Medication interaction hub

What Supplements Interact with Sacubitril, Valsartan?

Sacubitril, Valsartan brand name: Entresto. Every interaction below applies to the brands too.

249 Interactions 7 Major 206 Moderate 36 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Sacubitril, Valsartan? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Sacubitril, Valsartan against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Entresto (sacubitril and valsartan) is a heart failure medicine, and heart failure patients tend to be heavy supplement users, reaching for fish oil, potassium, and herbal blood-pressure remedies. That instinct carries real risk here. Of the 249 ingredients on this page, seven carry a major rating, and the bulk of the rest either stack with Entresto's blood-pressure-lowering effect, risking dizziness and fainting, or pile onto its diuretic action and unsettle fluid and potassium balance.

Potassium supplements are a good example: valsartan already holds potassium in the body, so adding more can push levels dangerously high. Activated charcoal, one of the seven majors, causes trouble the opposite way, binding the medicine in the gut so less gets absorbed. With 206 moderate and 36 minor entries beyond the majors, treat anything sold for heart or blood pressure as a probable overlap and check it against the full list first.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 206 Minor 36 No known interaction 1,203

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Sacubitril, Valsartan: Top Interactions at a Glance

The Sacubitril, Valsartan supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 249 interacting ingredients — plus 1,203 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Sacubitril, Valsartan Combinations Today

The Sacubitril, Valsartan + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Berberine + Sacubitril, Valsartani

Theoretically, berberine might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Magnesium + Sacubitril, Valsartani

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.

Read the full interaction Moderate Likelihood Probable Wine + Sacubitril, Valsartani

Theoretically, concomitant use may interfere with blood pressure control.

Read the full interaction Moderate Likelihood Possible Grapefruit + Sacubitril, Valsartani

Theoretically, grapefruit juice might increase levels of drugs metabolized by CYP2C9.

Read the full interaction Moderate Likelihood Possible Sea Buckthorn + Sacubitril, Valsartani

Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Stinging Nettle + Sacubitril, Valsartani

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.

Read the full interaction
The complete list

Every Supplement Checked Against Sacubitril, Valsartan

All 1,452 ingredients in our database, ranked by severity — 249 with a Sacubitril, Valsartan interaction on file and 1,203 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Sacubitril, Valsartan?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Berberine with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might have additive effects with antihypertensive drugs.

Full Berberine + Sacubitril, Valsartan answer

Can you take Magnesium with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.

Full Magnesium + Sacubitril, Valsartan answer

Can you take Wine with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may interfere with blood pressure control.

Full Wine + Sacubitril, Valsartan answer

Can you take Grapefruit with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grapefruit juice might increase levels of drugs metabolized by CYP2C9.

Full Grapefruit + Sacubitril, Valsartan answer

Can you take Sea Buckthorn with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.

Full Sea Buckthorn + Sacubitril, Valsartan answer

Can you take Star Of Bethlehem with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.

Full Star Of Bethlehem + Sacubitril, Valsartan answer

Can you take Stinging Nettle with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining stinging nettle with diuretic drugs may have additive effects.

Full Stinging Nettle + Sacubitril, Valsartan answer

Can you take Strophanthus with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and strophanthus can increase the risk of cardiac glycoside toxicity due to...

Full Strophanthus + Sacubitril, Valsartan answer

Can you take Swamp Milkweed with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, potassium depleting diuretics might increase the risk of toxicity with swamp milkweed.

Full Swamp Milkweed + Sacubitril, Valsartan answer

Can you take Terminalia with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.

Full Terminalia + Sacubitril, Valsartan answer

Can you take Theanine with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.

Full Theanine + Sacubitril, Valsartan answer

Can you take Tinospora Cordifolia with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.

Full Tinospora Cordifolia + Sacubitril, Valsartan answer

Can you take Tragacanth with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Sacubitril, Valsartan answer

Can you take Tree Turmeric with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.

Full Tree Turmeric + Sacubitril, Valsartan answer

Can you take Tribulus with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Full Tribulus + Sacubitril, Valsartan answer

Can you take Uzara with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassi...

Full Uzara + Sacubitril, Valsartan answer

Can you take Vinpocetine with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vinpocetine might increase levels of drugs metabolized by CYP2C9.

Full Vinpocetine + Sacubitril, Valsartan answer

Can you take Vitamin B6 with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Full Vitamin B6 + Sacubitril, Valsartan answer

Can you take Wahoo with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics with wahoo can increase the risk of cardiac glycoside toxicity due to potass...

Full Wahoo + Sacubitril, Valsartan answer

Can you take Wallflower with Sacubitril, Valsartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and wallflower can increase the risk of cardiac glycoside toxicity due to po...

Full Wallflower + Sacubitril, Valsartan answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Sacubitril, Valsartan is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Sacubitril, Valsartan, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Sacubitril, Valsartan sits in 6 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Sacubitril, Valsartan through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Sacubitril, Valsartan through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Sacubitril, Valsartan through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Sacubitril, Valsartan through this category.

Potassium-Sparing Diuretics 8 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

8 of the supplement ingredients on this page reach Sacubitril, Valsartan through this category.

Angiotensin Receptor Blockers (Arbs) 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Sacubitril, Valsartan through this category.

About Sacubitril, Valsartan

Sacubitril and valsartan is a two-drug combination tablet used to treat chronic heart failure in adults and children, reducing the risk of hospitalization and cardiovascular death.

Generic name: Sacubitril, Valsartan  ·  Brand name: Entresto.

See the full Valsartan and Sacubitril drug information

Related: does Sacubitril, Valsartan deplete any nutrients?

Sacubitril, Valsartan has 7 reported nutrient associations in the research literature — see the Sacubitril, Valsartan nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Sacubitril, Valsartan

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Sacubitril, Valsartan.

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Products that contain Sacubitril, Valsartan-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Sacubitril, Valsartan.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Sacubitril, Valsartan & Supplements: Common Questions

What supplements interact with Sacubitril, Valsartan?
More than you might expect — 249 in total, though they are far from equal: 7 are rated major, 206 moderate, and 36 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Sacubitril, Valsartan supplement interactions are the most serious?
The 7 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Lithium — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Sacubitril, Valsartan?
Usually yes — most people on Sacubitril, Valsartan can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Entresto have the same supplement interactions as Sacubitril, Valsartan?
Yes — Entresto all contain Sacubitril, Valsartan, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Sacubitril, Valsartan deplete any vitamins or nutrients?
It might — Sacubitril, Valsartan has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Sacubitril, Valsartan nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Sacubitril, Valsartan and my other medications?
This page covers Sacubitril, Valsartan against supplements and herbal ingredients. Checking Sacubitril, Valsartan against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Valsartan and Sacubitril drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.