Amoxicillin / Omeprazole / Rifabutin
A three-ingredient combination of two antibiotics and an acid reducer used to treat Helicobacter pylori (H. pylori) bacterial infection in adults.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 1 clinical label set within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
📖 Amoxicillin / Omeprazole / Rifabutin: Patient Information Guide
A plain-language walkthrough of Amoxicillin / Omeprazole / Rifabutin — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.
🎯What it's used for▾
Talicia is a prescription combination product indicated for a specific bacterial stomach infection.
- Talicia (amoxicillin / omeprazole / rifabutin) delayed-release capsules are approved to treat Helicobacter pylori (H. pylori) infection in adults.
- Talicia should only be used when an H. pylori infection is confirmed or strongly suspected — using it unnecessarily can contribute to antibiotic resistance.
⚙️How it works▾
Talicia combines two antibiotics (amoxicillin and rifabutin) with a proton pump inhibitor, or PPI (omeprazole). The two antibiotics work together to kill H. pylori bacteria. Omeprazole suppresses stomach acid production, which makes the stomach environment less hospitable to the bacteria and helps the antibiotics reach effective levels in the stomach lining.
Omeprazole's acid-suppressing effect starts within about one hour of taking a dose and builds with repeated daily dosing. When Talicia is stopped, stomach acid levels return gradually over 3 to 5 days.
💊How it's taken▾
Talicia comes as delayed-release capsules taken by mouth. The standard course is three times daily — spaced at least 4 hours apart (for example, morning, midday, and evening) — with food for 14 days. Capsules must be swallowed whole with a full glass of water; do not crush or chew them. Alcohol must be avoided throughout the treatment course.
- If you miss a dose and the next one is more than 4 hours away: take the missed dose as soon as you remember.
- If the next dose is within 4 hours: take the missed dose right away, then delay the next dose so there are still at least 4 hours between the two.
🤒Side effects — in detail▾
The most commonly reported side effects with Talicia include:
- Diarrhea
- Headache
- Nausea
- Stomach (abdominal) pain
- Chromaturia (discolored urine — a known effect of rifabutin)
- Rash
- Indigestion (dyspepsia)
- Vomiting
- Sore throat (oropharyngeal pain)
- Vaginal yeast infection (vulvovaginal candidiasis)
Seek immediate medical attention for signs of a severe allergic reaction, serious skin reactions (blistering, peeling), severe or bloody diarrhea, eye pain or vision changes, or signs of kidney problems — these are serious and require prompt evaluation.
⚠️Warnings & precautions▾
- Serious allergic reactions: Anaphylaxis (sudden, life-threatening allergic reaction), severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, AGEP), and other hypersensitivity reactions have been reported with all three components of Talicia. Stop the medication and get emergency help immediately if these occur.
- C. difficile-associated diarrhea (CDAD): Antibiotic use can allow dangerous C. diff bacteria to overgrow in the gut, causing severe diarrhea or colitis. This can occur even weeks after finishing treatment. Contact your doctor if you develop persistent diarrhea.
- Hormonal contraceptive failure: Talicia can reduce the effectiveness of hormonal birth control. Use an additional non-hormonal method throughout treatment.
- Kidney inflammation (acute tubulointerstitial nephritis): Has been reported with PPI and penicillin use. Discontinue Talicia and see a doctor if you notice signs of decreased kidney function.
- Lupus-like reactions: New or worsening cutaneous (skin) or systemic lupus erythematosus has been reported with PPI use. Discontinue if signs develop.
- Uveitis (eye inflammation): May occur especially when rifabutin is used alongside clarithromycin or fluconazole. See an eye doctor if you have eye pain or vision changes.
- Mononucleosis: Avoid Talicia in patients with mono — amoxicillin commonly triggers a rash in this setting.
- Drug interactions: Talicia has multiple significant drug interactions (see Interactions section). Some combinations are contraindicated; others require monitoring or dose adjustments.
🔀What it interacts with▾
Talicia's three components interact with a wide range of medications. Tell your prescriber and pharmacist about everything you take.
- Rilpivirine-containing HIV products: Contraindicated — omeprazole reduces rilpivirine absorption.
- Delavirdine (HIV drug): Contraindicated with rifabutin — do not combine.
- Voriconazole (antifungal): Contraindicated — significantly raises rifabutin levels.
- St. John's Wort / rifampin: Can sharply lower omeprazole levels — avoid.
- Fluconazole, itraconazole, posaconazole: Can raise rifabutin and omeprazole blood levels — avoid if possible; if unavoidable, monitor closely.
- Clopidogrel (blood thinner): Omeprazole reduces its effectiveness — avoid Talicia in patients on clopidogrel.
- Warfarin and other oral anticoagulants: May increase bleeding risk — INR monitoring required.
- High-dose methotrexate: Omeprazole can raise methotrexate levels and increase toxicity — avoid combination.
- HIV protease inhibitors (e.g., amprenavir, indinavir, saquinavir, ritonavir): Complex interactions — most should be avoided; see specific prescribing information.
- Hormonal contraceptives: Amoxicillin and rifabutin may reduce their effectiveness — use additional non-hormonal contraception.
- Digoxin / tacrolimus: Omeprazole may increase blood levels — monitor levels and adjust doses as needed.
- Alcohol: Must be avoided during the entire Talicia treatment course.
This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.
📋Before taking it▾
- Tell your doctor if you have ever had an allergic reaction to penicillins, cephalosporin antibiotics, rifamycin antibiotics, or proton pump inhibitors (PPIs).
- Do not use Talicia if you have severe kidney impairment — amoxicillin is mainly cleared by the kidneys, and rifabutin exposure increases significantly in severe kidney disease.
- Do not use Talicia if you have any degree of liver (hepatic) impairment.
- Talicia may cause harm to a developing baby — it is generally not recommended during pregnancy. If you are pregnant or planning to become pregnant, discuss the risks with your doctor.
- Use a reliable non-hormonal method of birth control during treatment, in addition to or instead of hormonal contraceptives.
- Tell your doctor if you have mononucleosis (mono) — amoxicillin commonly triggers a rash in this condition and Talicia should be avoided.
- Tell your doctor about all prescription and over-the-counter medications, supplements, and herbal products you take — especially any HIV medications, antifungals, blood thinners, immunosuppressants, or St. John's Wort.
- Talicia is indicated for adults; it has not been established for use in pediatric patients.
🚑If you take too much▾
There is no specific antidote for a Talicia overdose. If you or someone else takes too much, contact a doctor, poison control center (1-800-222-1222), or emergency room right away. With omeprazole, reported overdose symptoms have included confusion, drowsiness, blurred vision, rapid heartbeat, nausea, vomiting, sweating, flushing, and headache — symptoms were generally temporary. With amoxicillin, very large overdoses may carry a risk of kidney injury; staying well hydrated is important. Treatment is supportive and based on symptoms.
📡Pharmacodynamics — effects in the body▾
Omeprazole, a component of Talicia, begins suppressing stomach acid within about one hour of an oral dose, with peak effect at around two hours. The acid-reducing effect lasts longer than the drug's short time in the bloodstream, because omeprazole binds tightly and for an extended period to the enzyme (H+/K+ ATPase) responsible for acid secretion in the stomach. With repeated daily doses, the acid-suppressing effect builds over time. After stopping Talicia, normal stomach acid production returns gradually over 3 to 5 days.
🔬Pharmacokinetics — how your body processes it▾
Each of Talicia's three components is absorbed at different speeds after an oral dose, and food has different effects on each: a high-fat meal significantly reduces omeprazole absorption (by over 80%) while having a much smaller effect on amoxicillin and rifabutin — this is why Talicia should be taken with food but not a very high-fat meal beyond typical. Amoxicillin is mostly excreted unchanged through the kidneys within a few hours. Omeprazole is extensively broken down by liver enzymes (mainly CYP2C19) and eliminated in urine. Rifabutin has a much longer half-life (averaging about 34 hours) and is cleared through both urine and feces, primarily as metabolites. Patients with severe kidney impairment may have significantly higher rifabutin and amoxicillin levels, which is why Talicia is not recommended in that population.
📦How to store it▾
Store at 20°C to 25°C (68°F to 77°F) . Store and Dispense in original container with a child-resistant closure.
📄 Written from Amoxicillin / Omeprazole / Rifabutin’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →
🩺 Pharmacist Counseling Corner
Quick, plain-English answers to the questions patients ask most about Amoxicillin / Omeprazole / Rifabutin — the kind of thing our pharmacy team would talk through with you at the counter.
What exactly is Talicia treating — is this the same as a stomach ulcer medication? ▾
Do I really have to take it three times a day with food for two full weeks? ▾
Why can't I drink alcohol while on Talicia? ▾
Will this affect my birth control pills? ▾
What side effects should I just watch for versus what should make me call the doctor right away? ▾
I take other medications — is it safe to keep taking them with Talicia? ▾
Is Amoxicillin / Omeprazole / Rifabutin available over the counter? ▾
When was Amoxicillin / Omeprazole / Rifabutin first available? ▾
💬 Answers drafted from Amoxicillin / Omeprazole / Rifabutin’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →
🧰 Keep exploring
💊 How Amoxicillin / Omeprazole / Rifabutin comes
Amoxicillin / Omeprazole / Rifabutin is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Delayed-release capsule
How this form is used
- Talicia delayed-release capsules are used to treat Helicobacter pylori (H. pylori) infection in adults
- Talicia: Take four capsules three times daily, at least 4 hours apart, with food, for 14 days
- Talicia: Swallow capsules whole with a full glass of water — do not crush or chew
- Talicia: Do not take with alcohol
- Talicia: If you miss a dose and the next dose is more than 4 hours away, take the missed dose as soon as possible; if it's within 4 hours, take the missed dose right away and delay the next dose to keep at least 4 hours between doses
📊 Amoxicillin / Omeprazole / Rifabutin across the U.S. market
How Amoxicillin / Omeprazole / Rifabutin appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
📈 How widely Amoxicillin / Omeprazole / Rifabutin is used
A general measure of how commonly Amoxicillin / Omeprazole / Rifabutin is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Amoxicillin / Omeprazole / Rifabutin is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Amoxicillin / Omeprazole / Rifabutin prescribed? Of the 1,596 medications we measure, Amoxicillin / Omeprazole / Rifabutin ranks #1,013 by Medicaid prescriptions — more than 37% of them.
Utilization by Amoxicillin / Omeprazole / Rifabutin product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
amoxicillin 250 MG / omeprazole 10 MG / rifabutin 12.5 MG Delayed Release Oral Capsule
Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2262026
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Amoxicillin / Omeprazole / Rifabutin, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 1 of 4 listed Amoxicillin / Omeprazole / Rifabutin NDCs with Medicaid activity.
🔍 Compare Amoxicillin / Omeprazole / Rifabutin products
A representative set of FDA-listed product records for Amoxicillin / Omeprazole / Rifabutin — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Delayed-release capsule | ||||
| OMEPRAZOLE MAGNESIUM 10 mg/1; AMOXICILLIN 250 mg/1; RIFABUTIN 12.5 mg | Oral | RedHill Biopharma Ltd | NDA | View NDC → |
| 250; 10; 12.5 mg/1; mg/1; mg | Oral | RedHill Biopharma Ltd × 2 listings | NDA | View NDC → |
Showing 3 of 3 products — FDA National Drug Code Directory. See every product, package size and price: browse all 3 Amoxicillin / Omeprazole / Rifabutin NDCs →
📈 What people report — real-world data (FDA FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Amoxicillin / Omeprazole / Rifabutin — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Amoxicillin / Omeprazole / Rifabutin in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
🏛️ The road to your pharmacy
How Amoxicillin / Omeprazole / Rifabutin went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
🚨 Recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
Source: openFDA drug enforcement (recall) reports.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one exact multiple-ingredient concept (MIN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). A product with a different ingredient combination belongs on a different page.
RxCUI 2262025 1 dose form · 1 strength
-
Dose form (SCDF) Delayed Release Oral Capsule RxCUI 2262024In current FDA listingsClinical drug / strength (SCD) amoxicillin 250 MG / omeprazole 10 MG / rifabutin 12.5 MGRxCUI 2262026
Look up RxCUI 2262025 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
📦 Supply & shortage status
Whether Amoxicillin / Omeprazole / Rifabutin is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
🏷️ Sold under these brand names
🏭 Manufacturers & labelers
RxNorm drug class
Amoxicillin / Omeprazole / Rifabutin belongs to the Rifamycin Antimycobacterial class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
🔬 Where this comes from
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How we combine label and product data
HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 1 FDA-filed SPL label set within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.
For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. RedHill Biopharma Ltd is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.
This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.