Diclofenac

Generic name: Pronounced as (dye kloe' fen ak)
Brand names
  • Cambia®
  • Cataflam®
  • Voltaren XR®
  • Zipsor®
  • Zorvolex®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2021

People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as diclofenac may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as diclofenac if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take diclofenac right before or right after the surgery.

NSAIDs such as diclofenac may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while taking diclofenac. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking diclofenac and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to diclofenac. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with diclofenac and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

Diclofenac capsules (Zipsor, Zorvolex) and tablets (Cataflam) are used to relieve mild to moderate pain. Diclofenac extended-release tablets (Voltaren XR), tablets (Cataflam), and delayed-release tablets (available generically) are used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Diclofenac extended-release tablets and delayed-release tablets are also used to treat ankylosing spondylitis (arthritis that mainly affects the spine). Diclofenac tablets (Cataflam) are also used to treat painful menstrual periods. Diclofenac solution (Cambia) is used to treat migraine headaches in adults, but cannot be used to prevent migraines or to treat other types of headaches. Diclofenac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

Diclofenac comes as a tablet, and liquid-filled capsule, a hard gelatin capsule, an extended-release (long-acting) tablet, a delayed-release (releases medication in the intestine) tablet, and as packets of powder for solution (to be mixed with water) and taken by mouth. Diclofenac liquid-filled capsules are usually taken 4 times a day and diclofenac hard gelatin capsules are usually taken 3 times a day on an empty stomach. Diclofenac extended-release tablets are usually taken once a day, and in rare cases are taken twice a day, if needed to control pain. Diclofenac tablets and diclofenac delayed-release tablets are usually taken 2, 3, or 4 times a day. Diclofenac solution is taken without food as a one dose treatment to relieve the pain of migraine headaches. If you were told to take diclofenac on a regular basis, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take diclofenac exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Different diclofenac products release the medication differently in your body and cannot be used interchangeably. Only take the diclofenac product prescribed by your doctor and do not switch to a different diclofenac product unless your doctor says that you should.

Your doctor may adjust the dose of your medication during your treatment depending on your response to the medication. Talk to your doctor about how you are feeling during your treatment with diclofenac.

If you are taking the powder for solution, you will need to mix it with water before you take it. To mix the medication, first remove one packet from a row of three attached packets. Place 2 to 4 tablespoons (1 to 2 ounces; 30 to 60 mL) of water in a cup. Add the contents of the packet and mix well. Drink the entire mixture right away. Throw away the empty packet in a trash can that is out of the reach of children and pets.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking diclofenac,

  • tell your doctor and pharmacist if you are allergic to diclofenac (also available as Solaraze and Pennsaid, in Arthrotec), aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), any other medications, or any of the inactive ingredients in the diclofenac product you plan to take. Ask your pharmacist or check the medication guide for a list of the inactive ingredients. If you will be taking diclofenac capsules (Zipsor), tell your doctor if you are allergic to bovine (cow) proteins such as those found in milk, beef, or gelatin.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: acetaminophen (Tylenol, in other products), angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such as azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); diuretics ('water pills'); insulin and oral medication for diabetes; lithium (Lithobid); medications for seizures; methotrexate (Otrexup, Rasuvo, Trexall), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), and voriconazole (Vfend). Many other medications may also interact with diclofenac, so be sure to tell your doctor about all the medications you are taking even if they do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); porphyria (an abnormal increase in the amount of certain natural substances made by the liver); heart failure; swelling of the hands, feet, ankles, or lower legs; or liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant; or are breast-feeding. Diclofenac may harm the fetus and cause problems with delivery if it is taken around 20 weeks or later during pregnancy. Do not take diclofenac around or after 20 weeks of pregnancy, unless you are told to do so by your doctor. If you become pregnant while taking diclofenac, call your doctor.

  • talk to your doctor about the risks and benefits of taking diclofenac if you are 75 years of age or older. Do not take this medication for a longer period of time or at a higher dose than recommended by your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking diclofenac.

  • if you have phenylketonuria (PKU; an inherited condition in which a special diet must be followed to prevent mental retardation), you should know that the powder for solution contains aspartame, a source of phenylalanine.

Unless your doctor tells you otherwise, continue your normal diet.

The powder for solution is usually taken as needed for migraine headaches. If you are taking any other diclofenac product and you forget to take a dose, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Diclofenac may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • constipation

    • gas or bloating

    • headache

    • dizziness

    • ringing in the ears

  • Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical help. Do not take any more diclofenac until you speak to your doctor.

    • unexplained weight gain

    • shortness of breath or difficulty breathing

    • swelling of the abdomen, feet, ankles, or lower legs

    • excessive tiredness

    • lack of energy

    • nausea

    • loss of appetite

    • itching

    • pain in the upper right part of the stomach

    • yellowing of the skin or eyes

    • flu-like symptoms

    • fever

    • blisters

    • rash

    • hives

    • swelling of the eyes, face, tongue, lips, throat, arms, or hands

    • difficulty breathing or swallowing

    • hoarseness

    • pale skin

    • fast heartbeat

    • cloudy, discolored, or bloody urine

    • back pain

    • difficult or painful urination

  • Diclofenac may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • nausea

  • vomiting

  • stomach pain

  • bloody, black, or tarry stools

  • vomiting a substance that is bloody or looks like coffee grounds

  • drowsiness

  • slow, shallow, or irregular breathing

  • loss of consciousness

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Diclofenac can be decreased when combined with Moxifloxacin.
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Diclofenac.
Montelukast Montelukast The metabolism of Diclofenac can be decreased when combined with Montelukast.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Diclofenac can be increased when combined with Insulin glargine.
Leflunomide Leflunomide The serum concentration of Diclofenac can be decreased when it is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Diclofenac can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Diclofenac can be increased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Diclofenac.
Alendronate Alendronate The risk or severity of adverse effects can be increased when Diclofenac is combined with Alendronic acid.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Diclofenac.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Diclofenac.
Candesartan Candesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Candesartan is combined with Diclofenac.
Cilostazol Cilostazol The risk or severity of bleeding can be increased when Diclofenac is combined with Cilostazol.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Diclofenac is combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole Diclofenac may decrease the excretion rate of Erythromycin which could result in a higher serum level.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Diclofenac may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate Diclofenac may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The therapeutic efficacy of Guanfacine can be decreased when used in combination with Diclofenac.
Magnesium Hydroxide Magnesium Hydroxide Diclofenac may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Diclofenac.
Mycophenolate Mycophenolate Diclofenac may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of hypertension can be increased when Diclofenac is combined with Naratriptan.
Olsalazine Olsalazine The therapeutic efficacy of Olsalazine can be decreased when used in combination with Diclofenac.
Paregoric Paregoric The metabolism of Diclofenac can be decreased when combined with Morphine.
Penbutolol Penbutolol Diclofenac may decrease the antihypertensive activities of Acebutolol.
Potassium Potassium Diclofenac may decrease the excretion rate of Potassium cation which could result in a higher serum level.
Prednisone Prednisone The risk or severity of gastrointestinal irritation can be increased when Diclofenac is combined with Prednisone.
Ranitidine Ranitidine The excretion of Ranitidine can be decreased when combined with Diclofenac.
Reserpine Reserpine Reserpine may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Rizatriptan Rizatriptan Diclofenac may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan Diclofenac may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The risk or severity of renal failure can be increased when Diclofenac is combined with Tacrolimus.
Tiludronate Tiludronate The risk or severity of gastrointestinal bleeding can be increased when Diclofenac is combined with Etidronic acid.
Tizanidine Tizanidine The metabolism of Tizanidine can be decreased when combined with Diclofenac.
Triamcinolone Triamcinolone The risk or severity of gastrointestinal irritation can be increased when Triamcinolone is combined with Diclofenac.
Zolmitriptan Zolmitriptan The metabolism of Diclofenac can be decreased when combined with Zolmitriptan.
Ampicillin Injection Ampicillin Injection Diclofenac may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Diclofenac may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Famotidine Injection Famotidine Injection The excretion of Famotidine can be decreased when combined with Diclofenac.
Fluconazole Injection Fluconazole Injection The metabolism of Diclofenac can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection Diclofenac may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
Interferon Beta-1b Injection Interferon Beta-1b Injection The metabolism of Diclofenac can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The metabolism of Diclofenac can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection Levofloxacin Injection Diclofenac may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection The metabolism of Diclofenac can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone is combined with Diclofenac.
Metoclopramide Injection Metoclopramide Injection Diclofenac may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Metronidazole Injection Metronidazole Injection The metabolism of Diclofenac can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Diclofenac can be decreased when combined with Morphine.
Pamidronate Injection Pamidronate Injection The risk or severity of gastrointestinal bleeding can be increased when Diclofenac is combined with Pamidronic acid.
Vancomycin Injection Vancomycin Injection Diclofenac may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The risk or severity of bleeding can be increased when Zidovudine is combined with Diclofenac.
Altretamine Altretamine Diclofenac may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Cefuroxime Cefuroxime The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefuroxime.
Cyclosporine Cyclosporine The serum concentration of Diclofenac can be increased when it is combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Diclofenac can be decreased when combined with Ondansetron.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Enoxaparin.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Diclofenac.
Olanzapine Olanzapine The metabolism of Diclofenac can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Diclofenac can be decreased when combined with Alosetron.
Eprosartan Eprosartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Eprosartan is combined with Diclofenac.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Diclofenac.
Meloxicam Meloxicam The risk or severity of adverse effects can be increased when Diclofenac is combined with Meloxicam.
Pantoprazole Pantoprazole Diclofenac may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Risedronate Risedronate The risk or severity of gastrointestinal bleeding can be increased when Diclofenac is combined with Risedronic acid.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Diclofenac resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Telmisartan is combined with Diclofenac.
Temozolomide Temozolomide Diclofenac may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Diclofenac may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Anakinra Anakinra The metabolism of Diclofenac can be increased when combined with Anakinra.
Linezolid Linezolid The risk or severity of hypertension can be increased when Diclofenac is combined with Linezolid.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Pentosan polysulfate.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Diclofenac.
Etanercept Injection Etanercept Injection The metabolism of Diclofenac can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Diclofenac can be increased when combined with Modafinil.
Perindopril Perindopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Perindopril.
Tenofovir Tenofovir Diclofenac may increase the nephrotoxic activities of Tenofovir.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of adverse effects can be increased when Diclofenac is combined with Choline magnesium trisalicylate.
Sirolimus Sirolimus The risk or severity of angioedema can be increased when Diclofenac is combined with Sirolimus.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Diclofenac is combined with Dutasteride.
Epinephrine Injection Epinephrine Injection The metabolism of Diclofenac can be decreased when combined with Epinephrine.
Eplerenone Eplerenone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Diclofenac.
Escitalopram Escitalopram The risk or severity of gastrointestinal bleeding can be increased when Escitalopram is combined with Diclofenac.
Olmesartan Olmesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Olmesartan is combined with Diclofenac.
Zonisamide Zonisamide Diclofenac may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Adalimumab Injection Adalimumab Injection The metabolism of Diclofenac can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of hypertension can be increased when Diclofenac is combined with Aripiprazole.
Atomoxetine Atomoxetine Diclofenac may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
Dexmethylphenidate Dexmethylphenidate The risk or severity of hypertension can be increased when Diclofenac is combined with Dexmethylphenidate.
Ezetimibe Ezetimibe Diclofenac may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Atazanavir Atazanavir The metabolism of Diclofenac can be decreased when combined with Atazanavir.
Almotriptan Almotriptan Diclofenac may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Eletriptan Eletriptan The metabolism of Diclofenac can be decreased when combined with Eletriptan.
Rosuvastatin Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Diclofenac.
Aprepitant Aprepitant The metabolism of Diclofenac can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Diclofenac may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Diclofenac can be decreased when combined with Interferon beta-1a.
Memantine Memantine The metabolism of Diclofenac can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Diclofenac can be decreased when combined with Tegaserod.
Tadalafil Tadalafil The therapeutic efficacy of Tadalafil can be decreased when used in combination with Diclofenac.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Diclofenac.
Gemifloxacin Gemifloxacin The metabolism of Diclofenac can be decreased when combined with Gemifloxacin.
Progesterone Progesterone Progesterone may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Diclofenac.
Infliximab Injection Infliximab Injection The metabolism of Diclofenac can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Diclofenac can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The risk or severity of hypertension can be increased when Protriptyline is combined with Diclofenac.
Rifaximin Rifaximin The metabolism of Diclofenac can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Diclofenac.
Tinidazole Tinidazole Diclofenac may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan Bosentan Bosentan may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Cefditoren Cefditoren The excretion of Cefdinir can be decreased when combined with Diclofenac.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Diclofenac.
Cyanocobalamin Injection Cyanocobalamin Injection Diclofenac may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Diclofenac can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone Diclofenac may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ganciclovir Ganciclovir Diclofenac may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Diclofenac may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of hypertension can be increased when Diclofenac is combined with Solifenacin.
Valganciclovir Valganciclovir Diclofenac may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Diclofenac can be decreased when combined with Voriconazole.
Zoledronic Acid Injection Zoledronic Acid Injection The risk or severity of gastrointestinal bleeding can be increased when Diclofenac is combined with Zoledronic acid.
Adefovir Adefovir The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Adefovir.
Dextroamphetamine Dextroamphetamine Diclofenac may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Entecavir Entecavir The metabolism of Diclofenac can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The metabolism of Diclofenac can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Diclofenac can be increased when it is combined with Peginterferon alfa-2b.
Ibandronate Ibandronate The risk or severity of gastrointestinal bleeding can be increased when Diclofenac is combined with Ibandronate.
Isocarboxazid Isocarboxazid The risk or severity of hypertension can be increased when Diclofenac is combined with Isocarboxazid.
Ramelteon Ramelteon Diclofenac may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Diclofenac may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pregabalin Pregabalin Diclofenac may decrease the excretion rate of Pregabalin which could result in a higher serum level.
Deferasirox Deferasirox The risk or severity of gastrointestinal bleeding and peptic ulcer can be increased when Diclofenac is combined with Deferasirox.
Phenylephrine Phenylephrine The metabolism of Diclofenac can be increased when combined with Phenylephrine.
Tipranavir Tipranavir Tipranavir may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Felbamate Felbamate The metabolism of Diclofenac can be decreased when combined with Felbamate.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Diclofenac can be increased when combined with Abatacept.
Rasagiline Rasagiline Diclofenac may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Imatinib Imatinib The metabolism of Diclofenac can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Diclofenac may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Diclofenac may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Diclofenac can be decreased when combined with Gefitinib.
Albuterol Albuterol Diclofenac may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone Diclofenac may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Bortezomib Bortezomib The metabolism of Diclofenac can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The excretion of Clofarabine can be decreased when combined with Diclofenac.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Diclofenac can be increased when combined with Insulin glulisine.
Lubiprostone Lubiprostone Diclofenac may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Primaquine Primaquine The metabolism of Diclofenac can be decreased when combined with Primaquine.
Aliskiren Aliskiren The risk or severity of renal failure and hypertension can be increased when Diclofenac is combined with Aliskiren.
Bismuth Subsalicylate Bismuth Subsalicylate The therapeutic efficacy of Bismuth subsalicylate can be decreased when used in combination with Diclofenac.
Pemetrexed Injection Pemetrexed Injection Diclofenac may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lisdexamfetamine Lisdexamfetamine The risk or severity of hypertension can be increased when Diclofenac is combined with Lisdexamfetamine.
Nabilone Nabilone The metabolism of Diclofenac can be decreased when combined with Nabilone.
Sorafenib Sorafenib The metabolism of Diclofenac can be decreased when combined with Sorafenib.
Dronabinol Dronabinol The metabolism of Diclofenac can be decreased when combined with Dronabinol.
Lapatinib Lapatinib The metabolism of Diclofenac can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine Diclofenac may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Diclofenac may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Diclofenac.
Mexiletine Mexiletine The metabolism of Diclofenac can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Diclofenac can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Diclofenac may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Temsirolimus Temsirolimus The risk or severity of angioedema can be increased when Diclofenac is combined with Temsirolimus.
Lenalidomide Lenalidomide Diclofenac may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Diclofenac can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Diclofenac can be decreased when combined with Bexarotene.
Budesonide Budesonide The risk or severity of gastrointestinal irritation can be increased when Budesonide is combined with Diclofenac.
Desmopressin Desmopressin The risk or severity of hypertension, hyponatremia, and water intoxication can be increased when Diclofenac is combined with Desmopressin.
Doripenem Injection Doripenem Injection Diclofenac may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Diclofenac can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Diclofenac may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine The risk or severity of gastrointestinal bleeding can be increased when Desvenlafaxine is combined with Diclofenac.
Cevimeline Cevimeline Diclofenac may decrease the excretion rate of Cevimeline which could result in a higher serum level.
Nebivolol Nebivolol Diclofenac may decrease the antihypertensive activities of Nebivolol.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Diclofenac.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Diclofenac.
Leucovorin Injection Leucovorin Injection The excretion of Leucovorin can be decreased when combined with Diclofenac.
Flecainide Flecainide The metabolism of Diclofenac can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Diclofenac can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Diclofenac.
Daptomycin Injection Daptomycin Injection Diclofenac may decrease the excretion rate of Daptomycin which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Diclofenac.
Methylnaltrexone Injection Methylnaltrexone Injection Diclofenac may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Midazolam Midazolam Diclofenac may decrease the excretion rate of Midazolam which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Diclofenac may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Diclofenac can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Diclofenac.
Plerixafor Injection Plerixafor Injection Diclofenac may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The risk or severity of renal failure can be increased when Sodium phosphate, monobasic is combined with Diclofenac.
Fesoterodine Fesoterodine Diclofenac may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Betaxolol Betaxolol Diclofenac may decrease the antihypertensive activities of Betaxolol.
Iloperidone Iloperidone The risk or severity of hypertension can be increased when Diclofenac is combined with Iloperidone.
Prasugrel Prasugrel The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Prasugrel.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Diclofenac.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The risk or severity of hyperkalemia can be increased when Diclofenac is combined with Tolvaptan.
Dronedarone Dronedarone The risk or severity of hypertension can be increased when Diclofenac is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Diclofenac may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Diclofenac may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Saxagliptin Saxagliptin Diclofenac may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Diclofenac may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Diclofenac.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Diclofenac.
Topotecan Topotecan Diclofenac may decrease the excretion rate of Topotecan which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Diclofenac can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Diclofenac can be decreased when combined with Pazopanib.
Asenapine Asenapine The metabolism of Asenapine can be decreased when combined with Diclofenac.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Diclofenac.
Albendazole Albendazole The metabolism of Diclofenac can be decreased when combined with Albendazole.
Dabigatran Dabigatran The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Dabigatran.
Tocilizumab Injection Tocilizumab Injection The metabolism of Diclofenac can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Diclofenac may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Diclofenac.
Ceftaroline Injection Ceftaroline Injection The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Ceftaroline fosamil.
Lurasidone Lurasidone The risk or severity of hypertension can be increased when Diclofenac is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The risk or severity of adverse effects can be increased when Acetaminophen is combined with Diclofenac.
Vilazodone Vilazodone The risk or severity of hypertension can be increased when Diclofenac is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Diclofenac may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Diclofenac may decrease the excretion rate of Aldesleukin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Diclofenac may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Azilsartan medoxomil is combined with Diclofenac.
Roflumilast Roflumilast Diclofenac may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin The risk or severity of angioedema can be increased when Diclofenac is combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Diclofenac can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Diclofenac can be decreased when combined with Glecaprevir.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Diclofenac.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Diclofenac can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The serum concentration of Diclofenac can be increased when it is combined with Abiraterone.
Rivaroxaban Rivaroxaban The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Rivaroxaban.
Ticagrelor Ticagrelor The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Ticagrelor.
Ruxolitinib Ruxolitinib Diclofenac may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Diclofenac may decrease the excretion rate of Clobazam which could result in a higher serum level.
Vemurafenib Vemurafenib The serum concentration of Diclofenac can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Diclofenac can be decreased when combined with Vismodegib.
Deferiprone Deferiprone Diclofenac may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Diclofenac.
Cabergoline Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Diclofenac.
Naloxone Injection Naloxone Injection Diclofenac may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan Ambrisentan The therapeutic efficacy of Ambrisentan can be decreased when used in combination with Diclofenac.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Fondaparinux.
Iloprost Iloprost The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Iloprost.
Enzalutamide Enzalutamide The metabolism of Diclofenac can be decreased when combined with Enzalutamide.
Mirabegron Mirabegron Diclofenac may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Diclofenac can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Diclofenac can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of gastrointestinal irritation can be increased when Corticotropin is combined with Diclofenac.
Teriflunomide Teriflunomide The serum concentration of Diclofenac can be decreased when it is combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Diclofenac.
Teduglutide Injection Teduglutide Injection Diclofenac may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Diclofenac is combined with Icosapent ethyl.
Alogliptin Alogliptin Diclofenac may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Diclofenac can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide Diclofenac may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Apixaban Apixaban The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Apixaban.
Canagliflozin Canagliflozin Diclofenac may decrease the excretion rate of Canagliflozin which could result in a higher serum level.
Dabrafenib Dabrafenib The metabolism of Diclofenac can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Diclofenac.
Trametinib Trametinib The metabolism of Diclofenac can be decreased when combined with Trametinib.
Levomilnacipran Levomilnacipran The risk or severity of gastrointestinal bleeding can be increased when Levomilnacipran is combined with Diclofenac.
Ertapenem Injection Ertapenem Injection Diclofenac may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine Vortioxetine Diclofenac may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Diclofenac.
Ketorolac Injection Ketorolac Injection The risk or severity of adverse effects can be increased when Ketorolac is combined with Diclofenac.
Simeprevir Simeprevir Simeprevir may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Sofosbuvir Sofosbuvir Diclofenac may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Diclofenac can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Diclofenac can be increased when combined with Apremilast.
Droxidopa Droxidopa Diclofenac may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Diclofenac can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Diclofenac can be increased when combined with Siltuximab.
Belinostat Injection Belinostat Injection The metabolism of Diclofenac can be increased when combined with Belinostat.
Testosterone Injection Testosterone Injection Diclofenac may decrease the excretion rate of Testosterone which could result in a higher serum level.
Oritavancin Injection Oritavancin Injection The metabolism of Diclofenac can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Vorapaxar.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Diclofenac.
Edoxaban Edoxaban The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Edoxaban.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The metabolism of Diclofenac can be decreased when combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Diclofenac can be increased when combined with Olaparib.
Caspofungin Injection Caspofungin Injection The excretion of Caspofungin can be decreased when combined with Diclofenac.
Methamphetamine Methamphetamine Diclofenac may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Diclofenac may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat The therapeutic efficacy of Riociguat can be decreased when used in combination with Diclofenac.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Diclofenac.
Secukinumab Injection Secukinumab Injection The metabolism of Diclofenac can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of hypertension can be increased when Diclofenac is combined with Risperidone.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Diclofenac can be increased when combined with Insulin human.
Lenvatinib Lenvatinib Lenvatinib may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Diclofenac.
Deoxycholic Acid Injection Deoxycholic Acid Injection Deoxycholic acid may increase the excretion rate of Diclofenac which could result in a lower serum level and potentially a reduction in efficacy.
Amiloride Amiloride The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Amiloride.
Macitentan Macitentan The therapeutic efficacy of Macitentan can be decreased when used in combination with Diclofenac.
Flibanserin Flibanserin The risk or severity of hypertension can be increased when Diclofenac is combined with Flibanserin.
Prednisolone Prednisolone The risk or severity of gastrointestinal irritation can be increased when Prednisolone is combined with Diclofenac.
Brexpiprazole Brexpiprazole The risk or severity of hypertension can be increased when Diclofenac is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of hypertension can be increased when Ziprasidone is combined with Diclofenac.
Cariprazine Cariprazine The risk or severity of hypertension can be increased when Diclofenac is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Diclofenac may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Diclofenac.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Diclofenac can be increased when combined with Insulin degludec.
Cobimetinib Cobimetinib The excretion of Cobimetinib can be decreased when combined with Diclofenac.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Diclofenac.
Osimertinib Osimertinib The serum concentration of Diclofenac can be decreased when it is combined with Osimertinib.
Ixazomib Ixazomib Diclofenac may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Diclofenac can be increased when combined with Rifapentine.
Lesinurad Lesinurad Diclofenac may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The risk or severity of gastrointestinal irritation can be increased when Diclofenac is combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Defibrotide.
Brivaracetam Injection Brivaracetam Injection Diclofenac may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Midodrine Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Diclofenac.
Selexipag Selexipag The therapeutic efficacy of Selexipag can be decreased when used in combination with Diclofenac.
Obeticholic Acid Obeticholic Acid The metabolism of Diclofenac can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Diclofenac.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Diclofenac.
Rucaparib Rucaparib The metabolism of Diclofenac can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Diclofenac may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Diclofenac.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Diclofenac.
Deutetrabenazine Deutetrabenazine Diclofenac may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Diclofenac may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of gastrointestinal irritation can be increased when Deflazacort is combined with Diclofenac.
Safinamide Safinamide The metabolism of Diclofenac can be decreased when combined with Safinamide.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Diclofenac.
Naldemedine Naldemedine Diclofenac may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Diclofenac can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Diclofenac can be decreased when combined with Enasidenib.
Benznidazole Benznidazole Diclofenac may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Diclofenac may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Diclofenac.
Letermovir Letermovir Letermovir may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Ertugliflozin Ertugliflozin The metabolism of Diclofenac can be decreased when combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Diclofenac.
Apalutamide Apalutamide Diclofenac may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Penicillamine Penicillamine The excretion of Penicillamine can be decreased when combined with Diclofenac.
Fostamatinib Fostamatinib The metabolism of Diclofenac can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The metabolism of Diclofenac can be increased when combined with Avatrombopag.
Baricitinib Baricitinib Diclofenac may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Diclofenac.
Plazomicin Injection Plazomicin Injection Diclofenac may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Diclofenac.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Diclofenac.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Diclofenac.
Dacomitinib Dacomitinib The metabolism of Diclofenac can be decreased when combined with Dacomitinib.
Stiripentol Stiripentol The metabolism of Diclofenac can be decreased when combined with Stiripentol.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Diclofenac.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Diclofenac.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Diclofenac.
Rifamycin Rifamycin The metabolism of Diclofenac can be decreased when combined with Rifamycin.
Prucalopride Prucalopride Diclofenac may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Diclofenac can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Diclofenac.
Acyclovir Ophthalmic Acyclovir Ophthalmic Diclofenac may decrease the excretion rate of Acyclovir which could result in a higher serum level.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Diclofenac is combined with Caplacizumab.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Diclofenac.
Alpelisib Alpelisib The serum concentration of Diclofenac can be decreased when it is combined with Alpelisib.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Diclofenac.
Triclabendazole Triclabendazole The metabolism of Diclofenac can be decreased when combined with Triclabendazole.
Pexidartinib Pexidartinib The metabolism of Diclofenac can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Diclofenac.
Pitolisant Pitolisant The risk or severity of adverse effects can be increased when Diclofenac is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The serum concentration of Diclofenac can be increased when it is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Diclofenac can be decreased when combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Diclofenac.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Diclofenac.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Diclofenac.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Diclofenac.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Diclofenac.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Diclofenac.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Diclofenac.
Remdesivir Injection Remdesivir Injection The excretion of Remdesivir can be decreased when combined with Diclofenac.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Diclofenac.
Capmatinib Capmatinib The metabolism of Diclofenac can be decreased when combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Diclofenac can be decreased when it is combined with Lemborexant.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection Diclofenac may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Opicapone Opicapone The metabolism of Diclofenac can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Diclofenac can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Diclofenac is combined with Naxitamab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Diclofenac is combined with Drospirenone.
Viloxazine Viloxazine Diclofenac may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Diclofenac may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Theophylline Theophylline The metabolism of Diclofenac can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen The risk or severity of adverse effects can be increased when Diclofenac is combined with Fenoprofen.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Diclofenac is combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The risk or severity of adverse effects can be increased when Diclofenac is combined with Mefenamic acid.
Naproxen Naproxen The risk or severity of adverse effects can be increased when Diclofenac is combined with Naproxen.
Tolmetin Tolmetin The risk or severity of adverse effects can be increased when Diclofenac is combined with Tolmetin.
Sulindac Sulindac The risk or severity of adverse effects can be increased when Diclofenac is combined with Sulindac.
Trazodone Trazodone The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Diclofenac.
Isotretinoin Isotretinoin Diclofenac may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Diclofenac may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Floxuridine Floxuridine The metabolism of Diclofenac can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Diclofenac.
Metaxalone Metaxalone Diclofenac may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The serum concentration of Methotrexate can be increased when it is combined with Diclofenac.
Primidone Primidone The metabolism of Primidone can be increased when combined with Diclofenac.
Methsuximide Methsuximide The risk or severity of hyperkalemia can be increased when Diclofenac is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of hypertension can be increased when Diclofenac is combined with Diethylpropion.
Chlorpromazine Chlorpromazine Chlorpromazine may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Diazepam Diazepam Diclofenac may decrease the excretion rate of Diazepam which could result in a higher serum level.
Oxazepam Oxazepam Diclofenac may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Flurazepam Flurazepam Diclofenac may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate Clorazepate Diclofenac may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Diclofenac may decrease the excretion rate of Lorazepam which could result in a higher serum level.
Phenoxybenzamine Phenoxybenzamine The therapeutic efficacy of Phenoxybenzamine can be decreased when used in combination with Diclofenac.
Carmustine Carmustine Diclofenac may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine Amantadine Diclofenac may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine Diclofenac may decrease the excretion rate of Codeine which could result in a higher serum level.
Bromocriptine Bromocriptine The risk or severity of hypertension can be increased when Diclofenac is combined with Bromocriptine.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Diclofenac is combined with Orciprenaline.
Tranylcypromine Tranylcypromine The metabolism of Diclofenac can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine Diclofenac may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of hypertension can be increased when Diclofenac is combined with Ergoloid mesylate.
Tetracycline Tetracycline Diclofenac may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Thioridazine Thioridazine The risk or severity of hypertension can be increased when Diclofenac is combined with Thioridazine.
Trifluoperazine Trifluoperazine The metabolism of Trifluoperazine can be decreased when combined with Diclofenac.
Bleomycin Bleomycin Diclofenac may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Dapsone Dapsone The metabolism of Diclofenac can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine Diclofenac may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Methadone Methadone Diclofenac may decrease the excretion rate of Methadone which could result in a higher serum level.
Oxybutynin Oxybutynin The metabolism of Diclofenac can be decreased when combined with Oxybutynin.
Benztropine Benztropine Diclofenac may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Diclofenac resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline Diclofenac may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen The risk or severity of adverse effects can be increased when Diclofenac is combined with Ibuprofen.
Orphenadrine Orphenadrine The metabolism of Diclofenac can be decreased when combined with Orphenadrine.
Perphenazine Perphenazine The metabolism of Perphenazine can be decreased when combined with Diclofenac.
Azathioprine Azathioprine Diclofenac may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Phentermine Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Diclofenac.
Methylphenidate Methylphenidate Diclofenac may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine Amoxapine The risk or severity of hypertension can be increased when Amoxapine is combined with Diclofenac.
Sulfasalazine Sulfasalazine The therapeutic efficacy of Sulfasalazine can be decreased when used in combination with Diclofenac.
Hydrocortisone Hydrocortisone The risk or severity of gastrointestinal irritation can be increased when Diclofenac is combined with Hydrocortisone.
Doxorubicin Doxorubicin Diclofenac may decrease the excretion rate of Doxorubicin which could result in a higher serum level.
Phenazopyridine Phenazopyridine The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Phenazopyridine.
Carbamazepine Carbamazepine The metabolism of Diclofenac can be increased when combined with Carbamazepine.
Methyldopa Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Diclofenac.
Clonidine Clonidine The metabolism of Diclofenac can be decreased when combined with Clonidine.
Prazosin Prazosin The therapeutic efficacy of Prazosin can be decreased when used in combination with Diclofenac.
Hydralazine Hydralazine Diclofenac may decrease the antihypertensive activities of Hydralazine.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Diclofenac may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Warfarin Warfarin The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Warfarin.
Clonazepam Clonazepam Diclofenac may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Diclofenac.
Promethazine Promethazine Diclofenac may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate The risk or severity of adverse effects can be increased when Diclofenac is combined with Meclofenamic acid.
Daunorubicin Daunorubicin Diclofenac may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Diclofenac may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Diclofenac can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Diclofenac.
Chloroquine Chloroquine Diclofenac may decrease the excretion rate of Chloroquine which could result in a higher serum level.
Quinine Quinine The metabolism of Diclofenac can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of hyperkalemia can be increased when Diclofenac is combined with Ethosuximide.
Triamterene Triamterene The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Diclofenac is combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Diclofenac.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Diclofenac.
Metolazone Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Diclofenac.
Secobarbital Secobarbital The metabolism of Diclofenac can be increased when combined with Secobarbital.
Desipramine Desipramine Diclofenac may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline The metabolism of Diclofenac can be decreased when combined with Amitriptyline.
Imipramine Imipramine The metabolism of Diclofenac can be decreased when combined with Imipramine.
Probenecid Probenecid Probenecid may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Quinidine Quinidine The metabolism of Diclofenac can be decreased when combined with Quinidine.
Procainamide Procainamide Diclofenac may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid The metabolism of Diclofenac can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Diclofenac may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Rifampin Rifampin The metabolism of Diclofenac can be increased when combined with Rifampicin.
Disopyramide Disopyramide Diclofenac may decrease the excretion rate of Disopyramide which could result in a higher serum level.
Valproic Acid Valproic Acid The protein binding of Valproic acid can be decreased when combined with Diclofenac.
Tamoxifen Tamoxifen The metabolism of Diclofenac can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Diclofenac may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Levothyroxine Levothyroxine The metabolism of Diclofenac can be decreased when combined with Levothyroxine.
Liothyronine Liothyronine Diclofenac may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole Methimazole The metabolism of Diclofenac can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The protein binding of Chlorpropamide can be decreased when combined with Diclofenac.
Tolbutamide Tolbutamide The protein binding of Tolbutamide can be decreased when combined with Diclofenac.
Tolazamide Tolazamide The protein binding of Tolazamide can be decreased when combined with Diclofenac.
Dextromethorphan Dextromethorphan The metabolism of Diclofenac can be decreased when combined with Dextromethorphan.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Diclofenac.
Cyclobenzaprine Cyclobenzaprine The metabolism of Cyclobenzaprine can be decreased when combined with Diclofenac.
Baclofen Baclofen Diclofenac may decrease the excretion rate of Baclofen which could result in a higher serum level.
Brompheniramine Brompheniramine The metabolism of Brompheniramine can be decreased when combined with Diclofenac.
Ethambutol Ethambutol Diclofenac may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Diclofenac.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Diclofenac.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Diclofenac is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone Diclofenac may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Pyridoxine Pyridoxine Diclofenac may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
Folic Acid Folic Acid Diclofenac may decrease the excretion rate of Folic acid which could result in a higher serum level.
Disulfiram Disulfiram Diclofenac may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Diclofenac may decrease the antihypertensive activities of Propranolol.
Minoxidil Minoxidil The therapeutic efficacy of Minoxidil can be decreased when used in combination with Diclofenac.
Pseudoephedrine Pseudoephedrine The risk or severity of hypertension can be increased when Diclofenac is combined with Pseudoephedrine.
Nortriptyline Nortriptyline The risk or severity of hypertension can be increased when Nortriptyline is combined with Diclofenac.
Spironolactone Spironolactone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Amphotericin B.
Mercaptopurine Mercaptopurine The excretion of Mercaptopurine can be decreased when combined with Diclofenac.
Phytonadione Phytonadione Diclofenac may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Diclofenac may decrease the excretion rate of Amikacin which could result in a higher serum level.
Nadolol Nadolol Diclofenac may decrease the antihypertensive activities of Nadolol.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Diclofenac resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol Diclofenac may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Flavoxate Flavoxate Diclofenac may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Diclofenac can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Diclofenac can be decreased when combined with Colchicine.
Cefaclor Cefaclor Diclofenac may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cefadroxil Cefadroxil Diclofenac may decrease the excretion rate of Cefadroxil which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefazolin.
Cephalexin Cephalexin Diclofenac may decrease the excretion rate of Cephalexin which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefoxitin.
Dacarbazine Dacarbazine Diclofenac may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Cefotaxime Injection Cefotaxime Injection The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Diclofenac.
Calcitonin Salmon Injection Calcitonin Salmon Injection Diclofenac may decrease the excretion rate of Salmon calcitonin which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Diclofenac can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel Diclofenac may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The metabolism of Diclofenac can be decreased when combined with Thiotepa.
Vincristine Injection Vincristine Injection Vincristine may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Captopril Captopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Captopril.
Dipyridamole Dipyridamole The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Dipyridamole.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Diclofenac is combined with Isoxsuprine.
Vinblastine Vinblastine Vinblastine may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Diclofenac.
Colistimethate Injection Colistimethate Injection The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Colistimethate.
Metoprolol Metoprolol Diclofenac may decrease the antihypertensive activities of Metoprolol.
Thiothixene Thiothixene The metabolism of Thiothixene can be decreased when combined with Diclofenac.
Aspirin Aspirin The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Diclofenac.
Salsalate Salsalate The risk or severity of adverse effects can be increased when Diclofenac is combined with Salsalate.
Alprazolam Alprazolam Diclofenac may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Temazepam Temazepam Diclofenac may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam Triazolam Diclofenac may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Diclofenac may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Propantheline Propantheline Diclofenac may decrease the excretion rate of Propantheline which could result in a higher serum level.
Trimethoprim Trimethoprim The metabolism of Diclofenac can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Diclofenac can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Diclofenac can be decreased when combined with Nifedipine.
Timolol Timolol Diclofenac may decrease the antihypertensive activities of Timolol.
Verapamil Verapamil The metabolism of Diclofenac can be decreased when combined with Verapamil.
Atenolol Atenolol Diclofenac may decrease the antihypertensive activities of Atenolol.
Pindolol Pindolol Diclofenac may decrease the antihypertensive activities of Pindolol.
Cisplatin Injection Cisplatin Injection Diclofenac may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The therapeutic efficacy of Diflunisal can be decreased when used in combination with Diclofenac.
Piroxicam Piroxicam The risk or severity of adverse effects can be increased when Diclofenac is combined with Piroxicam.
Bumetanide Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Diclofenac.
Streptozocin Streptozocin The metabolism of Diclofenac can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Diclofenac.
Glyburide Glyburide Glyburide may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Glipizide Glipizide The protein binding of Glipizide can be decreased when combined with Diclofenac.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Diclofenac.
Amoxicillin Amoxicillin Diclofenac may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Nafcillin Injection Nafcillin Injection The metabolism of Diclofenac can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Diclofenac may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Diclofenac is combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection Diclofenac may decrease the excretion rate of Ceftriaxone which could result in a higher serum level.
Labetalol Labetalol Diclofenac may decrease the antihypertensive activities of Labetalol.
Auranofin Auranofin Diclofenac may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Diclofenac may decrease the excretion rate of Leuprolide which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Diclofenac can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Diclofenac.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Adefovir dipivoxil.
Ceftazidime Injection Ceftazidime Injection Diclofenac may decrease the excretion rate of Ceftazidime which could result in a higher serum level.
Ketoprofen Ketoprofen The risk or severity of adverse effects can be increased when Diclofenac is combined with Ketoprofen.
Cefotetan Injection Cefotetan Injection Diclofenac may decrease the excretion rate of Cefotetan which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Diclofenac.
Enalapril Enalapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Enalapril.
Flurbiprofen Flurbiprofen The risk or severity of adverse effects can be increased when Diclofenac is combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Diclofenac.
Aztreonam Injection Aztreonam Injection Diclofenac may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone Diclofenac may decrease the excretion rate of Buspirone which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Diclofenac.
Ciprofloxacin Ciprofloxacin The metabolism of Diclofenac can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine The therapeutic efficacy of Mesalazine can be decreased when used in combination with Diclofenac.
Fluoxetine Fluoxetine The risk or severity of gastrointestinal bleeding can be increased when Fluoxetine is combined with Diclofenac.
Nimodipine Nimodipine The therapeutic efficacy of Nimodipine can be decreased when used in combination with Diclofenac.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The metabolism of Diclofenac can be decreased when combined with Interferon alfa-2b.
Clozapine Clozapine The metabolism of Diclofenac can be decreased when combined with Clozapine.
Estazolam Estazolam Diclofenac may decrease the excretion rate of Estazolam which could result in a higher serum level.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Diclofenac.
Ofloxacin Ofloxacin The metabolism of Diclofenac can be decreased when combined with Ofloxacin.
Didanosine Didanosine Diclofenac may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Diclofenac may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Clarithromycin Clarithromycin Diclofenac may decrease the excretion rate of Clarithromycin which could result in a higher serum level.
Benazepril Benazepril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Benazepril.
Etodolac Etodolac The risk or severity of adverse effects can be increased when Diclofenac is combined with Etodolac.
Felodipine Felodipine The metabolism of Diclofenac can be decreased when combined with Felodipine.
Fosinopril Fosinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Fosinopril.
Nabumetone Nabumetone The risk or severity of adverse effects can be increased when Diclofenac is combined with Nabumetone.
Pravastatin Pravastatin The excretion of Pravastatin can be decreased when combined with Diclofenac.
Quinapril Quinapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Quinapril.
Ramipril Ramipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Ramipril.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Diclofenac.
Amlodipine Amlodipine Diclofenac may decrease the antihypertensive activities of Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Diclofenac can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Diclofenac can be decreased when combined with Itraconazole.
Lisinopril Lisinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Lisinopril.
Oxaprozin Oxaprozin The risk or severity of adverse effects can be increased when Diclofenac is combined with Oxaprozin.
Atovaquone Atovaquone The metabolism of Diclofenac can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Diclofenac can be increased when combined with Rifabutin.
Sotalol Sotalol Diclofenac may decrease the antihypertensive activities of Sotalol.
Bisoprolol Bisoprolol Diclofenac may decrease the antihypertensive activities of Bisoprolol.
Zolpidem Zolpidem The metabolism of Diclofenac can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The therapeutic efficacy of Doxazosin can be decreased when used in combination with Diclofenac.
Terazosin Terazosin The therapeutic efficacy of Terazosin can be decreased when used in combination with Diclofenac.
Isradipine Isradipine The therapeutic efficacy of Isradipine can be decreased when used in combination with Diclofenac.
Omeprazole Omeprazole The metabolism of Diclofenac can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Diclofenac can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Diclofenac can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the antiplatelet activities of Diclofenac.
Stavudine Stavudine The excretion of Stavudine can be decreased when combined with Diclofenac.
Fluvoxamine Fluvoxamine The risk or severity of gastrointestinal bleeding can be increased when Fluvoxamine is combined with Diclofenac.
Nefazodone Nefazodone The risk or severity of gastrointestinal bleeding can be increased when Nefazodone is combined with Diclofenac.
Lamotrigine Lamotrigine The metabolism of Diclofenac can be increased when combined with Lamotrigine.
Losartan Losartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Losartan is combined with Diclofenac.
Valacyclovir Valacyclovir Diclofenac may decrease the excretion rate of Valaciclovir which could result in a higher serum level.
Tramadol Tramadol Diclofenac may decrease the excretion rate of Tramadol which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Diclofenac may decrease the excretion rate of Carboplatin which could result in a higher serum level.
Moexipril Moexipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Moexipril.
Lansoprazole Lansoprazole The metabolism of Diclofenac can be decreased when combined with Lansoprazole.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Diclofenac.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Diclofenac.
Nicardipine Nicardipine The metabolism of Diclofenac can be decreased when combined with Nicardipine.
Bupropion Bupropion Diclofenac may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine The risk or severity of bleeding can be increased when Diclofenac is combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Diclofenac can be decreased when combined with Saquinavir.
Metformin Metformin Diclofenac may decrease the excretion rate of Metformin which could result in a higher serum level.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Dalteparin.
Nisoldipine Nisoldipine The therapeutic efficacy of Nisoldipine can be decreased when used in combination with Diclofenac.
Lamivudine Lamivudine Diclofenac may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole The metabolism of Riluzole can be decreased when combined with Diclofenac.
Acarbose Acarbose Diclofenac may decrease the excretion rate of Acarbose which could result in a higher serum level.
Glimepiride Glimepiride The protein binding of Glimepiride can be decreased when combined with Diclofenac.
Anastrozole Anastrozole The metabolism of Diclofenac can be decreased when combined with Anastrozole.
Gemcitabine Injection Gemcitabine Injection Diclofenac may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Indinavir Indinavir Indinavir may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Ritonavir Ritonavir The serum concentration of Diclofenac can be increased when it is combined with Ritonavir.
Cidofovir Injection Cidofovir Injection Diclofenac may decrease the excretion rate of Cidofovir which could result in a higher serum level.
Meropenem Injection Meropenem Injection Diclofenac may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Diclofenac.
Zafirlukast Zafirlukast The metabolism of Diclofenac can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Diclofenac may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine The metabolism of Diclofenac can be decreased when combined with Mirtazapine.
Trandolapril Trandolapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Trandolapril.
Topiramate Topiramate Diclofenac may decrease the excretion rate of Topiramate which could result in a higher serum level.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Diclofenac.
Valsartan Valsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Valsartan is combined with Diclofenac.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Diclofenac can be increased when combined with Insulin lispro.
Pramipexole Pramipexole Diclofenac may decrease the excretion rate of Pramipexole which could result in a higher serum level.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Diclofenac.
Nelfinavir Nelfinavir The metabolism of Diclofenac can be decreased when combined with Nelfinavir.
Fexofenadine Fexofenadine The excretion of Fexofenadine can be decreased when combined with Diclofenac.
Loratadine Loratadine The metabolism of Diclofenac can be decreased when combined with Loratadine.
Carvedilol Carvedilol Diclofenac may decrease the antihypertensive activities of Carvedilol.
Nilutamide Nilutamide Diclofenac may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Diclofenac may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Diclofenac.
Bicalutamide Bicalutamide The metabolism of Diclofenac can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Diclofenac.
Propafenone Propafenone Diclofenac may decrease the antihypertensive activities of Propafenone.
Raloxifene Raloxifene The metabolism of Diclofenac can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Diclofenac.
Tamsulosin Tamsulosin Diclofenac may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Finasteride Finasteride The risk or severity of hypertension can be increased when Diclofenac is combined with Finasteride.
Quetiapine Quetiapine Diclofenac may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefepime.
Cefprozil Cefprozil The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefprozil.
Cefpodoxime Cefpodoxime The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefpodoxime.
Cetirizine Cetirizine Diclofenac may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Diclofenac.
Tolcapone Tolcapone Diclofenac may decrease the excretion rate of Tolcapone which could result in a higher serum level.
Citalopram Citalopram The risk or severity of gastrointestinal bleeding can be increased when Diclofenac is combined with Citalopram.
Capecitabine Capecitabine The metabolism of Diclofenac can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Diclofenac can be decreased when combined with Efavirenz.
Abacavir Abacavir Diclofenac may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Diclofenac can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Diclofenac can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The risk or severity of adverse effects can be increased when Diclofenac is combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Diclofenac can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Diclofenac may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Diclofenac.
Oseltamivir Oseltamivir Diclofenac may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Diclofenac resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The therapeutic efficacy of Balsalazide can be decreased when used in combination with Diclofenac.
Nateglinide Nateglinide Diclofenac may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Rabeprazole Rabeprazole The metabolism of Diclofenac can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Diclofenac.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

Still Confused? Ask the pharmacist a question here!