Lusutrombopag

Generic name: Pronounced as (loo" soo trom' boe pag)
Brand names
  • Mulpleta®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 09/15/2018

Lusutrombopag is used treat thrombocytopenia (a low number of platelets [type of blood cell needed for blood clotting]) in patients with chronic (ongoing) liver disease who are scheduled to have a medical or dental procedure to help prevent bleeding complications. Lusutrombopag is in a class of medications called thrombopoietin (TPO) receptor agonists. It works by causing the body to produce more platelets.

Lusutrombopag comes as a tablet to take by mouth. It is usually taken with or without food once a day for 7 days, starting 8 to 14 days before the scheduled procedure. Take lusutrombopag at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lusutrombopag exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking lusutrombopag,

  • tell your doctor and pharmacist if you are allergic to lusutrombopag, any other medications, or any of the ingredients in lusutrombopag tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.

  • tell your doctor if you have or have ever had a blood clot or a genetic condition that could lead to blood clots.

  • tell your doctor if you are pregnant, or plan to become pregnant. If you become pregnant while taking lusutrombopag, call your doctor.

  • tell your doctor if you are breastfeeding. Your doctor will probably tell you not to breastfeed during your treatment and for 4 weeks after your final dose.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it on the same day. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Lusutrombopag may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

  • Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:

    • swollen, painful, red, or tender leg

    • shortness of breath, cough, chest pain, fast heartbeat

    • stomach pain or tenderness

  • Lusutrombopag may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • swollen, painful, red or tender leg

  • shortness of breath, cough, chest pain, fast heartbeat

  • stomach pain or tenderness

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to lusutrombopag.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Lusutrombopag can be increased when it is combined with Erythromycin.
Paregoric Paregoric The serum concentration of Lusutrombopag can be increased when it is combined with Morphine.
Reserpine Reserpine The serum concentration of Lusutrombopag can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus The serum concentration of Lusutrombopag can be increased when it is combined with Tacrolimus.
Fluconazole Injection Fluconazole Injection The serum concentration of Lusutrombopag can be increased when it is combined with Fluconazole.
Morphine Injection Morphine Injection The serum concentration of Lusutrombopag can be increased when it is combined with Morphine.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Lusutrombopag.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Lusutrombopag.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Lusutrombopag.
Zonisamide Zonisamide The serum concentration of Lusutrombopag can be increased when it is combined with Zonisamide.
Vardenafil Vardenafil The serum concentration of Lusutrombopag can be increased when it is combined with Vardenafil.
Tegaserod Tegaserod The serum concentration of Lusutrombopag can be increased when it is combined with Tegaserod.
Progesterone Progesterone Progesterone may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Erlotinib Erlotinib Erlotinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Tipranavir Tipranavir The serum concentration of Lusutrombopag can be increased when it is combined with Tipranavir.
Ranolazine Ranolazine The serum concentration of Lusutrombopag can be increased when it is combined with Ranolazine.
Imatinib Imatinib Imatinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Sitagliptin Sitagliptin The serum concentration of Lusutrombopag can be increased when it is combined with Sitagliptin.
Gefitinib Gefitinib Gefitinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Paliperidone Paliperidone The serum concentration of Lusutrombopag can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Lusutrombopag.
Posaconazole Posaconazole The serum concentration of Lusutrombopag can be increased when it is combined with Posaconazole.
Sorafenib Sorafenib The serum concentration of Lusutrombopag can be increased when it is combined with Sorafenib.
Sunitinib Sunitinib Sunitinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Lapatinib Lapatinib The serum concentration of Lusutrombopag can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib Dasatinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Temsirolimus Temsirolimus The serum concentration of Lusutrombopag can be increased when it is combined with Temsirolimus.
Nilotinib Nilotinib The serum concentration of Lusutrombopag can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Lusutrombopag can be increased when it is combined with Toremifene.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Lusutrombopag.
Silodosin Silodosin The serum concentration of Lusutrombopag can be increased when it is combined with Silodosin.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Everolimus Everolimus The serum concentration of Lusutrombopag can be increased when it is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Lusutrombopag can be increased when it is combined with Tolvaptan.
Dronedarone Dronedarone The serum concentration of Lusutrombopag can be increased when it is combined with Dronedarone.
Romidepsin Injection Romidepsin Injection The serum concentration of Lusutrombopag can be increased when it is combined with Romidepsin.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Lusutrombopag.
Pazopanib Pazopanib The serum concentration of Lusutrombopag can be increased when it is combined with Pazopanib.
Cabazitaxel Injection Cabazitaxel Injection Cabazitaxel may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Linagliptin Linagliptin The serum concentration of Lusutrombopag can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Telaprevir Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Lusutrombopag.
Rivaroxaban Rivaroxaban The serum concentration of Lusutrombopag can be increased when it is combined with Rivaroxaban.
Ticagrelor Ticagrelor The serum concentration of Lusutrombopag can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Lusutrombopag.
Vandetanib Vandetanib Vandetanib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Clobazam Clobazam The serum concentration of Lusutrombopag can be increased when it is combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Lusutrombopag can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Ivacaftor Ivacaftor The serum concentration of Lusutrombopag can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Lusutrombopag.
Crizotinib Crizotinib The serum concentration of Lusutrombopag can be increased when it is combined with Crizotinib.
Cabergoline Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Lusutrombopag.
Ambrisentan Ambrisentan The serum concentration of Lusutrombopag can be increased when it is combined with Ambrisentan.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Lusutrombopag.
Enzalutamide Enzalutamide The serum concentration of Lusutrombopag can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Lusutrombopag can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The serum concentration of Lusutrombopag can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Lusutrombopag.
Teriflunomide Teriflunomide Teriflunomide may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Ponatinib Ponatinib The serum concentration of Lusutrombopag can be increased when it is combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Lusutrombopag can be increased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Lusutrombopag can be increased when it is combined with Trastuzumab emtansine.
Apixaban Apixaban The serum concentration of Lusutrombopag can be increased when it is combined with Apixaban.
Canagliflozin Canagliflozin The serum concentration of Lusutrombopag can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib Dabrafenib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Dolutegravir Dolutegravir The serum concentration of Lusutrombopag can be increased when it is combined with Dolutegravir.
Afatinib Afatinib Afatinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Lomitapide Lomitapide The serum concentration of Lusutrombopag can be increased when it is combined with Lomitapide.
Simeprevir Simeprevir The serum concentration of Lusutrombopag can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Lusutrombopag can be increased when it is combined with Sofosbuvir.
Ceritinib Ceritinib The serum concentration of Lusutrombopag can be increased when it is combined with Ceritinib.
Belinostat Injection Belinostat Injection The serum concentration of Lusutrombopag can be increased when it is combined with Belinostat.
Idelalisib Idelalisib The serum concentration of Lusutrombopag can be increased when it is combined with Idelalisib.
Vorapaxar Vorapaxar The serum concentration of Lusutrombopag can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Lusutrombopag can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Lusutrombopag can be increased when it is combined with Edoxaban.
Olaparib Olaparib Olaparib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Nintedanib Nintedanib The serum concentration of Lusutrombopag can be increased when it is combined with Nintedanib.
Palbociclib Palbociclib Palbociclib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Lenvatinib Lenvatinib The serum concentration of Lusutrombopag can be increased when it is combined with Lenvatinib.
Panobinostat Panobinostat The serum concentration of Lusutrombopag can be increased when it is combined with Panobinostat.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Lusutrombopag can be increased when it is combined with Isavuconazonium.
Flibanserin Flibanserin The serum concentration of Lusutrombopag can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Lusutrombopag can be increased when it is combined with Rolapitant.
Daclatasvir Daclatasvir The serum concentration of Lusutrombopag can be increased when it is combined with Daclatasvir.
Cobimetinib Cobimetinib The serum concentration of Lusutrombopag can be increased when it is combined with Cobimetinib.
Osimertinib Osimertinib The serum concentration of Lusutrombopag can be increased when it is combined with Osimertinib.
Alectinib Alectinib Alectinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection Dexamethasone may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Venetoclax Venetoclax The serum concentration of Lusutrombopag can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Lusutrombopag can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Lusutrombopag can be increased when it is combined with Selexipag.
Rucaparib Rucaparib The serum concentration of Lusutrombopag can be increased when it is combined with Rucaparib.
Brigatinib Brigatinib Brigatinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Safinamide Safinamide Safinamide may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Neratinib Neratinib The serum concentration of Lusutrombopag can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The serum concentration of Lusutrombopag can be increased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Lusutrombopag can be increased when it is combined with Inotuzumab ozogamicin.
Copanlisib Injection Copanlisib Injection The serum concentration of Lusutrombopag can be increased when it is combined with Copanlisib.
Abemaciclib Abemaciclib Abemaciclib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Betrixaban Betrixaban The serum concentration of Lusutrombopag can be increased when it is combined with Betrixaban.
Letermovir Letermovir Letermovir may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Ertugliflozin Ertugliflozin The serum concentration of Lusutrombopag can be increased when it is combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Apalutamide Apalutamide The serum concentration of Lusutrombopag can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib Fostamatinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Baricitinib Baricitinib Baricitinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Eliglustat Eliglustat The serum concentration of Lusutrombopag can be increased when it is combined with Eliglustat.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Lusutrombopag.
Ivosidenib Ivosidenib The serum concentration of Ivosidenib can be increased when it is combined with Lusutrombopag.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Lusutrombopag.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Dacomitinib Dacomitinib Dacomitinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Duvelisib Duvelisib The serum concentration of Lusutrombopag can be increased when it is combined with Duvelisib.
Omadacycline Omadacycline The serum concentration of Lusutrombopag can be increased when it is combined with Omadacycline.
Sarecycline Sarecycline The serum concentration of Lusutrombopag can be increased when it is combined with Sarecycline.
Talazoparib Talazoparib The serum concentration of Lusutrombopag can be increased when it is combined with Talazoparib.
Gilteritinib Gilteritinib Gilteritinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Glasdegib Glasdegib Glasdegib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Lusutrombopag.
Rifamycin Rifamycin The serum concentration of Lusutrombopag can be increased when it is combined with Rifamycin.
Erdafitinib Erdafitinib The serum concentration of Lusutrombopag can be increased when it is combined with Erdafitinib.
Darolutamide Darolutamide The serum concentration of Lusutrombopag can be increased when it is combined with Darolutamide.
Entrectinib Entrectinib The serum concentration of Lusutrombopag can be increased when it is combined with Entrectinib.
Istradefylline Istradefylline Istradefylline may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Pitolisant Pitolisant The serum concentration of Lusutrombopag can be increased when it is combined with Pitolisant.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Lefamulin Lefamulin The serum concentration of Lusutrombopag can be increased when it is combined with Lefamulin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Lusutrombopag can be increased when it is combined with Enfortumab vedotin.
Lasmiditan Lasmiditan The serum concentration of Lusutrombopag can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Lusutrombopag.
Tazemetostat Tazemetostat The serum concentration of Lusutrombopag can be increased when it is combined with Tazemetostat.
Selumetinib Selumetinib The serum concentration of Lusutrombopag can be increased when it is combined with Selumetinib.
Rimegepant Rimegepant The serum concentration of Lusutrombopag can be increased when it is combined with Rimegepant.
Tucatinib Tucatinib Tucatinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Lusutrombopag.
Ripretinib Ripretinib Ripretinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Capmatinib Capmatinib The serum concentration of Lusutrombopag can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lusutrombopag can be increased when it is combined with Lemborexant.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Lusutrombopag.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Dactinomycin Dactinomycin The serum concentration of Lusutrombopag can be increased when it is combined with Dactinomycin.
Loperamide Loperamide The serum concentration of Lusutrombopag can be increased when it is combined with Loperamide.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Lusutrombopag.
Loxapine Loxapine The serum concentration of Lusutrombopag can be increased when it is combined with Loxapine.
Quinine Quinine The serum concentration of Lusutrombopag can be increased when it is combined with Quinine.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Lusutrombopag.
Quinidine Quinidine The serum concentration of Lusutrombopag can be increased when it is combined with Quinidine.
Tamoxifen Tamoxifen The serum concentration of Lusutrombopag can be increased when it is combined with Tamoxifen.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Lusutrombopag.
Clomiphene Clomiphene The serum concentration of Lusutrombopag can be increased when it is combined with Clomifene.
Colchicine Colchicine The serum concentration of Lusutrombopag can be increased when it is combined with Colchicine.
Ketoconazole Ketoconazole The serum concentration of Lusutrombopag can be increased when it is combined with Ketoconazole.
Vincristine Injection Vincristine Injection The serum concentration of Vincristine can be increased when it is combined with Lusutrombopag.
Vinblastine Vinblastine The serum concentration of Lusutrombopag can be increased when it is combined with Vinblastine.
Verapamil Verapamil The serum concentration of Lusutrombopag can be increased when it is combined with Verapamil.
Etoposide Etoposide The serum concentration of Lusutrombopag can be increased when it is combined with Etoposide.
Amiodarone Amiodarone The serum concentration of Lusutrombopag can be increased when it is combined with Amiodarone.
Clarithromycin Clarithromycin The serum concentration of Lusutrombopag can be increased when it is combined with Clarithromycin.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Simvastatin Simvastatin The serum concentration of Lusutrombopag can be increased when it is combined with Simvastatin.
Itraconazole Itraconazole The serum concentration of Lusutrombopag can be increased when it is combined with Itraconazole.
Bisoprolol Bisoprolol The serum concentration of Lusutrombopag can be increased when it is combined with Bisoprolol.
Omeprazole Omeprazole Omeprazole may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Venlafaxine Venlafaxine Venlafaxine may increase the excretion rate of Lusutrombopag which could result in a lower serum level and potentially a reduction in efficacy.
Lansoprazole Lansoprazole Lansoprazole may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Saquinavir Saquinavir The serum concentration of Lusutrombopag can be increased when it is combined with Saquinavir.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Lusutrombopag.
Ritonavir Ritonavir The serum concentration of Lusutrombopag can be increased when it is combined with Ritonavir.
Nelfinavir Nelfinavir Nelfinavir may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Fexofenadine Fexofenadine The serum concentration of Lusutrombopag can be increased when it is combined with Fexofenadine.
Carvedilol Carvedilol The serum concentration of Lusutrombopag can be increased when it is combined with Carvedilol.
Propafenone Propafenone The serum concentration of Lusutrombopag can be increased when it is combined with Propafenone.
Sildenafil Sildenafil The serum concentration of Lusutrombopag can be increased when it is combined with Sildenafil.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists