaction
No interaction 2,703 drugs checked — show the list
We also checked Calcium D-glucarate against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Clopidogrel ›
- Docusate ›
- Valacyclovir ›
- Abemaciclib ›
- Hydroxyurea ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Warfarin Sodium ›
- Tirzepatide ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Dapsone ›
- Cyclopentolate ›
Showing the 60 most looked-up of 2,703 medications checked with no known interaction — see the full Calcium D-glucarate list.
Calcium D-glucarate References
The 5 references that drive our Calcium D-glucarate monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92.
- Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3. PubMed
- Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42.
- Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
- Anon. Calcium-D-Glucarate. Altern Med Review 2002;7(4):336-9.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Calcium D-glucarate and Lusutrombopag Together: Common Questions
Is it safe to take Calcium D-glucarate with Lusutrombopag?
How was the Calcium D-glucarate and Lusutrombopag combination checked?
Does Calcium D-glucarate interact with any other medications?
Does Lusutrombopag interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.