Piroxicam

Generic name: Pronounced as (peer ox' i kam)
Brand names
  • Feldene®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2021

People who take nonsteroidal anti-inflammatory medications (NSAIDs) (other than aspirin) such as piroxicam may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as piroxicam if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take piroxicam right before or right after the surgery.

NSAIDs such as piroxicam may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while you are taking piroxicam. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines or other bleeding disorders. If you experience any of the following symptoms, stop taking piroxicam and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to piroxicam. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with piroxicam and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Piroxicam is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Piroxicam is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

Piroxicam comes as a capsule to take by mouth. It is usually taken once or twice a day. Take piroxicam at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take piroxicam exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Piroxicam will help control your symptoms but will not cure your condition. It may take 8 to 12 weeks or longer before you feel the full benefit of piroxicam.

Piroxicam is also sometimes used to treat gouty arthritis (attacks of severe joint pain and swelling caused by a build-up of certain substances in the joints) and ankylosing spondylitis (arthritis that mainly affects the spine). It is also sometimes used to relieve muscle pain and swelling, menstrual pain, and pain after surgery or childbirth. Talk to your doctor about the risks of using this medication for your condition.

Before taking piroxicam,

  • tell your doctor and pharmacist if you are allergic to piroxicam, aspirin, or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), any other medications, or any of the inactive ingredients in piroxicam capsules. Ask your pharmacist for a list of the inactive ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers (ARBs) such as azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); diuretics ('water pills'); lithium (Lithobid); medications for diabetes; methotrexate (Otrexup, Rasuvo, Trexall); and phenytoin (Dilantin, Phenytek). Your doctor may need to change the doses of your medication or monitor you more carefully for side effects.

  • tell your doctor if you have or have ever had asthma, especially if you also have frequent stuffy or runny nose or nasal polyps (swelling of the lining of the nose); heart failure; swelling of the hands, feet, ankles, or lower legs; or liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant; or are breast-feeding. Piroxicam may harm the fetus and cause problems with delivery if it is taken around 20 weeks or later during pregnancy. Do not take piroxicam around or after 20 weeks of pregnancy, unless you are told to do so by your doctor. If you become pregnant while taking piroxicam, call your doctor.

  • talk to your doctor about the risks and benefits of taking piroxicam if you are 75 years of age or older. Do not take this medication for a longer period of time or at a higher dose than recommended by your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking piroxicam.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Piroxicam may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • constipation

    • gas

    • headache

    • dizziness

    • ringing in the ears

  • Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more piroxicam until you speak to your doctor.

    • vision problems

    • unexplained weight gain

    • shortness of breath or difficulty breathing

    • swelling in the abdomen, ankles, feet, or legs

    • fever

    • blisters

    • joint pain

    • rash

    • itching

    • hives

    • swelling of the eyes, face, lips, tongue, throat, arms, or hands

    • difficulty breathing or swallowing

    • hoarseness

    • pale skin

    • fast heartbeat

    • excessive tiredness

    • unusual bleeding or bruising

    • lack of energy

    • upset stomach

    • loss of appetite

    • pain in the upper right part of the stomach

    • flu-like symptoms

    • yellowing of the skin or eyes

    • cloudy, discolored, or bloody urine

    • back pain

    • difficult or painful urination

  • Piroxicam may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • lack of energy

  • drowsiness

  • upset stomach

  • vomiting

  • stomach pain

  • bloody, black, or tarry stools

  • vomiting a substance that is bloody or looks like coffee grounds

  • difficulty breathing

  • coma (loss of consciousness for a period of time)

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin Piroxicam may increase the neuroexcitatory activities of Moxifloxacin.
Leflunomide Leflunomide The metabolism of Piroxicam can be decreased when combined with Leflunomide.
Nevirapine Nevirapine The metabolism of Piroxicam can be decreased when combined with Nevirapine.
Alendronate Alendronate The risk or severity of adverse effects can be increased when Piroxicam is combined with Alendronic acid.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Piroxicam is combined with Anagrelide.
Candesartan Candesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Candesartan is combined with Piroxicam.
Cilostazol Cilostazol The risk or severity of bleeding can be increased when Piroxicam is combined with Cilostazol.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Piroxicam is combined with Clopidogrel.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Piroxicam may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Guanfacine Guanfacine The therapeutic efficacy of Guanfacine can be decreased when used in combination with Piroxicam.
Magnesium Hydroxide Magnesium Hydroxide Piroxicam may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of hypertension can be increased when Piroxicam is combined with Naratriptan.
Olsalazine Olsalazine The therapeutic efficacy of Olsalazine can be decreased when used in combination with Piroxicam.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Piroxicam.
Penbutolol Penbutolol Piroxicam may decrease the antihypertensive activities of Acebutolol.
Sumatriptan Sumatriptan Piroxicam may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The risk or severity of renal failure can be increased when Piroxicam is combined with Tacrolimus.
Tiludronate Tiludronate The risk or severity of gastrointestinal bleeding can be increased when Piroxicam is combined with Etidronic acid.
Triamcinolone Triamcinolone The risk or severity of gastrointestinal irritation can be increased when Triamcinolone is combined with Piroxicam.
Zolmitriptan Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Piroxicam.
Doxycycline Injection Doxycycline Injection Piroxicam may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Famotidine Injection Famotidine Injection The excretion of Famotidine can be decreased when combined with Piroxicam.
Fluconazole Injection Fluconazole Injection The metabolism of Piroxicam can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection The risk or severity of nephrotoxicity can be increased when Piroxicam is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection Piroxicam may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
Meperidine Injection Meperidine Injection Piroxicam may decrease the excretion rate of Meperidine which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection The risk or severity of gastrointestinal bleeding can be increased when Piroxicam is combined with Pamidronic acid.
Vancomycin Injection Vancomycin Injection Piroxicam may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The risk or severity of bleeding can be increased when Zidovudine is combined with Piroxicam.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Cyclosporine Cyclosporine The risk or severity of renal failure and hypertension can be increased when Piroxicam is combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Piroxicam.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Enoxaparin.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Piroxicam.
Olanzapine Olanzapine The metabolism of Piroxicam can be decreased when combined with Olanzapine.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Piroxicam.
Meloxicam Meloxicam The risk or severity of adverse effects can be increased when Piroxicam is combined with Meloxicam.
Pantoprazole Pantoprazole Piroxicam may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Piroxicam resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temozolomide Temozolomide Piroxicam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Linezolid Linezolid The risk or severity of hypertension can be increased when Piroxicam is combined with Linezolid.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Pentosan polysulfate.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Piroxicam.
Etanercept Injection Etanercept Injection The metabolism of Piroxicam can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Piroxicam can be decreased when combined with Modafinil.
Perindopril Perindopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Perindopril.
Tenofovir Tenofovir Piroxicam may increase the nephrotoxic activities of Tenofovir.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of adverse effects can be increased when Piroxicam is combined with Choline magnesium trisalicylate.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Piroxicam is combined with Dutasteride.
Epinephrine Injection Epinephrine Injection The metabolism of Piroxicam can be decreased when combined with Epinephrine.
Eplerenone Eplerenone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Eplerenone.
Escitalopram Escitalopram The risk or severity of gastrointestinal bleeding can be increased when Escitalopram is combined with Piroxicam.
Olmesartan Olmesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Olmesartan is combined with Piroxicam.
Zonisamide Zonisamide Piroxicam may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Adalimumab Injection Adalimumab Injection The metabolism of Piroxicam can be increased when combined with Adalimumab.
Atomoxetine Atomoxetine Piroxicam may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
Dexmethylphenidate Dexmethylphenidate The risk or severity of hypertension can be increased when Piroxicam is combined with Dexmethylphenidate.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Almotriptan Almotriptan Piroxicam may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Eletriptan Eletriptan The metabolism of Piroxicam can be decreased when combined with Eletriptan.
Rosuvastatin Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Piroxicam.
Aprepitant Aprepitant The metabolism of Piroxicam can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Piroxicam may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Piroxicam may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod Tegaserod The metabolism of Piroxicam can be decreased when combined with Tegaserod.
Tadalafil Tadalafil Piroxicam may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan Frovatriptan The risk or severity of hypertension can be increased when Piroxicam is combined with Frovatriptan.
Gemifloxacin Gemifloxacin Piroxicam may increase the neuroexcitatory activities of Gemifloxacin.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Piroxicam.
Infliximab Injection Infliximab Injection The metabolism of Piroxicam can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Piroxicam can be increased when combined with Rifaximin.
Tinidazole Tinidazole Piroxicam may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Cefditoren Cefditoren The excretion of Cefdinir can be decreased when combined with Piroxicam.
Cyanocobalamin Injection Cyanocobalamin Injection Piroxicam may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Piroxicam can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone Piroxicam may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ganciclovir Ganciclovir Piroxicam may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of hypertension can be increased when Piroxicam is combined with Solifenacin.
Valganciclovir Valganciclovir Piroxicam may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Voriconazole can be decreased when combined with Piroxicam.
Adefovir Adefovir Adefovir may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Piroxicam may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Piroxicam can be increased when combined with Peginterferon alfa-2b.
Ibandronate Ibandronate The risk or severity of gastrointestinal bleeding can be increased when Piroxicam is combined with Ibandronate.
Isocarboxazid Isocarboxazid The risk or severity of hypertension can be increased when Piroxicam is combined with Isocarboxazid.
Ramelteon Ramelteon Piroxicam may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Piroxicam may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pregabalin Pregabalin Piroxicam may decrease the excretion rate of Pregabalin which could result in a higher serum level.
Deferasirox Deferasirox The risk or severity of gastrointestinal bleeding and peptic ulcer can be increased when Piroxicam is combined with Deferasirox.
Felbamate Felbamate The metabolism of Piroxicam can be decreased when combined with Felbamate.
Ranolazine Ranolazine Piroxicam may decrease the excretion rate of Ranolazine which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Piroxicam can be increased when combined with Abatacept.
Rasagiline Rasagiline Piroxicam may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Imatinib Imatinib The metabolism of Piroxicam can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Piroxicam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Piroxicam may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Piroxicam can be decreased when combined with Gefitinib.
Albuterol Albuterol Piroxicam may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone Piroxicam may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Bortezomib Bortezomib The metabolism of Piroxicam can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The excretion of Clofarabine can be decreased when combined with Piroxicam.
Lubiprostone Lubiprostone Piroxicam may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Aliskiren Aliskiren The risk or severity of renal failure and hypertension can be increased when Piroxicam is combined with Aliskiren.
Bismuth Subsalicylate Bismuth Subsalicylate The therapeutic efficacy of Bismuth subsalicylate can be decreased when used in combination with Piroxicam.
Nabilone Nabilone The metabolism of Piroxicam can be decreased when combined with Nabilone.
Sorafenib Sorafenib The metabolism of Piroxicam can be decreased when combined with Sorafenib.
Dronabinol Dronabinol The metabolism of Piroxicam can be decreased when combined with Dronabinol.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Piroxicam.
Levocetirizine Levocetirizine Piroxicam may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Piroxicam may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Armodafinil Armodafinil The metabolism of Piroxicam can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Piroxicam may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Lenalidomide Lenalidomide Piroxicam may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Piroxicam can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Piroxicam can be decreased when combined with Bexarotene.
Budesonide Budesonide The risk or severity of gastrointestinal irritation can be increased when Piroxicam is combined with Budesonide.
Desmopressin Desmopressin The risk or severity of hypertension, hyponatremia, and water intoxication can be increased when Piroxicam is combined with Desmopressin.
Doripenem Injection Doripenem Injection Piroxicam may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Piroxicam can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Piroxicam may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Cevimeline Cevimeline Piroxicam may decrease the excretion rate of Cevimeline which could result in a higher serum level.
Nebivolol Nebivolol Piroxicam may decrease the antihypertensive activities of Nebivolol.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Piroxicam.
Leucovorin Injection Leucovorin Injection The excretion of Leucovorin can be decreased when combined with Piroxicam.
Flecainide Flecainide The metabolism of Piroxicam can be decreased when combined with Flecainide.
Daptomycin Injection Daptomycin Injection Piroxicam may decrease the excretion rate of Daptomycin which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Piroxicam may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Piroxicam may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Milnacipran Milnacipran The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Piroxicam.
Sodium Phosphate Sodium Phosphate The risk or severity of renal failure can be increased when Sodium phosphate, monobasic is combined with Piroxicam.
Betaxolol Betaxolol Piroxicam may decrease the antihypertensive activities of Betaxolol.
Prasugrel Prasugrel The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Prasugrel.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Piroxicam.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Piroxicam may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone The risk or severity of hypertension can be increased when Piroxicam is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Piroxicam may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Telavancin Injection Telavancin Injection Piroxicam may decrease the excretion rate of Telavancin which could result in a higher serum level.
Topotecan Topotecan Piroxicam may decrease the excretion rate of Topotecan which could result in a higher serum level.
Dabigatran Dabigatran The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Dabigatran.
Tocilizumab Injection Tocilizumab Injection The metabolism of Piroxicam can be increased when combined with Tocilizumab.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of hypertension can be increased when Piroxicam is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The risk or severity of adverse effects can be increased when Acetaminophen is combined with Piroxicam.
Vilazodone Vilazodone The risk or severity of hypertension can be increased when Piroxicam is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Piroxicam may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Piroxicam may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Azilsartan medoxomil is combined with Piroxicam.
Roflumilast Roflumilast Piroxicam may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Piroxicam.
Abiraterone Abiraterone The metabolism of Piroxicam can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Rivaroxaban.
Ticagrelor Ticagrelor The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Ticagrelor.
Ruxolitinib Ruxolitinib Piroxicam may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Piroxicam may decrease the excretion rate of Clobazam which could result in a higher serum level.
Vemurafenib Vemurafenib The metabolism of Piroxicam can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Piroxicam can be decreased when combined with Vismodegib.
Deferiprone Deferiprone Piroxicam may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Cabergoline Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Piroxicam.
Ambrisentan Ambrisentan The therapeutic efficacy of Ambrisentan can be decreased when used in combination with Piroxicam.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Fondaparinux.
Iloprost Iloprost The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Iloprost.
Enzalutamide Enzalutamide The metabolism of Piroxicam can be decreased when combined with Enzalutamide.
Mirabegron Mirabegron Piroxicam may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Piroxicam can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Piroxicam can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of gastrointestinal irritation can be increased when Corticotropin is combined with Piroxicam.
Teriflunomide Teriflunomide The metabolism of Piroxicam can be decreased when combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Piroxicam can be decreased when combined with Cabozantinib.
Teduglutide Injection Teduglutide Injection Piroxicam may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Piroxicam is combined with Icosapent ethyl.
Alogliptin Alogliptin Piroxicam may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Piroxicam.
Pomalidomide Pomalidomide Piroxicam may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Apixaban Apixaban The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Apixaban.
Canagliflozin Canagliflozin Piroxicam may decrease the excretion rate of Canagliflozin which could result in a higher serum level.
Dabrafenib Dabrafenib The metabolism of Piroxicam can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Piroxicam.
Trametinib Trametinib The metabolism of Piroxicam can be decreased when combined with Trametinib.
Levomilnacipran Levomilnacipran The risk or severity of gastrointestinal bleeding can be increased when Levomilnacipran is combined with Piroxicam.
Ertapenem Injection Ertapenem Injection Piroxicam may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine Vortioxetine Piroxicam may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ketorolac Injection Ketorolac Injection The risk or severity of adverse effects can be increased when Ketorolac is combined with Piroxicam.
Sofosbuvir Sofosbuvir Piroxicam may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Piroxicam may increase the excretion rate of Dapagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast The metabolism of Piroxicam can be increased when combined with Apremilast.
Droxidopa Droxidopa Piroxicam may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Piroxicam can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Piroxicam can be increased when combined with Siltuximab.
Testosterone Injection Testosterone Injection Piroxicam may decrease the excretion rate of Testosterone which could result in a higher serum level.
Oritavancin Injection Oritavancin Injection The metabolism of Piroxicam can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Vorapaxar.
Edoxaban Edoxaban The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Edoxaban.
Tasimelteon Tasimelteon Piroxicam may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat The therapeutic efficacy of Riociguat can be decreased when used in combination with Piroxicam.
Secukinumab Injection Secukinumab Injection The metabolism of Piroxicam can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of hypertension can be increased when Piroxicam is combined with Risperidone.
Lenvatinib Lenvatinib The metabolism of Piroxicam can be decreased when combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The therapeutic efficacy of Haloperidol can be increased when used in combination with Piroxicam.
Amiloride Amiloride The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Amiloride.
Macitentan Macitentan The therapeutic efficacy of Macitentan can be decreased when used in combination with Piroxicam.
Flibanserin Flibanserin The risk or severity of hypertension can be increased when Piroxicam is combined with Flibanserin.
Brexpiprazole Brexpiprazole The risk or severity of hypertension can be increased when Piroxicam is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of hypertension can be increased when Ziprasidone is combined with Piroxicam.
Cariprazine Cariprazine The risk or severity of hypertension can be increased when Piroxicam is combined with Cariprazine.
Eluxadoline Eluxadoline The excretion of Eluxadoline can be decreased when combined with Piroxicam.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Piroxicam.
Ixazomib Ixazomib Piroxicam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Piroxicam can be increased when combined with Rifapentine.
Lesinurad Lesinurad Piroxicam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The risk or severity of gastrointestinal irritation can be increased when Dexamethasone is combined with Piroxicam.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Defibrotide.
Brivaracetam Injection Brivaracetam Injection Piroxicam may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Selexipag Selexipag The therapeutic efficacy of Selexipag can be decreased when used in combination with Piroxicam.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Piroxicam.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Piroxicam.
Rucaparib Rucaparib The metabolism of Piroxicam can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Piroxicam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Piroxicam.
Doxepin (Insomnia) Doxepin (Insomnia) Piroxicam may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Piroxicam may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Piroxicam may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of gastrointestinal irritation can be increased when Deflazacort is combined with Piroxicam.
Safinamide Safinamide The metabolism of Piroxicam can be decreased when combined with Safinamide.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Piroxicam.
Naldemedine Naldemedine Piroxicam may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Piroxicam can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Piroxicam.
Benznidazole Benznidazole Piroxicam may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Piroxicam may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Piroxicam.
Letermovir Letermovir The metabolism of Piroxicam can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Piroxicam which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Piroxicam.
Apalutamide Apalutamide The metabolism of Apalutamide can be decreased when combined with Piroxicam.
Avatrombopag Avatrombopag The metabolism of Piroxicam can be increased when combined with Avatrombopag.
Baricitinib Baricitinib Piroxicam may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Piroxicam.
Plazomicin Injection Plazomicin Injection Piroxicam may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Piroxicam.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Piroxicam.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Piroxicam.
Stiripentol Stiripentol Piroxicam may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Piroxicam.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Piroxicam.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Piroxicam.
Rifamycin Rifamycin The metabolism of Piroxicam can be increased when combined with Rifamycin.
Prucalopride Prucalopride Piroxicam may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Piroxicam can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Piroxicam.
Acyclovir Ophthalmic Acyclovir Ophthalmic Piroxicam may decrease the excretion rate of Acyclovir which could result in a higher serum level.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Piroxicam is combined with Caplacizumab.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Piroxicam.
Alpelisib Alpelisib The serum concentration of Piroxicam can be decreased when it is combined with Alpelisib.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Piroxicam.
Triclabendazole Triclabendazole The metabolism of Piroxicam can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Piroxicam.
Pitolisant Pitolisant The risk or severity of adverse effects can be increased when Piroxicam is combined with Pitolisant.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Piroxicam.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Piroxicam.
Cenobamate Cenobamate The metabolism of Piroxicam can be increased when combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Piroxicam.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Piroxicam.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Piroxicam.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Piroxicam.
Pralsetinib Pralsetinib The metabolism of Piroxicam can be decreased when combined with Pralsetinib.
Opicapone Opicapone The metabolism of Piroxicam can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Piroxicam can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Piroxicam is combined with Naxitamab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Drospirenone.
Viloxazine Viloxazine Piroxicam may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Piroxicam may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Piroxicam.
Fenoprofen Fenoprofen The risk or severity of adverse effects can be increased when Piroxicam is combined with Fenoprofen.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Piroxicam.
Mefenamic Acid Mefenamic Acid The risk or severity of adverse effects can be increased when Piroxicam is combined with Mefenamic acid.
Tolmetin Tolmetin The risk or severity of adverse effects can be increased when Tolmetin is combined with Piroxicam.
Sulindac Sulindac The risk or severity of adverse effects can be increased when Piroxicam is combined with Sulindac.
Trazodone Trazodone The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Piroxicam.
Isotretinoin Isotretinoin Piroxicam may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Piroxicam may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Floxuridine Floxuridine The metabolism of Piroxicam can be decreased when combined with Floxuridine.
Metaxalone Metaxalone Piroxicam may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methsuximide Methsuximide The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of hypertension can be increased when Piroxicam is combined with Diethylpropion.
Chlorpromazine Chlorpromazine Piroxicam may decrease the excretion rate of Chlorpromazine which could result in a higher serum level.
Diazepam Diazepam Piroxicam may decrease the excretion rate of Diazepam which could result in a higher serum level.
Flurazepam Flurazepam Piroxicam may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate Clorazepate Piroxicam may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Piroxicam may decrease the excretion rate of Lorazepam which could result in a higher serum level.
Carmustine Carmustine Piroxicam may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine Amantadine Piroxicam may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine Piroxicam may decrease the excretion rate of Codeine which could result in a higher serum level.
Bromocriptine Bromocriptine The risk or severity of hypertension can be increased when Piroxicam is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Piroxicam can be decreased when combined with Tranylcypromine.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of hypertension can be increased when Piroxicam is combined with Ergoloid mesylate.
Tetracycline Tetracycline Piroxicam may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Thioridazine Thioridazine The risk or severity of hypertension can be increased when Piroxicam is combined with Thioridazine.
Trifluoperazine Trifluoperazine The risk or severity of hypertension can be increased when Piroxicam is combined with Trifluoperazine.
Bleomycin Bleomycin Piroxicam may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Piroxicam.
Sulfadiazine Sulfadiazine Piroxicam may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Oxybutynin Oxybutynin The metabolism of Piroxicam can be decreased when combined with Oxybutynin.
Benztropine Benztropine Piroxicam may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Piroxicam resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline Piroxicam may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen The risk or severity of adverse effects can be increased when Piroxicam is combined with Ibuprofen.
Azathioprine Azathioprine Piroxicam may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Hydrocortisone Hydrocortisone The risk or severity of gastrointestinal irritation can be increased when Hydrocortisone is combined with Piroxicam.
Carbamazepine Carbamazepine Piroxicam may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Clonidine Clonidine The therapeutic efficacy of Clonidine can be decreased when used in combination with Piroxicam.
Hydralazine Hydralazine Piroxicam may decrease the antihypertensive activities of Hydralazine.
Cimetidine Cimetidine Piroxicam may decrease the excretion rate of Cimetidine which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Piroxicam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Warfarin Warfarin The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Warfarin.
Clonazepam Clonazepam Piroxicam may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Piroxicam.
Meclofenamate Meclofenamate The risk or severity of adverse effects can be increased when Piroxicam is combined with Meclofenamic acid.
Griseofulvin Griseofulvin The metabolism of Piroxicam can be increased when combined with Griseofulvin.
Digoxin Digoxin Piroxicam may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Piroxicam may decrease the excretion rate of Chloroquine which could result in a higher serum level.
Ethosuximide Ethosuximide The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Ethosuximide.
Triamterene Triamterene The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Piroxicam is combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Piroxicam.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Piroxicam.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Piroxicam which could result in a lower serum level and potentially a reduction in efficacy.
Desipramine Desipramine Piroxicam may decrease the excretion rate of Desipramine which could result in a higher serum level.
Imipramine Imipramine Imipramine may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Isoniazid Isoniazid Piroxicam may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Disopyramide Disopyramide Piroxicam may decrease the excretion rate of Disopyramide which could result in a higher serum level.
Valproic Acid Valproic Acid The protein binding of Valproic acid can be decreased when combined with Piroxicam.
Tamoxifen Tamoxifen The metabolism of Piroxicam can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Piroxicam may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Levothyroxine Levothyroxine The metabolism of Piroxicam can be decreased when combined with Levothyroxine.
Liothyronine Liothyronine Piroxicam may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Chlorpropamide Chlorpropamide The protein binding of Chlorpropamide can be decreased when combined with Piroxicam.
Tolbutamide Tolbutamide The protein binding of Tolbutamide can be decreased when combined with Piroxicam.
Tolazamide Tolazamide The protein binding of Tolazamide can be decreased when combined with Piroxicam.
Dextromethorphan Dextromethorphan The metabolism of Piroxicam can be decreased when combined with Dextromethorphan.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Piroxicam.
Baclofen Baclofen Piroxicam may decrease the excretion rate of Baclofen which could result in a higher serum level.
Ethambutol Ethambutol Piroxicam may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Piroxicam.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone Piroxicam may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Folic Acid Folic Acid Piroxicam may decrease the excretion rate of Folic acid which could result in a higher serum level.
Mercaptopurine Mercaptopurine The excretion of Mercaptopurine can be decreased when combined with Piroxicam.
Amikacin Injection Amikacin Injection Piroxicam may decrease the excretion rate of Amikacin which could result in a higher serum level.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Piroxicam resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol Piroxicam may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Flavoxate Flavoxate Piroxicam may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Piroxicam.
Colchicine Colchicine Piroxicam may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Piroxicam may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cefadroxil Cefadroxil Piroxicam may decrease the excretion rate of Cefadroxil which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Cephalexin Cephalexin Piroxicam may decrease the excretion rate of Cephalexin which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Dacarbazine Dacarbazine Piroxicam may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Piroxicam which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Piroxicam may decrease the excretion rate of Salmon calcitonin which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Piroxicam can be decreased when combined with Ketoconazole.
Captopril Captopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Captopril.
Dipyridamole Dipyridamole The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Dipyridamole.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Piroxicam is combined with Isoxsuprine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Piroxicam.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Aspirin Aspirin The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Piroxicam.
Salsalate Salsalate The risk or severity of adverse effects can be increased when Piroxicam is combined with Salsalate.
Alprazolam Alprazolam Piroxicam may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Temazepam Temazepam Piroxicam may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam Triazolam Piroxicam may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Piroxicam may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Trimethoprim Trimethoprim The metabolism of Piroxicam can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The therapeutic efficacy of Diltiazem can be decreased when used in combination with Piroxicam.
Timolol Timolol Piroxicam may decrease the antihypertensive activities of Timolol.
Verapamil Verapamil Piroxicam may decrease the excretion rate of Verapamil which could result in a higher serum level.
Atenolol Atenolol Piroxicam may decrease the antihypertensive activities of Atenolol.
Cisplatin Injection Cisplatin Injection Piroxicam may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The therapeutic efficacy of Diflunisal can be decreased when used in combination with Piroxicam.
Bumetanide Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Piroxicam.
Glyburide Glyburide The protein binding of Glyburide can be decreased when combined with Piroxicam.
Glipizide Glipizide The protein binding of Glipizide can be decreased when combined with Piroxicam.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Piroxicam.
Ceftriaxone Injection Ceftriaxone Injection Piroxicam may decrease the excretion rate of Ceftriaxone which could result in a higher serum level.
Labetalol Labetalol Piroxicam may decrease the antihypertensive activities of Labetalol.
Auranofin Auranofin Piroxicam may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Piroxicam may decrease the excretion rate of Leuprolide which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Piroxicam can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Piroxicam.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Ketoprofen Ketoprofen The risk or severity of adverse effects can be increased when Piroxicam is combined with Ketoprofen.
Cefotetan Injection Cefotetan Injection Piroxicam may decrease the excretion rate of Cefotetan which could result in a higher serum level.
Enalapril Enalapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Enalapril.
Flurbiprofen Flurbiprofen The risk or severity of adverse effects can be increased when Flurbiprofen is combined with Piroxicam.
Aztreonam Injection Aztreonam Injection Piroxicam may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone Piroxicam may decrease the excretion rate of Buspirone which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Piroxicam can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin Piroxicam may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Mesalamine Mesalamine The therapeutic efficacy of Mesalazine can be decreased when used in combination with Piroxicam.
Diclofenac Diclofenac The risk or severity of adverse effects can be increased when Diclofenac is combined with Piroxicam.
Fluoxetine Fluoxetine The risk or severity of gastrointestinal bleeding can be increased when Fluoxetine is combined with Piroxicam.
Clozapine Clozapine Piroxicam may decrease the excretion rate of Clozapine which could result in a higher serum level.
Estazolam Estazolam Piroxicam may decrease the excretion rate of Estazolam which could result in a higher serum level.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Piroxicam.
Didanosine Didanosine Piroxicam may decrease the excretion rate of Didanosine which could result in a higher serum level.
Benazepril Benazepril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Benazepril.
Etodolac Etodolac The risk or severity of adverse effects can be increased when Piroxicam is combined with Etodolac.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Piroxicam.
Fosinopril Fosinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Fosinopril.
Nabumetone Nabumetone The risk or severity of adverse effects can be increased when Nabumetone is combined with Piroxicam.
Pravastatin Pravastatin The excretion of Pravastatin can be decreased when combined with Piroxicam.
Quinapril Quinapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Quinapril.
Ramipril Ramipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Ramipril.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Piroxicam.
Amlodipine Amlodipine Piroxicam may decrease the antihypertensive activities of Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Piroxicam can be decreased when combined with Teniposide.
Itraconazole Itraconazole The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Itraconazole.
Lisinopril Lisinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Lisinopril.
Oxaprozin Oxaprozin The risk or severity of adverse effects can be increased when Piroxicam is combined with Oxaprozin.
Atovaquone Atovaquone The metabolism of Piroxicam can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Piroxicam can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol Piroxicam may decrease the antihypertensive activities of Bisoprolol.
Zolpidem Zolpidem The metabolism of Piroxicam can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The therapeutic efficacy of Doxazosin can be decreased when used in combination with Piroxicam.
Terazosin Terazosin The therapeutic efficacy of Terazosin can be decreased when used in combination with Piroxicam.
Isradipine Isradipine The therapeutic efficacy of Isradipine can be decreased when used in combination with Piroxicam.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Piroxicam.
Fluvastatin Fluvastatin The metabolism of Piroxicam can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the antiplatelet activities of Piroxicam.
Stavudine Stavudine The excretion of Stavudine can be decreased when combined with Piroxicam.
Fluvoxamine Fluvoxamine The risk or severity of gastrointestinal bleeding can be increased when Piroxicam is combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of gastrointestinal bleeding can be increased when Piroxicam is combined with Nefazodone.
Lamotrigine Lamotrigine Piroxicam may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
Losartan Losartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Losartan is combined with Piroxicam.
Tramadol Tramadol Piroxicam may decrease the excretion rate of Tramadol which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Piroxicam may decrease the excretion rate of Carboplatin which could result in a higher serum level.
Moexipril Moexipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Moexipril.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Piroxicam.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Piroxicam.
Ifosfamide Injection Ifosfamide Injection Piroxicam may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Bupropion Bupropion Piroxicam may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine The risk or severity of bleeding can be increased when Piroxicam is combined with Ticlopidine.
Metformin Metformin Piroxicam may decrease the excretion rate of Metformin which could result in a higher serum level.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Dalteparin.
Acarbose Acarbose Piroxicam may decrease the excretion rate of Acarbose which could result in a higher serum level.
Glimepiride Glimepiride The protein binding of Glimepiride can be decreased when combined with Piroxicam.
Gemcitabine Injection Gemcitabine Injection Piroxicam may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Meropenem Injection Meropenem Injection Piroxicam may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine Piroxicam may decrease the excretion rate of Clomipramine which could result in a higher serum level.
Zafirlukast Zafirlukast The metabolism of Piroxicam can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Piroxicam may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Piroxicam.
Trandolapril Trandolapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Trandolapril.
Topiramate Topiramate Piroxicam may decrease the excretion rate of Topiramate which could result in a higher serum level.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Piroxicam.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Piroxicam.
Nelfinavir Nelfinavir The metabolism of Piroxicam can be decreased when combined with Nelfinavir.
Loratadine Loratadine The metabolism of Piroxicam can be decreased when combined with Loratadine.
Carvedilol Carvedilol Piroxicam may decrease the antihypertensive activities of Carvedilol.
Nilutamide Nilutamide Piroxicam may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Piroxicam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Sertraline Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Piroxicam.
Finasteride Finasteride The risk or severity of hypertension can be increased when Piroxicam is combined with Finasteride.
Quetiapine Quetiapine Piroxicam may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Cetirizine Cetirizine Piroxicam may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Piroxicam.
Citalopram Citalopram The risk or severity of gastrointestinal bleeding can be increased when Citalopram is combined with Piroxicam.
Capecitabine Capecitabine The metabolism of Piroxicam can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Piroxicam can be decreased when combined with Efavirenz.
Abacavir Abacavir Piroxicam may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Piroxicam can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Piroxicam can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The risk or severity of adverse effects can be increased when Celecoxib is combined with Piroxicam.
Tolterodine Tolterodine Piroxicam may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Piroxicam.
Oseltamivir Oseltamivir Piroxicam may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Piroxicam resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The therapeutic efficacy of Balsalazide can be decreased when used in combination with Piroxicam.
Nateglinide Nateglinide Piroxicam may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Rabeprazole Rabeprazole The metabolism of Piroxicam can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Piroxicam.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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