Riociguat

Riociguat is used to treat pulmonary arterial hypertension (PAH; high blood pressure in the vessels that carry blood to the lungs). Riociguat is also used to treat chronic thromboembolic pulmonary hypertension (CTEPH; high blood pressure in the lung arteries caused by blood clots that narrow or block blood flow) in adults who cannot have surgery or for those treated with surgery who continue to have high lung blood pressure levels after surgery. Riociguat may improve the ability to exercise in people with PAH and CTEPH and may slow the worsening of symptoms in people with PAH. Riociguat is in a class of medications called soluble guanylate cyclase (sGC) stimulators. It works by relaxing the blood vessels in the lungs to allow blood to flow easily.

Riociguat comes as a tablet to take by mouth. It is usually taken with or without food 3 times a day. Take riociguat at around the same time(s) every day and space your doses about 6 to 8 hours apart. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take riociguat exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you cannot swallow the tablet whole, you can crush the tablet and mix the contents with a small amount of water or a soft food such as applesauce. Swallow the mixture right after you mix it.

Your doctor may start you on a low dose of riociguat and gradually increase your dose, not more than once every 2 weeks. Your doctor may decrease your dose if you experience side effects.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking riociguat,

• tell your doctor and pharmacist if you are allergic to riociguat, any other medications, or any of the ingredients in riociguat tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

• tell your doctor if you are taking or have recently taken a nitrate such as isosorbide dinitrate (Isordil, in BiDil), isosorbide mononitrate (Monoket), or nitroglycerin (Nitro-Dur, Nitromist, Nitrostat, Minitran, Rectiv, others),; phosphodiesterase inhibitors (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), or vardenafil (Levitra, Staxyn); or if you are taking dipyridamole (Persantine, in Aggrenox), or theophylline (Theo-24, Theochron, Theolair, others). Your doctor will probably tell you not to take riociguat if you are taking this one or more of these medications. Do not take riociguat within 24 hours before or after taking sildenafil or within 24 hours before or 48 hours after taking tadalafil.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antifungals such as itraconazole (Onmel, Sporanox) and ketoconazole (Extina, Nizoral, Xolegel); HIV protease inhibitors including ritonavir (Norvir, in Kaletra); certain medications for seizures such as carbamazepine (Epitol, Equetro, Tegretol, others), phenobarbital, and phenytoin (Dilantin, Phenytek); and medications for high blood pressure. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• if you are taking antacids containing aluminum hydroxide or magnesium hydroxide (Maalox, Mylanta, Tums, others), take them 1 hour before or 1 hour after taking riociguat.

• tell your doctor what herbal products you are taking, especially St. John's wort.

• tell your doctor if you have a pulmonary hypertension with idiopathic interstitial pneumonia (PH-IIP; lung disease). Your doctor will probably tell you not to take riociguat.

• tell your doctor if you currently smoke or start or stop smoking during treatment. Also tell your doctor if you have recently had diarrhea, vomiting, or sweating a lot which may have caused dehydration (loss of a large amount of body fluids); any bleeding from your lung(s); if you have had a procedure to stop you from coughing up blood; if you have low blood pressure, pulmonary veno-occlusive disease (a blockage of veins in the lungs); or heart, kidney, or liver disease.

• tell your doctor if you are breastfeeding. Do not breastfeed while you are taking riociguat.

• you should know that riociguat can cause dizziness and lightheadedness. Do not drive a car or operate machinery until you know how this medication affects you.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. If you miss taking riociguat for more than 3 days, call your doctor. Your doctor may want to restart your medication at a lower dose.

• Riociguat may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache

  • constipation

  • heartburn

  • upset stomach

  • nausea

  • vomiting

  • diarrhea

  • swelling of your hands, legs, feet, and ankles

• Some side effects can be serious. If you experience any of these symptoms or those in the SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

  • coughing up pink, frothy sputum or blood

  • fainting

  • chest pain

  • shortness of breath

• Riociguat may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor. Your doctor will check your blood pressure regularly during your treatment with riociguat.

Do not let anyone else take your medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Repaglinide	Repaglinide The metabolism of Riociguat can be decreased when combined with Repaglinide.
Montelukast	Montelukast The metabolism of Riociguat can be decreased when combined with Montelukast.
Delavirdine	Delavirdine The serum concentration of Riociguat can be increased when it is combined with Delavirdine.
Atorvastatin	Atorvastatin The metabolism of Riociguat can be decreased when combined with Atorvastatin.
Aminophylline	Aminophylline Aminophylline may increase the hypotensive activities of Riociguat.
Anagrelide	Anagrelide Anagrelide may increase the hypotensive activities of Riociguat.
Calcium Carbonate	Calcium Carbonate Calcium carbonate can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Candesartan	Candesartan The metabolism of Riociguat can be decreased when combined with Candesartan.
Cilostazol	Cilostazol Cilostazol may increase the hypotensive activities of Riociguat.
Clopidogrel	Clopidogrel The metabolism of Riociguat can be decreased when combined with Clopidogrel.
Fenofibrate	Fenofibrate The metabolism of Riociguat can be decreased when combined with Fenofibrate.
Guanfacine	Guanfacine Guanfacine may decrease the antihypertensive activities of Riociguat.
Magnesium Hydroxide	Magnesium Hydroxide Magnesium hydroxide can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium Oxide	Magnesium Oxide Magnesium oxide can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylergonovine	Methylergonovine Methylergometrine may decrease the antihypertensive activities of Riociguat.
Naratriptan	Naratriptan Naratriptan may decrease the antihypertensive activities of Riociguat.
Olsalazine	Olsalazine The therapeutic efficacy of Riociguat can be decreased when used in combination with Olsalazine.
Paregoric	Paregoric The metabolism of Riociguat can be decreased when combined with Morphine.
Penbutolol	Penbutolol Acebutolol may increase the hypotensive activities of Riociguat.
Ranitidine	Ranitidine Ranitidine can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Reserpine	Reserpine Reserpine may increase the hypotensive activities of Riociguat.
Rizatriptan	Rizatriptan Rizatriptan may decrease the antihypertensive activities of Riociguat.
Sumatriptan	Sumatriptan Sumatriptan may decrease the antihypertensive activities of Riociguat.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Riociguat.
Zolmitriptan	Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Riociguat.
Famotidine Injection	Famotidine Injection Famotidine can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Metronidazole Injection	Metronidazole Injection The metabolism of Riociguat can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection The metabolism of Riociguat can be decreased when combined with Morphine.
Zidovudine Injection	Zidovudine Injection The metabolism of Riociguat can be decreased when combined with Zidovudine.
Altretamine	Altretamine Amphetamine may increase the hypotensive activities of Riociguat.
Cyclosporine	Cyclosporine Cyclosporine may decrease the excretion rate of Riociguat which could result in a higher serum level.
Torsemide	Torsemide The metabolism of Riociguat can be decreased when combined with Torasemide.
Olanzapine	Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Riociguat.
Eprosartan	Eprosartan Eprosartan may increase the hypotensive activities of Riociguat.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Riociguat can be decreased when combined with Hydroxychloroquine.
Meloxicam	Meloxicam The therapeutic efficacy of Riociguat can be decreased when used in combination with Meloxicam.
Pantoprazole	Pantoprazole Pantoprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan	Telmisartan Telmisartan may decrease the excretion rate of Riociguat which could result in a higher serum level.
Anakinra	Anakinra The metabolism of Riociguat can be increased when combined with Anakinra.
Linezolid	Linezolid Linezolid may increase the hypotensive activities of Riociguat.
Trimipramine	Trimipramine Trimipramine may decrease the antihypertensive activities of Riociguat.
Etanercept Injection	Etanercept Injection The metabolism of Riociguat can be increased when combined with Etanercept.
Perindopril	Perindopril Perindopril may increase the hypotensive activities of Riociguat.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate The therapeutic efficacy of Riociguat can be decreased when used in combination with Choline magnesium trisalicylate.
Dutasteride	Dutasteride Dutasteride may decrease the antihypertensive activities of Riociguat.
Epinephrine Injection	Epinephrine Injection Epinephrine may decrease the antihypertensive activities of Riociguat.
Eplerenone	Eplerenone Eplerenone may increase the hypotensive activities of Riociguat.
Olmesartan	Olmesartan Olmesartan may increase the hypotensive activities of Riociguat.
Adalimumab Injection	Adalimumab Injection The metabolism of Riociguat can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The risk or severity of hypotension can be increased when Aripiprazole is combined with Riociguat.
Atomoxetine	Atomoxetine Atomoxetine may decrease the antihypertensive activities of Riociguat.
Dexmethylphenidate	Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Riociguat.
Atazanavir	Atazanavir The serum concentration of Riociguat can be increased when it is combined with Atazanavir.
Almotriptan	Almotriptan The metabolism of Riociguat can be decreased when combined with Almotriptan.
Eletriptan	Eletriptan Eletriptan may decrease the antihypertensive activities of Riociguat.
Vardenafil	Vardenafil Vardenafil may increase the hypotensive activities of Riociguat.
Alfuzosin	Alfuzosin Alfuzosin may increase the hypotensive activities of Riociguat.
Tegaserod	Tegaserod The metabolism of Riociguat can be decreased when combined with Tegaserod.
Tadalafil	Tadalafil The risk or severity of hypotension can be increased when Tadalafil is combined with Riociguat.
Frovatriptan	Frovatriptan Frovatriptan may decrease the antihypertensive activities of Riociguat.
Progesterone	Progesterone Progesterone may decrease the excretion rate of Riociguat which could result in a higher serum level.
Apomorphine Injection	Apomorphine Injection The metabolism of Riociguat can be decreased when combined with Apomorphine.
Infliximab Injection	Infliximab Injection The metabolism of Riociguat can be increased when combined with Infliximab.
Protriptyline	Protriptyline Protriptyline may decrease the antihypertensive activities of Riociguat.
Rifaximin	Rifaximin The metabolism of Riociguat can be increased when combined with Rifaximin.
Duloxetine	Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Riociguat is combined with Duloxetine.
Bosentan	Bosentan Bosentan may increase the hypotensive activities of Riociguat.
Erlotinib	Erlotinib The metabolism of Riociguat can be decreased when combined with Erlotinib.
Eszopiclone	Eszopiclone The metabolism of Riociguat can be decreased when combined with Eszopiclone.
Solifenacin	Solifenacin Solifenacin may decrease the antihypertensive activities of Riociguat.
Voriconazole	Voriconazole The serum concentration of Riociguat can be increased when it is combined with Voriconazole.
Dextroamphetamine	Dextroamphetamine Amphetamine may increase the hypotensive activities of Riociguat.
Isocarboxazid	Isocarboxazid Isocarboxazid may increase the hypotensive activities of Riociguat.
Fentanyl	Fentanyl Fentanyl may decrease the antihypertensive activities of Riociguat.
Deferasirox	Deferasirox The metabolism of Riociguat can be decreased when combined with Deferasirox.
Phenylephrine	Phenylephrine Phenylephrine may decrease the antihypertensive activities of Riociguat.
Tipranavir	Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Riociguat.
Abatacept Injection	Abatacept Injection The metabolism of Riociguat can be increased when combined with Abatacept.
Rasagiline	Rasagiline Rasagiline may increase the hypotensive activities of Riociguat.
Imatinib	Imatinib Imatinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Sitagliptin	Sitagliptin The metabolism of Riociguat can be decreased when combined with Sitagliptin.
Gefitinib	Gefitinib Gefitinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Albuterol	Albuterol Salbutamol may decrease the antihypertensive activities of Riociguat.
Paliperidone	Paliperidone Paliperidone may decrease the antihypertensive activities of Riociguat.
Clofarabine Injection	Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Riociguat.
Posaconazole	Posaconazole The serum concentration of Riociguat can be increased when it is combined with Posaconazole.
Rituximab Injection	Rituximab Injection Riociguat may increase the hypotensive activities of Rituximab.
Aliskiren	Aliskiren Riociguat may increase the hypotensive activities of Aliskiren.
Darunavir	Darunavir The serum concentration of Darunavir can be increased when it is combined with Riociguat.
Lisdexamfetamine	Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Riociguat.
Nabilone	Nabilone The metabolism of Riociguat can be decreased when combined with Nabilone.
Sorafenib	Sorafenib The metabolism of Riociguat can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib Sunitinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Dronabinol	Dronabinol Dronabinol may decrease the excretion rate of Riociguat which could result in a higher serum level.
Lapatinib	Lapatinib The metabolism of Riociguat can be decreased when combined with Lapatinib.
Dasatinib	Dasatinib Dasatinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Nilotinib	Nilotinib The serum concentration of Riociguat can be increased when it is combined with Nilotinib.
Bexarotene	Bexarotene The metabolism of Riociguat can be decreased when combined with Bexarotene.
Desmopressin	Desmopressin Desmopressin may decrease the antihypertensive activities of Riociguat.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Riociguat.
Nebivolol	Nebivolol Nebivolol may increase the hypotensive activities of Riociguat.
Tretinoin	Tretinoin The metabolism of Riociguat can be decreased when combined with Tretinoin.
Certolizumab Injection	Certolizumab Injection The metabolism of Riociguat can be increased when combined with Certolizumab pegol.
Eltrombopag	Eltrombopag Eltrombopag may decrease the excretion rate of Riociguat which could result in a higher serum level.
Dexlansoprazole	Dexlansoprazole Dexlansoprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Betaxolol	Betaxolol Betaxolol may increase the hypotensive activities of Riociguat.
Iloperidone	Iloperidone Iloperidone may decrease the antihypertensive activities of Riociguat.
Dronedarone	Dronedarone Dronedarone may decrease the antihypertensive activities of Riociguat.
Golimumab Injection	Golimumab Injection The metabolism of Riociguat can be increased when combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Riociguat can be decreased when combined with Pazopanib.
Asenapine	Asenapine Asenapine may decrease the antihypertensive activities of Riociguat.
Pitavastatin	Pitavastatin The metabolism of Riociguat can be decreased when combined with Pitavastatin.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Riociguat can be increased when combined with Tocilizumab.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Riociguat can be decreased when combined with Cabazitaxel.
Lurasidone	Lurasidone Lurasidone may decrease the antihypertensive activities of Riociguat.
Vilazodone	Vilazodone Vilazodone may decrease the antihypertensive activities of Riociguat.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Riociguat.
Terbutaline Injection	Terbutaline Injection Terbutaline may decrease the antihypertensive activities of Riociguat.
Azilsartan	Azilsartan The risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Riociguat.
Roflumilast	Roflumilast Roflumilast may increase the hypotensive activities of Riociguat.
Rilpivirine	Rilpivirine Rilpivirine may decrease the excretion rate of Riociguat which could result in a higher serum level.
Telaprevir	Telaprevir Glecaprevir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Riociguat can be increased when combined with Cyclophosphamide.
Abiraterone	Abiraterone The metabolism of Riociguat can be decreased when combined with Abiraterone.
Vandetanib	Vandetanib Vandetanib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Vemurafenib	Vemurafenib Vemurafenib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Vismodegib	Vismodegib Vismodegib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Cabergoline	Cabergoline Cabergoline may decrease the antihypertensive activities of Riociguat.
Naloxone Injection	Naloxone Injection The serum concentration of Riociguat can be increased when it is combined with Naloxone.
Ambrisentan	Ambrisentan Ambrisentan may increase the hypotensive activities of Riociguat.
Iloprost	Iloprost Iloprost may increase the hypotensive activities of Riociguat.
Enzalutamide	Enzalutamide The metabolism of Riociguat can be decreased when combined with Enzalutamide.
Mirabegron	Mirabegron Mirabegron may decrease the antihypertensive activities of Riociguat.
Regorafenib	Regorafenib Regorafenib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Bosutinib	Bosutinib The metabolism of Riociguat can be decreased when combined with Bosutinib.
Teriflunomide	Teriflunomide Teriflunomide may decrease the excretion rate of Riociguat which could result in a higher serum level.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Riociguat can be decreased when combined with Cabozantinib.
Ponatinib	Ponatinib The metabolism of Riociguat can be decreased when combined with Ponatinib.
Apixaban	Apixaban The metabolism of Riociguat can be decreased when combined with Apixaban.
Canagliflozin	Canagliflozin The risk or severity of adverse effects can be increased when Canagliflozin is combined with Riociguat.
Methazolamide	Methazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Riociguat.
Dabrafenib	Dabrafenib The metabolism of Riociguat can be decreased when combined with Dabrafenib.
Trametinib	Trametinib The metabolism of Riociguat can be decreased when combined with Trametinib.
Afatinib	Afatinib Afatinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Levomilnacipran	Levomilnacipran The metabolism of Riociguat can be decreased when combined with Levomilnacipran.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Riociguat.
Avanafil	Avanafil Avanafil may increase the hypotensive activities of Riociguat.
Ketorolac Injection	Ketorolac Injection The therapeutic efficacy of Riociguat can be decreased when used in combination with Ketorolac.
Obinutuzumab Injection	Obinutuzumab Injection Riociguat may increase the hypotensive activities of Obinutuzumab.
Simeprevir	Simeprevir Simeprevir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Dapagliflozin	Dapagliflozin The risk or severity of adverse effects can be increased when Dapagliflozin is combined with Riociguat.
Apremilast	Apremilast Apremilast may increase the hypotensive activities of Riociguat.
Droxidopa	Droxidopa Droxidopa may decrease the antihypertensive activities of Riociguat.
Siltuximab Injection	Siltuximab Injection The metabolism of Riociguat can be increased when combined with Siltuximab.
Empagliflozin	Empagliflozin The risk or severity of adverse effects can be increased when Empagliflozin is combined with Riociguat.
Olaparib	Olaparib Olaparib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Methamphetamine	Methamphetamine Metamfetamine may decrease the antihypertensive activities of Riociguat.
Secukinumab Injection	Secukinumab Injection The metabolism of Riociguat can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection Riociguat may increase the hypotensive activities of Risperidone.
Palbociclib	Palbociclib Palbociclib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Lenvatinib	Lenvatinib The metabolism of Riociguat can be decreased when combined with Lenvatinib.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Riociguat.
Haloperidol Injection	Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Riociguat.
Amiloride	Amiloride The risk or severity of adverse effects can be increased when Amiloride is combined with Riociguat.
Macitentan	Macitentan Riociguat may increase the hypotensive activities of Macitentan.
Flibanserin	Flibanserin Flibanserin may decrease the antihypertensive activities of Riociguat.
Rolapitant	Rolapitant Rolapitant may decrease the excretion rate of Riociguat which could result in a higher serum level.
Daclatasvir	Daclatasvir Daclatasvir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Brexpiprazole	Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Riociguat.
Ziprasidone Injection	Ziprasidone Injection Ziprasidone may increase the antihypertensive activities of Riociguat.
Cariprazine	Cariprazine Cariprazine may decrease the antihypertensive activities of Riociguat.
Alectinib	Alectinib Alectinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Rifapentine	Rifapentine The metabolism of Riociguat can be increased when combined with Rifapentine.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Riociguat.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Riociguat can be increased when combined with Dexamethasone.
Venetoclax	Venetoclax Venetoclax may decrease the excretion rate of Riociguat which could result in a higher serum level.
Cobicistat	Cobicistat The serum concentration of Riociguat can be increased when it is combined with Cobicistat.
Midodrine	Midodrine Midodrine may decrease the antihypertensive activities of Riociguat.
Selexipag	Selexipag The metabolism of Selexipag can be decreased when combined with Riociguat.
Furosemide Injection	Furosemide Injection Furosemide may increase the hypotensive activities of Riociguat.
Rucaparib	Rucaparib Rucaparib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Ribociclib	Ribociclib The serum concentration of Riociguat can be increased when it is combined with Ribociclib.
Brigatinib	Brigatinib The metabolism of Riociguat can be decreased when combined with Brigatinib.
Doxepin (Insomnia)	Doxepin (Insomnia) Doxepin may decrease the antihypertensive activities of Riociguat.
Safinamide	Safinamide Safinamide may increase the hypotensive activities of Riociguat.
Midostaurin	Midostaurin The serum concentration of Riociguat can be increased when it is combined with Midostaurin.
Enasidenib	Enasidenib The metabolism of Riociguat can be decreased when combined with Enasidenib.
Abemaciclib	Abemaciclib Abemaciclib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Letermovir	Letermovir Letermovir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Buprenorphine Injection	Buprenorphine Injection Buprenorphine may decrease the excretion rate of Riociguat which could result in a higher serum level.
Apalutamide	Apalutamide The metabolism of Apalutamide can be decreased when combined with Riociguat.
Fostamatinib	Fostamatinib Fostamatinib may increase the hypotensive activities of Riociguat.
Avatrombopag	Avatrombopag Avatrombopag may decrease the excretion rate of Riociguat which could result in a higher serum level.
Baricitinib	Baricitinib Baricitinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Sodium Zirconium Cyclosilicate	Sodium Zirconium Cyclosilicate Sodium zirconium cyclosilicate can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lofexidine	Lofexidine Lofexidine may decrease the antihypertensive activities of Riociguat.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Riociguat.
Cannabidiol	Cannabidiol Cannabidiol may decrease the excretion rate of Riociguat which could result in a higher serum level.
Dacomitinib	Dacomitinib Dacomitinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Stiripentol	Stiripentol The serum concentration of Riociguat can be increased when it is combined with Stiripentol.
Gilteritinib	Gilteritinib Gilteritinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Glasdegib	Glasdegib Glasdegib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Riociguat.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Riociguat.
Rifamycin	Rifamycin The metabolism of Riociguat can be decreased when combined with Rifamycin.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Riociguat can be increased when combined with Emapalumab.
Siponimod	Siponimod Siponimod may decrease the antihypertensive activities of Riociguat.
Esomeprazole Injection	Esomeprazole Injection Esomeprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Alpelisib	Alpelisib The metabolism of Riociguat can be decreased when combined with Alpelisib.
Solriamfetol	Solriamfetol Solriamfetol may decrease the antihypertensive activities of Riociguat.
Darolutamide	Darolutamide The serum concentration of Riociguat can be increased when it is combined with Darolutamide.
Triclabendazole	Triclabendazole The metabolism of Riociguat can be decreased when combined with Triclabendazole.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Riociguat.
Pitolisant	Pitolisant The serum concentration of Riociguat can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib Fedratinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Phenytoin Injection	Phenytoin Injection The metabolism of Riociguat can be decreased when combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Riociguat can be decreased when combined with Fosphenytoin.
Lasmiditan	Lasmiditan The serum concentration of Riociguat can be increased when it is combined with Lasmiditan.
Cenobamate	Cenobamate The serum concentration of Riociguat can be decreased when it is combined with Cenobamate.
Ozanimod	Ozanimod The metabolism of Ozanimod can be decreased when combined with Riociguat.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Riociguat.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Riociguat.
Ripretinib	Ripretinib Ripretinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Selpercatinib	Selpercatinib The serum concentration of Riociguat can be increased when it is combined with Selpercatinib.
Capmatinib	Capmatinib The serum concentration of Riociguat can be increased when it is combined with Capmatinib.
Fostemsavir	Fostemsavir Fostemsavir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Pralsetinib	Pralsetinib Pralsetinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Opicapone	Opicapone The metabolism of Riociguat can be decreased when combined with Opicapone.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Riociguat can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Riociguat.
Theophylline	Theophylline Theophylline may increase the hypotensive activities of Riociguat.
Fenoprofen	Fenoprofen The therapeutic efficacy of Riociguat can be decreased when used in combination with Fenoprofen.
Indomethacin	Indomethacin The therapeutic efficacy of Riociguat can be decreased when used in combination with Indomethacin.
Mefenamic Acid	Mefenamic Acid The therapeutic efficacy of Riociguat can be decreased when used in combination with Mefenamic acid.
Naproxen	Naproxen The therapeutic efficacy of Riociguat can be decreased when used in combination with Naproxen.
Tolmetin	Tolmetin The therapeutic efficacy of Riociguat can be decreased when used in combination with Tolmetin.
Sulindac	Sulindac The therapeutic efficacy of Riociguat can be decreased when used in combination with Sulindac.
Trazodone	Trazodone Trazodone may decrease the antihypertensive activities of Riociguat.
Sodium Bicarbonate	Sodium Bicarbonate Sodium bicarbonate can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Phenobarbital	Phenobarbital The metabolism of Riociguat can be increased when combined with Phenobarbital.
Primidone	Primidone Primidone may increase the hypotensive activities of Riociguat.
Diethylpropion	Diethylpropion Diethylpropion may decrease the antihypertensive activities of Riociguat.
Chlorpromazine	Chlorpromazine Chlorpromazine may decrease the antihypertensive activities of Riociguat.
Phenoxybenzamine	Phenoxybenzamine Phenoxybenzamine may decrease the antihypertensive activities of Riociguat.
Bromocriptine	Bromocriptine Bromocriptine may decrease the antihypertensive activities of Riociguat.
Metaproterenol	Metaproterenol Orciprenaline may decrease the antihypertensive activities of Riociguat.
Tranylcypromine	Tranylcypromine Tranylcypromine may increase the hypotensive activities of Riociguat.
Phenelzine	Phenelzine Phenelzine may increase the hypotensive activities of Riociguat.
Procarbazine	Procarbazine Procarbazine may increase the hypotensive activities of Riociguat.
Ergoloid Mesylates	Ergoloid Mesylates Ergoloid mesylate may decrease the antihypertensive activities of Riociguat.
Thioridazine	Thioridazine Thioridazine may decrease the antihypertensive activities of Riociguat.
Trifluoperazine	Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Riociguat.
Dapsone	Dapsone The metabolism of Riociguat can be decreased when combined with Dapsone.
Sulfadiazine	Sulfadiazine The metabolism of Riociguat can be decreased when combined with Sulfadiazine.
Methadone	Methadone The metabolism of Riociguat can be decreased when combined with Methadone.
Oxybutynin	Oxybutynin The metabolism of Riociguat can be decreased when combined with Oxybutynin.
Ibuprofen	Ibuprofen The therapeutic efficacy of Riociguat can be decreased when used in combination with Ibuprofen.
Phentermine	Phentermine Phentermine may decrease the antihypertensive activities of Riociguat.
Methylphenidate	Methylphenidate Methylphenidate may decrease the antihypertensive activities of Riociguat.
Amoxapine	Amoxapine Amoxapine may decrease the antihypertensive activities of Riociguat.
Sulfasalazine	Sulfasalazine Sulfasalazine may decrease the excretion rate of Riociguat which could result in a higher serum level.
Hydrocortisone	Hydrocortisone The metabolism of Riociguat can be increased when combined with Hydrocortisone.
Methyldopa	Methyldopa Methyldopa may increase the hypotensive activities of Riociguat.
Clonidine	Clonidine The risk or severity of hypotension can be increased when Clonidine is combined with Riociguat.
Prazosin	Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Riociguat.
Hydralazine	Hydralazine Hydralazine may increase the hypotensive activities of Riociguat.
Cimetidine	Cimetidine Cimetidine can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Warfarin	Warfarin The metabolism of Riociguat can be decreased when combined with Warfarin.
Loperamide	Loperamide The serum concentration of Riociguat can be increased when it is combined with Loperamide.
Meclofenamate	Meclofenamate The therapeutic efficacy of Riociguat can be decreased when used in combination with Meclofenamic acid.
Griseofulvin	Griseofulvin The metabolism of Riociguat can be increased when combined with Griseofulvin.
Chloroquine	Chloroquine The metabolism of Riociguat can be decreased when combined with Chloroquine.
Quinine	Quinine The metabolism of Riociguat can be decreased when combined with Quinine.
Triamterene	Triamterene The risk or severity of adverse effects can be increased when Triamterene is combined with Riociguat.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Riociguat can be decreased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide The therapeutic efficacy of Riociguat can be increased when used in combination with Chlorothiazide.
Chlorthalidone	Chlorthalidone Chlorthalidone may increase the hypotensive activities of Riociguat.
Metolazone	Metolazone Metolazone may increase the hypotensive activities of Riociguat.
Isosorbide	Isosorbide Isosorbide may increase the hypotensive activities of Riociguat.
Secobarbital	Secobarbital The metabolism of Riociguat can be increased when combined with Secobarbital.
Desipramine	Desipramine Desipramine may decrease the antihypertensive activities of Riociguat.
Amitriptyline	Amitriptyline The metabolism of Riociguat can be decreased when combined with Amitriptyline.
Imipramine	Imipramine Imipramine may decrease the antihypertensive activities of Riociguat.
Probenecid	Probenecid The metabolism of Riociguat can be increased when combined with Probenecid.
Quinidine	Quinidine Quinidine may decrease the antihypertensive activities of Riociguat.
Rifampin	Rifampin The metabolism of Riociguat can be increased when combined with Rifampicin.
Valproic Acid	Valproic Acid The metabolism of Riociguat can be decreased when combined with Valproic acid.
Tamoxifen	Tamoxifen The metabolism of Riociguat can be decreased when combined with Tamoxifen.
Butabarbital	Butabarbital Butabarbital may increase the hypotensive activities of Riociguat.
Levothyroxine	Levothyroxine The metabolism of Riociguat can be decreased when combined with Levothyroxine.
Methimazole	Methimazole The serum concentration of Riociguat can be increased when it is combined with Methimazole.
Tolbutamide	Tolbutamide The metabolism of Riociguat can be decreased when combined with Tolbutamide.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Riociguat.
Methyclothiazide	Methyclothiazide The therapeutic efficacy of Riociguat can be increased when used in combination with Methyclothiazide.
Hydrochlorothiazide	Hydrochlorothiazide The therapeutic efficacy of Riociguat can be increased when used in combination with Hydrochlorothiazide.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) Propranolol may increase the hypotensive activities of Riociguat.
Minoxidil	Minoxidil Minoxidil may increase the hypotensive activities of Riociguat.
Pseudoephedrine	Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Riociguat.
Nortriptyline	Nortriptyline Nortriptyline may decrease the antihypertensive activities of Riociguat.
Spironolactone	Spironolactone The metabolism of Riociguat can be decreased when combined with Spironolactone.
Amphotericin B Injection	Amphotericin B Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Riociguat.
Mercaptopurine	Mercaptopurine Mercaptopurine may increase the hypotensive activities of Riociguat.
Nadolol	Nadolol Nadolol may increase the hypotensive activities of Riociguat.
Papaverine	Papaverine The risk or severity of adverse effects can be increased when Papaverine is combined with Riociguat.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Riociguat can be decreased when combined with Fluorouracil.
Colchicine	Colchicine The metabolism of Riociguat can be decreased when combined with Colchicine.
Ketoconazole	Ketoconazole The serum concentration of Riociguat can be increased when it is combined with Ketoconazole.
Captopril	Captopril Captopril may increase the hypotensive activities of Riociguat.
Dipyridamole	Dipyridamole Dipyridamole may increase the hypotensive activities of Riociguat.
Isoxsuprine	Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Riociguat.
Ethacrynic Acid	Ethacrynic Acid The risk or severity of adverse effects can be increased when Etacrynic acid is combined with Riociguat.
Metoprolol	Metoprolol Metoprolol may increase the hypotensive activities of Riociguat.
Aspirin	Aspirin Acetylsalicylic acid may decrease the antihypertensive activities of Riociguat.
Salsalate	Salsalate The therapeutic efficacy of Riociguat can be decreased when used in combination with Salsalate.
Trimethoprim	Trimethoprim The metabolism of Riociguat can be decreased when combined with Trimethoprim.
Diltiazem	Diltiazem The metabolism of Riociguat can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine The metabolism of Riociguat can be decreased when combined with Nifedipine.
Timolol	Timolol Timolol may increase the hypotensive activities of Riociguat.
Verapamil	Verapamil The metabolism of Riociguat can be decreased when combined with Verapamil.
Atenolol	Atenolol Atenolol may increase the hypotensive activities of Riociguat.
Pindolol	Pindolol Pindolol may increase the hypotensive activities of Riociguat.
Diflunisal	Diflunisal The therapeutic efficacy of Riociguat can be decreased when used in combination with Diflunisal.
Piroxicam	Piroxicam The therapeutic efficacy of Riociguat can be decreased when used in combination with Piroxicam.
Bumetanide	Bumetanide The risk or severity of adverse effects can be increased when Bumetanide is combined with Riociguat.
Indapamide	Indapamide The therapeutic efficacy of Riociguat can be increased when used in combination with Indapamide.
Pentoxifylline	Pentoxifylline Pentoxifylline may increase the hypotensive activities of Riociguat.
Labetalol	Labetalol Labetalol may increase the hypotensive activities of Riociguat.
Gemfibrozil	Gemfibrozil The metabolism of Riociguat can be decreased when combined with Gemfibrozil.
Guanabenz	Guanabenz Riociguat may decrease the antihypertensive activities of Guanabenz.
Ketoprofen	Ketoprofen The therapeutic efficacy of Riociguat can be decreased when used in combination with Ketoprofen.
Enalapril	Enalapril Enalapril may increase the hypotensive activities of Riociguat.
Flurbiprofen	Flurbiprofen The therapeutic efficacy of Riociguat can be decreased when used in combination with Flurbiprofen.
Amiodarone	Amiodarone The metabolism of Amiodarone can be decreased when combined with Riociguat.
Buspirone	Buspirone Buspirone may decrease the antihypertensive activities of Riociguat.
Lovastatin	Lovastatin The metabolism of Riociguat can be decreased when combined with Lovastatin.
Mesalamine	Mesalamine The therapeutic efficacy of Riociguat can be decreased when used in combination with Mesalazine.
Diclofenac	Diclofenac The therapeutic efficacy of Riociguat can be decreased when used in combination with Diclofenac.
Nimodipine	Nimodipine Nimodipine may increase the hypotensive activities of Riociguat.
Clozapine	Clozapine Clozapine may decrease the antihypertensive activities of Riociguat.
Clarithromycin	Clarithromycin The serum concentration of Riociguat can be increased when it is combined with Clarithromycin.
Benazepril	Benazepril Benazepril may increase the hypotensive activities of Riociguat.
Etodolac	Etodolac The therapeutic efficacy of Riociguat can be decreased when used in combination with Etodolac.
Felodipine	Felodipine The metabolism of Riociguat can be decreased when combined with Felodipine.
Fosinopril	Fosinopril Fosinopril may increase the hypotensive activities of Riociguat.
Nabumetone	Nabumetone The therapeutic efficacy of Riociguat can be decreased when used in combination with Nabumetone.
Pravastatin	Pravastatin Pravastatin may decrease the excretion rate of Riociguat which could result in a higher serum level.
Quinapril	Quinapril Quinapril may increase the hypotensive activities of Riociguat.
Ramipril	Ramipril Ramipril may increase the hypotensive activities of Riociguat.
Simvastatin	Simvastatin The metabolism of Riociguat can be decreased when combined with Simvastatin.
Amlodipine	Amlodipine Amlodipine may increase the hypotensive activities of Riociguat.
Itraconazole	Itraconazole The serum concentration of Riociguat can be increased when it is combined with Itraconazole.
Lisinopril	Lisinopril Lisinopril may increase the hypotensive activities of Riociguat.
Oxaprozin	Oxaprozin The therapeutic efficacy of Riociguat can be decreased when used in combination with Oxaprozin.
Rifabutin	Rifabutin The metabolism of Riociguat can be increased when combined with Rifabutin.
Sotalol	Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Riociguat.
Bisoprolol	Bisoprolol Bisoprolol may increase the hypotensive activities of Riociguat.
Doxazosin	Doxazosin Doxazosin may increase the hypotensive activities of Riociguat.
Terazosin	Terazosin Terazosin may increase the hypotensive activities of Riociguat.
Isradipine	Isradipine Isradipine may increase the hypotensive activities of Riociguat.
Omeprazole	Omeprazole Omeprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cisapride	Cisapride The metabolism of Riociguat can be decreased when combined with Cisapride.
Fluvastatin	Fluvastatin The metabolism of Riociguat can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine Venlafaxine may increase the excretion rate of Riociguat which could result in a lower serum level and potentially a reduction in efficacy.
Nizatidine	Nizatidine Nizatidine can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nefazodone	Nefazodone The serum concentration of Riociguat can be increased when it is combined with Nefazodone.
Losartan	Losartan The metabolism of Riociguat can be decreased when combined with Losartan.
Moexipril	Moexipril Moexipril may increase the hypotensive activities of Riociguat.
Lansoprazole	Lansoprazole Lansoprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Riociguat can be increased when combined with Ifosfamide.
Nicardipine	Nicardipine The metabolism of Riociguat can be decreased when combined with Nicardipine.
Ticlopidine	Ticlopidine The metabolism of Riociguat can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Riociguat.
Nisoldipine	Nisoldipine Nisoldipine may increase the hypotensive activities of Riociguat.
Amifostine Injection	Amifostine Injection Riociguat may increase the hypotensive activities of Amifostine.
Anastrozole	Anastrozole The metabolism of Riociguat can be decreased when combined with Anastrozole.
Ritonavir	Ritonavir The serum concentration of Riociguat can be increased when it is combined with Ritonavir.
Clomipramine	Clomipramine Clomipramine may decrease the antihypertensive activities of Riociguat.
Zafirlukast	Zafirlukast The metabolism of Riociguat can be decreased when combined with Zafirlukast.
Mirtazapine	Mirtazapine Mirtazapine may decrease the antihypertensive activities of Riociguat.
Trandolapril	Trandolapril Trandolapril may increase the hypotensive activities of Riociguat.
Valsartan	Valsartan Valsartan may increase the hypotensive activities of Riociguat.
Pramipexole	Pramipexole The risk or severity of adverse effects can be increased when Pramipexole is combined with Riociguat.
Nelfinavir	Nelfinavir Nelfinavir may decrease the excretion rate of Riociguat which could result in a higher serum level.
Loratadine	Loratadine The metabolism of Riociguat can be decreased when combined with Loratadine.
Carvedilol	Carvedilol Carvedilol may increase the hypotensive activities of Riociguat.
Nilutamide	Nilutamide The metabolism of Riociguat can be decreased when combined with Nilutamide.
Selegiline	Selegiline Selegiline may increase the hypotensive activities of Riociguat.
Propafenone	Propafenone Propafenone may decrease the antihypertensive activities of Riociguat.
Raloxifene	Raloxifene The metabolism of Riociguat can be decreased when combined with Raloxifene.
Irbesartan	Irbesartan The metabolism of Riociguat can be decreased when combined with Irbesartan.
Tamsulosin	Tamsulosin The risk or severity of adverse effects can be increased when Tamsulosin is combined with Riociguat.
Ropinirole	Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Riociguat.
Finasteride	Finasteride Finasteride may decrease the antihypertensive activities of Riociguat.
Quetiapine	Quetiapine Quetiapine may increase the hypotensive activities of Riociguat.
Tolcapone	Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Riociguat.
Efavirenz	Efavirenz The serum concentration of Riociguat can be increased when it is combined with Efavirenz.
Sildenafil	Sildenafil The risk or severity of hypotension can be increased when Sildenafil is combined with Riociguat.
Pioglitazone	Pioglitazone The metabolism of Riociguat can be decreased when combined with Pioglitazone.
Celecoxib	Celecoxib The therapeutic efficacy of Riociguat can be decreased when used in combination with Celecoxib.
Rosiglitazone	Rosiglitazone The metabolism of Riociguat can be decreased when combined with Rosiglitazone.
Thalidomide	Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Riociguat.
Aluminum Hydroxide	Aluminum Hydroxide Aluminum hydroxide can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide	Balsalazide The therapeutic efficacy of Riociguat can be decreased when used in combination with Balsalazide.
Rabeprazole	Rabeprazole Rabeprazole can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Terbinafine	Terbinafine The metabolism of Riociguat can be decreased when combined with Terbinafine.