Probenecid

Generic name: Pronounced as (proe ben' e sid)
Brand names
  • Benemid®
  • Probalan®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 07/15/2017

Probenecid is used to treat chronic gout and gouty arthritis. It is used to prevent attacks related to gout, not treat them once they occur. It acts on the kidneys to help the body eliminate uric acid. Probenecid is also used to make certain antibiotics more effective by preventing the body from passing them in the urine.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Probenecid comes in a tablet to take by mouth. It usually is taken two times a day when prescribed for chronic gout or gouty arthritis and four times a day when prescribed with antibiotics to make them more effective. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take probenecid exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Probenecid may increase the frequency of gout attacks during the first 6 to 12 months that you take it, although it will eventually prevent them. Another drug, such as colchicine, may be prescribed to decrease this effect.

Before taking probenecid,

  • tell your doctor and pharmacist if you are allergic to probenecid or any other drugs.

  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially aminosalicylic acid, antibiotics, aspirin, cancer chemotherapy agents (methotrexate), clofibrate (Atromid-S), dapsone, diflunisal (Dolobid), diuretics ('water pills'), heparin, indomethacin (Indocin), medication for anxiety, nitrofurantoin (Macrodantin, Macrobid), oral diabetes medications, pyrazinamide, salsalate (Disalcid), and vitamins. Because aspirin products may affect the way your body responds to probenecid, you should avoid them while taking probenecid. If you need something to relieve minor pain or fever, ask your doctor or pharmacist to recommend an aspirin substitute, such as acetaminophen (Tylenol).

  • tell your doctor if you have or have ever had ulcers, kidney stones, a kidney disorder, or a blood disorder.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking probenecid, call your doctor immediately.

  • tell your doctor if you plan to have surgery involving a general anesthetic.

  • if you are having any urine tests done, tell your doctor and the laboratory personnel that you are taking probenecid because it may affect the results of the test.

Drink at least six to eight full glasses of water a day while taking probenecid to prevent kidney stones, unless directed to do otherwise by your doctor.

Probenecid may cause an upset stomach. Take with food or antacids.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Probenecid may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • upset stomach

    • vomiting

    • loss of appetite

    • dizziness

  • If you experience any of the following symptoms, call your doctor immediately:

    • severe skin rash

    • difficulty breathing or swallowing

    • unusual bleeding or bruising

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to probenecid.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Colbenemid® (containing Colchicine, Probenecid)
  • Proben-C® (containing Colchicine, Probenecid)

Drug Interaction
Moxifloxacin Moxifloxacin Probenecid may decrease the excretion rate of Moxifloxacin which could result in a higher serum level.
Repaglinide Repaglinide The therapeutic efficacy of Repaglinide can be increased when used in combination with Probenecid.
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Probenecid.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The therapeutic efficacy of Insulin glargine can be increased when used in combination with Probenecid.
Leflunomide Leflunomide The metabolism of Leflunomide can be decreased when combined with Probenecid.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Probenecid.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be increased when combined with Probenecid.
Aminophylline Aminophylline The serum concentration of Aminophylline can be increased when it is combined with Probenecid.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Probenecid.
Cilostazol Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Probenecid.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Probenecid.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The excretion of Conjugated estrogens can be decreased when combined with Probenecid.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be increased when combined with Probenecid.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Probenecid.
Magnesium Hydroxide Magnesium Hydroxide Probenecid may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Miglitol Miglitol The therapeutic efficacy of Miglitol can be increased when used in combination with Probenecid.
Mycophenolate Mycophenolate The metabolism of Mycophenolic acid can be decreased when combined with Probenecid.
Olsalazine Olsalazine Probenecid may decrease the excretion rate of Olsalazine which could result in a higher serum level.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Probenecid.
Potassium Potassium Potassium may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may decrease the excretion rate of Probenecid which could result in a higher serum level.
Ranitidine Ranitidine The risk or severity of adverse effects can be increased when Probenecid is combined with Ranitidine.
Reserpine Reserpine The serum concentration of Reserpine can be increased when it is combined with Probenecid.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Probenecid which could result in a higher serum level.
Sumatriptan Sumatriptan Sumatriptan may decrease the excretion rate of Probenecid which could result in a higher serum level.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be increased when combined with Probenecid.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Probenecid which could result in a higher serum level.
Famotidine Injection Famotidine Injection The excretion of Famotidine can be decreased when combined with Probenecid.
Fluconazole Injection Fluconazole Injection Fluconazole may decrease the excretion rate of Probenecid which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Probenecid which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The metabolism of Probenecid can be decreased when combined with Hydromorphone.
Levofloxacin Injection Levofloxacin Injection The serum concentration of Levofloxacin can be increased when it is combined with Probenecid.
Meperidine Injection Meperidine Injection The metabolism of Probenecid can be increased when combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection Probenecid may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Probenecid.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Probenecid.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Probenecid which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Probenecid may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Probenecid.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Cefuroxime Cefuroxime The serum concentration of Cefuroxime can be increased when it is combined with Probenecid.
Cyclosporine Cyclosporine The risk or severity of renal failure can be increased when Probenecid is combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Probenecid.
Torsemide Torsemide The risk or severity of adverse effects can be increased when Probenecid is combined with Torasemide.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Probenecid.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Probenecid.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be increased when combined with Probenecid.
Meloxicam Meloxicam Probenecid may decrease the excretion rate of Meloxicam which could result in a higher serum level.
Pantoprazole Pantoprazole The metabolism of Pantoprazole can be decreased when combined with Probenecid.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Probenecid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Probenecid which could result in a higher serum level.
Zaleplon Zaleplon Zaleplon may decrease the excretion rate of Probenecid which could result in a higher serum level.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Probenecid.
Perindopril Perindopril Perindopril may decrease the excretion rate of Probenecid which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Probenecid which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Probenecid may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Probenecid.
Epinephrine Injection Epinephrine Injection The serum concentration of Epinephrine can be increased when it is combined with Probenecid.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The metabolism of Escitalopram can be decreased when combined with Probenecid.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Probenecid.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Probenecid.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Ezetimibe Ezetimibe The metabolism of Ezetimibe can be decreased when combined with Probenecid.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Probenecid which could result in a higher serum level.
Almotriptan Almotriptan The metabolism of Probenecid can be increased when combined with Almotriptan.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Probenecid.
Rosuvastatin Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Probenecid.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Memantine Memantine The serum concentration of Memantine can be increased when it is combined with Probenecid.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Probenecid which could result in a higher serum level.
Gemifloxacin Gemifloxacin Probenecid may decrease the excretion rate of Gemifloxacin which could result in a higher serum level.
Progesterone Progesterone The metabolism of Progesterone can be increased when combined with Probenecid.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be increased when combined with Probenecid.
Duloxetine Duloxetine The metabolism of Probenecid can be increased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Probenecid.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Probenecid which could result in a higher serum level.
Bosentan Bosentan The metabolism of Bosentan can be decreased when combined with Probenecid.
Cefditoren Cefditoren Probenecid may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Probenecid.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Probenecid.
Ganciclovir Ganciclovir Probenecid may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The therapeutic efficacy of Insulin aspart can be increased when used in combination with Probenecid.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Valganciclovir Valganciclovir Probenecid may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Voriconazole can be decreased when combined with Probenecid.
Adefovir Adefovir Adefovir may decrease the excretion rate of Probenecid which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Pramlintide Injection Pramlintide Injection The therapeutic efficacy of Pramlintide can be increased when used in combination with Probenecid.
Exenatide Injection Exenatide Injection The therapeutic efficacy of Exenatide can be increased when used in combination with Probenecid.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Probenecid.
Fentanyl Fentanyl Fentanyl may decrease the excretion rate of Probenecid which could result in a higher serum level.
Pregabalin Pregabalin Pregabalin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Deferasirox Deferasirox The metabolism of Deferasirox can be decreased when combined with Probenecid.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The therapeutic efficacy of Insulin detemir can be increased when used in combination with Probenecid.
Ranolazine Ranolazine The metabolism of Probenecid can be increased when combined with Ranolazine.
Rasagiline Rasagiline Probenecid may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Imatinib Imatinib The metabolism of Imatinib can be increased when combined with Probenecid.
Sitagliptin Sitagliptin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Probenecid.
Varenicline Varenicline The excretion of Varenicline can be decreased when combined with Probenecid.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Probenecid which could result in a higher serum level.
Paliperidone Paliperidone Probenecid may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Bortezomib Bortezomib The metabolism of Bortezomib can be increased when combined with Probenecid.
Clofarabine Injection Clofarabine Injection The serum concentration of Probenecid can be increased when it is combined with Clofarabine.
Fulvestrant Injection Fulvestrant Injection The metabolism of Fulvestrant can be decreased when combined with Probenecid.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Probenecid.
Lubiprostone Lubiprostone Probenecid may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The serum concentration of Oxaliplatin can be increased when it is combined with Probenecid.
Bismuth Subsalicylate Bismuth Subsalicylate The therapeutic efficacy of Probenecid can be decreased when used in combination with Bismuth subsalicylate.
Pemetrexed Injection Pemetrexed Injection Probenecid may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Retapamulin Retapamulin The metabolism of Retapamulin can be increased when combined with Probenecid.
Sorafenib Sorafenib The metabolism of Probenecid can be increased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Probenecid.
Dronabinol Dronabinol The metabolism of Dronabinol can be decreased when combined with Probenecid.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Probenecid.
Levocetirizine Levocetirizine Probenecid may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Probenecid may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Probenecid.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Probenecid.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Probenecid which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Nilotinib can be increased when combined with Probenecid.
Raltegravir Raltegravir The metabolism of Raltegravir can be decreased when combined with Probenecid.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Probenecid.
Budesonide Budesonide Probenecid may decrease the excretion rate of Budesonide which could result in a higher serum level.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Doripenem Injection Doripenem Injection The excretion of Doripenem can be decreased when combined with Probenecid.
Etravirine Etravirine The metabolism of Etravirine can be decreased when combined with Probenecid.
Arsenic Trioxide Injection Arsenic Trioxide Injection Probenecid may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine Probenecid may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Probenecid which could result in a higher serum level.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Probenecid.
Tretinoin Tretinoin The metabolism of Tretinoin can be increased when combined with Probenecid.
Leucovorin Injection Leucovorin Injection The excretion of Leucovorin can be decreased when combined with Probenecid.
Certolizumab Injection Certolizumab Injection Probenecid may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Probenecid.
Irinotecan Injection Irinotecan Injection The risk or severity of neutropenia can be increased when Probenecid is combined with Irinotecan.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Probenecid.
Methylnaltrexone Injection Methylnaltrexone Injection Probenecid may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Probenecid.
Midazolam Midazolam Midazolam may decrease the excretion rate of Probenecid which could result in a higher serum level.
Naltrexone Injection Naltrexone Injection The metabolism of Naltrexone can be decreased when combined with Probenecid.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Probenecid which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Probenecid.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Probenecid.
Dexlansoprazole Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Probenecid.
Plerixafor Injection Plerixafor Injection Probenecid may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Probenecid may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Probenecid.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Probenecid.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Probenecid.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Probenecid can be increased when combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Dronedarone can be increased when combined with Probenecid.
Pralatrexate Injection Pralatrexate Injection The serum concentration of Pralatrexate can be increased when it is combined with Probenecid.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Probenecid which could result in a higher serum level.
Saxagliptin Saxagliptin The therapeutic efficacy of Saxagliptin can be increased when used in combination with Probenecid.
Telavancin Injection Telavancin Injection Probenecid may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Probenecid.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Probenecid.
Topotecan Topotecan Topotecan may decrease the excretion rate of Probenecid which could result in a higher serum level.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Probenecid.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be increased when combined with Probenecid.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Probenecid.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Probenecid.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Probenecid.
Liraglutide Injection Liraglutide Injection The therapeutic efficacy of Liraglutide can be increased when used in combination with Probenecid.
Dalfampridine Dalfampridine The serum concentration of Dalfampridine can be increased when it is combined with Probenecid.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Probenecid.
Ceftaroline Injection Ceftaroline Injection The serum concentration of Ceftaroline fosamil can be increased when it is combined with Probenecid.
Pegloticase Injection Pegloticase Injection The risk or severity of adverse effects can be increased when Probenecid is combined with Pegloticase.
Acetaminophen Injection Acetaminophen Injection Probenecid may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Probenecid.
Ipilimumab Injection Ipilimumab Injection Probenecid may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Probenecid which could result in a higher serum level.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Probenecid.
Roflumilast Roflumilast The metabolism of Roflumilast can be increased when combined with Probenecid.
Linagliptin Linagliptin The therapeutic efficacy of Linagliptin can be increased when used in combination with Probenecid.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Probenecid.
Rivaroxaban Rivaroxaban Probenecid may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Probenecid.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Probenecid.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Probenecid.
Clobazam Clobazam The metabolism of Clobazam can be decreased when combined with Probenecid.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be increased when combined with Probenecid.
Vismodegib Vismodegib The metabolism of Vismodegib can be decreased when combined with Probenecid.
Deferiprone Deferiprone Probenecid may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Probenecid.
Crizotinib Crizotinib The metabolism of Crizotinib can be increased when combined with Probenecid.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Probenecid.
Naloxone Injection Naloxone Injection The metabolism of Naloxone can be decreased when combined with Probenecid.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Probenecid which could result in a higher serum level.
Ezogabine Ezogabine The metabolism of Tiagabine can be decreased when combined with Probenecid.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be increased when combined with Probenecid.
Mirabegron Mirabegron Probenecid may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Regorafenib can be increased when combined with Probenecid.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Probenecid.
Lorcaserin Lorcaserin The therapeutic efficacy of Mecasermin can be increased when used in combination with Probenecid.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Probenecid.
Teduglutide Injection Teduglutide Injection Probenecid may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin The therapeutic efficacy of Alogliptin can be increased when used in combination with Probenecid.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Probenecid.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Probenecid.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Probenecid.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Probenecid.
Canagliflozin Canagliflozin The therapeutic efficacy of Canagliflozin can be increased when used in combination with Probenecid.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Probenecid.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Probenecid.
Trametinib Trametinib Probenecid may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dolutegravir Dolutegravir The metabolism of Dolutegravir can be decreased when combined with Probenecid.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Probenecid.
Ertapenem Injection Ertapenem Injection Probenecid may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Probenecid.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Probenecid.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Probenecid.
Ketorolac Injection Ketorolac Injection The serum concentration of Ketorolac can be increased when it is combined with Probenecid.
Sofosbuvir Sofosbuvir Probenecid may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Probenecid.
Apremilast Apremilast Probenecid may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Probenecid may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Probenecid.
Albiglutide Injection Albiglutide Injection The therapeutic efficacy of Albiglutide can be increased when used in combination with Probenecid.
Eslicarbazepine Eslicarbazepine The metabolism of Eslicarbazepine can be decreased when combined with Probenecid.
Belinostat Injection Belinostat Injection The metabolism of Belinostat can be decreased when combined with Probenecid.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Probenecid.
Testosterone Injection Testosterone Injection The metabolism of Probenecid can be decreased when combined with Testosterone.
Empagliflozin Empagliflozin The therapeutic efficacy of Empagliflozin can be increased when used in combination with Probenecid.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Probenecid.
Suvorexant Suvorexant The metabolism of Suvorexant can be increased when combined with Probenecid.
Dulaglutide Injection Dulaglutide Injection The therapeutic efficacy of Dulaglutide can be increased when used in combination with Probenecid.
Edoxaban Edoxaban Probenecid may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Probenecid.
Methamphetamine Methamphetamine Probenecid may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Probenecid.
Riociguat Riociguat The metabolism of Riociguat can be increased when combined with Probenecid.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Probenecid.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Probenecid.
Insulin Human Inhalation Insulin Human Inhalation The therapeutic efficacy of Insulin human can be increased when used in combination with Probenecid.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Probenecid.
Haloperidol Injection Haloperidol Injection The metabolism of Probenecid can be decreased when combined with Haloperidol.
Amiloride Amiloride Amiloride may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Probenecid may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Probenecid.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Probenecid.
Penicillin G Procaine Injection Penicillin G Procaine Injection The excretion of Procaine benzylpenicillin can be decreased when combined with Probenecid.
Eluxadoline Eluxadoline The excretion of Eluxadoline can be decreased when combined with Probenecid.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The therapeutic efficacy of Insulin degludec can be increased when used in combination with Probenecid.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Probenecid.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Probenecid.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Probenecid.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Probenecid.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Probenecid.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Probenecid.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Probenecid which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The excretion of Dexamethasone can be decreased when combined with Probenecid.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Probenecid.
Venetoclax Venetoclax The metabolism of Venetoclax can be increased when combined with Probenecid.
Selexipag Selexipag The metabolism of Selexipag can be increased when combined with Probenecid.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Probenecid.
Furosemide Injection Furosemide Injection The risk or severity of adverse effects can be increased when Probenecid is combined with Furosemide.
Lixisenatide Injection Lixisenatide Injection The therapeutic efficacy of Lixisenatide can be increased when used in combination with Probenecid.
Ribociclib Ribociclib The metabolism of Ribociclib can be increased when combined with Probenecid.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Probenecid.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Probenecid.
Deutetrabenazine Deutetrabenazine Probenecid may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Probenecid may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Probenecid.
Naldemedine Naldemedine Probenecid may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Midostaurin can be increased when combined with Probenecid.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Probenecid.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Probenecid.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Probenecid.
Benznidazole Benznidazole Probenecid may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Probenecid.
Delafloxacin Delafloxacin Probenecid may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Probenecid.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Probenecid.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Probenecid.
Semaglutide Injection Semaglutide Injection The therapeutic efficacy of Semaglutide can be increased when used in combination with Probenecid.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Ertugliflozin can be increased when used in combination with Probenecid.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Probenecid.
Apalutamide Apalutamide The metabolism of Apalutamide can be increased when combined with Probenecid.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Probenecid.
Lofexidine Lofexidine Probenecid may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Probenecid may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Probenecid.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Probenecid.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Probenecid.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Probenecid.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be increased when combined with Probenecid.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Probenecid.
Stiripentol Stiripentol Probenecid may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be increased when combined with Probenecid.
Glasdegib Glasdegib The metabolism of Glasdegib can be increased when combined with Probenecid.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be increased when combined with Probenecid.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Probenecid.
Prucalopride Prucalopride The metabolism of Prucalopride can be increased when combined with Probenecid.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Probenecid.
Acyclovir Ophthalmic Acyclovir Ophthalmic Probenecid may decrease the excretion rate of Acyclovir which could result in a higher serum level.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Probenecid.
Esomeprazole Injection Esomeprazole Injection The metabolism of Esomeprazole can be decreased when combined with Probenecid.
Alpelisib Alpelisib The metabolism of Alpelisib can be increased when combined with Probenecid.
Solriamfetol Solriamfetol The serum concentration of Solriamfetol can be increased when it is combined with Probenecid.
Darolutamide Darolutamide The metabolism of Darolutamide can be decreased when combined with Probenecid.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Probenecid.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Probenecid.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Probenecid.
Istradefylline Istradefylline The metabolism of Istradefylline can be increased when combined with Probenecid.
Pitolisant Pitolisant Probenecid may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Probenecid.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Probenecid.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Probenecid.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Probenecid.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Probenecid.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Probenecid.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Probenecid.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Probenecid.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Probenecid.
Cenobamate Cenobamate The metabolism of Cenobamate can be decreased when combined with Probenecid.
Ozanimod Ozanimod The metabolism of Ozanimod can be increased when combined with Probenecid.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Probenecid.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Probenecid.
Tucatinib Tucatinib The metabolism of Tucatinib can be increased when combined with Probenecid.
Sacituzumab govitecan-hziy Injection Sacituzumab govitecan-hziy Injection The serum concentration of Sacituzumab govitecan can be increased when it is combined with Probenecid.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Probenecid.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Probenecid.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Probenecid.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Probenecid.
Viloxazine Viloxazine Probenecid may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Theophylline Theophylline The serum concentration of Theophylline can be increased when it is combined with Probenecid.
Fenoprofen Fenoprofen Probenecid may decrease the excretion rate of Fenoprofen which could result in a higher serum level.
Indomethacin Indomethacin Probenecid may decrease the excretion rate of Indomethacin which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Probenecid may decrease the excretion rate of Mefenamic acid which could result in a higher serum level.
Naproxen Naproxen The serum concentration of Naproxen can be increased when it is combined with Probenecid.
Tolmetin Tolmetin Probenecid may decrease the excretion rate of Tolmetin which could result in a higher serum level.
Sulindac Sulindac Probenecid may decrease the excretion rate of Sulindac which could result in a higher serum level.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Probenecid which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Probenecid.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Probenecid which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The serum concentration of Methotrexate can be increased when it is combined with Probenecid.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Probenecid.
Methsuximide Methsuximide The metabolism of Methsuximide can be decreased when combined with Probenecid.
Chlorpromazine Chlorpromazine The metabolism of Probenecid can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Probenecid.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Probenecid which could result in a higher serum level.
Flurazepam Flurazepam Flurazepam may decrease the excretion rate of Probenecid which could result in a higher serum level.
Clorazepate Clorazepate Clorazepic acid may decrease the excretion rate of Probenecid which could result in a higher serum level.
Lorazepam Lorazepam The serum concentration of Lorazepam can be increased when it is combined with Probenecid.
Carmustine Carmustine Carmustine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Amantadine Amantadine The serum concentration of Amantadine can be increased when it is combined with Probenecid.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Probenecid.
Bromocriptine Bromocriptine The therapeutic efficacy of Bromocriptine can be increased when used in combination with Probenecid.
Phenelzine Phenelzine Phenelzine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Tetracycline Tetracycline The excretion of Tetracycline can be decreased when combined with Probenecid.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Probenecid.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Probenecid.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Dapsone Dapsone Probenecid may decrease the excretion rate of Dapsone which could result in a higher serum level.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Probenecid.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Probenecid.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Probenecid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline Maprotiline may decrease the excretion rate of Probenecid which could result in a higher serum level.
Ibuprofen Ibuprofen Probenecid may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Azathioprine Azathioprine Azathioprine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Phentermine Phentermine The metabolism of Phentermine can be increased when combined with Probenecid.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Probenecid which could result in a higher serum level.
Sulfasalazine Sulfasalazine Probenecid may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Hydrocortisone Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Probenecid.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be increased when combined with Probenecid.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Probenecid is combined with Cytarabine.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Probenecid.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Probenecid which could result in a higher serum level.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Probenecid.
Prazosin Prazosin The serum concentration of Prazosin can be increased when it is combined with Probenecid.
Hydralazine Hydralazine Probenecid may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The excretion of Cimetidine can be decreased when combined with Probenecid.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Probenecid.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Probenecid.
Loperamide Loperamide The metabolism of Loperamide can be increased when combined with Probenecid.
Promethazine Promethazine Probenecid may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate Probenecid may decrease the excretion rate of Meclofenamic acid which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin The serum concentration of Nitrofurantoin can be increased when it is combined with Probenecid.
Digoxin Digoxin Probenecid may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine The metabolism of Probenecid can be increased when combined with Chloroquine.
Quinine Quinine The therapeutic efficacy of Quinine can be increased when used in combination with Probenecid.
Triamterene Triamterene Triamterene may decrease the excretion rate of Probenecid which could result in a higher serum level.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Probenecid can be decreased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Probenecid.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Probenecid.
Secobarbital Secobarbital Secobarbital may decrease the excretion rate of Probenecid which could result in a higher serum level.
Desipramine Desipramine Probenecid may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Probenecid.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be increased when combined with Probenecid.
Procainamide Procainamide The serum concentration of Procainamide can be increased when it is combined with Probenecid.
Isoniazid Isoniazid Isoniazid may decrease the excretion rate of Probenecid which could result in a higher serum level.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Probenecid which could result in a higher serum level.
Disopyramide Disopyramide The therapeutic efficacy of Disopyramide can be increased when used in combination with Probenecid.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Probenecid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Probenecid.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Probenecid which could result in a higher serum level.
Levothyroxine Levothyroxine The metabolism of Levothyroxine can be decreased when combined with Probenecid.
Liothyronine Liothyronine The metabolism of Probenecid can be decreased when combined with Liothyronine.
Methimazole Methimazole Methimazole may decrease the excretion rate of Probenecid which could result in a higher serum level.
Chlorpropamide Chlorpropamide The protein binding of Chlorpropamide can be decreased when combined with Probenecid.
Tolbutamide Tolbutamide The protein binding of Tolbutamide can be decreased when combined with Probenecid.
Tolazamide Tolazamide The protein binding of Tolazamide can be decreased when combined with Probenecid.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Probenecid.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Probenecid.
Baclofen Baclofen Baclofen may decrease the excretion rate of Probenecid which could result in a higher serum level.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Probenecid which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Probenecid can be decreased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Probenecid can be decreased when used in combination with Hydrochlorothiazide.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Probenecid which could result in a higher serum level.
Carisoprodol Carisoprodol The metabolism of Carisoprodol can be decreased when combined with Probenecid.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Probenecid which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Probenecid.
Minoxidil Minoxidil The serum concentration of Minoxidil can be increased when it is combined with Probenecid.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Probenecid.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Probenecid which could result in a higher serum level.
Mercaptopurine Mercaptopurine The serum concentration of Mercaptopurine can be increased when it is combined with Probenecid.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Probenecid which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Nadolol Nadolol Probenecid may decrease the excretion rate of Nadolol which could result in a higher serum level.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Probenecid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol The excretion of Probenecid can be increased when combined with Allopurinol.
Flavoxate Flavoxate Probenecid may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be increased when combined with Probenecid.
Cefaclor Cefaclor The serum concentration of Cefaclor can be increased when it is combined with Probenecid.
Cefadroxil Cefadroxil The serum concentration of Cefadroxil can be increased when it is combined with Probenecid.
Cefazolin Injection Cefazolin Injection The serum concentration of Cefazolin can be increased when it is combined with Probenecid.
Cephalexin Cephalexin The serum concentration of Cephalexin can be increased when it is combined with Probenecid.
Cefoxitin Injection Cefoxitin Injection The serum concentration of Cefoxitin can be increased when it is combined with Probenecid.
Dacarbazine Dacarbazine Dacarbazine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection The serum concentration of Cefotaxime can be increased when it is combined with Probenecid.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Pyrantel Pyrantel Probenecid may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Probenecid.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Probenecid.
Captopril Captopril The excretion of Captopril can be decreased when combined with Probenecid.
Vinblastine Vinblastine The metabolism of Vinblastine can be increased when combined with Probenecid.
Ethacrynic Acid Ethacrynic Acid The risk or severity of adverse effects can be increased when Probenecid is combined with Etacrynic acid.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Probenecid which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Probenecid can be increased when combined with Metoprolol.
Aspirin Aspirin Probenecid may decrease the excretion rate of Acetylsalicylic acid which could result in a higher serum level.
Salsalate Salsalate Probenecid may decrease the excretion rate of Salsalate which could result in a higher serum level.
Alprazolam Alprazolam Alprazolam may decrease the excretion rate of Probenecid which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Probenecid which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Probenecid which could result in a higher serum level.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Probenecid which could result in a higher serum level.
Trimethoprim Trimethoprim The metabolism of Probenecid can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Diltiazem can be increased when combined with Probenecid.
Nifedipine Nifedipine Probenecid may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol The metabolism of Probenecid can be decreased when combined with Timolol.
Verapamil Verapamil The metabolism of Probenecid can be increased when combined with Verapamil.
Pindolol Pindolol Pindolol may decrease the excretion rate of Probenecid which could result in a higher serum level.
Cisplatin Injection Cisplatin Injection The serum concentration of Cisplatin can be increased when it is combined with Probenecid.
Diflunisal Diflunisal Probenecid may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Piroxicam Piroxicam Probenecid may decrease the excretion rate of Piroxicam which could result in a higher serum level.
Bumetanide Bumetanide The risk or severity of adverse effects can be increased when Probenecid is combined with Bumetanide.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Probenecid.
Glyburide Glyburide The protein binding of Glyburide can be decreased when combined with Probenecid.
Glipizide Glipizide The protein binding of Glipizide can be decreased when combined with Probenecid.
Indapamide Indapamide Indapamide may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin The excretion of Amoxicillin can be decreased when combined with Probenecid.
Dicloxacillin Dicloxacillin The excretion of Dicloxacillin can be decreased when combined with Probenecid.
Nafcillin Injection Nafcillin Injection The excretion of Nafcillin can be decreased when combined with Probenecid.
Oxacillin Injection Oxacillin Injection The excretion of Oxacillin can be decreased when combined with Probenecid.
Pentoxifylline Pentoxifylline The serum concentration of Pentoxifylline can be increased when it is combined with Probenecid.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Pentamidine can be increased when used in combination with Probenecid.
Ceftriaxone Injection Ceftriaxone Injection The serum concentration of Ceftriaxone can be increased when it is combined with Probenecid.
Labetalol Labetalol The metabolism of Probenecid can be decreased when combined with Labetalol.
Auranofin Auranofin Auranofin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Probenecid which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Gemfibrozil can be decreased when combined with Probenecid.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Probenecid which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection The serum concentration of Ceftazidime can be increased when it is combined with Probenecid.
Ketoprofen Ketoprofen The serum concentration of Ketoprofen can be increased when it is combined with Probenecid.
Cefotetan Injection Cefotetan Injection The serum concentration of Cefotetan can be increased when it is combined with Probenecid.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Probenecid.
Flurbiprofen Flurbiprofen Probenecid may decrease the excretion rate of Flurbiprofen which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Probenecid.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Probenecid which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Probenecid which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Lovastatin can be increased when combined with Probenecid.
Ciprofloxacin Ciprofloxacin Probenecid may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Mesalamine Mesalamine Probenecid may decrease the excretion rate of Mesalazine which could result in a higher serum level.
Diclofenac Diclofenac Probenecid may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Probenecid.
Cefixime Cefixime The serum concentration of Cefixime can be increased when it is combined with Probenecid.
Clozapine Clozapine The metabolism of Probenecid can be decreased when combined with Clozapine.
Estazolam Estazolam Probenecid may decrease the excretion rate of Estazolam which could result in a higher serum level.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Probenecid.
Ofloxacin Ofloxacin Probenecid may decrease the excretion rate of Ofloxacin which could result in a higher serum level.
Didanosine Didanosine Didanosine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Etodolac Etodolac Probenecid may decrease the excretion rate of Etodolac which could result in a higher serum level.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Probenecid which could result in a higher serum level.
Nabumetone Nabumetone Probenecid may decrease the excretion rate of Nabumetone which could result in a higher serum level.
Pravastatin Pravastatin The excretion of Pravastatin can be decreased when combined with Probenecid.
Quinapril Quinapril The excretion of Quinapril can be decreased when combined with Probenecid.
Simvastatin Simvastatin The metabolism of Simvastatin can be increased when combined with Probenecid.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Probenecid.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be increased when combined with Probenecid.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Probenecid which could result in a higher serum level.
Oxaprozin Oxaprozin Probenecid may decrease the excretion rate of Oxaprozin which could result in a higher serum level.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Probenecid which could result in a higher serum level.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Probenecid.
Doxazosin Doxazosin The metabolism of Doxazosin can be increased when combined with Probenecid.
Isradipine Isradipine Isradipine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Probenecid.
Cisapride Cisapride The metabolism of Cisapride can be increased when combined with Probenecid.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Probenecid.
Venlafaxine Venlafaxine The metabolism of Probenecid can be decreased when combined with Venlafaxine.
Stavudine Stavudine The excretion of Stavudine can be decreased when combined with Probenecid.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Probenecid.
Fluvoxamine Fluvoxamine Fluvoxamine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Nefazodone Nefazodone Probenecid may decrease the excretion rate of Nefazodone which could result in a higher serum level.
Lamotrigine Lamotrigine The metabolism of Lamotrigine can be decreased when combined with Probenecid.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Probenecid.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Probenecid which could result in a higher serum level.
Tramadol Tramadol The metabolism of Tramadol can be increased when combined with Probenecid.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Probenecid.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Probenecid.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Probenecid.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Probenecid.
Nicardipine Nicardipine The metabolism of Nicardipine can be increased when combined with Probenecid.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Probenecid.
Ticlopidine Ticlopidine The metabolism of Probenecid can be increased when combined with Ticlopidine.
Metformin Metformin The therapeutic efficacy of Metformin can be increased when used in combination with Probenecid.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Lamivudine Lamivudine The serum concentration of Lamivudine can be increased when it is combined with Probenecid.
Acarbose Acarbose The therapeutic efficacy of Acarbose can be increased when used in combination with Probenecid.
Glimepiride Glimepiride The protein binding of Glimepiride can be decreased when combined with Probenecid.
Anastrozole Anastrozole The metabolism of Anastrozole can be increased when combined with Probenecid.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Probenecid.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Probenecid which could result in a higher serum level.
Meropenem Injection Meropenem Injection The excretion of Meropenem can be decreased when combined with Probenecid.
Clomipramine Clomipramine The metabolism of Clomipramine can be increased when combined with Probenecid.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be increased when combined with Probenecid.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Topiramate Topiramate Topiramate may decrease the excretion rate of Probenecid which could result in a higher serum level.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Probenecid.
Valsartan Valsartan The metabolism of Valsartan can be decreased when combined with Probenecid.
Insulin Lispro Injection Insulin Lispro Injection The therapeutic efficacy of Insulin lispro can be increased when used in combination with Probenecid.
Pramipexole Pramipexole The serum concentration of Pramipexole can be increased when it is combined with Probenecid.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Probenecid.
Fexofenadine Fexofenadine The excretion of Fexofenadine can be decreased when combined with Probenecid.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Probenecid.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Probenecid.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Probenecid which could result in a higher serum level.
Flutamide Flutamide Flutamide may decrease the excretion rate of Probenecid which could result in a higher serum level.
Selegiline Selegiline The metabolism of Selegiline can be increased when combined with Probenecid.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be increased when combined with Probenecid.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Probenecid.
Raloxifene Raloxifene The metabolism of Raloxifene can be decreased when combined with Probenecid.
Irbesartan Irbesartan The metabolism of Irbesartan can be increased when combined with Probenecid.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quetiapine Quetiapine Probenecid may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection The serum concentration of Cefepime can be increased when it is combined with Probenecid.
Cefprozil Cefprozil The serum concentration of Cefprozil can be increased when it is combined with Probenecid.
Cefpodoxime Cefpodoxime The serum concentration of Cefpodoxime can be increased when it is combined with Probenecid.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Probenecid which could result in a higher serum level.
Paroxetine Paroxetine The metabolism of Paroxetine can be decreased when combined with Probenecid.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Probenecid which could result in a higher serum level.
Citalopram Citalopram Probenecid may increase the QTc-prolonging activities of Citalopram.
Capecitabine Capecitabine The metabolism of Capecitabine can be decreased when combined with Probenecid.
Abacavir Abacavir The metabolism of Abacavir can be decreased when combined with Probenecid.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Probenecid.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be increased when combined with Probenecid.
Celecoxib Celecoxib Probenecid may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Rosiglitazone Rosiglitazone The therapeutic efficacy of Rosiglitazone can be increased when used in combination with Probenecid.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Probenecid.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Probenecid.
Oseltamivir Oseltamivir The serum concentration of the active metabolites of Oseltamivir can be increased when Oseltamivir is used in combination with Probenecid.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Probenecid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide Probenecid may decrease the excretion rate of Balsalazide which could result in a higher serum level.
Nateglinide Nateglinide The therapeutic efficacy of Nateglinide can be increased when used in combination with Probenecid.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Probenecid.
Terbinafine Terbinafine The metabolism of Terbinafine can be increased when combined with Probenecid.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists