Drug & supplement interaction

Indole-3-carbinol + Lusutrombopag

Lusutrombopag brand name: Mulpleta.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Indole-3-carbinol and Lusutrombopag in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Indole-3-carbinol and Lusutrombopag

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lusutrombopag and Indole-3-carbinol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Indole-3-carbinol safety at a glance

Indole-3-carbinol overall Use caution Likely fine in food amounts, but supplement doses are less studied and should be used cautiously.

Pregnancy Avoid Not enough safety data and possible hormone effects, so concentrated supplements should be avoided.

Breastfeeding Avoid Safety has not been established, so supplement use is not recommended while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lusutrombopag and Indole-3-carbinol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Lusutrombopag

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lusutrombopag is filed under 2 classifications — p-glycoprotein substrates, oral drugs. Indole-3-carbinol has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and estrogens (moderate) — and none of Lusutrombopag’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Indole-3-carbinol Does Interact With Other Medications

Indole-3-carbinol has 294 moderate known drug interactions in our database — Lusutrombopag isn’t one of them. If you take anything else, check it against the full list below.

Moderate 294 No known interaction 2,536 (incl. Lusutrombopag)

Taking anything else?

Check Another of Your Medications Against Indole-3-carbinol

Covers the 2,830 medications we’ve checked against Indole-3-carbinol. Pick one to open its full report.

What to actually watch for

What Indole-3-carbinol Itself Has Been Linked To

This is not an interaction — nothing below involves Lusutrombopag. It is the side-effect record for Indole-3-carbinol on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Indole-3-carbinol, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

Unsteadiness Worth acting on Additional detail
“Indole-3-carbinol has been associated with reports of unsteadiness and imbalance, especially at higher doses. An adult male taking 400 mg twice daily for treatment of recurrent respiratory papillomatosis developed imbalance and tremor after 10 days of treatment. This resolved when the dose was halved.”

Indole-3-carbinol · Natural Medicines adverse-effect record, reported in myasthenia gravis.
2 sources cited

7172. Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810-5. PubMed

93238. Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
Tremor or shakiness / Nausea Additional detail

Recorded for Indole-3-carbinol in the same Natural Medicines adverse-effect record shown under Unsteadiness above.
Diarrhea Additional detail
“Orally, indole-3-carbinol increases gastrointestinal motility and has been associated with diarrhea.”

Indole-3-carbinol · Natural Medicines adverse-effect record, reported in diarrhea.
2 sources cited

93242. Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed

93243. Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591-5.
A skin rash Additional detail
“Orally, indole-3-carbinol has been associated with reports of rash. A woman taking indole-3-carbinol 375 mg daily for treatment of systemic lupus erythematosus (SLE) developed a generalized maculopapular rash which resolved when indole-3-carbinol was discontinued and recurred when it was restarted.”

Indole-3-carbinol · Natural Medicines adverse-effect record, reported in myasthenia gravis.
2 sources cited

93242. Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed

93240. McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Indole-3-carbinol — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Lusutrombopag’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Lusutrombopag column appears here.

Overlapping uses

What Lusutrombopag Is Prescribed For, and What Indole-3-carbinol Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Lusutrombopag is a prescription medicine with approved uses on its FDA label. Indole-3-carbinol is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Lusutrombopag is prescribed for: Mulpleta (lusutrombopag) is used to treat thrombocytopenia — a low platelet count — in adults who have chronic liver disease and are scheduled to have a procedure. Raising the platelet count before the procedure helps reduce the risk of bleeding. Mulpleta is taken for a short, fixed course before the procedure. It is not meant to be used to bring platelet counts all the way to normal, or for long-term management of chronic liver disease.

Indole-3-carbinol has been studied for:

Liver disease studied, not established Indole-3-carbinol has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Indole-3-carbinol for liver disease

Although there has been interest in using oral indole-3-carbinol for liver disease, there is insufficient reliable information about the clinical effects of indole-3-carbinol for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Lusutrombopag on your own; if you are taking Indole-3-carbinol for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Lusutrombopag

This page covers Indole-3-carbinol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lusutrombopag page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 35 moderate · 17 minor.

From our pharmacist’s overview on the Lusutrombopag page

“If you take lusutrombopag (Mulpleta), it is probably a short course meant to raise your platelet count before a procedure, and that narrow window is exactly why these 54 interactions deserve real respect. The two rated major, St.”

Reviewed by 2 · Jul 18, 2026

Open the Lusutrombopag interaction page

One more smart check

Taking Indole-3-carbinol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 287 real supplement products containing Indole-3-carbinol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Indole-3-carbinol. Even though Indole-3-carbinol itself has no known interaction with Lusutrombopag, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Indole-3-carbinol and Lusutrombopag Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Indole-3-carbinol

Top 25%

#332 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Lusutrombopag

Steady interest

#1,606 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Indole-3-carbinol reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Indole-3-carbinol and Lusutrombopag records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Indole-3-carbinol

What is Indole-3-carbinol?

Estrogen and hormone balance support
Breast and cervical health
Prostate health
Antioxidant and 'detox' support
General cancer-prevention interest

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effects. Most human evidence is preliminary or comes from lab and animal studies, so it should not be relied on to prevent or treat any disease. Talk to your pharmacist or doctor before using it, and avoid it in pregnancy and breastfeeding.

Brassicaceae · Derived from glucosinolates found in cruciferous vegetables (broccoli, cabbage, Brussels sprouts, cauliflower) · Capsules, tablets, softgels; sometimes combined with or compared to diindolylmethane (DIM)

An interaction check asks whether these two react with each other — it does not ask whether Indole-3-carbinol is a good idea for someone in your situation. Here is what our Indole-3-carbinol record says about it on its own.

Indole-3-carbinol: dosing

There is no officially established or standardized dose for I3C. Different products and studies have used different amounts, and there is no agreed-upon 'best' dose.The safest approach is to follow the directions on the product label and not exceed them. They can help you decide whether I3C is appropriate for you.

From our Indole-3-carbinol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Indole-3-carbinol monograph & all interactions

Medication

About Lusutrombopag

What Is Lusutrombopag Used For?

Brand name: Mulpleta

Mulpleta (lusutrombopag) is used to treat thrombocytopenia — a low platelet count — in adults who have chronic liver disease and are scheduled to have a procedure. Raising the platelet count before the procedure helps reduce the risk of bleeding.

Mulpleta is taken for a short, fixed course before the procedure. It is not meant to be used to bring platelet counts all the way to normal, or for long-term management of chronic liver disease.

See full Lusutrombopag drug information

Keep checking

Other Drugs & Indole-3-carbinol

Browse every other medication we’ve checked against Indole-3-carbinol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

294Moderate

0Minor

2,535No known interaction

294 Moderate 2,535 No interaction

Moderate

294 interactions

Showing 60 of 294 moderate interactions — see all 294 on the Indole-3-carbinol page.

No interaction 2,535 drugs checked — show the list

We also checked Indole-3-carbinol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,535 medications checked with no known interaction — see the full Indole-3-carbinol list.

See the full Indole-3-carbinol interactions page

See every supplement checked against Lusutrombopag, ranked by severity

Evidence & sources

Indole-3-carbinol References

The 9 references that drive our Indole-3-carbinol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810-5. PubMed
Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123-9. PubMed
He YH, Friesen MD, Ruch RJ, Schut HA. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytoch
Kim, Y. S. and Milner, J. A. Targets for indole-3-carbinol in cancer prevention. J.Nutr.Biochem. 2005;16(2):65-73. PubMed
Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83. PubMed
Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed
Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591-5.
Paliwal P, Chauhan G, Gautam D, Dash D, Patne SCU, Krishnamurthy S. Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(6):613-625. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Indole-3-carbinol and Lusutrombopag Together: Common Questions

Is it safe to take Indole-3-carbinol with Lusutrombopag?

We do not list a known interaction between Indole-3-carbinol and Lusutrombopag. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Are Indole-3-carbinol and Lusutrombopag used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Indole-3-carbinol in each. That is a conversation for your prescriber, especially if Lusutrombopag is being adjusted to a target.

How was the Indole-3-carbinol and Lusutrombopag combination checked?

Interactions in our licensed database are recorded against drug classes. Lusutrombopag is filed under 2 classifications, and Indole-3-carbinol has documented interactions with 3 drug classes — none of Lusutrombopag's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Indole-3-carbinol interact with any other medications?

Yes. Indole-3-carbinol has 294 documented drug interactions in our database — Lusutrombopag is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Lusutrombopag interact with any supplements?

Yes. Lusutrombopag has documented interactions with 54 supplements in our database — Indole-3-carbinol is not one of them. The Lusutrombopag interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Indole-3-carbinol monograph Uses, safety profile, and every drug interaction in one place Lusutrombopag drug information The full plain-English guide to this medication Lusutrombopag supplement interactions Every supplement checked against Lusutrombopag, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lusutrombopag and Indole-3-carbinol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.