Riociguat

Generic name: Pronounced as (rye'' oh sig' ue at)
Brand names
  • Adempas®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 04/15/2023

Do not take riociguat if you are pregnant or plan to become pregnant. Riociguat may harm the fetus. If you are sexually active and able to become pregnant, you should not begin taking riociguat until a pregnancy test has shown that you are not pregnant. You must use reliable methods of birth control during treatment and for one month after stopping riociguat. Do not have unprotected sex. Talk to your doctor about birth control methods that are effective and will work for you. Call your doctor immediately if you miss a menstrual period or think you may be pregnant while you are taking riociguat.

If you are a parent or guardian of a female who had not yet reached puberty, check your child regularly to see if she is developing any signs of puberty (breast buds, pubic hair )and let her doctor know about any changes. Your child may reach puberty before having her first menstrual period.

Because of the risk of birth defects, riociguat is available only through a special restricted distribution program. A program called Adempas Risk Evaluation and Mitigation Strategies (REMS) Program has been set up for all female patients to make sure that they are tested for pregnancy every month during treatment and for 1 month after stopping riociguat.Female patients can get riociguat only if they are registered with Adempas REMS Program. During enrollment you will choose a certified specialty pharmacy that will ship your medication to you. Ask your doctor if you have any questions about how you will receive your medication.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with riociguat and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

Talk to your doctor about the risks of taking riociguat.

Riociguat is used to treat pulmonary arterial hypertension (PAH; high blood pressure in the vessels that carry blood to the lungs). Riociguat is also used to treat chronic thromboembolic pulmonary hypertension (CTEPH; high blood pressure in the lung arteries caused by blood clots that narrow or block blood flow) in adults who cannot have surgery or for those treated with surgery who continue to have high lung blood pressure levels after surgery. Riociguat may improve the ability to exercise in people with PAH and CTEPH and may slow the worsening of symptoms in people with PAH. Riociguat is in a class of medications called soluble guanylate cyclase (sGC) stimulators. It works by relaxing the blood vessels in the lungs to allow blood to flow easily.

Riociguat comes as a tablet to take by mouth. It is usually taken with or without food 3 times a day. Take riociguat at around the same time(s) every day and space your doses about 6 to 8 hours apart. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take riociguat exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you cannot swallow the tablet whole, you can crush the tablet and mix the contents with a small amount of water or a soft food such as applesauce. Swallow the mixture right after you mix it.

Your doctor may start you on a low dose of riociguat and gradually increase your dose, not more than once every 2 weeks. Your doctor may decrease your dose if you experience side effects.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking riociguat,

  • tell your doctor and pharmacist if you are allergic to riociguat, any other medications, or any of the ingredients in riociguat tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor if you are taking or have recently taken a nitrate such as isosorbide dinitrate (Isordil, in BiDil), isosorbide mononitrate (Monoket), or nitroglycerin (Nitro-Dur, Nitromist, Nitrostat, Minitran, Rectiv, others),; phosphodiesterase inhibitors (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), or vardenafil (Levitra, Staxyn); or if you are taking dipyridamole (Persantine, in Aggrenox), or theophylline (Theo-24, Theochron, Theolair, others). Your doctor will probably tell you not to take riociguat if you are taking this one or more of these medications. Do not take riociguat within 24 hours before or after taking sildenafil or within 24 hours before or 48 hours after taking tadalafil.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antifungals such as itraconazole (Onmel, Sporanox) and ketoconazole (Extina, Nizoral, Xolegel); HIV protease inhibitors including ritonavir (Norvir, in Kaletra); certain medications for seizures such as carbamazepine (Epitol, Equetro, Tegretol, others), phenobarbital, and phenytoin (Dilantin, Phenytek); and medications for high blood pressure. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • if you are taking antacids containing aluminum hydroxide or magnesium hydroxide (Maalox, Mylanta, Tums, others), take them 1 hour before or 1 hour after taking riociguat.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have a pulmonary hypertension with idiopathic interstitial pneumonia (PH-IIP; lung disease). Your doctor will probably tell you not to take riociguat.

  • tell your doctor if you currently smoke or start or stop smoking during treatment. Also tell your doctor if you have recently had diarrhea, vomiting, or sweating a lot which may have caused dehydration (loss of a large amount of body fluids); any bleeding from your lung(s); if you have had a procedure to stop you from coughing up blood; if you have low blood pressure, pulmonary veno-occlusive disease (a blockage of veins in the lungs); or heart, kidney, or liver disease.

  • tell your doctor if you are breastfeeding. Do not breastfeed while you are taking riociguat.

  • you should know that riociguat can cause dizziness and lightheadedness. Do not drive a car or operate machinery until you know how this medication affects you.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. If you miss taking riociguat for more than 3 days, call your doctor. Your doctor may want to restart your medication at a lower dose.

  • Riociguat may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • constipation

    • heartburn

    • upset stomach

    • nausea

    • vomiting

    • diarrhea

    • swelling of your hands, legs, feet, and ankles

  • Some side effects can be serious. If you experience any of these symptoms or those in the SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

    • coughing up pink, frothy sputum or blood

    • fainting

    • chest pain

    • shortness of breath

  • Riociguat may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor. Your doctor will check your blood pressure regularly during your treatment with riociguat.

Do not let anyone else take your medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Riociguat can be decreased when combined with Repaglinide.
Montelukast Montelukast The metabolism of Riociguat can be decreased when combined with Montelukast.
Delavirdine Delavirdine The serum concentration of Riociguat can be increased when it is combined with Delavirdine.
Atorvastatin Atorvastatin The metabolism of Riociguat can be decreased when combined with Atorvastatin.
Aminophylline Aminophylline Aminophylline may increase the hypotensive activities of Riociguat.
Anagrelide Anagrelide Anagrelide may increase the hypotensive activities of Riociguat.
Calcium Carbonate Calcium Carbonate Calcium carbonate can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Candesartan Candesartan The metabolism of Riociguat can be decreased when combined with Candesartan.
Cilostazol Cilostazol Cilostazol may increase the hypotensive activities of Riociguat.
Clopidogrel Clopidogrel The metabolism of Riociguat can be decreased when combined with Clopidogrel.
Fenofibrate Fenofibrate The metabolism of Riociguat can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine Guanfacine may decrease the antihypertensive activities of Riociguat.
Magnesium Hydroxide Magnesium Hydroxide Magnesium hydroxide can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium Oxide Magnesium Oxide Magnesium oxide can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylergonovine Methylergonovine Methylergometrine may decrease the antihypertensive activities of Riociguat.
Naratriptan Naratriptan Naratriptan may decrease the antihypertensive activities of Riociguat.
Olsalazine Olsalazine The therapeutic efficacy of Riociguat can be decreased when used in combination with Olsalazine.
Paregoric Paregoric The metabolism of Riociguat can be decreased when combined with Morphine.
Penbutolol Penbutolol Acebutolol may increase the hypotensive activities of Riociguat.
Ranitidine Ranitidine Ranitidine can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Reserpine Reserpine Reserpine may increase the hypotensive activities of Riociguat.
Rizatriptan Rizatriptan Rizatriptan may decrease the antihypertensive activities of Riociguat.
Sumatriptan Sumatriptan Sumatriptan may decrease the antihypertensive activities of Riociguat.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Riociguat.
Zolmitriptan Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Riociguat.
Famotidine Injection Famotidine Injection Famotidine can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Metronidazole Injection Metronidazole Injection The metabolism of Riociguat can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Riociguat can be decreased when combined with Morphine.
Zidovudine Injection Zidovudine Injection The metabolism of Riociguat can be decreased when combined with Zidovudine.
Altretamine Altretamine Amphetamine may increase the hypotensive activities of Riociguat.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Riociguat which could result in a higher serum level.
Torsemide Torsemide The metabolism of Riociguat can be decreased when combined with Torasemide.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Riociguat.
Eprosartan Eprosartan Eprosartan may increase the hypotensive activities of Riociguat.
Hydroxychloroquine Hydroxychloroquine The metabolism of Riociguat can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The therapeutic efficacy of Riociguat can be decreased when used in combination with Meloxicam.
Pantoprazole Pantoprazole Pantoprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Riociguat which could result in a higher serum level.
Anakinra Anakinra The metabolism of Riociguat can be increased when combined with Anakinra.
Linezolid Linezolid Linezolid may increase the hypotensive activities of Riociguat.
Trimipramine Trimipramine Trimipramine may decrease the antihypertensive activities of Riociguat.
Etanercept Injection Etanercept Injection The metabolism of Riociguat can be increased when combined with Etanercept.
Perindopril Perindopril Perindopril may increase the hypotensive activities of Riociguat.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The therapeutic efficacy of Riociguat can be decreased when used in combination with Choline magnesium trisalicylate.
Dutasteride Dutasteride Dutasteride may decrease the antihypertensive activities of Riociguat.
Epinephrine Injection Epinephrine Injection Epinephrine may decrease the antihypertensive activities of Riociguat.
Eplerenone Eplerenone Eplerenone may increase the hypotensive activities of Riociguat.
Olmesartan Olmesartan Olmesartan may increase the hypotensive activities of Riociguat.
Adalimumab Injection Adalimumab Injection The metabolism of Riociguat can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of hypotension can be increased when Aripiprazole is combined with Riociguat.
Atomoxetine Atomoxetine Atomoxetine may decrease the antihypertensive activities of Riociguat.
Dexmethylphenidate Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Riociguat.
Atazanavir Atazanavir The serum concentration of Riociguat can be increased when it is combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Riociguat can be decreased when combined with Almotriptan.
Eletriptan Eletriptan Eletriptan may decrease the antihypertensive activities of Riociguat.
Vardenafil Vardenafil Vardenafil may increase the hypotensive activities of Riociguat.
Alfuzosin Alfuzosin Alfuzosin may increase the hypotensive activities of Riociguat.
Tegaserod Tegaserod The metabolism of Riociguat can be decreased when combined with Tegaserod.
Tadalafil Tadalafil The risk or severity of hypotension can be increased when Tadalafil is combined with Riociguat.
Frovatriptan Frovatriptan Frovatriptan may decrease the antihypertensive activities of Riociguat.
Progesterone Progesterone Progesterone may decrease the excretion rate of Riociguat which could result in a higher serum level.
Apomorphine Injection Apomorphine Injection The metabolism of Riociguat can be decreased when combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Riociguat can be increased when combined with Infliximab.
Protriptyline Protriptyline Protriptyline may decrease the antihypertensive activities of Riociguat.
Rifaximin Rifaximin The metabolism of Riociguat can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Riociguat is combined with Duloxetine.
Bosentan Bosentan Bosentan may increase the hypotensive activities of Riociguat.
Erlotinib Erlotinib The metabolism of Riociguat can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Riociguat can be decreased when combined with Eszopiclone.
Solifenacin Solifenacin Solifenacin may decrease the antihypertensive activities of Riociguat.
Voriconazole Voriconazole The serum concentration of Riociguat can be increased when it is combined with Voriconazole.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the hypotensive activities of Riociguat.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypotensive activities of Riociguat.
Fentanyl Fentanyl Fentanyl may decrease the antihypertensive activities of Riociguat.
Deferasirox Deferasirox The metabolism of Riociguat can be decreased when combined with Deferasirox.
Phenylephrine Phenylephrine Phenylephrine may decrease the antihypertensive activities of Riociguat.
Tipranavir Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Riociguat.
Abatacept Injection Abatacept Injection The metabolism of Riociguat can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may increase the hypotensive activities of Riociguat.
Imatinib Imatinib Imatinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Sitagliptin Sitagliptin The metabolism of Riociguat can be decreased when combined with Sitagliptin.
Gefitinib Gefitinib Gefitinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Albuterol Albuterol Salbutamol may decrease the antihypertensive activities of Riociguat.
Paliperidone Paliperidone Paliperidone may decrease the antihypertensive activities of Riociguat.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Riociguat.
Posaconazole Posaconazole The serum concentration of Riociguat can be increased when it is combined with Posaconazole.
Rituximab Injection Rituximab Injection Riociguat may increase the hypotensive activities of Rituximab.
Aliskiren Aliskiren Riociguat may increase the hypotensive activities of Aliskiren.
Darunavir Darunavir The serum concentration of Darunavir can be increased when it is combined with Riociguat.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Riociguat.
Nabilone Nabilone The metabolism of Riociguat can be decreased when combined with Nabilone.
Sorafenib Sorafenib The metabolism of Riociguat can be decreased when combined with Sorafenib.
Sunitinib Sunitinib Sunitinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Riociguat which could result in a higher serum level.
Lapatinib Lapatinib The metabolism of Riociguat can be decreased when combined with Lapatinib.
Dasatinib Dasatinib Dasatinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Nilotinib Nilotinib The serum concentration of Riociguat can be increased when it is combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Riociguat can be decreased when combined with Bexarotene.
Desmopressin Desmopressin Desmopressin may decrease the antihypertensive activities of Riociguat.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Riociguat.
Nebivolol Nebivolol Nebivolol may increase the hypotensive activities of Riociguat.
Tretinoin Tretinoin The metabolism of Riociguat can be decreased when combined with Tretinoin.
Certolizumab Injection Certolizumab Injection The metabolism of Riociguat can be increased when combined with Certolizumab pegol.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Riociguat which could result in a higher serum level.
Dexlansoprazole Dexlansoprazole Dexlansoprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Betaxolol Betaxolol Betaxolol may increase the hypotensive activities of Riociguat.
Iloperidone Iloperidone Iloperidone may decrease the antihypertensive activities of Riociguat.
Dronedarone Dronedarone Dronedarone may decrease the antihypertensive activities of Riociguat.
Golimumab Injection Golimumab Injection The metabolism of Riociguat can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Riociguat can be decreased when combined with Pazopanib.
Asenapine Asenapine Asenapine may decrease the antihypertensive activities of Riociguat.
Pitavastatin Pitavastatin The metabolism of Riociguat can be decreased when combined with Pitavastatin.
Tocilizumab Injection Tocilizumab Injection The metabolism of Riociguat can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Riociguat can be decreased when combined with Cabazitaxel.
Lurasidone Lurasidone Lurasidone may decrease the antihypertensive activities of Riociguat.
Vilazodone Vilazodone Vilazodone may decrease the antihypertensive activities of Riociguat.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Riociguat.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the antihypertensive activities of Riociguat.
Azilsartan Azilsartan The risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Riociguat.
Roflumilast Roflumilast Roflumilast may increase the hypotensive activities of Riociguat.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Riociguat which could result in a higher serum level.
Telaprevir Telaprevir Glecaprevir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Riociguat can be increased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Riociguat can be decreased when combined with Abiraterone.
Vandetanib Vandetanib Vandetanib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Vemurafenib Vemurafenib Vemurafenib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Cabergoline Cabergoline Cabergoline may decrease the antihypertensive activities of Riociguat.
Naloxone Injection Naloxone Injection The serum concentration of Riociguat can be increased when it is combined with Naloxone.
Ambrisentan Ambrisentan Ambrisentan may increase the hypotensive activities of Riociguat.
Iloprost Iloprost Iloprost may increase the hypotensive activities of Riociguat.
Enzalutamide Enzalutamide The metabolism of Riociguat can be decreased when combined with Enzalutamide.
Mirabegron Mirabegron Mirabegron may decrease the antihypertensive activities of Riociguat.
Regorafenib Regorafenib Regorafenib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Bosutinib Bosutinib The metabolism of Riociguat can be decreased when combined with Bosutinib.
Teriflunomide Teriflunomide Teriflunomide may decrease the excretion rate of Riociguat which could result in a higher serum level.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Riociguat can be decreased when combined with Cabozantinib.
Ponatinib Ponatinib The metabolism of Riociguat can be decreased when combined with Ponatinib.
Apixaban Apixaban The metabolism of Riociguat can be decreased when combined with Apixaban.
Canagliflozin Canagliflozin The risk or severity of adverse effects can be increased when Canagliflozin is combined with Riociguat.
Methazolamide Methazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Riociguat.
Dabrafenib Dabrafenib The metabolism of Riociguat can be decreased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Riociguat can be decreased when combined with Trametinib.
Afatinib Afatinib Afatinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Levomilnacipran Levomilnacipran The metabolism of Riociguat can be decreased when combined with Levomilnacipran.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Riociguat.
Avanafil Avanafil Avanafil may increase the hypotensive activities of Riociguat.
Ketorolac Injection Ketorolac Injection The therapeutic efficacy of Riociguat can be decreased when used in combination with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection Riociguat may increase the hypotensive activities of Obinutuzumab.
Simeprevir Simeprevir Simeprevir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Dapagliflozin Dapagliflozin The risk or severity of adverse effects can be increased when Dapagliflozin is combined with Riociguat.
Apremilast Apremilast Apremilast may increase the hypotensive activities of Riociguat.
Droxidopa Droxidopa Droxidopa may decrease the antihypertensive activities of Riociguat.
Siltuximab Injection Siltuximab Injection The metabolism of Riociguat can be increased when combined with Siltuximab.
Empagliflozin Empagliflozin The risk or severity of adverse effects can be increased when Empagliflozin is combined with Riociguat.
Olaparib Olaparib Olaparib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Methamphetamine Methamphetamine Metamfetamine may decrease the antihypertensive activities of Riociguat.
Secukinumab Injection Secukinumab Injection The metabolism of Riociguat can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection Riociguat may increase the hypotensive activities of Risperidone.
Palbociclib Palbociclib Palbociclib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Lenvatinib Lenvatinib The metabolism of Riociguat can be decreased when combined with Lenvatinib.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Riociguat.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Riociguat.
Amiloride Amiloride The risk or severity of adverse effects can be increased when Amiloride is combined with Riociguat.
Macitentan Macitentan Riociguat may increase the hypotensive activities of Macitentan.
Flibanserin Flibanserin Flibanserin may decrease the antihypertensive activities of Riociguat.
Rolapitant Rolapitant Rolapitant may decrease the excretion rate of Riociguat which could result in a higher serum level.
Daclatasvir Daclatasvir Daclatasvir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Brexpiprazole Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Riociguat.
Ziprasidone Injection Ziprasidone Injection Ziprasidone may increase the antihypertensive activities of Riociguat.
Cariprazine Cariprazine Cariprazine may decrease the antihypertensive activities of Riociguat.
Alectinib Alectinib Alectinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Riociguat can be increased when combined with Rifapentine.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Riociguat.
Dexamethasone Injection Dexamethasone Injection The metabolism of Riociguat can be increased when combined with Dexamethasone.
Venetoclax Venetoclax Venetoclax may decrease the excretion rate of Riociguat which could result in a higher serum level.
Cobicistat Cobicistat The serum concentration of Riociguat can be increased when it is combined with Cobicistat.
Midodrine Midodrine Midodrine may decrease the antihypertensive activities of Riociguat.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Riociguat.
Furosemide Injection Furosemide Injection Furosemide may increase the hypotensive activities of Riociguat.
Rucaparib Rucaparib Rucaparib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Ribociclib Ribociclib The serum concentration of Riociguat can be increased when it is combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Riociguat can be decreased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may decrease the antihypertensive activities of Riociguat.
Safinamide Safinamide Safinamide may increase the hypotensive activities of Riociguat.
Midostaurin Midostaurin The serum concentration of Riociguat can be increased when it is combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Riociguat can be decreased when combined with Enasidenib.
Abemaciclib Abemaciclib Abemaciclib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Letermovir Letermovir Letermovir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may decrease the excretion rate of Riociguat which could result in a higher serum level.
Apalutamide Apalutamide The metabolism of Apalutamide can be decreased when combined with Riociguat.
Fostamatinib Fostamatinib Fostamatinib may increase the hypotensive activities of Riociguat.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Riociguat which could result in a higher serum level.
Baricitinib Baricitinib Baricitinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Sodium Zirconium Cyclosilicate Sodium Zirconium Cyclosilicate Sodium zirconium cyclosilicate can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lofexidine Lofexidine Lofexidine may decrease the antihypertensive activities of Riociguat.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Riociguat.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Riociguat which could result in a higher serum level.
Dacomitinib Dacomitinib Dacomitinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Stiripentol Stiripentol The serum concentration of Riociguat can be increased when it is combined with Stiripentol.
Gilteritinib Gilteritinib Gilteritinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Glasdegib Glasdegib Glasdegib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Riociguat.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Riociguat.
Rifamycin Rifamycin The metabolism of Riociguat can be decreased when combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Riociguat can be increased when combined with Emapalumab.
Siponimod Siponimod Siponimod may decrease the antihypertensive activities of Riociguat.
Esomeprazole Injection Esomeprazole Injection Esomeprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Alpelisib Alpelisib The metabolism of Riociguat can be decreased when combined with Alpelisib.
Solriamfetol Solriamfetol Solriamfetol may decrease the antihypertensive activities of Riociguat.
Darolutamide Darolutamide The serum concentration of Riociguat can be increased when it is combined with Darolutamide.
Triclabendazole Triclabendazole The metabolism of Riociguat can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Riociguat.
Pitolisant Pitolisant The serum concentration of Riociguat can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The metabolism of Riociguat can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Riociguat can be decreased when combined with Fosphenytoin.
Lasmiditan Lasmiditan The serum concentration of Riociguat can be increased when it is combined with Lasmiditan.
Cenobamate Cenobamate The serum concentration of Riociguat can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Riociguat.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Riociguat.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Riociguat.
Ripretinib Ripretinib Ripretinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Selpercatinib Selpercatinib The serum concentration of Riociguat can be increased when it is combined with Selpercatinib.
Capmatinib Capmatinib The serum concentration of Riociguat can be increased when it is combined with Capmatinib.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Opicapone Opicapone The metabolism of Riociguat can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Riociguat can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Riociguat.
Theophylline Theophylline Theophylline may increase the hypotensive activities of Riociguat.
Fenoprofen Fenoprofen The therapeutic efficacy of Riociguat can be decreased when used in combination with Fenoprofen.
Indomethacin Indomethacin The therapeutic efficacy of Riociguat can be decreased when used in combination with Indomethacin.
Mefenamic Acid Mefenamic Acid The therapeutic efficacy of Riociguat can be decreased when used in combination with Mefenamic acid.
Naproxen Naproxen The therapeutic efficacy of Riociguat can be decreased when used in combination with Naproxen.
Tolmetin Tolmetin The therapeutic efficacy of Riociguat can be decreased when used in combination with Tolmetin.
Sulindac Sulindac The therapeutic efficacy of Riociguat can be decreased when used in combination with Sulindac.
Trazodone Trazodone Trazodone may decrease the antihypertensive activities of Riociguat.
Sodium Bicarbonate Sodium Bicarbonate Sodium bicarbonate can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Phenobarbital Phenobarbital The metabolism of Riociguat can be increased when combined with Phenobarbital.
Primidone Primidone Primidone may increase the hypotensive activities of Riociguat.
Diethylpropion Diethylpropion Diethylpropion may decrease the antihypertensive activities of Riociguat.
Chlorpromazine Chlorpromazine Chlorpromazine may decrease the antihypertensive activities of Riociguat.
Phenoxybenzamine Phenoxybenzamine Phenoxybenzamine may decrease the antihypertensive activities of Riociguat.
Bromocriptine Bromocriptine Bromocriptine may decrease the antihypertensive activities of Riociguat.
Metaproterenol Metaproterenol Orciprenaline may decrease the antihypertensive activities of Riociguat.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypotensive activities of Riociguat.
Phenelzine Phenelzine Phenelzine may increase the hypotensive activities of Riociguat.
Procarbazine Procarbazine Procarbazine may increase the hypotensive activities of Riociguat.
Ergoloid Mesylates Ergoloid Mesylates Ergoloid mesylate may decrease the antihypertensive activities of Riociguat.
Thioridazine Thioridazine Thioridazine may decrease the antihypertensive activities of Riociguat.
Trifluoperazine Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Riociguat.
Dapsone Dapsone The metabolism of Riociguat can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Riociguat can be decreased when combined with Sulfadiazine.
Methadone Methadone The metabolism of Riociguat can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Riociguat can be decreased when combined with Oxybutynin.
Ibuprofen Ibuprofen The therapeutic efficacy of Riociguat can be decreased when used in combination with Ibuprofen.
Phentermine Phentermine Phentermine may decrease the antihypertensive activities of Riociguat.
Methylphenidate Methylphenidate Methylphenidate may decrease the antihypertensive activities of Riociguat.
Amoxapine Amoxapine Amoxapine may decrease the antihypertensive activities of Riociguat.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Riociguat which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Riociguat can be increased when combined with Hydrocortisone.
Methyldopa Methyldopa Methyldopa may increase the hypotensive activities of Riociguat.
Clonidine Clonidine The risk or severity of hypotension can be increased when Clonidine is combined with Riociguat.
Prazosin Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Riociguat.
Hydralazine Hydralazine Hydralazine may increase the hypotensive activities of Riociguat.
Cimetidine Cimetidine Cimetidine can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Warfarin Warfarin The metabolism of Riociguat can be decreased when combined with Warfarin.
Loperamide Loperamide The serum concentration of Riociguat can be increased when it is combined with Loperamide.
Meclofenamate Meclofenamate The therapeutic efficacy of Riociguat can be decreased when used in combination with Meclofenamic acid.
Griseofulvin Griseofulvin The metabolism of Riociguat can be increased when combined with Griseofulvin.
Chloroquine Chloroquine The metabolism of Riociguat can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Riociguat can be decreased when combined with Quinine.
Triamterene Triamterene The risk or severity of adverse effects can be increased when Triamterene is combined with Riociguat.
Sulfinpyrazone Sulfinpyrazone The metabolism of Riociguat can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Riociguat can be increased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the hypotensive activities of Riociguat.
Metolazone Metolazone Metolazone may increase the hypotensive activities of Riociguat.
Isosorbide Isosorbide Isosorbide may increase the hypotensive activities of Riociguat.
Secobarbital Secobarbital The metabolism of Riociguat can be increased when combined with Secobarbital.
Desipramine Desipramine Desipramine may decrease the antihypertensive activities of Riociguat.
Amitriptyline Amitriptyline The metabolism of Riociguat can be decreased when combined with Amitriptyline.
Imipramine Imipramine Imipramine may decrease the antihypertensive activities of Riociguat.
Probenecid Probenecid The metabolism of Riociguat can be increased when combined with Probenecid.
Quinidine Quinidine Quinidine may decrease the antihypertensive activities of Riociguat.
Rifampin Rifampin The metabolism of Riociguat can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Riociguat can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Riociguat can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Butabarbital may increase the hypotensive activities of Riociguat.
Levothyroxine Levothyroxine The metabolism of Riociguat can be decreased when combined with Levothyroxine.
Methimazole Methimazole The serum concentration of Riociguat can be increased when it is combined with Methimazole.
Tolbutamide Tolbutamide The metabolism of Riociguat can be decreased when combined with Tolbutamide.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Riociguat.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Riociguat can be increased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Riociguat can be increased when used in combination with Hydrochlorothiazide.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may increase the hypotensive activities of Riociguat.
Minoxidil Minoxidil Minoxidil may increase the hypotensive activities of Riociguat.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Riociguat.
Nortriptyline Nortriptyline Nortriptyline may decrease the antihypertensive activities of Riociguat.
Spironolactone Spironolactone The metabolism of Riociguat can be decreased when combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Riociguat.
Mercaptopurine Mercaptopurine Mercaptopurine may increase the hypotensive activities of Riociguat.
Nadolol Nadolol Nadolol may increase the hypotensive activities of Riociguat.
Papaverine Papaverine The risk or severity of adverse effects can be increased when Papaverine is combined with Riociguat.
Fluorouracil Injection Fluorouracil Injection The metabolism of Riociguat can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Riociguat can be decreased when combined with Colchicine.
Ketoconazole Ketoconazole The serum concentration of Riociguat can be increased when it is combined with Ketoconazole.
Captopril Captopril Captopril may increase the hypotensive activities of Riociguat.
Dipyridamole Dipyridamole Dipyridamole may increase the hypotensive activities of Riociguat.
Isoxsuprine Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Riociguat.
Ethacrynic Acid Ethacrynic Acid The risk or severity of adverse effects can be increased when Etacrynic acid is combined with Riociguat.
Metoprolol Metoprolol Metoprolol may increase the hypotensive activities of Riociguat.
Aspirin Aspirin Acetylsalicylic acid may decrease the antihypertensive activities of Riociguat.
Salsalate Salsalate The therapeutic efficacy of Riociguat can be decreased when used in combination with Salsalate.
Trimethoprim Trimethoprim The metabolism of Riociguat can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Riociguat can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Riociguat can be decreased when combined with Nifedipine.
Timolol Timolol Timolol may increase the hypotensive activities of Riociguat.
Verapamil Verapamil The metabolism of Riociguat can be decreased when combined with Verapamil.
Atenolol Atenolol Atenolol may increase the hypotensive activities of Riociguat.
Pindolol Pindolol Pindolol may increase the hypotensive activities of Riociguat.
Diflunisal Diflunisal The therapeutic efficacy of Riociguat can be decreased when used in combination with Diflunisal.
Piroxicam Piroxicam The therapeutic efficacy of Riociguat can be decreased when used in combination with Piroxicam.
Bumetanide Bumetanide The risk or severity of adverse effects can be increased when Bumetanide is combined with Riociguat.
Indapamide Indapamide The therapeutic efficacy of Riociguat can be increased when used in combination with Indapamide.
Pentoxifylline Pentoxifylline Pentoxifylline may increase the hypotensive activities of Riociguat.
Labetalol Labetalol Labetalol may increase the hypotensive activities of Riociguat.
Gemfibrozil Gemfibrozil The metabolism of Riociguat can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz Riociguat may decrease the antihypertensive activities of Guanabenz.
Ketoprofen Ketoprofen The therapeutic efficacy of Riociguat can be decreased when used in combination with Ketoprofen.
Enalapril Enalapril Enalapril may increase the hypotensive activities of Riociguat.
Flurbiprofen Flurbiprofen The therapeutic efficacy of Riociguat can be decreased when used in combination with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Riociguat.
Buspirone Buspirone Buspirone may decrease the antihypertensive activities of Riociguat.
Lovastatin Lovastatin The metabolism of Riociguat can be decreased when combined with Lovastatin.
Mesalamine Mesalamine The therapeutic efficacy of Riociguat can be decreased when used in combination with Mesalazine.
Diclofenac Diclofenac The therapeutic efficacy of Riociguat can be decreased when used in combination with Diclofenac.
Nimodipine Nimodipine Nimodipine may increase the hypotensive activities of Riociguat.
Clozapine Clozapine Clozapine may decrease the antihypertensive activities of Riociguat.
Clarithromycin Clarithromycin The serum concentration of Riociguat can be increased when it is combined with Clarithromycin.
Benazepril Benazepril Benazepril may increase the hypotensive activities of Riociguat.
Etodolac Etodolac The therapeutic efficacy of Riociguat can be decreased when used in combination with Etodolac.
Felodipine Felodipine The metabolism of Riociguat can be decreased when combined with Felodipine.
Fosinopril Fosinopril Fosinopril may increase the hypotensive activities of Riociguat.
Nabumetone Nabumetone The therapeutic efficacy of Riociguat can be decreased when used in combination with Nabumetone.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Riociguat which could result in a higher serum level.
Quinapril Quinapril Quinapril may increase the hypotensive activities of Riociguat.
Ramipril Ramipril Ramipril may increase the hypotensive activities of Riociguat.
Simvastatin Simvastatin The metabolism of Riociguat can be decreased when combined with Simvastatin.
Amlodipine Amlodipine Amlodipine may increase the hypotensive activities of Riociguat.
Itraconazole Itraconazole The serum concentration of Riociguat can be increased when it is combined with Itraconazole.
Lisinopril Lisinopril Lisinopril may increase the hypotensive activities of Riociguat.
Oxaprozin Oxaprozin The therapeutic efficacy of Riociguat can be decreased when used in combination with Oxaprozin.
Rifabutin Rifabutin The metabolism of Riociguat can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Riociguat.
Bisoprolol Bisoprolol Bisoprolol may increase the hypotensive activities of Riociguat.
Doxazosin Doxazosin Doxazosin may increase the hypotensive activities of Riociguat.
Terazosin Terazosin Terazosin may increase the hypotensive activities of Riociguat.
Isradipine Isradipine Isradipine may increase the hypotensive activities of Riociguat.
Omeprazole Omeprazole Omeprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cisapride Cisapride The metabolism of Riociguat can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Riociguat can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the excretion rate of Riociguat which could result in a lower serum level and potentially a reduction in efficacy.
Nizatidine Nizatidine Nizatidine can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nefazodone Nefazodone The serum concentration of Riociguat can be increased when it is combined with Nefazodone.
Losartan Losartan The metabolism of Riociguat can be decreased when combined with Losartan.
Moexipril Moexipril Moexipril may increase the hypotensive activities of Riociguat.
Lansoprazole Lansoprazole Lansoprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ifosfamide Injection Ifosfamide Injection The metabolism of Riociguat can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Riociguat can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Riociguat can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Riociguat.
Nisoldipine Nisoldipine Nisoldipine may increase the hypotensive activities of Riociguat.
Amifostine Injection Amifostine Injection Riociguat may increase the hypotensive activities of Amifostine.
Anastrozole Anastrozole The metabolism of Riociguat can be decreased when combined with Anastrozole.
Ritonavir Ritonavir The serum concentration of Riociguat can be increased when it is combined with Ritonavir.
Clomipramine Clomipramine Clomipramine may decrease the antihypertensive activities of Riociguat.
Zafirlukast Zafirlukast The metabolism of Riociguat can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine Mirtazapine may decrease the antihypertensive activities of Riociguat.
Trandolapril Trandolapril Trandolapril may increase the hypotensive activities of Riociguat.
Valsartan Valsartan Valsartan may increase the hypotensive activities of Riociguat.
Pramipexole Pramipexole The risk or severity of adverse effects can be increased when Pramipexole is combined with Riociguat.
Nelfinavir Nelfinavir Nelfinavir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Loratadine Loratadine The metabolism of Riociguat can be decreased when combined with Loratadine.
Carvedilol Carvedilol Carvedilol may increase the hypotensive activities of Riociguat.
Nilutamide Nilutamide The metabolism of Riociguat can be decreased when combined with Nilutamide.
Selegiline Selegiline Selegiline may increase the hypotensive activities of Riociguat.
Propafenone Propafenone Propafenone may decrease the antihypertensive activities of Riociguat.
Raloxifene Raloxifene The metabolism of Riociguat can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Riociguat can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The risk or severity of adverse effects can be increased when Tamsulosin is combined with Riociguat.
Ropinirole Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Riociguat.
Finasteride Finasteride Finasteride may decrease the antihypertensive activities of Riociguat.
Quetiapine Quetiapine Quetiapine may increase the hypotensive activities of Riociguat.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Riociguat.
Efavirenz Efavirenz The serum concentration of Riociguat can be increased when it is combined with Efavirenz.
Sildenafil Sildenafil The risk or severity of hypotension can be increased when Sildenafil is combined with Riociguat.
Pioglitazone Pioglitazone The metabolism of Riociguat can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The therapeutic efficacy of Riociguat can be decreased when used in combination with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Riociguat can be decreased when combined with Rosiglitazone.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Riociguat.
Aluminum Hydroxide Aluminum Hydroxide Aluminum hydroxide can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The therapeutic efficacy of Riociguat can be decreased when used in combination with Balsalazide.
Rabeprazole Rabeprazole Rabeprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Terbinafine Terbinafine The metabolism of Riociguat can be decreased when combined with Terbinafine.

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