Drug & supplement interaction

Tyramine + Diclofenac Sodium

Diclofenac Sodium brand names: Voltaren XR, Voltaren, Voltaren SR, Diclo, Difenac, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tyramine and Diclofenac Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tyramine and Diclofenac Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diclofenac Sodium and Tyramine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tyramine safety at a glance

Tyramine overall Use caution Tyramine in normal foods is fine for most people, but it can be harmful for those who are sensitive or taking certain drugs.
Pregnancy Use caution Tyramine from ordinary food is generally fine, but concentrated supplemental use is not recommended and not well studied.
Breastfeeding Use caution Tyramine from a normal diet is generally fine, but deliberately taking it in supplement form is not advised due to a lack of safety data.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diclofenac Sodium and Tyramine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Diclofenac Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diclofenac Sodium is filed under 11 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, anticoagulant/antiplatelet drugs. Tyramine has documented interactions with 4 drug classes — the most serious being antihypertensive drugs (major), monoamine oxidase inhibitors (maois) (major) and alcohol (moderate) — and none of Diclofenac Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tyramine Does Interact With Other Medications

Tyramine has 181 major, 1 moderate, 171 minor known drug interactions in our database — Diclofenac Sodium isn’t one of them. If you take anything else, check it against the full list below.

Major 181 Moderate 1 Minor 171 No known interaction 2,477 (incl. Diclofenac Sodium)
Taking anything else?

Check Another of Your Medications Against Tyramine

Covers the 2,830 medications we’ve checked against Tyramine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Tyramine and Diclofenac Sodium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • A heart attack / Chest pain / Raised blood pressure Worth acting on Additional detail

    Tyramine

    “Orally and intravenously, unspecified doses of tyramine have increased systolic, but not diastolic, blood pressure. Intravenous tyramine is not used clinically but is commonly used to examine safety and interaction outcomes. A single dose of oral tyramine 400 mg has been reported to cause heart palpitations and elevations in systolic blood pressure in healthy volunteers.”

    Tyramine · Natural Medicines adverse-effect record, reported in angina.

    6 sources cited
    1. 100189. VanDenBerg CM, Blob LF, Kemper EM, Azzaro AJ. Tyramine pharmacokinetics and reduced bioavailability with food. J Clin Pharmacol. 2003;43(6):604-9. DOI
    2. 100190. Meck JV, Martin DS, D'Aunno DS, Waters WW. Pressor response to intravenous tyramine is a marker of cardiac, but not vascular, adrenergic function. J Cardiovasc Pharmacol. 2003;41(1):126-31. PubMed
    3. 101013. Colombo F, Porro T, del Rosso G, Bertalero P, Orlandi L, Libretti A. Cardiovascular responses to physical exercise and tyramine infusion in hypertensive and normotensive subjects. J Hum Hypertens. 1989;3(4):245-9.
    4. 101014. Pace DG, Reele SB, Rozik LM, Rogers-Phillips CA, Dabice JA, Givens SV. Evaluation of methods of administering tyramine to raise systolic blood pressure. Clin Pharmacol Ther. 1988;44(2):137-44. PubMed
    5. 105519. Rafehi M, Faltraco F, Matthaei J, et al. Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A. Front Pharmacol. 2019 Oct 30;10:1297. PubMed
    6. 101018. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.

    Diclofenac Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›

  • Blurred vision / Dry mouth / Numbness or tingling / Dizziness / Headache Additional detail

    Tyramine

    “Orally, a single dose of tyramine 400 mg has been reported to cause dry mouth, restlessness, dizziness, and headache in healthy volunteers. In a case series, consuming foods thought to contain tyramine, including cheese, was associated with headache, dizziness, memory dysfunction, blurred vision, numbness, and tingling. However, tyramine levels of the implicated foods were not determined.”

    Tyramine · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 105519. Rafehi M, Faltraco F, Matthaei J, et al. Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A. Front Pharmacol. 2019 Oct 30;10:1297. PubMed
    2. 101018. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.

    Diclofenac Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Tyramine

    “In a case series, consuming foods thought to contain tyramine, including cheese, was associated with panic attacks with palpitations. However, tyramine levels of the implicated foods were not determined.”

    Tyramine · Natural Medicines adverse-effect record, reported in panic disorder.

    1 source cited
    1. 101018. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.

    Diclofenac Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Tyramine

    Recorded for Tyramine in the same Natural Medicines adverse-effect record shown under Blurred vision / Dry mouth / Numbness or tingling / Dizziness / Headache above.

    Diclofenac Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›

Reported for Tyramine but not commonly for Diclofenac Sodium: dehydration.

Effects for Diclofenac Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Tyramine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 155,962 voluntary FDA FAERS reports for Diclofenac Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Tyramine or Diclofenac Sodium

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Tyramine or Diclofenac Sodium, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diclofenac Sodium

This page covers Tyramine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diclofenac Sodium page lists 308 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 266 moderate · 35 minor.

From our pharmacist’s overview on the Diclofenac Sodium page

“Diclofenac (Voltaren), a daily mainstay for arthritis and joint pain, comes with a supplement list that calls for real vigilance. Of the 308 ingredients on file, 7 rate major, and roughly two hundred entries share a single theme: anything with blood-thinning activity adds to diclofenac's own bleeding risk, especially in the stomach.”

Reviewed by 2 · Jul 18, 2026

Open the Diclofenac Sodium interaction page

One more smart check

Taking Tyramine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 20 real supplement products containing Tyramine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tyramine. Even though Tyramine itself has no known interaction with Diclofenac Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tyramine and Diclofenac Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tyramine
Steady interest

#732 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diclofenac Sodium
Top 10%

#255 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tyramine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tyramine and Diclofenac Sodium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tyramine

What is Tyramine?

  • Studied for effects on blood pressure
  • Discussed in relation to migraine and headache triggers
  • Of interest in food and diet science
  • Subject of research on the nervous system

Tyramine is a natural compound formed when certain proteins break down, and it is found in aged cheeses, cured meats, fermented foods, and some other items. It is not a typical health supplement and is best known for the problems it can cause—such as dangerous spikes in blood pressure—in people taking certain medications or in those who are sensitive to it. If you have been told to follow a low-tyramine diet, talk with your pharmacist or doctor before making changes.

Not a plant part; tyramine is a naturally occurring compound found in many foods · Naturally present in aged and fermented foods; not commonly sold as a stand-alone supplement

An interaction check asks whether these two react with each other — it does not ask whether Tyramine is a good idea for someone in your situation. Here is what our Tyramine record says about it on its own.

Tyramine: dosing

There is no recommended supplement dose for tyramine, because it is not meant to be taken as a health product. Instead, the main guidance is about how much tyramine to allow in the diet for people who are sensitive to it.If you have been placed on a low-tyramine diet, the goal is usually to limit aged, fermented, cured, or spoiled foods rather than to count exact milligrams. Your pharmacist or doctor can give you a food list suited to your situation.Do not try to take tyramine on purpose.

From our Tyramine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tyramine monograph & all interactions
Medication

About Diclofenac

What Is Diclofenac Used For?

Brand names: Voltaren XR, Voltaren, Voltaren SR, Diclo, Difenac, Diclo SR, Voltarol, Acoflam, Defenac, Dicloflex, Diclovol, Diclozip, Fenactol, Flamrase, Volraman, Diclomax SR, Diclomax Retard, Motifene 75 mg, Voltarol 75 mg SR, Acoflam 75 SR, Defenac SR, Dexomon 75 SR, Dicloflex 75 SR, Diclovol SR, Fenactol 75 mg SR, Flamatak 75 MR, Flamrase SR, Flexotard MR 75, Rheumatac Retard 75, Rhumalgan CR, Slofenac SR, Volsaid Retard 75, Voltarol Retard, Acoflam Retard, Defenac Retard, Dexomon Retard 100, Dicloflex Retard, Diclovol Retard, Fenactol Retard 100 mg, Flamatak 100 MR, Volsaid Retard 100, Voltarol Ophtha Multidose, Voltarol Ophtha, Pennsaid, Voltaren Emulgel, Dyloject

Diclofenac sodium topical gel is used to treat actinic keratoses (AK) — rough, scaly skin patches that form after years of sun exposure. These patches are considered precancerous, meaning they can develop into skin cancer if left untreated.

This is a topical gel, meaning it is applied directly to the skin over the affected area rather than taken by mouth. It belongs to the NSAID (nonsteroidal anti-inflammatory drug) family.

Most-Reported Side Effects for Diclofenac Sodium

From FAERS, the FDA’s public side-effect reporting system (155,962 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 13,844 reports
Arthralgia 11,333 reports
Rash 10,855 reports
Rheumatoid arthritis 10,744 reports
Abdominal discomfort 9,636 reports
See full Diclofenac drug information
Keep checking

Other Drugs & Tyramine

Browse every other medication we’ve checked against Tyramine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

181Major
1Moderate
171Minor
2,476No known interaction
181 Major 1 Moderate 171 Minor 2,476 No interaction
Major

181 interactions

Showing 60 of 181 major interactions — see all 181 on the Tyramine page.

Moderate

1 interaction

Minor

171 interactions

Showing 60 of 171 minor interactions — see all 171 on the Tyramine page.

No interaction 2,476 drugs checked — show the list

We also checked Tyramine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,476 medications checked with no known interaction — see the full Tyramine list.

See the full Tyramine interactions page
See every supplement checked against Diclofenac Sodium, ranked by severity
Evidence & sources

Tyramine References

The 15 references that drive our Tyramine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal 2017;9:500-517. PubMed
  2. Smedema JP, Müller GJ. Coronary spasm and thrombosis in a bodybuilder using a nutritional supplement containing synephrine, octopamine, tyramine and caffeine. S Afr Med J. 2008;98(5):372-3.
  3. Gilliam LK, Palmer JP, Taborsky GJ Jr. Tyramine-mediated activation of sympathetic nerves inhibits insulin secretion in humans. J Clin Endocrinol Metab. 2007;92(10):4035-8. PubMed
  4. VanDenBerg CM, Blob LF, Kemper EM, Azzaro AJ. Tyramine pharmacokinetics and reduced bioavailability with food. J Clin Pharmacol. 2003;43(6):604-9. DOI
  5. Meck JV, Martin DS, D'Aunno DS, Waters WW. Pressor response to intravenous tyramine is a marker of cardiac, but not vascular, adrenergic function. J Cardiovasc Pharmacol. 2003;41(1):126-31. PubMed
  6. Peet M, Yates RA, Carroll JA, Middlemiss DN. The interaction of tyramine with a single dose of tranylcypromine in healthy volunteers. Br J Clin Pharmacol. 1981;11(2):212-4. PubMed
  7. Del Rio B, Redruello B, Linares DM, et al. The dietary biogenic amines tyramine and histamine show synergistic toxicity towards intestinal cells in culture. Food Chem. 2017;218:249-255. PubMed
  8. Linares DM, del Rio B, Redruello B, et al. Comparative analysis of the in vitro cytotoxicity of the dietary biogenic amines tyramine and histamine. Food Chem. 2016;197(Pt A):658-63. PubMed
  9. National Institutes of Health. Dietary Supplement Label Database. http://www.dsld.nlm.nih.gov/dsld/rptQSearch.jsp?item=tyramine&db=adsld. Accessed October 23, 2019.
  10. Rapaport MH. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: the state of the art. J Clin Psychiatry. 2007;68 Suppl 8:42-6.
  11. Colombo F, Porro T, del Rosso G, Bertalero P, Orlandi L, Libretti A. Cardiovascular responses to physical exercise and tyramine infusion in hypertensive and normotensive subjects. J Hum Hypertens. 1989;3(4):245-9.
  12. Pace DG, Reele SB, Rozik LM, Rogers-Phillips CA, Dabice JA, Givens SV. Evaluation of methods of administering tyramine to raise systolic blood pressure. Clin Pharmacol Ther. 1988;44(2):137-44. PubMed
  13. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.
  14. European Food Safety Authority. Scientific opinion on risk based control of biogenic amine formation in fermented foods. EFSA Journal. 2011;9(10):2393. DOI
  15. Rafehi M, Faltraco F, Matthaei J, et al. Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A. Front Pharmacol. 2019 Oct 30;10:1297. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tyramine and Diclofenac Sodium Together: Common Questions

Is it safe to take Tyramine with Diclofenac Sodium?
We do not list a known interaction between Tyramine and Diclofenac Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tyramine and Diclofenac Sodium have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Tyramine and Diclofenac Sodium combination checked?
Interactions in our licensed database are recorded against drug classes. Diclofenac Sodium is filed under 11 classifications, and Tyramine has documented interactions with 4 drug classes — none of Diclofenac Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Tyramine interact with any other medications?
Yes. Tyramine has 353 documented drug interactions in our database — Diclofenac Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Diclofenac Sodium interact with any supplements?
Yes. Diclofenac Sodium has documented interactions with 308 supplements in our database — Tyramine is not one of them. The Diclofenac Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tyramine monograph Uses, safety profile, and every drug interaction in one place Diclofenac drug information The full plain-English guide to this medication Diclofenac Sodium supplement interactions Every supplement checked against Diclofenac Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 15 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diclofenac Sodium and Tyramine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.