Herb & supplement monograph

Tyramine Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Tyramine interacts with medications. The heart of this page is the interaction list — every drug Tyramine is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Tyramine is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Tyramine Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the risk of a clinically significant Tyramine drug interaction is real and can be serious for many people, especially those taking blood pressure medicines or certain antidepressants. About half of the listed interactions are rated major, and the most important ones are backed by human studies showing tyramine can raise blood pressure.

Interactions deserving the most attention

The combination that deserves the most caution is tyramine with monoamine oxidase inhibitors (MAOIs). These medicines block the enzyme the body uses to break down tyramine, and numerous reports link the combination to severe headaches, high blood pressure, and hypertensive crisis. Tyramine can also work against blood pressure medications, since human studies show it raises systolic blood pressure and may blunt their effect. Both concerns are well documented in people, not just in theory.

What the rest of the list means

The rest of the long list is far less worrying. Most of the remaining interactions are rated minor, and concerns with alcohol and stimulant drugs are theoretical, based on lab research or the idea that tyramine has mild stimulant effects rather than on proven harm in people.

Check your medications against Tyramine

Based on HelloPharmacist’s Tyramine interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Tyramine

353 medications have a known interaction with Tyramine, graded by severity. Select any drug for the full evidence-based detail.

181 major interactions. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Tyramine.

2,830 drugs
AcebutololRhotral, Sectral› AcetazolamideAk-Zol, Diamox› AliskirenTekturna› AmbrisentanLetairis, Volibris› AmilorideAmilamont, Midamor› Amiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic› AmlodipineNorliqva› Amlodipine BenzoateKaterzia› Amlodipine BesilateIstin› Amlodipine BesylateNorvasc› Amlodipine Besylate, BenazeprilLotrel› Amlodipine, CelecoxibConsensi› Ammonium ChlorideAmmonium Chloride› AmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis› AprocitentanTryvio› AtenololAtenix, Tenormin› Atenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic› Atenolol, ChlorthalidoneTenoretic› AzilsartanEdarbi› Azilsartan, ChlorthalidoneEdarbyclor› BenazeprilLotensin› Benazepril, HydrochlorothiazideLotensin HCT› BendroflumethiazideAprinox, Naturetin, Neo-NaClex› Bendroflumethiazide, NadololCorzide› Bendroflumethiazide, Rauwolfia SerpentinaRauzide› BenzthiazideExna› BetaxololBetoptic, Kerlone› BisoprololZebeta› Bisoprolol, HydrochlorothiazideZiac› BosentanTracleer›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Tyramine combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Tyramine affects

Every type of medication (drug category) Tyramine is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 4 drug categories Tyramine interacts with
Antihypertensive DrugsMonoamine Oxidase Inhibitors (maois)AlcoholStimulant Drugs
Antihypertensive Drugs

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.
In humans, oral and intravenous tyramine increases systolic blood pressure.

Likelihood Likely Evidence B
Monoamine Oxidase Inhibitors (Maois)

Concomitant use of tyramine with MAOIs may increase the risk of serious adverse effects from tyramine.
Tyramine is metabolized by monoamine oxidase. Concurrent use of MAOIs with tyramine can lead to elevated levels of tyramine in the body. This can increase the effects of tyramine, which has been reported to cause hypertension, headache, and hypertensive crisis in numerous cases. Sensitivity to tyramine can increase up to 10-fold to 100-fold in people using an MAOI. The European Food Safety Authority states that meals containing more than 50 mg of tyramine might present a risk to patients that are using third generation MAOI medications. Meals containing more than 6 mg of tyramine are likely to present a risk to patients who are taking classic MAOI medications.

Likelihood Likely Evidence B
Alcohol

Theoretically, concomitant use of alcohol and tyramine might increase the risk of adverse effects from tyramine.
In vitro research suggests that alcohol may potentiate the toxic effects of biogenic amines, including tyramine, possibly by decreasing their breakdown.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, taking tyramine with stimulant drugs might increase the risk of adverse cardiovascular effects.
Tyramine is thought to have stimulant effects.

Likelihood Possible Evidence D
Monograph

Tyramine: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Tyramine is a natural compound formed when certain proteins break down, and it is found in aged cheeses, cured meats, fermented foods, and some other items. It is not a typical health supplement and is best known for the problems it can cause—such as dangerous spikes in blood pressure—in people taking certain medications or in those who are sensitive to it. If you have been told to follow a low-tyramine diet, talk with your pharmacist or doctor before making changes.

Part used
Not a plant part; tyramine is a naturally occurring compound found in many foods
Common forms
Naturally present in aged and fermented foods; not commonly sold as a stand-alone supplement
People commonly use it for
  • Studied for effects on blood pressure
  • Discussed in relation to migraine and headache triggers
  • Of interest in food and diet science
  • Subject of research on the nervous system

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Tyramine in normal foods is fine for most people, but it can be harmful for those who are sensitive or taking certain drugs.

PregnancyInsufficient reliable information

Insufficient reliable information is available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information is available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Tyramine is a natural compound called a monoamine. It is made in the body and in foods when an amino acid named tyrosine breaks down. This often happens as foods age, ferment, or spoil.

Because of this, tyramine builds up in foods like aged cheeses, cured or smoked meats, fermented soy products (such as soy sauce and miso), sauerkraut, certain beans, draft beer, and some wines. The longer many of these foods sit, the more tyramine they tend to have.

Unlike most herbs or supplements, tyramine is not something people usually take on purpose to improve health. It is mostly discussed in nutrition and medicine because of the effects it can have on blood pressure and the nervous system, and because some people are told to limit it.

How it works

Tyramine can cause the body to release norepinephrine, a chemical that raises blood pressure and heart rate. Normally, the body has an enzyme called monoamine oxidase (MAO) that quickly breaks tyramine down in the gut and liver, so most of it never causes problems.

The trouble comes when that breakdown is blocked or overwhelmed. If MAO is not working well—or if a person eats a large amount of high-tyramine food at once—tyramine can build up. This can trigger a sudden release of norepinephrine and a sharp rise in blood pressure.

These mechanisms are well described in pharmacology, but they explain tyramine's risks rather than any health benefit.

Effectiveness

Does Tyramine work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 2 uses evaluated
2 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Tyramine, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 2 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral tyramine for athletic performance, there is insufficient reliable information about the clinical effects of tyramine for this purpose.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral tyramine for obesity, there is insufficient reliable information about the clinical effects of tyramine for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

For most healthy people, the tyramine found in a normal diet is handled by the body without any problem. However, some people are more sensitive and may react to high-tyramine foods.

People who should be especially careful include those who have been told to follow a low-tyramine diet, those with certain blood pressure issues, and anyone advised by their doctor or pharmacist to limit it. A large amount of tyramine in a sensitive person can cause a dangerous spike in blood pressure, sometimes called a hypertensive crisis.

Pregnancy: Tyramine from ordinary food is generally fine, but taking it in concentrated or supplement form is not recommended and has not been well studied. Breastfeeding: The same caution applies—normal food amounts are generally fine, but deliberate supplemental use is not advised. When in doubt, ask your pharmacist or doctor.

Side effects

From everyday foods, tyramine usually causes no symptoms in healthy people. In sensitive individuals or in those whose ability to break it down is reduced, tyramine can cause:

  • Headache, sometimes severe
  • High blood pressure, which may rise suddenly
  • Flushing, sweating, or a pounding heartbeat
  • Nausea

A very high rise in blood pressure can be a medical emergency. Warning signs include a severe sudden headache, chest pain, vision changes, or trouble breathing. If these happen, seek emergency care right away.

Tyramine: Reported Adverse Effects

Documented safety reports on Tyramine from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, tyramine that occurs naturally in foods seems to be generally well tolerated when consumed in quantities of no more than 600 mg per meal. Higher quantities might increase the risk for adverse effects.

Reports by condition
Angina Cardiovascular

Orally and intravenously, unspecified doses of tyramine have increased systolic, but not diastolic, blood pressure. Intravenous tyramine is not used clinically but is commonly used to examine safety and interaction outcomes. A single dose of oral tyramine 400 mg has been reported to cause heart palpitations and elevations in systolic blood pressure in healthy volunteers. In one case series, consuming foods thought to contain tyramine, including cheese, was associated with hypertension. However, tyramine levels of the implicated foods were not determined.

In a previously healthy, 39-year-old male, chronic use of a multi-ingredient sports supplement was associated with the development of a thrombus, angina, and acute myocardial infarction. The product claimed to contain synephrine 40 mg, caffeine 400 mg, and unspecified amounts of octopamine and tyramine, in addition to various other products such as St. John's Wort. It is not clear if these effects were due to tyramine, the other ingredients, the patient's concomitant dehydration, or a combination of these factors.

  1. VanDenBerg CM, Blob LF, Kemper EM, Azzaro AJ. Tyramine pharmacokinetics and reduced bioavailability with food. J Clin Pharmacol. 2003;43(6):604-9.
  2. Meck JV, Martin DS, D'Aunno DS, Waters WW. Pressor response to intravenous tyramine is a marker of cardiac, but not vascular, adrenergic function. J Cardiovasc Pharmacol. 2003;41(1):126-31.
  3. Colombo F, Porro T, del Rosso G, Bertalero P, Orlandi L, Libretti A. Cardiovascular responses to physical exercise and tyramine infusion in hypertensive and normotensive subjects. J Hum Hypertens. 1989;3(4):245-9.
  4. Pace DG, Reele SB, Rozik LM, Rogers-Phillips CA, Dabice JA, Givens SV. Evaluation of methods of administering tyramine to raise systolic blood pressure. Clin Pharmacol Ther. 1988;44(2):137-44.
  5. Rafehi M, Faltraco F, Matthaei J, et al. Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A. Front Pharmacol. 2019 Oct 30;10:1297.
  6. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.
  7. Smedema JP, Müller GJ. Coronary spasm and thrombosis in a bodybuilder using a nutritional supplement containing synephrine, octopamine, tyramine and caffeine. S Afr Med J. 2008;98(5):372-3.
Cluster headache Neurologic/CNS

Orally, a single dose of tyramine 400 mg has been reported to cause dry mouth, restlessness, dizziness, and headache in healthy volunteers. In a case series, consuming foods thought to contain tyramine, including cheese, was associated with headache, dizziness, memory dysfunction, blurred vision, numbness, and tingling. However, tyramine levels of the implicated foods were not determined.

  1. Rafehi M, Faltraco F, Matthaei J, et al. Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A. Front Pharmacol. 2019 Oct 30;10:1297.
  2. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.
Panic disorder Psychiatric

In a case series, consuming foods thought to contain tyramine, including cheese, was associated with panic attacks with palpitations. However, tyramine levels of the implicated foods were not determined.

  1. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no recommended supplement dose for tyramine, because it is not meant to be taken as a health product. Instead, the main guidance is about how much tyramine to allow in the diet for people who are sensitive to it.

If you have been placed on a low-tyramine diet, the goal is usually to limit aged, fermented, cured, or spoiled foods rather than to count exact milligrams. Your pharmacist or doctor can give you a food list suited to your situation.

Do not try to take tyramine on purpose. If you see a product that contains it, talk with a pharmacist before using it.

Pregnancy & Breastfeeding

Tyramine & Pregnancy

Insufficient reliable information

Insufficient reliable information is available; avoid using.

Tyramine & Breastfeeding

Insufficient reliable information

Insufficient reliable information is available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 15 references that drive our Tyramine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal 2017;9:500-517. PubMed
  2. Smedema JP, Müller GJ. Coronary spasm and thrombosis in a bodybuilder using a nutritional supplement containing synephrine, octopamine, tyramine and caffeine. S Afr Med J. 2008;98(5):372-3.
  3. Gilliam LK, Palmer JP, Taborsky GJ Jr. Tyramine-mediated activation of sympathetic nerves inhibits insulin secretion in humans. J Clin Endocrinol Metab. 2007;92(10):4035-8. PubMed
  4. VanDenBerg CM, Blob LF, Kemper EM, Azzaro AJ. Tyramine pharmacokinetics and reduced bioavailability with food. J Clin Pharmacol. 2003;43(6):604-9. DOI
  5. Meck JV, Martin DS, D'Aunno DS, Waters WW. Pressor response to intravenous tyramine is a marker of cardiac, but not vascular, adrenergic function. J Cardiovasc Pharmacol. 2003;41(1):126-31. PubMed
  6. Peet M, Yates RA, Carroll JA, Middlemiss DN. The interaction of tyramine with a single dose of tranylcypromine in healthy volunteers. Br J Clin Pharmacol. 1981;11(2):212-4. PubMed
  7. Del Rio B, Redruello B, Linares DM, et al. The dietary biogenic amines tyramine and histamine show synergistic toxicity towards intestinal cells in culture. Food Chem. 2017;218:249-255. PubMed
  8. Linares DM, del Rio B, Redruello B, et al. Comparative analysis of the in vitro cytotoxicity of the dietary biogenic amines tyramine and histamine. Food Chem. 2016;197(Pt A):658-63. PubMed
  9. National Institutes of Health. Dietary Supplement Label Database. http://www.dsld.nlm.nih.gov/dsld/rptQSearch.jsp?item=tyramine&db=adsld. Accessed October 23, 2019.
  10. Rapaport MH. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: the state of the art. J Clin Psychiatry. 2007;68 Suppl 8:42-6.
  11. Colombo F, Porro T, del Rosso G, Bertalero P, Orlandi L, Libretti A. Cardiovascular responses to physical exercise and tyramine infusion in hypertensive and normotensive subjects. J Hum Hypertens. 1989;3(4):245-9.
  12. Pace DG, Reele SB, Rozik LM, Rogers-Phillips CA, Dabice JA, Givens SV. Evaluation of methods of administering tyramine to raise systolic blood pressure. Clin Pharmacol Ther. 1988;44(2):137-44. PubMed
  13. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.
  14. European Food Safety Authority. Scientific opinion on risk based control of biogenic amine formation in fermented foods. EFSA Journal. 2011;9(10):2393. DOI
  15. Rafehi M, Faltraco F, Matthaei J, et al. Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A. Front Pharmacol. 2019 Oct 30;10:1297. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Tyramine

12 brands in our database make a supplement containing Tyramine.

Product directory

Supplement products with Tyramine

20 products in our database contain Tyramine. Open any to see its full ingredient list and every drug interaction we check.

2 Methyl 13-C by Iron-Tek Capsule 120 Capsule(s) View ingredients & interactions Black Mamba Hyperbrush by Innovative Diet Labs Capsule 90 Capsule(s) View ingredients & interactions D-Stunner Fruit Punch by Betancourt Nutrition Powder 9.2 oz. · 260.4 Gram(s) View ingredients & interactions D-Stunner Grape by Betancourt Nutrition Powder 9.2 oz. · 260.4 Gram(s) View ingredients & interactions Diablos ECA Fire Caps by Innovative Laboratories Capsule 90 Capsule(s) View ingredients & interactions Diablos Hyperburn 6.0 by Innovative Laboratories Capsule 100 Capsule(s) View ingredients & interactions Final Cutz by Infinite Labs Capsule 100 Capsule(s) View ingredients & interactions Final Cutz by Infinite Labs Capsule 100 Capsule(s) View ingredients & interactions Lipo 6X by Nutrex Research Capsule 120 Multi-Phase Capsule(s) View ingredients & interactions Lipo 6X by Nutrex Research Capsule 240 Multi-Phase Capsule(s) View ingredients & interactions Mr Hyde Intense Energy Pre Workout Fruit Punch by PS ProSupps Powder 9.4 Ounce(s) · 268 Gram(s) View ingredients & interactions Oxotrim With Meratrim by NewtonEverett Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Phenyl Core by Infinite Labs Capsule 100 Capsule(s) View ingredients & interactions TNT Thermanite by GEC Genetic Edge Compounds Capsule 60 Capsule(s) View ingredients & interactions Ultimate Burn by Schwartz Laboratories Capsule 90 Capsule(s) View ingredients & interactions Advantrim 1166 mg by NewtonEverett Capsule 90 Vegetarian Capsule(s) Off market View ingredients & interactions Arsenal Liquid-Gels by PMD Platinum Capsule 120 Capsule(s) Off market View ingredients & interactions Diablos ECA Fire Caps by Innovative Laboratories Capsule 100 Capsule(s) Off market View ingredients & interactions Diablos ECA Fire Caps by Innovative Bio-Labs Capsule 100 Capsule(s) Off market View ingredients & interactions Phenyl Core by Infinite Labs Capsule 100 Capsule(s) Off market View ingredients & interactions
Pharmacist Counseling Corner

Tyramine: Common Questions

What is Tyramine used for, and does it work?
People use Tyramine for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Tyramine interact with prescription medications?
Yes. We list 353 medications with a known interaction with Tyramine, including 181 rated major. Use the checker above to see how Tyramine interacts with a specific drug.
How are Tyramine interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Tyramine with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Tyramine interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Tyramine and where does it come from?
Tyramine is a natural compound that forms when proteins break down. It is found in aged cheeses, cured and smoked meats, fermented foods, draft beer, and some wines, and it is also made in the body.
Is Tyramine dangerous?
For most healthy people, the Tyramine in food is broken down safely and causes no problems. It can be dangerous for people who are sensitive to it or who have been told to limit it, because it may cause a sudden, sharp rise in blood pressure.
Should I avoid foods with Tyramine?
Most people do not need to avoid them. You only need to limit high-Tyramine foods if your doctor or pharmacist has told you to follow a low-Tyramine diet.
Can Tyramine cause headaches?
Some people feel that high-Tyramine foods trigger their migraines, but the research is mixed. If you notice a pattern, keeping a food and headache diary and discussing it with your doctor can help.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Tyramine

A rotating sample of real supplements in our database that list Tyramine — open any to see its full ingredients and every drug interaction we check.

See all 20 products with Tyramine →
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