Piroxicam
Generic name: Pronounced as (peer ox' i kam)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 03/15/2021
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
IMPORTANT WARNING
People who take nonsteroidal anti-inflammatory medications (NSAIDs) (other than aspirin) such as piroxicam may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as piroxicam if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.
If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take piroxicam right before or right after the surgery.
NSAIDs such as piroxicam may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while you are taking piroxicam. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines or other bleeding disorders. If you experience any of the following symptoms, stop taking piroxicam and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.
Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to piroxicam. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with piroxicam and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Why is this medication prescribed?
Piroxicam is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Piroxicam is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.
How should this medicine be used?
Piroxicam comes as a capsule to take by mouth. It is usually taken once or twice a day. Take piroxicam at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take piroxicam exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Piroxicam will help control your symptoms but will not cure your condition. It may take 8 to 12 weeks or longer before you feel the full benefit of piroxicam.
Other uses for this medicine
Piroxicam is also sometimes used to treat gouty arthritis (attacks of severe joint pain and swelling caused by a build-up of certain substances in the joints) and ankylosing spondylitis (arthritis that mainly affects the spine). It is also sometimes used to relieve muscle pain and swelling, menstrual pain, and pain after surgery or childbirth. Talk to your doctor about the risks of using this medication for your condition.
What special precautions should I follow?
Before taking piroxicam,
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tell your doctor and pharmacist if you are allergic to piroxicam, aspirin, or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), any other medications, or any of the inactive ingredients in piroxicam capsules. Ask your pharmacist for a list of the inactive ingredients.
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tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers (ARBs) such as azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); diuretics ('water pills'); lithium (Lithobid); medications for diabetes; methotrexate (Otrexup, Rasuvo, Trexall); and phenytoin (Dilantin, Phenytek). Your doctor may need to change the doses of your medication or monitor you more carefully for side effects.
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tell your doctor if you have or have ever had asthma, especially if you also have frequent stuffy or runny nose or nasal polyps (swelling of the lining of the nose); heart failure; swelling of the hands, feet, ankles, or lower legs; or liver or kidney disease.
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tell your doctor if you are pregnant, plan to become pregnant; or are breast-feeding. Piroxicam may harm the fetus and cause problems with delivery if it is taken around 20 weeks or later during pregnancy. Do not take piroxicam around or after 20 weeks of pregnancy, unless you are told to do so by your doctor. If you become pregnant while taking piroxicam, call your doctor.
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talk to your doctor about the risks and benefits of taking piroxicam if you are 75 years of age or older. Do not take this medication for a longer period of time or at a higher dose than recommended by your doctor.
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if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking piroxicam.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
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Piroxicam may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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diarrhea
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constipation
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gas
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headache
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dizziness
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ringing in the ears
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Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more piroxicam until you speak to your doctor.
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vision problems
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unexplained weight gain
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shortness of breath or difficulty breathing
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swelling in the abdomen, ankles, feet, or legs
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fever
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blisters
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joint pain
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rash
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itching
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hives
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swelling of the eyes, face, lips, tongue, throat, arms, or hands
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difficulty breathing or swallowing
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hoarseness
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pale skin
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fast heartbeat
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excessive tiredness
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unusual bleeding or bruising
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lack of energy
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upset stomach
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loss of appetite
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pain in the upper right part of the stomach
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flu-like symptoms
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yellowing of the skin or eyes
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cloudy, discolored, or bloody urine
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back pain
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difficult or painful urination
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Piroxicam may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
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lack of energy
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drowsiness
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upset stomach
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vomiting
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stomach pain
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bloody, black, or tarry stools
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vomiting a substance that is bloody or looks like coffee grounds
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difficulty breathing
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coma (loss of consciousness for a period of time)
What OTHER INFORMATION should I know?
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Moxifloxacin | Moxifloxacin Piroxicam may increase the neuroexcitatory activities of Moxifloxacin. |
Leflunomide | Leflunomide The metabolism of Piroxicam can be decreased when combined with Leflunomide. |
Nevirapine | Nevirapine The metabolism of Piroxicam can be decreased when combined with Nevirapine. |
Alendronate | Alendronate The risk or severity of adverse effects can be increased when Piroxicam is combined with Alendronic acid. |
Anagrelide | Anagrelide The risk or severity of bleeding can be increased when Piroxicam is combined with Anagrelide. |
Candesartan | Candesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Candesartan is combined with Piroxicam. |
Cilostazol | Cilostazol The risk or severity of bleeding can be increased when Piroxicam is combined with Cilostazol. |
Clopidogrel | Clopidogrel The risk or severity of bleeding can be increased when Piroxicam is combined with Clopidogrel. |
Estrogen and Progestin (Oral Contraceptives) | Estrogen and Progestin (Oral Contraceptives) Piroxicam may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level. |
Guanfacine | Guanfacine The therapeutic efficacy of Guanfacine can be decreased when used in combination with Piroxicam. |
Magnesium Hydroxide | Magnesium Hydroxide Piroxicam may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level. |
Naratriptan | Naratriptan The risk or severity of hypertension can be increased when Piroxicam is combined with Naratriptan. |
Olsalazine | Olsalazine The therapeutic efficacy of Olsalazine can be decreased when used in combination with Piroxicam. |
Paregoric | Paregoric The metabolism of Morphine can be decreased when combined with Piroxicam. |
Penbutolol | Penbutolol Piroxicam may decrease the antihypertensive activities of Acebutolol. |
Sumatriptan | Sumatriptan Piroxicam may decrease the excretion rate of Sumatriptan which could result in a higher serum level. |
Tacrolimus | Tacrolimus The risk or severity of renal failure can be increased when Piroxicam is combined with Tacrolimus. |
Tiludronate | Tiludronate The risk or severity of gastrointestinal bleeding can be increased when Piroxicam is combined with Etidronic acid. |
Triamcinolone | Triamcinolone The risk or severity of gastrointestinal irritation can be increased when Triamcinolone is combined with Piroxicam. |
Zolmitriptan | Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Piroxicam. |
Doxycycline Injection | Doxycycline Injection Piroxicam may decrease the excretion rate of Doxycycline which could result in a higher serum level. |
Famotidine Injection | Famotidine Injection The excretion of Famotidine can be decreased when combined with Piroxicam. |
Fluconazole Injection | Fluconazole Injection The metabolism of Piroxicam can be decreased when combined with Fluconazole. |
Foscarnet Injection | Foscarnet Injection The risk or severity of nephrotoxicity can be increased when Piroxicam is combined with Foscarnet. |
Hydromorphone Injection | Hydromorphone Injection Piroxicam may decrease the excretion rate of Hydromorphone which could result in a higher serum level. |
Meperidine Injection | Meperidine Injection Piroxicam may decrease the excretion rate of Meperidine which could result in a higher serum level. |
Pamidronate Injection | Pamidronate Injection The risk or severity of gastrointestinal bleeding can be increased when Piroxicam is combined with Pamidronic acid. |
Vancomycin Injection | Vancomycin Injection Piroxicam may decrease the excretion rate of Vancomycin which could result in a higher serum level. |
Zidovudine Injection | Zidovudine Injection The risk or severity of bleeding can be increased when Zidovudine is combined with Piroxicam. |
Cefuroxime | Cefuroxime Cefuroxime may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Cyclosporine | Cyclosporine The risk or severity of renal failure and hypertension can be increased when Piroxicam is combined with Cyclosporine. |
Ondansetron | Ondansetron The metabolism of Ondansetron can be decreased when combined with Piroxicam. |
Enoxaparin Injection | Enoxaparin Injection The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Enoxaparin. |
Torsemide | Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Piroxicam. |
Olanzapine | Olanzapine The metabolism of Piroxicam can be decreased when combined with Olanzapine. |
Hydroxychloroquine | Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Piroxicam. |
Meloxicam | Meloxicam The risk or severity of adverse effects can be increased when Piroxicam is combined with Meloxicam. |
Pantoprazole | Pantoprazole Piroxicam may decrease the excretion rate of Pantoprazole which could result in a higher serum level. |
Sevelamer | Sevelamer Sevelamer can cause a decrease in the absorption of Piroxicam resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Temozolomide | Temozolomide Piroxicam may decrease the excretion rate of Temozolomide which could result in a higher serum level. |
Linezolid | Linezolid The risk or severity of hypertension can be increased when Piroxicam is combined with Linezolid. |
Pentosan Polysulfate | Pentosan Polysulfate The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Pentosan polysulfate. |
Trimipramine | Trimipramine The metabolism of Trimipramine can be decreased when combined with Piroxicam. |
Etanercept Injection | Etanercept Injection The metabolism of Piroxicam can be increased when combined with Etanercept. |
Modafinil | Modafinil The metabolism of Piroxicam can be decreased when combined with Modafinil. |
Perindopril | Perindopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Perindopril. |
Tenofovir | Tenofovir Piroxicam may increase the nephrotoxic activities of Tenofovir. |
Choline Magnesium Trisalicylate | Choline Magnesium Trisalicylate The risk or severity of adverse effects can be increased when Piroxicam is combined with Choline magnesium trisalicylate. |
Dutasteride | Dutasteride The risk or severity of hypertension can be increased when Piroxicam is combined with Dutasteride. |
Epinephrine Injection | Epinephrine Injection The metabolism of Piroxicam can be decreased when combined with Epinephrine. |
Eplerenone | Eplerenone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Eplerenone. |
Escitalopram | Escitalopram The risk or severity of gastrointestinal bleeding can be increased when Escitalopram is combined with Piroxicam. |
Olmesartan | Olmesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Olmesartan is combined with Piroxicam. |
Zonisamide | Zonisamide Piroxicam may decrease the excretion rate of Zonisamide which could result in a higher serum level. |
Adalimumab Injection | Adalimumab Injection The metabolism of Piroxicam can be increased when combined with Adalimumab. |
Atomoxetine | Atomoxetine Piroxicam may decrease the excretion rate of Atomoxetine which could result in a higher serum level. |
Dexmethylphenidate | Dexmethylphenidate The risk or severity of hypertension can be increased when Piroxicam is combined with Dexmethylphenidate. |
Atazanavir | Atazanavir Atazanavir may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Almotriptan | Almotriptan Piroxicam may decrease the excretion rate of Almotriptan which could result in a higher serum level. |
Eletriptan | Eletriptan The metabolism of Piroxicam can be decreased when combined with Eletriptan. |
Rosuvastatin | Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Piroxicam. |
Aprepitant | Aprepitant The metabolism of Piroxicam can be decreased when combined with Aprepitant. |
Emtricitabine | Emtricitabine Piroxicam may decrease the excretion rate of Emtricitabine which could result in a higher serum level. |
Memantine | Memantine Piroxicam may decrease the excretion rate of Memantine which could result in a higher serum level. |
Tegaserod | Tegaserod The metabolism of Piroxicam can be decreased when combined with Tegaserod. |
Tadalafil | Tadalafil Piroxicam may decrease the excretion rate of Tadalafil which could result in a higher serum level. |
Frovatriptan | Frovatriptan The risk or severity of hypertension can be increased when Piroxicam is combined with Frovatriptan. |
Gemifloxacin | Gemifloxacin Piroxicam may increase the neuroexcitatory activities of Gemifloxacin. |
Apomorphine Injection | Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Piroxicam. |
Infliximab Injection | Infliximab Injection The metabolism of Piroxicam can be increased when combined with Infliximab. |
Rifaximin | Rifaximin The metabolism of Piroxicam can be increased when combined with Rifaximin. |
Tinidazole | Tinidazole Piroxicam may decrease the excretion rate of Tinidazole which could result in a higher serum level. |
Cefditoren | Cefditoren The excretion of Cefdinir can be decreased when combined with Piroxicam. |
Cyanocobalamin Injection | Cyanocobalamin Injection Piroxicam may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level. |
Erlotinib | Erlotinib The metabolism of Piroxicam can be decreased when combined with Erlotinib. |
Eszopiclone | Eszopiclone Piroxicam may decrease the excretion rate of Eszopiclone which could result in a higher serum level. |
Ganciclovir | Ganciclovir Piroxicam may decrease the excretion rate of Ganciclovir which could result in a higher serum level. |
Solifenacin | Solifenacin The risk or severity of hypertension can be increased when Piroxicam is combined with Solifenacin. |
Valganciclovir | Valganciclovir Piroxicam may decrease the excretion rate of Valganciclovir which could result in a higher serum level. |
Voriconazole | Voriconazole The metabolism of Voriconazole can be decreased when combined with Piroxicam. |
Adefovir | Adefovir Adefovir may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Dextroamphetamine | Dextroamphetamine Piroxicam may decrease the excretion rate of Amphetamine which could result in a higher serum level. |
Peginterferon Alfa-2b (PEG-Intron) | Peginterferon Alfa-2b (PEG-Intron) The metabolism of Piroxicam can be increased when combined with Peginterferon alfa-2b. |
Ibandronate | Ibandronate The risk or severity of gastrointestinal bleeding can be increased when Piroxicam is combined with Ibandronate. |
Isocarboxazid | Isocarboxazid The risk or severity of hypertension can be increased when Piroxicam is combined with Isocarboxazid. |
Ramelteon | Ramelteon Piroxicam may decrease the excretion rate of Ramelteon which could result in a higher serum level. |
Fentanyl | Fentanyl Piroxicam may decrease the excretion rate of Fentanyl which could result in a higher serum level. |
Pregabalin | Pregabalin Piroxicam may decrease the excretion rate of Pregabalin which could result in a higher serum level. |
Deferasirox | Deferasirox The risk or severity of gastrointestinal bleeding and peptic ulcer can be increased when Piroxicam is combined with Deferasirox. |
Felbamate | Felbamate The metabolism of Piroxicam can be decreased when combined with Felbamate. |
Ranolazine | Ranolazine Piroxicam may decrease the excretion rate of Ranolazine which could result in a higher serum level. |
Abatacept Injection | Abatacept Injection The metabolism of Piroxicam can be increased when combined with Abatacept. |
Rasagiline | Rasagiline Piroxicam may decrease the excretion rate of Rasagiline which could result in a higher serum level. |
Imatinib | Imatinib The metabolism of Piroxicam can be decreased when combined with Imatinib. |
Sitagliptin | Sitagliptin Piroxicam may decrease the excretion rate of Sitagliptin which could result in a higher serum level. |
Varenicline | Varenicline Piroxicam may decrease the excretion rate of Varenicline which could result in a higher serum level. |
Gefitinib | Gefitinib The metabolism of Piroxicam can be decreased when combined with Gefitinib. |
Albuterol | Albuterol Piroxicam may decrease the excretion rate of Salbutamol which could result in a higher serum level. |
Paliperidone | Paliperidone Piroxicam may decrease the excretion rate of Paliperidone which could result in a higher serum level. |
Bortezomib | Bortezomib The metabolism of Piroxicam can be decreased when combined with Bortezomib. |
Clofarabine Injection | Clofarabine Injection The excretion of Clofarabine can be decreased when combined with Piroxicam. |
Lubiprostone | Lubiprostone Piroxicam may decrease the excretion rate of Lubiprostone which could result in a higher serum level. |
Aliskiren | Aliskiren The risk or severity of renal failure and hypertension can be increased when Piroxicam is combined with Aliskiren. |
Bismuth Subsalicylate | Bismuth Subsalicylate The therapeutic efficacy of Bismuth subsalicylate can be decreased when used in combination with Piroxicam. |
Nabilone | Nabilone The metabolism of Piroxicam can be decreased when combined with Nabilone. |
Sorafenib | Sorafenib The metabolism of Piroxicam can be decreased when combined with Sorafenib. |
Dronabinol | Dronabinol The metabolism of Piroxicam can be decreased when combined with Dronabinol. |
Lapatinib | Lapatinib The metabolism of Lapatinib can be decreased when combined with Piroxicam. |
Levocetirizine | Levocetirizine Piroxicam may decrease the excretion rate of Levocetirizine which could result in a higher serum level. |
Pegaptanib Injection | Pegaptanib Injection Piroxicam may decrease the excretion rate of Pegaptanib which could result in a higher serum level. |
Armodafinil | Armodafinil The metabolism of Piroxicam can be decreased when combined with Armodafinil. |
Azacitidine Injection | Azacitidine Injection Piroxicam may decrease the excretion rate of Azacitidine which could result in a higher serum level. |
Lenalidomide | Lenalidomide Piroxicam may decrease the excretion rate of Lenalidomide which could result in a higher serum level. |
Nilotinib | Nilotinib The metabolism of Piroxicam can be decreased when combined with Nilotinib. |
Bexarotene | Bexarotene The metabolism of Piroxicam can be decreased when combined with Bexarotene. |
Budesonide | Budesonide The risk or severity of gastrointestinal irritation can be increased when Piroxicam is combined with Budesonide. |
Desmopressin | Desmopressin The risk or severity of hypertension, hyponatremia, and water intoxication can be increased when Piroxicam is combined with Desmopressin. |
Doripenem Injection | Doripenem Injection Piroxicam may decrease the excretion rate of Doripenem which could result in a higher serum level. |
Etravirine | Etravirine The metabolism of Piroxicam can be decreased when combined with Etravirine. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection Piroxicam may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level. |
Cevimeline | Cevimeline Piroxicam may decrease the excretion rate of Cevimeline which could result in a higher serum level. |
Nebivolol | Nebivolol Piroxicam may decrease the antihypertensive activities of Nebivolol. |
Tretinoin | Tretinoin The metabolism of Tretinoin can be decreased when combined with Piroxicam. |
Leucovorin Injection | Leucovorin Injection The excretion of Leucovorin can be decreased when combined with Piroxicam. |
Flecainide | Flecainide The metabolism of Piroxicam can be decreased when combined with Flecainide. |
Daptomycin Injection | Daptomycin Injection Piroxicam may decrease the excretion rate of Daptomycin which could result in a higher serum level. |
Methylnaltrexone Injection | Methylnaltrexone Injection Piroxicam may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level. |
Dexrazoxane Injection | Dexrazoxane Injection Piroxicam may decrease the excretion rate of Dexrazoxane which could result in a higher serum level. |
Milnacipran | Milnacipran The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Piroxicam. |
Sodium Phosphate | Sodium Phosphate The risk or severity of renal failure can be increased when Sodium phosphate, monobasic is combined with Piroxicam. |
Betaxolol | Betaxolol Piroxicam may decrease the antihypertensive activities of Betaxolol. |
Prasugrel | Prasugrel The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Prasugrel. |
Lacosamide | Lacosamide The metabolism of Lacosamide can be decreased when combined with Piroxicam. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) Piroxicam may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy. |
Dronedarone | Dronedarone The risk or severity of hypertension can be increased when Piroxicam is combined with Dronedarone. |
Pralatrexate Injection | Pralatrexate Injection Piroxicam may decrease the excretion rate of Pralatrexate which could result in a higher serum level. |
Telavancin Injection | Telavancin Injection Piroxicam may decrease the excretion rate of Telavancin which could result in a higher serum level. |
Topotecan | Topotecan Piroxicam may decrease the excretion rate of Topotecan which could result in a higher serum level. |
Dabigatran | Dabigatran The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Dabigatran. |
Tocilizumab Injection | Tocilizumab Injection The metabolism of Piroxicam can be increased when combined with Tocilizumab. |
Ceftaroline Injection | Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Lurasidone | Lurasidone The risk or severity of hypertension can be increased when Piroxicam is combined with Lurasidone. |
Acetaminophen Injection | Acetaminophen Injection The risk or severity of adverse effects can be increased when Acetaminophen is combined with Piroxicam. |
Vilazodone | Vilazodone The risk or severity of hypertension can be increased when Piroxicam is combined with Vilazodone. |
Ipilimumab Injection | Ipilimumab Injection Piroxicam may decrease the excretion rate of Ipilimumab which could result in a higher serum level. |
Terbutaline Injection | Terbutaline Injection Piroxicam may decrease the excretion rate of Terbutaline which could result in a higher serum level. |
Azilsartan | Azilsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Azilsartan medoxomil is combined with Piroxicam. |
Roflumilast | Roflumilast Piroxicam may decrease the excretion rate of Roflumilast which could result in a higher serum level. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Piroxicam. |
Abiraterone | Abiraterone The metabolism of Piroxicam can be decreased when combined with Abiraterone. |
Rivaroxaban | Rivaroxaban The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Rivaroxaban. |
Ticagrelor | Ticagrelor The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Ticagrelor. |
Ruxolitinib | Ruxolitinib Piroxicam may decrease the excretion rate of Ruxolitinib which could result in a higher serum level. |
Clobazam | Clobazam Piroxicam may decrease the excretion rate of Clobazam which could result in a higher serum level. |
Vemurafenib | Vemurafenib The metabolism of Piroxicam can be decreased when combined with Vemurafenib. |
Vismodegib | Vismodegib The metabolism of Piroxicam can be decreased when combined with Vismodegib. |
Deferiprone | Deferiprone Piroxicam may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
Cabergoline | Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Piroxicam. |
Ambrisentan | Ambrisentan The therapeutic efficacy of Ambrisentan can be decreased when used in combination with Piroxicam. |
Fondaparinux Injection | Fondaparinux Injection The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Fondaparinux. |
Iloprost | Iloprost The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Iloprost. |
Enzalutamide | Enzalutamide The metabolism of Piroxicam can be decreased when combined with Enzalutamide. |
Mirabegron | Mirabegron Piroxicam may decrease the excretion rate of Mirabegron which could result in a higher serum level. |
Regorafenib | Regorafenib The metabolism of Piroxicam can be decreased when combined with Regorafenib. |
Bosutinib | Bosutinib The metabolism of Piroxicam can be decreased when combined with Bosutinib. |
Corticotropin, Repository Injection | Corticotropin, Repository Injection The risk or severity of gastrointestinal irritation can be increased when Corticotropin is combined with Piroxicam. |
Teriflunomide | Teriflunomide The metabolism of Piroxicam can be decreased when combined with Teriflunomide. |
Cabozantinib (thyroid cancer) | Cabozantinib (thyroid cancer) The metabolism of Piroxicam can be decreased when combined with Cabozantinib. |
Teduglutide Injection | Teduglutide Injection Piroxicam may decrease the excretion rate of Teduglutide which could result in a higher serum level. |
Icosapent Ethyl | Icosapent Ethyl The risk or severity of bleeding can be increased when Piroxicam is combined with Icosapent ethyl. |
Alogliptin | Alogliptin Piroxicam may decrease the excretion rate of Alogliptin which could result in a higher serum level. |
Ponatinib | Ponatinib The metabolism of Ponatinib can be decreased when combined with Piroxicam. |
Pomalidomide | Pomalidomide Piroxicam may decrease the excretion rate of Pomalidomide which could result in a higher serum level. |
Apixaban | Apixaban The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Apixaban. |
Canagliflozin | Canagliflozin Piroxicam may decrease the excretion rate of Canagliflozin which could result in a higher serum level. |
Dabrafenib | Dabrafenib The metabolism of Piroxicam can be decreased when combined with Dabrafenib. |
Ospemifene | Ospemifene The metabolism of Ospemifene can be decreased when combined with Piroxicam. |
Trametinib | Trametinib The metabolism of Piroxicam can be decreased when combined with Trametinib. |
Levomilnacipran | Levomilnacipran The risk or severity of gastrointestinal bleeding can be increased when Levomilnacipran is combined with Piroxicam. |
Ertapenem Injection | Ertapenem Injection Piroxicam may decrease the excretion rate of Ertapenem which could result in a higher serum level. |
Vortioxetine | Vortioxetine Piroxicam may decrease the excretion rate of Vortioxetine which could result in a higher serum level. |
Ketorolac Injection | Ketorolac Injection The risk or severity of adverse effects can be increased when Ketorolac is combined with Piroxicam. |
Sofosbuvir | Sofosbuvir Piroxicam may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. |
Dapagliflozin | Dapagliflozin Piroxicam may increase the excretion rate of Dapagliflozin which could result in a lower serum level and potentially a reduction in efficacy. |
Apremilast | Apremilast The metabolism of Piroxicam can be increased when combined with Apremilast. |
Droxidopa | Droxidopa Piroxicam may decrease the excretion rate of Droxidopa which could result in a higher serum level. |
Ceritinib | Ceritinib The metabolism of Piroxicam can be decreased when combined with Ceritinib. |
Siltuximab Injection | Siltuximab Injection The metabolism of Piroxicam can be increased when combined with Siltuximab. |
Testosterone Injection | Testosterone Injection Piroxicam may decrease the excretion rate of Testosterone which could result in a higher serum level. |
Oritavancin Injection | Oritavancin Injection The metabolism of Piroxicam can be decreased when combined with Oritavancin. |
Vorapaxar | Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Vorapaxar. |
Edoxaban | Edoxaban The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Edoxaban. |
Tasimelteon | Tasimelteon Piroxicam may decrease the excretion rate of Tasimelteon which could result in a higher serum level. |
Riociguat | Riociguat The therapeutic efficacy of Riociguat can be decreased when used in combination with Piroxicam. |
Secukinumab Injection | Secukinumab Injection The metabolism of Piroxicam can be increased when combined with Secukinumab. |
Risperidone Injection | Risperidone Injection The risk or severity of hypertension can be increased when Piroxicam is combined with Risperidone. |
Lenvatinib | Lenvatinib The metabolism of Piroxicam can be decreased when combined with Lenvatinib. |
Haloperidol Injection | Haloperidol Injection The therapeutic efficacy of Haloperidol can be increased when used in combination with Piroxicam. |
Amiloride | Amiloride The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Amiloride. |
Macitentan | Macitentan The therapeutic efficacy of Macitentan can be decreased when used in combination with Piroxicam. |
Flibanserin | Flibanserin The risk or severity of hypertension can be increased when Piroxicam is combined with Flibanserin. |
Brexpiprazole | Brexpiprazole The risk or severity of hypertension can be increased when Piroxicam is combined with Brexpiprazole. |
Ziprasidone Injection | Ziprasidone Injection The risk or severity of hypertension can be increased when Ziprasidone is combined with Piroxicam. |
Cariprazine | Cariprazine The risk or severity of hypertension can be increased when Piroxicam is combined with Cariprazine. |
Eluxadoline | Eluxadoline The excretion of Eluxadoline can be decreased when combined with Piroxicam. |
Trabectedin Injection | Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Piroxicam. |
Ixazomib | Ixazomib Piroxicam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
Rifapentine | Rifapentine The metabolism of Piroxicam can be increased when combined with Rifapentine. |
Lesinurad | Lesinurad Piroxicam may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
Amphotericin B Liposomal Injection | Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Dexamethasone Injection | Dexamethasone Injection The risk or severity of gastrointestinal irritation can be increased when Dexamethasone is combined with Piroxicam. |
Defibrotide Injection | Defibrotide Injection The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Defibrotide. |
Brivaracetam Injection | Brivaracetam Injection Piroxicam may decrease the excretion rate of Brivaracetam which could result in a higher serum level. |
Selexipag | Selexipag The therapeutic efficacy of Selexipag can be decreased when used in combination with Piroxicam. |
Diphenhydramine Injection | Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Piroxicam. |
Furosemide Injection | Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Piroxicam. |
Rucaparib | Rucaparib The metabolism of Piroxicam can be decreased when combined with Rucaparib. |
Lixisenatide Injection | Lixisenatide Injection Piroxicam may decrease the excretion rate of Lixisenatide which could result in a higher serum level. |
Brigatinib | Brigatinib The metabolism of Brigatinib can be decreased when combined with Piroxicam. |
Doxepin (Insomnia) | Doxepin (Insomnia) Piroxicam may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Deutetrabenazine | Deutetrabenazine Piroxicam may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level. |
Valbenazine | Valbenazine Piroxicam may decrease the excretion rate of Valbenazine which could result in a higher serum level. |
Deflazacort | Deflazacort The risk or severity of gastrointestinal irritation can be increased when Deflazacort is combined with Piroxicam. |
Safinamide | Safinamide The metabolism of Piroxicam can be decreased when combined with Safinamide. |
Edaravone Injection | Edaravone Injection The excretion of Edaravone can be decreased when combined with Piroxicam. |
Naldemedine | Naldemedine Piroxicam may decrease the excretion rate of Naldemedine which could result in a higher serum level. |
Midostaurin | Midostaurin The metabolism of Piroxicam can be decreased when combined with Midostaurin. |
Enasidenib | Enasidenib The metabolism of Enasidenib can be decreased when combined with Piroxicam. |
Benznidazole | Benznidazole Piroxicam may decrease the excretion rate of Benznidazole which could result in a higher serum level. |
Delafloxacin | Delafloxacin Piroxicam may decrease the excretion rate of Delafloxacin which could result in a higher serum level. |
Betrixaban | Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Piroxicam. |
Letermovir | Letermovir The metabolism of Piroxicam can be decreased when combined with Letermovir. |
Ertugliflozin | Ertugliflozin Ertugliflozin may increase the excretion rate of Piroxicam which could result in a lower serum level and potentially a reduction in efficacy. |
Buprenorphine Injection | Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Piroxicam. |
Apalutamide | Apalutamide The metabolism of Apalutamide can be decreased when combined with Piroxicam. |
Avatrombopag | Avatrombopag The metabolism of Piroxicam can be increased when combined with Avatrombopag. |
Baricitinib | Baricitinib Piroxicam may decrease the excretion rate of Baricitinib which could result in a higher serum level. |
Lofexidine | Lofexidine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Piroxicam. |
Plazomicin Injection | Plazomicin Injection Piroxicam may decrease the excretion rate of Plazomicin which could result in a higher serum level. |
Elagolix | Elagolix The metabolism of Elagolix can be decreased when combined with Piroxicam. |
Cannabidiol | Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Piroxicam. |
Dacomitinib | Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Piroxicam. |
Stiripentol | Stiripentol Piroxicam may decrease the excretion rate of Stiripentol which could result in a higher serum level. |
Glasdegib | Glasdegib The metabolism of Glasdegib can be decreased when combined with Piroxicam. |
Lorlatinib | Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Piroxicam. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Piroxicam. |
Rifamycin | Rifamycin The metabolism of Piroxicam can be increased when combined with Rifamycin. |
Prucalopride | Prucalopride Piroxicam may decrease the excretion rate of Prucalopride which could result in a higher serum level. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The metabolism of Piroxicam can be increased when combined with Emapalumab. |
Siponimod | Siponimod The metabolism of Siponimod can be decreased when combined with Piroxicam. |
Acyclovir Ophthalmic | Acyclovir Ophthalmic Piroxicam may decrease the excretion rate of Acyclovir which could result in a higher serum level. |
Caplacizumab-yhdp Injection | Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Piroxicam is combined with Caplacizumab. |
Erdafitinib | Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Piroxicam. |
Alpelisib | Alpelisib The serum concentration of Piroxicam can be decreased when it is combined with Alpelisib. |
Solriamfetol | Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Piroxicam. |
Triclabendazole | Triclabendazole The metabolism of Piroxicam can be decreased when combined with Triclabendazole. |
Istradefylline | Istradefylline The metabolism of Istradefylline can be decreased when combined with Piroxicam. |
Pitolisant | Pitolisant The risk or severity of adverse effects can be increased when Piroxicam is combined with Pitolisant. |
Voxelotor | Voxelotor The metabolism of Voxelotor can be decreased when combined with Piroxicam. |
Avapritinib | Avapritinib The metabolism of Avapritinib can be decreased when combined with Piroxicam. |
Cenobamate | Cenobamate The metabolism of Piroxicam can be increased when combined with Cenobamate. |
Ozanimod | Ozanimod The metabolism of Ozanimod can be decreased when combined with Piroxicam. |
Selumetinib | Selumetinib The metabolism of Selumetinib can be decreased when combined with Piroxicam. |
Tucatinib | Tucatinib The metabolism of Tucatinib can be decreased when combined with Piroxicam. |
Selpercatinib | Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Piroxicam. |
Pralsetinib | Pralsetinib The metabolism of Piroxicam can be decreased when combined with Pralsetinib. |
Opicapone | Opicapone The metabolism of Piroxicam can be decreased when combined with Opicapone. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Piroxicam can be decreased when it is combined with Satralizumab. |
Naxitamab-gqgk Injection | Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Piroxicam is combined with Naxitamab. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Drospirenone. |
Viloxazine | Viloxazine Piroxicam may decrease the excretion rate of Viloxazine which could result in a higher serum level. |
Tobramycin Injection | Tobramycin Injection Piroxicam may decrease the excretion rate of Tobramycin which could result in a higher serum level. |
Theophylline | Theophylline The metabolism of Theophylline can be decreased when combined with Piroxicam. |
Fenoprofen | Fenoprofen The risk or severity of adverse effects can be increased when Piroxicam is combined with Fenoprofen. |
Indomethacin | Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Piroxicam. |
Mefenamic Acid | Mefenamic Acid The risk or severity of adverse effects can be increased when Piroxicam is combined with Mefenamic acid. |
Tolmetin | Tolmetin The risk or severity of adverse effects can be increased when Tolmetin is combined with Piroxicam. |
Sulindac | Sulindac The risk or severity of adverse effects can be increased when Piroxicam is combined with Sulindac. |
Trazodone | Trazodone The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Piroxicam. |
Isotretinoin | Isotretinoin Piroxicam may decrease the excretion rate of Isotretinoin which could result in a higher serum level. |
Sucralfate | Sucralfate Piroxicam may decrease the excretion rate of Sucralfate which could result in a higher serum level. |
Floxuridine | Floxuridine The metabolism of Piroxicam can be decreased when combined with Floxuridine. |
Metaxalone | Metaxalone Piroxicam may decrease the excretion rate of Metaxalone which could result in a higher serum level. |
Methsuximide | Methsuximide The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Methsuximide. |
Diethylpropion | Diethylpropion The risk or severity of hypertension can be increased when Piroxicam is combined with Diethylpropion. |
Chlorpromazine | Chlorpromazine Piroxicam may decrease the excretion rate of Chlorpromazine which could result in a higher serum level. |
Diazepam | Diazepam Piroxicam may decrease the excretion rate of Diazepam which could result in a higher serum level. |
Flurazepam | Flurazepam Piroxicam may decrease the excretion rate of Flurazepam which could result in a higher serum level. |
Clorazepate | Clorazepate Piroxicam may decrease the excretion rate of Clorazepic acid which could result in a higher serum level. |
Lorazepam | Lorazepam Piroxicam may decrease the excretion rate of Lorazepam which could result in a higher serum level. |
Carmustine | Carmustine Piroxicam may decrease the excretion rate of Carmustine which could result in a higher serum level. |
Amantadine | Amantadine Piroxicam may decrease the excretion rate of Amantadine which could result in a higher serum level. |
Codeine | Codeine Piroxicam may decrease the excretion rate of Codeine which could result in a higher serum level. |
Bromocriptine | Bromocriptine The risk or severity of hypertension can be increased when Piroxicam is combined with Bromocriptine. |
Tranylcypromine | Tranylcypromine The metabolism of Piroxicam can be decreased when combined with Tranylcypromine. |
Ergoloid Mesylates | Ergoloid Mesylates The risk or severity of hypertension can be increased when Piroxicam is combined with Ergoloid mesylate. |
Tetracycline | Tetracycline Piroxicam may decrease the excretion rate of Tetracycline which could result in a higher serum level. |
Thioridazine | Thioridazine The risk or severity of hypertension can be increased when Piroxicam is combined with Thioridazine. |
Trifluoperazine | Trifluoperazine The risk or severity of hypertension can be increased when Piroxicam is combined with Trifluoperazine. |
Bleomycin | Bleomycin Piroxicam may decrease the excretion rate of Bleomycin which could result in a higher serum level. |
Dapsone | Dapsone The metabolism of Dapsone can be decreased when combined with Piroxicam. |
Sulfadiazine | Sulfadiazine Piroxicam may decrease the excretion rate of Sulfadiazine which could result in a higher serum level. |
Oxybutynin | Oxybutynin The metabolism of Piroxicam can be decreased when combined with Oxybutynin. |
Benztropine | Benztropine Piroxicam may decrease the excretion rate of Benzatropine which could result in a higher serum level. |
Colestipol | Colestipol Colestipol can cause a decrease in the absorption of Piroxicam resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Maprotiline | Maprotiline Piroxicam may decrease the excretion rate of Maprotiline which could result in a higher serum level. |
Ibuprofen | Ibuprofen The risk or severity of adverse effects can be increased when Piroxicam is combined with Ibuprofen. |
Azathioprine | Azathioprine Piroxicam may decrease the excretion rate of Azathioprine which could result in a higher serum level. |
Hydrocortisone | Hydrocortisone The risk or severity of gastrointestinal irritation can be increased when Hydrocortisone is combined with Piroxicam. |
Carbamazepine | Carbamazepine Piroxicam may decrease the excretion rate of Carbamazepine which could result in a higher serum level. |
Clonidine | Clonidine The therapeutic efficacy of Clonidine can be decreased when used in combination with Piroxicam. |
Hydralazine | Hydralazine Piroxicam may decrease the antihypertensive activities of Hydralazine. |
Cimetidine | Cimetidine Piroxicam may decrease the excretion rate of Cimetidine which could result in a higher serum level. |
Gentamicin Injection | Gentamicin Injection Piroxicam may decrease the excretion rate of Gentamicin which could result in a higher serum level. |
Warfarin | Warfarin The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Warfarin. |
Clonazepam | Clonazepam Piroxicam may decrease the excretion rate of Clonazepam which could result in a higher serum level. |
Loperamide | Loperamide The metabolism of Loperamide can be decreased when combined with Piroxicam. |
Meclofenamate | Meclofenamate The risk or severity of adverse effects can be increased when Piroxicam is combined with Meclofenamic acid. |
Griseofulvin | Griseofulvin The metabolism of Piroxicam can be increased when combined with Griseofulvin. |
Digoxin | Digoxin Piroxicam may decrease the excretion rate of Digoxin which could result in a higher serum level. |
Chloroquine | Chloroquine Piroxicam may decrease the excretion rate of Chloroquine which could result in a higher serum level. |
Ethosuximide | Ethosuximide The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Ethosuximide. |
Triamterene | Triamterene The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Triamterene. |
Sulfinpyrazone | Sulfinpyrazone The risk or severity of bleeding can be increased when Piroxicam is combined with Sulfinpyrazone. |
Chlorothiazide | Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Piroxicam. |
Chlorthalidone | Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Piroxicam. |
Isosorbide | Isosorbide Isosorbide may increase the excretion rate of Piroxicam which could result in a lower serum level and potentially a reduction in efficacy. |
Desipramine | Desipramine Piroxicam may decrease the excretion rate of Desipramine which could result in a higher serum level. |
Imipramine | Imipramine Imipramine may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Isoniazid | Isoniazid Piroxicam may decrease the excretion rate of Isoniazid which could result in a higher serum level. |
Disopyramide | Disopyramide Piroxicam may decrease the excretion rate of Disopyramide which could result in a higher serum level. |
Valproic Acid | Valproic Acid The protein binding of Valproic acid can be decreased when combined with Piroxicam. |
Tamoxifen | Tamoxifen The metabolism of Piroxicam can be decreased when combined with Tamoxifen. |
Butabarbital | Butabarbital Piroxicam may decrease the excretion rate of Butabarbital which could result in a higher serum level. |
Levothyroxine | Levothyroxine The metabolism of Piroxicam can be decreased when combined with Levothyroxine. |
Liothyronine | Liothyronine Piroxicam may decrease the excretion rate of Liothyronine which could result in a higher serum level. |
Chlorpropamide | Chlorpropamide The protein binding of Chlorpropamide can be decreased when combined with Piroxicam. |
Tolbutamide | Tolbutamide The protein binding of Tolbutamide can be decreased when combined with Piroxicam. |
Tolazamide | Tolazamide The protein binding of Tolazamide can be decreased when combined with Piroxicam. |
Dextromethorphan | Dextromethorphan The metabolism of Piroxicam can be decreased when combined with Dextromethorphan. |
Dinoprostone | Dinoprostone The excretion of Dinoprostone can be decreased when combined with Piroxicam. |
Baclofen | Baclofen Piroxicam may decrease the excretion rate of Baclofen which could result in a higher serum level. |
Ethambutol | Ethambutol Piroxicam may decrease the excretion rate of Ethambutol which could result in a higher serum level. |
Hydrochlorothiazide | Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Piroxicam. |
Dantrolene | Dantrolene The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Dantrolene. |
Chlorzoxazone | Chlorzoxazone Piroxicam may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level. |
Folic Acid | Folic Acid Piroxicam may decrease the excretion rate of Folic acid which could result in a higher serum level. |
Mercaptopurine | Mercaptopurine The excretion of Mercaptopurine can be decreased when combined with Piroxicam. |
Amikacin Injection | Amikacin Injection Piroxicam may decrease the excretion rate of Amikacin which could result in a higher serum level. |
Cholestyramine Resin | Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Piroxicam resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Allopurinol | Allopurinol Piroxicam may decrease the excretion rate of Allopurinol which could result in a higher serum level. |
Flavoxate | Flavoxate Piroxicam may decrease the excretion rate of Flavoxate which could result in a higher serum level. |
Fluorouracil Injection | Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Piroxicam. |
Colchicine | Colchicine Piroxicam may decrease the excretion rate of Colchicine which could result in a higher serum level. |
Cefaclor | Cefaclor Piroxicam may decrease the excretion rate of Cefaclor which could result in a higher serum level. |
Cefadroxil | Cefadroxil Piroxicam may decrease the excretion rate of Cefadroxil which could result in a higher serum level. |
Cefazolin Injection | Cefazolin Injection Cefazolin may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Cephalexin | Cephalexin Piroxicam may decrease the excretion rate of Cephalexin which could result in a higher serum level. |
Cefoxitin Injection | Cefoxitin Injection Cefoxitin may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Dacarbazine | Dacarbazine Piroxicam may decrease the excretion rate of Dacarbazine which could result in a higher serum level. |
Acetazolamide | Acetazolamide Acetazolamide may increase the excretion rate of Piroxicam which could result in a lower serum level and potentially a reduction in efficacy. |
Cefotaxime Injection | Cefotaxime Injection Cefotaxime may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Calcitonin Salmon Injection | Calcitonin Salmon Injection Piroxicam may decrease the excretion rate of Salmon calcitonin which could result in a higher serum level. |
Ketoconazole | Ketoconazole The metabolism of Piroxicam can be decreased when combined with Ketoconazole. |
Captopril | Captopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Captopril. |
Dipyridamole | Dipyridamole The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Dipyridamole. |
Isoxsuprine | Isoxsuprine The risk or severity of hypertension can be increased when Piroxicam is combined with Isoxsuprine. |
Ethacrynic Acid | Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Piroxicam. |
Colistimethate Injection | Colistimethate Injection Colistimethate may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Aspirin | Aspirin The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Piroxicam. |
Salsalate | Salsalate The risk or severity of adverse effects can be increased when Piroxicam is combined with Salsalate. |
Alprazolam | Alprazolam Piroxicam may decrease the excretion rate of Alprazolam which could result in a higher serum level. |
Temazepam | Temazepam Piroxicam may decrease the excretion rate of Temazepam which could result in a higher serum level. |
Triazolam | Triazolam Piroxicam may decrease the excretion rate of Triazolam which could result in a higher serum level. |
Dicyclomine | Dicyclomine Piroxicam may decrease the excretion rate of Dicyclomine which could result in a higher serum level. |
Trimethoprim | Trimethoprim The metabolism of Piroxicam can be decreased when combined with Trimethoprim. |
Diltiazem | Diltiazem The therapeutic efficacy of Diltiazem can be decreased when used in combination with Piroxicam. |
Timolol | Timolol Piroxicam may decrease the antihypertensive activities of Timolol. |
Verapamil | Verapamil Piroxicam may decrease the excretion rate of Verapamil which could result in a higher serum level. |
Atenolol | Atenolol Piroxicam may decrease the antihypertensive activities of Atenolol. |
Cisplatin Injection | Cisplatin Injection Piroxicam may decrease the excretion rate of Cisplatin which could result in a higher serum level. |
Diflunisal | Diflunisal The therapeutic efficacy of Diflunisal can be decreased when used in combination with Piroxicam. |
Bumetanide | Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Piroxicam. |
Glyburide | Glyburide The protein binding of Glyburide can be decreased when combined with Piroxicam. |
Glipizide | Glipizide The protein binding of Glipizide can be decreased when combined with Piroxicam. |
Indapamide | Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Piroxicam. |
Ceftriaxone Injection | Ceftriaxone Injection Piroxicam may decrease the excretion rate of Ceftriaxone which could result in a higher serum level. |
Labetalol | Labetalol Piroxicam may decrease the antihypertensive activities of Labetalol. |
Auranofin | Auranofin Piroxicam may decrease the excretion rate of Auranofin which could result in a higher serum level. |
Leuprolide Injection | Leuprolide Injection Piroxicam may decrease the excretion rate of Leuprolide which could result in a higher serum level. |
Gemfibrozil | Gemfibrozil The metabolism of Piroxicam can be decreased when combined with Gemfibrozil. |
Guanabenz | Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Piroxicam. |
Dipivefrin Ophthalmic | Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Ceftazidime Injection | Ceftazidime Injection Ceftazidime may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Ketoprofen | Ketoprofen The risk or severity of adverse effects can be increased when Piroxicam is combined with Ketoprofen. |
Cefotetan Injection | Cefotetan Injection Piroxicam may decrease the excretion rate of Cefotetan which could result in a higher serum level. |
Enalapril | Enalapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Enalapril. |
Flurbiprofen | Flurbiprofen The risk or severity of adverse effects can be increased when Flurbiprofen is combined with Piroxicam. |
Aztreonam Injection | Aztreonam Injection Piroxicam may decrease the excretion rate of Aztreonam which could result in a higher serum level. |
Buspirone | Buspirone Piroxicam may decrease the excretion rate of Buspirone which could result in a higher serum level. |
Lovastatin | Lovastatin The metabolism of Piroxicam can be decreased when combined with Lovastatin. |
Ciprofloxacin | Ciprofloxacin Piroxicam may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level. |
Mesalamine | Mesalamine The therapeutic efficacy of Mesalazine can be decreased when used in combination with Piroxicam. |
Diclofenac | Diclofenac The risk or severity of adverse effects can be increased when Diclofenac is combined with Piroxicam. |
Fluoxetine | Fluoxetine The risk or severity of gastrointestinal bleeding can be increased when Fluoxetine is combined with Piroxicam. |
Clozapine | Clozapine Piroxicam may decrease the excretion rate of Clozapine which could result in a higher serum level. |
Estazolam | Estazolam Piroxicam may decrease the excretion rate of Estazolam which could result in a higher serum level. |
Idarubicin | Idarubicin The metabolism of Idarubicin can be decreased when combined with Piroxicam. |
Didanosine | Didanosine Piroxicam may decrease the excretion rate of Didanosine which could result in a higher serum level. |
Benazepril | Benazepril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Benazepril. |
Etodolac | Etodolac The risk or severity of adverse effects can be increased when Piroxicam is combined with Etodolac. |
Felodipine | Felodipine The metabolism of Felodipine can be decreased when combined with Piroxicam. |
Fosinopril | Fosinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Fosinopril. |
Nabumetone | Nabumetone The risk or severity of adverse effects can be increased when Nabumetone is combined with Piroxicam. |
Pravastatin | Pravastatin The excretion of Pravastatin can be decreased when combined with Piroxicam. |
Quinapril | Quinapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Quinapril. |
Ramipril | Ramipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Ramipril. |
Simvastatin | Simvastatin The metabolism of Simvastatin can be decreased when combined with Piroxicam. |
Amlodipine | Amlodipine Piroxicam may decrease the antihypertensive activities of Amlodipine. |
Teniposide Injection | Teniposide Injection The metabolism of Piroxicam can be decreased when combined with Teniposide. |
Itraconazole | Itraconazole The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Itraconazole. |
Lisinopril | Lisinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Lisinopril. |
Oxaprozin | Oxaprozin The risk or severity of adverse effects can be increased when Piroxicam is combined with Oxaprozin. |
Atovaquone | Atovaquone The metabolism of Piroxicam can be decreased when combined with Atovaquone. |
Rifabutin | Rifabutin The metabolism of Piroxicam can be increased when combined with Rifabutin. |
Bisoprolol | Bisoprolol Piroxicam may decrease the antihypertensive activities of Bisoprolol. |
Zolpidem | Zolpidem The metabolism of Piroxicam can be decreased when combined with Zolpidem. |
Doxazosin | Doxazosin The therapeutic efficacy of Doxazosin can be decreased when used in combination with Piroxicam. |
Terazosin | Terazosin The therapeutic efficacy of Terazosin can be decreased when used in combination with Piroxicam. |
Isradipine | Isradipine The therapeutic efficacy of Isradipine can be decreased when used in combination with Piroxicam. |
Cisapride | Cisapride The metabolism of Cisapride can be decreased when combined with Piroxicam. |
Fluvastatin | Fluvastatin The metabolism of Piroxicam can be decreased when combined with Fluvastatin. |
Venlafaxine | Venlafaxine Venlafaxine may increase the antiplatelet activities of Piroxicam. |
Stavudine | Stavudine The excretion of Stavudine can be decreased when combined with Piroxicam. |
Fluvoxamine | Fluvoxamine The risk or severity of gastrointestinal bleeding can be increased when Piroxicam is combined with Fluvoxamine. |
Nefazodone | Nefazodone The risk or severity of gastrointestinal bleeding can be increased when Piroxicam is combined with Nefazodone. |
Lamotrigine | Lamotrigine Piroxicam may decrease the excretion rate of Lamotrigine which could result in a higher serum level. |
Losartan | Losartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Losartan is combined with Piroxicam. |
Tramadol | Tramadol Piroxicam may decrease the excretion rate of Tramadol which could result in a higher serum level. |
Carboplatin Injection | Carboplatin Injection Piroxicam may decrease the excretion rate of Carboplatin which could result in a higher serum level. |
Moexipril | Moexipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Moexipril. |
Lansoprazole | Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Piroxicam. |
Alprostadil Urogenital | Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Piroxicam. |
Ifosfamide Injection | Ifosfamide Injection Piroxicam may decrease the excretion rate of Ifosfamide which could result in a higher serum level. |
Bupropion | Bupropion Piroxicam may decrease the excretion rate of Bupropion which could result in a higher serum level. |
Ticlopidine | Ticlopidine The risk or severity of bleeding can be increased when Piroxicam is combined with Ticlopidine. |
Metformin | Metformin Piroxicam may decrease the excretion rate of Metformin which could result in a higher serum level. |
Dalteparin Injection | Dalteparin Injection The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Dalteparin. |
Acarbose | Acarbose Piroxicam may decrease the excretion rate of Acarbose which could result in a higher serum level. |
Glimepiride | Glimepiride The protein binding of Glimepiride can be decreased when combined with Piroxicam. |
Gemcitabine Injection | Gemcitabine Injection Piroxicam may decrease the excretion rate of Gemcitabine which could result in a higher serum level. |
Meropenem Injection | Meropenem Injection Piroxicam may decrease the excretion rate of Meropenem which could result in a higher serum level. |
Clomipramine | Clomipramine Piroxicam may decrease the excretion rate of Clomipramine which could result in a higher serum level. |
Zafirlukast | Zafirlukast The metabolism of Piroxicam can be decreased when combined with Zafirlukast. |
Fosfomycin | Fosfomycin Piroxicam may decrease the excretion rate of Fosfomycin which could result in a higher serum level. |
Mirtazapine | Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Piroxicam. |
Trandolapril | Trandolapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Trandolapril. |
Topiramate | Topiramate Piroxicam may decrease the excretion rate of Topiramate which could result in a higher serum level. |
Zileuton | Zileuton The metabolism of Zileuton can be decreased when combined with Piroxicam. |
Donepezil | Donepezil The metabolism of Donepezil can be decreased when combined with Piroxicam. |
Nelfinavir | Nelfinavir The metabolism of Piroxicam can be decreased when combined with Nelfinavir. |
Loratadine | Loratadine The metabolism of Piroxicam can be decreased when combined with Loratadine. |
Carvedilol | Carvedilol Piroxicam may decrease the antihypertensive activities of Carvedilol. |
Nilutamide | Nilutamide Piroxicam may decrease the excretion rate of Nilutamide which could result in a higher serum level. |
Flutamide | Flutamide Piroxicam may decrease the excretion rate of Flutamide which could result in a higher serum level. |
Sertraline | Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Piroxicam. |
Finasteride | Finasteride The risk or severity of hypertension can be increased when Piroxicam is combined with Finasteride. |
Quetiapine | Quetiapine Piroxicam may decrease the excretion rate of Quetiapine which could result in a higher serum level. |
Cefepime Injection | Cefepime Injection Cefepime may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Cefprozil | Cefprozil Cefprozil may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Cefpodoxime | Cefpodoxime Cefpodoxime may decrease the excretion rate of Piroxicam which could result in a higher serum level. |
Cetirizine | Cetirizine Piroxicam may decrease the excretion rate of Cetirizine which could result in a higher serum level. |
Paroxetine | Paroxetine The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Piroxicam. |
Citalopram | Citalopram The risk or severity of gastrointestinal bleeding can be increased when Citalopram is combined with Piroxicam. |
Capecitabine | Capecitabine The metabolism of Piroxicam can be decreased when combined with Capecitabine. |
Efavirenz | Efavirenz The metabolism of Piroxicam can be decreased when combined with Efavirenz. |
Abacavir | Abacavir Piroxicam may decrease the excretion rate of Abacavir which could result in a higher serum level. |
Sildenafil | Sildenafil The metabolism of Piroxicam can be decreased when combined with Sildenafil. |
Pioglitazone | Pioglitazone The metabolism of Piroxicam can be decreased when combined with Pioglitazone. |
Celecoxib | Celecoxib The risk or severity of adverse effects can be increased when Celecoxib is combined with Piroxicam. |
Tolterodine | Tolterodine Piroxicam may decrease the excretion rate of Tolterodine which could result in a higher serum level. |
Thalidomide | Thalidomide The metabolism of Thalidomide can be decreased when combined with Piroxicam. |
Oseltamivir | Oseltamivir Piroxicam may decrease the excretion rate of Oseltamivir which could result in a higher serum level. |
Colesevelam | Colesevelam Colesevelam can cause a decrease in the absorption of Piroxicam resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Balsalazide | Balsalazide The therapeutic efficacy of Balsalazide can be decreased when used in combination with Piroxicam. |
Nateglinide | Nateglinide Piroxicam may decrease the excretion rate of Nateglinide which could result in a higher serum level. |
Rabeprazole | Rabeprazole The metabolism of Piroxicam can be decreased when combined with Rabeprazole. |
Terbinafine | Terbinafine The metabolism of Terbinafine can be decreased when combined with Piroxicam. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists