Ampicillin Injection

Generic name: Pronounced as (am" pi sil' in)
Brand names
  • Omnipen-N®
  • Penbritin-S®
  • Polycillin-N®
  • Totacillin-N®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 12/15/2015

Ampicillin injection is used to treat certain infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and lung, blood, heart, urinary tract, and gastrointestinal tract infections. Ampicillin injection is in a class of medications called penicillins. It works by killing bacteria.

Antibiotics such as ampicillin injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Ampicillin injection comes as a powder to be mixed with fluid and injected intravenously (into a vein) or intramuscularly (into a muscle). The frequency and length of your treatment depends on the type of infection you have.

You may receive ampicillin injection in a hospital or you may administer the medication at home. If you will be receiving ampicillin injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions.

You should begin to feel better during the first few days of treatment with ampicillin injection. If your symptoms do not improve or get worse, call your doctor.

Use ampicillin injection until you finish the prescription, even if you feel better. If you stop using ampicillin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Ampicillin injection is also used in some pregnant women to prevent passing an infection to the baby during birth. Ampicillin injection is also sometimes used to prevent infection in people who are having certain types of surgery. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving ampicillin injection,

  • tell your doctor and pharmacist if you are allergic to ampicillin; penicillins; cephalosporin antibiotics such as cefaclor, cefadroxil, cefazolin (Ancef, Kefzol), cefdinir, cefditoren (Spectracef), cefepime (Maxipime), cefixime (Suprax), cefotaxime (Claforan), cefotetan, cefoxitin (Mefoxin), cefpodoxime, cefprozil, ceftaroline (Teflaro), ceftazidime (Fortaz, Tazicef, in Avycaz), ceftibuten (Cedax), ceftriaxone (Rocephin), cefuroxime (Zinacef), and cephalexin (Keflex); any other medications; or any of the ingredients in ampicillin injection. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: allopurinol (Aloprim, Zyloprim); other antibiotics; oral contraceptives; and probenecid (in Col-Probenecid, Probalan). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have mononucleosis (a virus also called 'mono') or have or have ever had allergies, asthma, hives, or hay fever.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while receiving ampicillin injection, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

  • Ampicillin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • diarrhea

    • vomiting

  • Some side effects can be serious. If you experience any of these symptoms, stop receiving ampicillin injection and call your doctor immediately or get emergency medical treatment:

    • rash

    • itching

    • hives

    • difficulty breathing or swallowing

    • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)

    • seizures

    • a return of fever, cough, sore throat, chills, and other signs of infection

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Your healthcare provider will tell you how to store your medication. Store your medication only as directed. Make sure you understand how to store your medication properly.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to ampicillin injection.

If you are diabetic and test your urine for sugar, use Clinistix or TesTape (not Clinitest) to test your urine while using this medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Aminobenzylpenicillin

Drug Interaction
Moxifloxacin Moxifloxacin The serum concentration of Moxifloxacin can be increased when it is combined with Ampicillin.
Cilostazol Cilostazol Ampicillin may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Ampicillin may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Gemifloxacin Gemifloxacin The serum concentration of Gemifloxacin can be increased when it is combined with Ampicillin.
Tinidazole Tinidazole Ampicillin may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Pregabalin Pregabalin Pregabalin may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Rasagiline Rasagiline Ampicillin may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Ampicillin may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Budesonide Budesonide Ampicillin may decrease the excretion rate of Budesonide which could result in a higher serum level.
Doripenem Injection Doripenem Injection Ampicillin may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Ampicillin may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Ulipristal Ulipristal The therapeutic efficacy of Ulipristal can be decreased when used in combination with Ampicillin.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Ampicillin may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Ampicillin may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Roflumilast Roflumilast Ampicillin may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Rivaroxaban Rivaroxaban Ampicillin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib Ruxolitinib Ampicillin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Clobazam may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Deferiprone Deferiprone Ampicillin may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Enzalutamide Enzalutamide Ampicillin may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Ampicillin may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Teduglutide Injection Teduglutide Injection Ampicillin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Ampicillin may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Pomalidomide Pomalidomide Ampicillin may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Canagliflozin Canagliflozin Ampicillin may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Trametinib Trametinib Ampicillin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran Ampicillin may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Vortioxetine Vortioxetine Ampicillin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Sofosbuvir Sofosbuvir Ampicillin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast Ampicillin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Ampicillin may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Testosterone Injection Testosterone Injection Ampicillin may decrease the excretion rate of Testosterone which could result in a higher serum level.
Edoxaban Edoxaban Ampicillin may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Tasimelteon Tasimelteon Ampicillin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Macitentan Macitentan Ampicillin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ixazomib Ixazomib Ampicillin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Ampicillin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection Ampicillin may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Lixisenatide Injection Lixisenatide Injection Ampicillin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Ampicillin may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Ampicillin may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Naldemedine Naldemedine Ampicillin may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Benznidazole Benznidazole Ampicillin may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin The serum concentration of Delafloxacin can be increased when it is combined with Ampicillin.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy.
Apalutamide Apalutamide Ampicillin may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib Baricitinib Ampicillin may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Ampicillin may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eravacycline Injection Eravacycline Injection The therapeutic efficacy of Ampicillin can be decreased when used in combination with Eravacycline.
Omadacycline Omadacycline The therapeutic efficacy of Ampicillin can be decreased when used in combination with Omadacycline.
Sarecycline Sarecycline The therapeutic efficacy of Ampicillin can be decreased when used in combination with Sarecycline.
Stiripentol Stiripentol Ampicillin may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Prucalopride Prucalopride Ampicillin may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Solriamfetol Solriamfetol Ampicillin may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Pitolisant Pitolisant Ampicillin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Ampicillin may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Ampicillin may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Ampicillin may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Carmustine Carmustine Carmustine may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Tetracycline Tetracycline The therapeutic efficacy of Ampicillin can be decreased when used in combination with Tetracycline.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Azathioprine Azathioprine Ampicillin may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Carbamazepine Carbamazepine Ampicillin may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Ampicillin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Warfarin Warfarin Ampicillin may decrease the excretion rate of Warfarin which could result in a higher serum level.
Triamterene Triamterene Triamterene may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Tolbutamide Tolbutamide Ampicillin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Ampicillin may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Baclofen Baclofen Baclofen may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Triazolam Triazolam Ampicillin may decrease the excretion rate of Triazolam which could result in a higher serum level.
Trimethoprim Trimethoprim Ampicillin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Timolol Timolol Timolol may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Verapamil Verapamil Ampicillin may decrease the excretion rate of Verapamil which could result in a higher serum level.
Atenolol Atenolol The bioavailability of Atenolol can be decreased when combined with Ampicillin.
Bumetanide Bumetanide Ampicillin may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Auranofin Auranofin Ampicillin may decrease the excretion rate of Auranofin which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Buspirone Buspirone Ampicillin may decrease the excretion rate of Buspirone which could result in a higher serum level.
Bisoprolol Bisoprolol Ampicillin may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Acarbose Acarbose Acarbose may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Ampicillin may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Capecitabine Capecitabine Ampicillin may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Abacavir Abacavir Ampicillin may decrease the excretion rate of Abacavir which could result in a higher serum level.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Tolterodine Tolterodine Ampicillin may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Rabeprazole Rabeprazole Ampicillin may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists