Drug & supplement interaction

Rupturewort + Sacubitril, Valsartan

Sacubitril, Valsartan brand name: Entresto.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Rupturewort and Sacubitril, Valsartan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Rupturewort and Sacubitril, Valsartan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sacubitril, Valsartan and Rupturewort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rupturewort safety at a glance

Rupturewort overall Use caution Limited safety data exist, so use carefully and under professional guidance.
Pregnancy Avoid Not enough safety information; traditional diuretic use makes it best avoided in pregnancy.
Breastfeeding Avoid No reliable safety data, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sacubitril, Valsartan and Rupturewort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sacubitril, Valsartan

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sacubitril, Valsartan is filed under 6 classifications — including angiotensin receptor blockers (arbs), potassium-sparing diuretics, diuretic drugs. Rupturewort has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Sacubitril, Valsartan’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rupturewort Does Interact With Other Medications

Rupturewort has 1 moderate known drug interaction in our database — Sacubitril, Valsartan isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Sacubitril, Valsartan)
Taking anything else?

Check Another of Your Medications Against Rupturewort

Covers the 2,830 medications we’ve checked against Rupturewort. Pick one to open its full report.

What to actually watch for

What Sacubitril, Valsartan’s Own FDA Label Lists

This is not an interaction — none of it involves Rupturewort. These are the most notable effects listed in the ADVERSE REACTIONS section of Sacubitril, Valsartan’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • High potassium Worth acting on
  • Heart failure Worth acting on
  • Kidney problems Worth acting on
  • A severe allergic reaction Worth acting on
  • An allergic reaction Worth acting on
  • Cough
  • Low blood pressure
  • Itching
  • Dizziness
  • A skin rash

From the ADVERSE REACTIONS section of the FDA label for Sacubitril, Valsartan. Read the label on DailyMed › Rupturewort’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Rupturewort side to compare — that is a limit of the record, not a statement that Rupturewort has no side effects.

Everything else you take

See Every Supplement That Interacts With Sacubitril, Valsartan

This page covers Rupturewort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sacubitril, Valsartan page lists 249 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 206 moderate · 36 minor.

From our pharmacist’s overview on the Sacubitril, Valsartan page

“Entresto (sacubitril and valsartan) is a heart failure medicine, and heart failure patients tend to be heavy supplement users, reaching for fish oil, potassium, and herbal blood-pressure remedies. That instinct carries real risk here.”

Reviewed by 2 · Jul 18, 2026

Open the Sacubitril, Valsartan interaction page

One more smart check

Taking Rupturewort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 19 real supplement products containing Rupturewort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rupturewort. Even though Rupturewort itself has no known interaction with Sacubitril, Valsartan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rupturewort and Sacubitril, Valsartan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rupturewort
Steady interest

#862 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sacubitril, Valsartan
Top 25%

#330 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rupturewort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rupturewort and Sacubitril, Valsartan records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rupturewort

What is Rupturewort?

  • Urinary tract complaints
  • Mild fluid retention (as a diuretic)
  • Kidney and bladder support
  • Wound healing and inflammation (topical, traditional)
  • Spasms or cramping (traditional)

Rupturewort is a traditional European herb mainly used as a mild diuretic and for urinary complaints. Solid human research is very limited, so its true benefits and long-term safety are not well established. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Herniaria glabra · Caryophyllaceae · Aerial parts (the above-ground flowering herb) · Tea, dried herb, tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Rupturewort is a good idea for someone in your situation. Here is what our Rupturewort record says about it on its own.

Rupturewort: dosing

There is no well-established or standardized dose for rupturewort. Traditional use involves brewing the dried herb as a tea, but reliable dosing guidance from clinical research does not exist.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Rupturewort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rupturewort monograph & all interactions
Medication

About Valsartan and Sacubitril

What Is Valsartan and Sacubitril Used For?

Brand name: Entresto

Sacubitril and valsartan is used to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. The benefit is most clearly seen in patients whose heart pumps with a lower-than-normal ejection fraction (the percentage of blood the heart pushes out with each beat).

It is also approved to treat symptomatic heart failure with reduced left ventricular function in children aged 1 year and older. In pediatric patients, it lowers a blood marker of heart stress (NT-proBNP) and is expected to improve heart outcomes.

See full Valsartan and Sacubitril drug information
Keep checking

Other Drugs & Rupturewort

Browse every other medication we’ve checked against Rupturewort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Rupturewort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Rupturewort list.

See the full Rupturewort interactions page
See every supplement checked against Sacubitril, Valsartan, ranked by severity
Evidence & sources

Rupturewort References

The 1 references that drive our Rupturewort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hakim EM, Sivak KV, Kaukhova IE. Evaluation of the diuretic effect of crude ethanol and saponin-rich extracts of Herniaria glabra L. in rats. J Ethnopharmacol. 2021 Jun 12;273:113942. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rupturewort and Sacubitril, Valsartan Together: Common Questions

Is it safe to take Rupturewort with Sacubitril, Valsartan?
We do not list a known interaction between Rupturewort and Sacubitril, Valsartan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Rupturewort and Sacubitril, Valsartan combination checked?
Interactions in our licensed database are recorded against drug classes. Sacubitril, Valsartan is filed under 6 classifications, and Rupturewort has documented interactions with 1 drug class — none of Sacubitril, Valsartan's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rupturewort interact with any other medications?
Yes. Rupturewort has 1 documented drug interaction in our database — Sacubitril, Valsartan is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sacubitril, Valsartan interact with any supplements?
Yes. Sacubitril, Valsartan has documented interactions with 249 supplements in our database — Rupturewort is not one of them. The Sacubitril, Valsartan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rupturewort monograph Uses, safety profile, and every drug interaction in one place Valsartan and Sacubitril drug information The full plain-English guide to this medication Sacubitril, Valsartan supplement interactions Every supplement checked against Sacubitril, Valsartan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sacubitril, Valsartan and Rupturewort?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.