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Probenecid

Probenecid is an oral tablet that lowers uric acid in people with gout and also boosts blood levels of certain penicillin-type antibiotics.

Brand names ProbalanBenemid
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 8 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026
Probenecid at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Probenecid is an older gout medicine, on the market since about 1951 and available as a generic, usually a second choice after allopurinol; it lowers uric acid by helping the kidneys flush more into the urine, and also slows the kidneys' removal of penicillin-type antibiotics. Most people tolerate it fairly well, and headache and an upset stomach are the usual complaints. Watch for a serious allergic reaction (trouble breathing, swelling, hives or fever), rare but most likely within hours of restarting after a break, and stop it and get help right away. Skip aspirin and other salicylates, which cancel its effect, and reach for acetaminophen for mild pain.

Clinical pearls

  • Drink plenty of fluids, since extra uric acid in the urine can form kidney stones; report back or side pain.
  • Start it only after a gout attack settles; if a flare hits later, keep taking it and treat the flare separately.
  • Probenecid raises methotrexate levels and strengthens sulfonylurea diabetes medicines, so make sure every prescriber knows you take it.
  • Before surgery, tell the anesthesia team you take probenecid, since you may need less of some anesthesia drugs.
How you get itPrescription only
Comes asTablet
Earliest FDA record1951
Companies listing it with the FDA6
FDA label last updatedNov 18, 2025
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Probenecid, written from its FDA label.

What Probenecid is used for

▾

Probenecid has two main uses.

  • Treating the high uric acid (hyperuricemia) that comes with gout and gouty arthritis (Probenecid tablets).
  • Acting as an add-on to penicillin, ampicillin, methicillin, oxacillin, cloxacillin or nafcillin to raise and prolong antibiotic levels in the blood (Probenecid tablets).

How Probenecid works

▾

Probenecid is a uricosuric. It blocks the kidney tubules from reabsorbing uric acid, so more is passed in the urine and blood levels drop. Over time this lowers the pool of uric acid in the body and helps break down uric acid deposits.

It also blocks the kidney from clearing penicillin, which usually raises penicillin blood levels two- to four-fold.

Probenecid dosage

▾

Probenecid tablets are taken by mouth, usually in divided doses through the day. Your prescriber chooses the schedule based on whether it is for gout or with an antibiotic.

  • For gout, treatment starts after an acute attack has settled.
  • Drink plenty of fluids. Your doctor may add something to keep your urine less acidic.
  • Your doctor may adjust the amount over time based on uric acid levels and how you tolerate it.
  • Stomach upset can mean the dose is too high, so let your prescriber know.

Follow your label and prescriber for exact directions.

Dosing details from the FDA-approved label

From the Probenecid prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Gout
    • 250 mg (1/2 tablet of probenecid) twice a day for one week, followed by 500 mg (1 tablet) twice a day thereafter
    • A daily dosage of 1000 mg may be adequate
    • If necessary the daily dosage may be increased by 500 mg increments every 4 weeks within tolerance if symptoms of gouty arthritis are not controlled or the 24 hour uric acid excretion is not above 700 mg
    • Maximum: usually not above 2000 mg per day
    • Do not start until an acute gouty attack has subsided; may not be effective in chronic renal insufficiency, particularly when glomerular filtration rate is 30 mL/minute or less; when acute attacks have been absent for 6 months or more and serum urate levels are normal, daily dosage may be decreased by 500 mg every 6 months
  • Penicillin therapy (general) - Adults
    • 2000 mg (4 tablets of probenecid) daily in divided doses
    • Dosage should be reduced in older patients in whom renal impairment may be present
  • Penicillin therapy (general) - Children 2 to 14 years of age
    • Initial dose: 25 mg/kg body weight (or 0.7 g/square meter body surface)
    • Maintenance dose: 40 mg/kg body weight (or 1.2 g/square meter body surface) per day, divided into 4 doses
    • For children weighing more than 50 kg (110 lb) the adult dosage is recommended; contraindicated in children under 2 years of age
  • Penicillin therapy (gonorrhea) - uncomplicated gonococcal infections in men and women (urethral, cervical, rectal)
    • 1 g of probenecid given orally with 4.8 million units of aqueous procaine penicillin G (given IM), or 3 g of amoxicillin (given orally), or 3.5 g of ampicillin (given orally)
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION Gout Therapy with probenecid should not be started until an acute gouty attack has subsided. However, if an acute attack is precipitated during therapy, probenecid may be continued without changing the dosage, and full therapeutic dosage of colchicine or other appropriate therapy should be given to control the acute attack. The recommended adult dosage is 250 mg (1/2 tablet of probenecid) twice a day for one week, followed by 500 mg (1 tablet) twice a day thereafter. Some degree of renal impairment may be present in patients with gout. A daily dosage of 1000 mg may be adequate. However, if necessary, the daily dosage may be increased by 500 mg increments every 4 weeks within tolerance (and usually not above 2000 mg per day) if symptoms of gouty arthritis are not controlled or the 24 hour uric acid excretion is not above 700 mg. As noted, probenecid may not be effective in chronic renal insufficiency, particularly when the glomerular filtration rate is 30 mL/minute or less. Gastric intolerance may be indicative of overdosage, and may be corrected by decreasing the dosage. As uric acid tends to crystallize out of an acid urine, a liberal fluid intake is recommended, as well as sufficient sodium bicarbonate (3 to 7.5 g daily), or potassium citrate (7.5 g daily) to maintain an alkaline urine (see PRECAUTIONS ). Alkalization of the urine is recommended until the serum urate level returns to normal limits and tophaceous deposits disappear, i.e., during the period when urinary excretion of uric acid is at a high level. Thereafter, alkalization of the urine and the usual restriction of purine-producing foods may be somewhat relaxed. Probenecid should be continued at the dosage that will maintain normal serum urate levels. When acute attacks have been absent for 6 months or more and serum urate levels remain within normal limits, the daily dosage may be decreased by 500 mg every 6 months. The maintenance dosage should not be reduced to the point where serum urate levels tend to rise. Probenecid and Penicillin Therapy (General) Adults The recommended dosage is 2000 mg (4 tablets of probenecid) daily in divided doses. This dosage should be reduced in older patients in whom renal impairment may be present. Children 2 to 14 years of age Initial dose: 25 mg/kg body weight ( or 0.7 g/square meter body surface).

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Probenecid side effects

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Most side effects are mild.

Common side effects

  • Headache
  • Dizziness
  • Nausea and vomiting
  • Loss of appetite
  • Sore gums
  • Urinary frequency
  • Itching, hives or rash
  • Flushing or hair loss

When to get medical help

  • Signs of a severe allergic reaction, such as trouble breathing, swelling, hives or fever. Stop the medicine and get help right away.
  • Back or side pain, blood in the urine or kidney-stone-type pain.
  • A gout flare that starts or gets worse after you begin treatment.
  • Unusual tiredness, paleness, frequent infections or easy bruising, which can signal blood problems such as anemia or low white blood cells.
  • Signs of liver trouble, such as ongoing nausea, vomiting or loss of appetite.
  • Swelling or other kidney-related changes (nephrotic syndrome).

Probenecid warnings and precautions

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  • Severe allergic reactions (including anaphylaxis) are rare but possible. Stop the drug if they appear.
  • Gout can flare after starting. Other treatment, such as colchicine, may be needed.
  • Aspirin and other salicylates work against it and should not be used.
  • It raises methotrexate levels and can increase its toxicity.
  • It may not work well in chronic kidney disease.

Probenecid interactions

▾

Probenecid changes how the body handles many other drugs.

  • Salicylates (aspirin): block its effect.
  • Pyrazinamide: also blocks its effect.
  • Methotrexate: levels rise, raising toxicity risk.
  • Penicillins and other beta-lactam antibiotics: levels rise, which may increase their side effects.
  • Sulfonylureas: effects may be stronger, raising low blood sugar risk.
  • Sulfonamides: levels rise, so monitoring may be needed.
  • Indomethacin, naproxen, ketoprofen, meclofenamate, lorazepam, acetaminophen, rifampin: levels may rise, so dose changes should be cautious.
  • Thiopental anesthesia: you may need less.

Interactions listed in the FDA-approved label

From the Probenecid prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Penicillin or other beta-lactams: High plasma concentrations of the other drug may increase the incidence of its adverse reactions; psychic disturbances have been reported with penicillin or other beta-lactams.
  • Salicylates: Salicylates antagonize the uricosuric action of probenecid. See WARNINGS
  • Pyrazinamide: The uricosuric action of probenecid is antagonized by pyrazinamide.
  • Sulfonamides: Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels, because it decreases renal excretion of conjugated sulfonamides. Determine plasma concentrations of conjugated sulfonamides from time to time when coadministered for prolonged periods.
  • Oral sulfonylureas: Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia.
  • Thiopental and ketamine: Patients receiving probenecid require significantly less thiopental for induction of anesthesia; ketamine and thiopental anesthesia were significantly prolonged in rats receiving probenecid.
  • Indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, rifampin: Probenecid increases the mean plasma elimination half-life of these drugs, which can lead to increased plasma concentrations. A lower dosage may be required; increase dosage cautiously and in small increments when probenecid is coadministered.
  • Sulindac: Sulindac had only a slight effect on plasma sulfide levels while plasma levels of sulindac and sulfone were increased; sulindac produced a modest reduction in the uricosuric action of probenecid, which probably is not significant under most circumstances.
  • Methotrexate: Probenecid has been reported to increase plasma concentrations of methotrexate in animals and humans. See WARNINGS
  • Theophylline: Falsely high theophylline readings have been reported in an in vitro study using the Schack and Waxler technique when therapeutic concentrations of theophylline and probenecid were added to human plasma.
Read the label’s full interactions text

Drug Interactions: When probenecid is used to elevate plasma concentrations of penicillin or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. In the case of penicillin or other beta-lactams, psychic disturbances have been reported. The use of salicylates antagonizes the uricosuric action of probenecid (see WARNINGS ). The uricosuric action of probenecid is also antagonized by pyrazinamide. Probenecid produces an insignificant increase in free sulfonamide plasma concentrations, but a significant increase in total sulfonamide plasma levels. Since probenecid decreases the renal excretion of conjugated sulfonamides, plasma concentrations of the latter should be determined from time to time when a sulfonamide and probenecid are coadministered for prolonged periods. Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia. It has been reported that patients receiving probenecid require significantly less thiopental for induction of anesthesia. In addition, ketamine and thiopental anesthesia were significantly prolonged in rats receiving probenecid. The concomitant administration of probenecid increases the mean plasma elimination half-life of a number of drugs which can lead to increased plasma concentrations. These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. Although the clinical significance of this observation has not been established, a lower dosage of the drug may be required to produce a therapeutic effect, and increases in dosage of the drug in question should be made cautiously and in small increments when probenecid is being coadministered.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

Before taking Probenecid

▾
  • Allergy to probenecid.
  • Children under 2 years old (must not take it).
  • Known blood disorders or uric acid kidney stones.
  • An active gout attack.
  • Kidney problems, since it may not work well and older adults may need lower doses with penicillin.
  • Pregnancy: it crosses the placenta, so benefit and risk must be weighed.

What Probenecid does in the body

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Probenecid increases the amount of uric acid passed in urine and lowers uric acid levels in the blood. This reduces the body’s uric acid pool, slows new deposits and helps existing deposits dissolve. It also slows kidney clearance of penicillin and several other drugs.

How to store Probenecid

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STORE AT 20˚ to 25˚C (68˚-77˚F) PROTECT FROM LIGHT. Dispense in a well closed, light-resistant container using a child-resistant closure as defined in the USP.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

30

Supplements & herbs that interact with Probenecid

30 supplements and herbal products have documented interactions with Probenecid in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 3
  • Moderate · 17
  • Minor · 10
Every supplement checked against Probenecid — ranked by severity The full interaction hub: 3 major · 17 moderate · 10 minor · every one linked to its full report. Check Probenecid against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Probenecid has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

See the full Probenecid nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Probenecid: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Probenecid — the kind of thing our pharmacy team would talk through with you at the counter.

What is probenecid for?

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It treats the high uric acid that causes gout and gouty arthritis. It is also sometimes paired with penicillin-type antibiotics to keep their levels in your blood higher for longer.

How should I take it?

▾
Take it by mouth as your prescriber directs, usually in divided doses through the day. Drink plenty of fluids, and if your doctor recommends something to make your urine less acidic, take that too. Don’t start it during a gout attack.

Can I take aspirin for pain while on it?

▾
No. Aspirin and other salicylates cancel out probenecid’s effect. If you need a mild pain reliever, acetaminophen is preferred, but check with me or your doctor first.

Will my gout get worse at first?

▾
It can. Flares sometimes happen after starting. Don’t stop on your own. Your doctor may add colchicine or another treatment to calm the attack.

What side effects should I expect, and which are worrying?

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Headache, dizziness, nausea, poor appetite and sore gums are the more usual ones. Call right away for hives, trouble breathing, swelling, fever, back or side pain, blood in your urine, or unusual tiredness or bruising.

Is it safe in pregnancy?

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Probenecid crosses the placenta and reaches the baby, so your doctor will weigh the benefits against possible risks. Tell us if you are pregnant or planning to be.

Is Probenecid available over the counter?

▾
No. Probenecid is a prescription medicine: every Probenecid product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Probenecid first available?

▾
The earliest FDA record we hold for Probenecid is from 1951: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Probenecid was first used.

Who makes Probenecid?

▾
6 companies currently list Probenecid products in the FDA's NDC Directory, including Bryant Ranch Prepack, Actavis Pharma, Inc., Lannett Company, Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Probenecid on HelloPharmacist

Detailed data & references for Probenecid Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Probenecid forms and strengths (how it comes)

Probenecid is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
How this form is used
What it may be used for
  • Probenecid tablets treat the high uric acid linked to gout and gouty arthritis.
  • Probenecid tablets are used as an add-on to penicillin and related antibiotics to raise and prolong antibiotic levels.
Important instructions
  • Probenecid tablets are taken by mouth, in divided doses through the day.
  • With Probenecid tablets for gout, drink plenty of fluids and follow your doctor’s advice on keeping urine less acidic.
  • Probenecid tablets should not be started until an acute gout attack has settled.
Available strengths 1 strength
14 FDA-listed product records ⓘ

Probenecid on the U.S. market: products, makers and brands

How Probenecid appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

6 companies list 7 Probenecid product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 1951. Brand names on the directory include Probalan, Benemid; the rest are generics.

1
Dose forms ⓘ
6
Labelers (makers, repackagers, distributors)
1
Brand names
7
FDA-listed product records ⓘ
1951
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (4) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack29%
Actavis Pharma, Inc.14%
Lannett Company, Inc.14%
Marlex Pharmaceuticals Inc14%
Remedyrepack Inc.14%
Rising Pharma Holdings, Inc.14%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Probenecid is used (Medicaid data)

A general measure of how commonly Probenecid is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Probenecid is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

3,947
Medicaid prescriptions filled (Q1–Q4 2025)
$229,900 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Probenecid prescribed? Of the 1,601 medications we measure, Probenecid ranks #1,086 by Medicaid prescriptions — more than 32% of them.

Where Probenecid ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

Utilization by Probenecid product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

probenecid 500 MG Oral Tablet

3,947 Medicaid prescriptions (Q1–Q4 2025) 100% of Probenecid prescriptions shown $229,900 gross reimbursement (before rebates) ≈ $58 per prescription (gross)

Summed across the 4 of 24 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198152

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Probenecid, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 4 of 24 listed Probenecid NDCs with Medicaid activity.

Compare Probenecid products

A representative set of FDA-listed product records for Probenecid — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category ⓘ Details
💊Tablet
500 mg Oral Actavis Pharma, Inc. ANDA View NDC →
500 mg Oral Bryant Ranch Prepack × 2 listings ANDA View NDC →
500 mg Oral Lannett Company, Inc. ANDA View NDC →
500 mg Oral Marlex Pharmaceuticals Inc ANDA View NDC →
500 mg Oral Remedyrepack Inc. ANDA View NDC →
500 mg Oral Rising Pharma Holdings, Inc. ANDA View NDC →

Showing 7 of 7 products — FDA National Drug Code Directory. See every product, package size and price: browse all 7 Probenecid NDCs →

Probenecid recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Probenecid recalls since July 2021.

✅No Probenecid recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Probenecid RxCUI 8698 1 dose form · 1 strength
  1. Dose form (SCDF) Oral Tablet RxCUI 373594 In current FDA listings
    Clinical drug / strength (SCD) 500 MG RxCUI 198152

Look up RxCUI 8698 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Probenecid costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Tablet, Film Coated · Oral 500 mg $0.636 per tablet NDC details & price history
Tablet · Oral 500 mg $0.636 per tablet NDC details & price history
Tablet, Film Coated 500 mg $0.636 per tablet NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Probenecid brand names

Probenecid is sold under 2 brand names in the FDA directory — Probalan, Benemid. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Probalan Benemid

Who makes Probenecid: manufacturers and labelers

6 companies list Probenecid products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Actavis Pharma, Inc., Lannett Company, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 2 Actavis Pharma, Inc. 1 Lannett Company, Inc. 1 Marlex Pharmaceuticals Inc 1 Remedyrepack Inc. 1 Rising Pharma Holdings, Inc. 1

Probenecid drug class (RxNorm)

Probenecid belongs to the Preparations with no effect on uric acid metabolism class.

Drug family (ATC) Preparations with no effect on uric acid metabolism, Other cephalosporins and penems, Preparations increasing uric acid excretion

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Probenecid page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Nov 18, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Probenecid.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Probenecid after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
8
Finished products in the current FDA directory
7
Companies listing them (makers, repackagers, distributors)
6
FDA labeler codes behind them ⓘ
6
Linked representative label ⓘ
Marlex Pharmaceuticals Inc
Linked label effective
Nov 18, 2025
Composite sections available
10
Linked SPL Set ID
5d552de5-2d18-4464-bcaf-0311fa3f080d
Linked SPL Document ID
43e0b999-0f40-3c9d-e063-6294a90ae477
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Marlex Pharmaceuticals Inc is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →