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Doxycycline

Doxycycline is a tetracycline-class antibiotic used to treat many bacterial infections, including rickettsial infections (such as Rocky Mountain spotted fever), sexually transmitted infections, respiratory tract infections, and eye infections, and to help prevent malaria and anthrax after exposure in some products.

Brand names ActiclateDoryx MpcDoryxMonodoxOracea +11 more
Drug class Tetracycline-class Drug
Rx Forms 8
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 251 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

How we combine label and product data →
Other forms & routes:
Injection
Doxycycline at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Doxycycline is a tetracycline-class antibiotic, around since the early 1980s and available as a generic, that blocks bacteria from making proteins they need; it is a go-to for tick-borne infections like Rocky Mountain spotted fever, chlamydia and malaria prevention. Most people handle it well, though many notice nausea, an upset stomach, or sunburning far faster than usual. Watch for severe or watery diarrhea, even weeks after finishing, which can mean C. difficile colitis (a serious bowel infection), and report a headache with vision changes or a blistering rash. It is avoided in pregnancy and children 8 and younger unless the infection is serious, because it can permanently stain developing teeth.

Clinical pearls

  • Space it well away from antacids, calcium, magnesium, iron supplements and bismuth (Pepto-Bismol), which bind it and block absorption.
  • Take it with a full glass of water and never right before bed, because it can burn the esophagus (food pipe).
  • Use sunscreen and cover up even on short outings, because doxycycline can make skin burn far faster than usual.
  • Do not combine it with isotretinoin for acne, because both can raise pressure inside the skull and threaten vision.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asCapsule, Tablet, Delayed-release tablet +5
Earliest FDA record1967
Companies listing it with the FDA142
FDA label last updatedApr 15, 2025
FDA’s strongest warning (boxed)None on the label

Patient information guide — a plain-language walkthrough of Doxycycline, written from its FDA label.

What Doxycycline is used for

▾

Doxycycline treats bacterial infections. The exact uses depend on the product.

  • Rickettsial infections, including Rocky Mountain spotted fever, typhus fever, Q fever, rickettsialpox and tick fevers
  • Sexually transmitted infections, including lymphogranuloma venereum
  • Respiratory tract infections, including those caused by Mycoplasma pneumoniae
  • Specific bacterial infections
  • Eye infections, including trachoma
  • Psittacosis (ornithosis)
  • Anthrax, including inhalational anthrax after exposure, in products that list it
  • Alternative treatment for selected infections when penicillin cannot be used
  • Add-on treatment for acute intestinal amebiasis and severe acne, and malaria prevention, in products that list them
  • Doxy 100 (intravenous) is approved for infections caused by a listed set of microorganisms, including relapsing fever and granuloma inguinale
  • Doxycycline capsules in a low-dose form are described for inflammatory lesions of rosacea

How Doxycycline works

▾

Doxycycline binds to the 30S ribosomal subunit in bacteria. This blocks the bacteria from making proteins, so they cannot grow and multiply. This is called a bacteriostatic effect.

Resistance to other tetracyclines is common. Bacteria can also become resistant if doxycycline is used when it is not needed. For rosacea, how the capsules work is unknown.

Doxycycline dosage

▾

Oral doxycycline is generally taken once or twice daily, often starting with a higher first-day amount. Doxy 100 is given intravenously by a healthcare professional. Do not exceed the recommended dose, since more can increase side effects.

  • Some products can be broken into pieces, and others must be swallowed whole. Follow the instructions for your product.
  • Take one specific capsule product at least one hour before or two hours after meals, since food and dairy lower absorption.
  • Avoid taking capsules right before lying down, because of the risk of esophagus irritation.

Dosing details from the FDA-approved label

From the Doxycycline prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Adults (usual dosage, delayed-release tablet)
    • 200 mg on the first day of treatment (administered 100 mg every 12 hours) followed by a maintenance dose of 100 mg daily
    • Maintenance dose may be administered as a single dose or as 50 mg every 12 hours; may be given with food or milk if gastric irritation occurs
  • More severe infections in adults (particularly chronic infections of the urinary tract)
    • 100 mg every 12 hours
  • Pediatric patients weighing less than 45 kg with severe or life-threatening infections (e.g., anthrax, Rocky Mountain spotted fever)
    • 2.2 mg per kg of body weight administered every 12 hours
    • Pediatric patients weighing 45 kg or more should receive the adult dose
  • Pediatric patients with less severe disease (greater than 8 years of age and weighing less than 45 kg)
    • 4.4 mg per kg of body weight divided into two doses on the first day of treatment, followed by a maintenance dose of 2.2 mg per kg of body weight (given as a single daily dose or divided into two doses)
    • Pediatric patients weighing over 45 kg should use the usual adult dose
  • Malaria prophylaxis, adults
    • 100 mg daily
    • Begin 1 or 2 days before travel to the malarious area, continue daily during travel and for 4 weeks after leaving the malarious area
  • Malaria prophylaxis, pediatric patients 8 years of age and older
    • 2 mg/kg administered once daily up to the adult dose
    • Maximum: Up to the adult dose
    • Patients weighing 45 kg or more should receive the adult dose
  • Inhalational anthrax (post-exposure), adults (oral)
    • 100 mg by mouth, twice-a-day for 60 days
  • Inhalational anthrax (post-exposure), pediatric patients weighing less than 45 kg (oral)
    • 2.2 mg/kg of body weight, by mouth, twice-a-day for 60 days
    • Patients weighing 45 kg or more should receive the adult dose
  • Adults, injection (intravenous)
    • 200 mg on the first day of treatment administered in one or two infusions
    • Subsequent daily dosage is 100 to 200 mg depending upon the severity of infection, with 200 mg administered in one or two infusions
    • Duration of infusion usually one to four hours; minimum infusion time for 100 mg of a 0.5 mg/mL solution is one hour
  • Primary and secondary syphilis, injection
    • 300 mg daily for at least 10 days
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION Important Administration Instructions for ACTICLATE and ACTICLATE CAP ACTICLATE Tablets (150 mg) can be broken into two-thirds or one-third to provide a 50 mg and 100 mg strength, respectively. ( 2.1 ) Swallow ACTICLATE CAP Capsule whole. Do not break, open, crush, dissolve or chew the capsule. ( 2.1 ) Dosage in Adults for ACTICLATE or ACTICLATE CAP: The usual dosage is 200 mg on the first day of treatment (administered 100 mg every 12 hours) followed by a maintenance dose of 100 mg daily. ( 2.1 ) In the management of more severe infections (particularly chronic infections of the urinary tract), 100 mg every 12 hours is recommended. ( 2.1 ) Dosage in Pediatric Patients for ACTICLATE or ACTICLATE CAP: For all pediatric patients weighing less than 45 kg with severe or life-threatening infections (e.g., anthrax, Rocky Mountain spotted fever), the recommended dose is 2.2 mg per kg of body weight administered every 12 hours. Pediatric patients weighing 45 kg or more should receive the adult dose. ( 2.3 ) For pediatric patients with less severe disease (greater than 8 years of age and weighing less than 45 kg), the recommended dose is 4.4 mg per kg of body weight divided into two doses on the first day of treatment, followed by a maintenance dose of 2.2 mg per kg of body weight (given as a single daily dose or divided into two doses. For pediatric patients weighing over 45 kg, the usual adult dose should be used. ( 2.3 ) See Full Prescribing Information for additional indication specific dosage information and important administration instructions for ACTICLATE and ACTICLATE CAP. ( 2.1 , 2.4 , 2.5 ) 2.1 Important Administration Instructions The usual dosage and frequency of administration of ACTICLATE and ACTICLATE CAP differs from that of the other tetracyclines. Exceeding the recommended dosage may result in an increased incidence of adverse reactions. Administer ACTICLATE and ACTICLATE CAP with adequate amounts of fluid to wash down the drugs and reduce the risk of esophageal irritation and ulceration [see Adverse Reactions ( 6 )] . If gastric irritation occurs, ACTICLATE and ACTICLATE CAP may be given with food or milk [see Clinical Pharmacology ( 12.3 )] Swallow ACTICLATE CAP whole. Do not break, open, crush, dissolve or chew the capsule.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Doxycycline side effects

▾

Common side effects

  • Diarrhea
  • Nausea and vomiting
  • Loss of appetite
  • Stomach pain or discomfort
  • Cold-like symptoms such as stuffy nose, sinusitis or nasopharyngitis (nose and throat irritation)
  • Skin rash
  • Higher blood pressure
  • Sunburn more easily (photosensitivity)

When to get medical help

  • Severe or watery diarrhea, even weeks or months after treatment, which may be C. difficile colitis
  • Severe skin reactions such as blistering, peeling or widespread rash
  • Headache with blurred vision, double vision or vision loss, which may signal raised pressure in the head (pseudotumor cerebri)
  • Fever, rash, joint pain and feeling unwell, which may signal an autoimmune reaction
  • Hives, swelling of the face or throat, or trouble breathing (allergic reaction)
  • Pain or trouble swallowing, or chest pain after taking a capsule
  • Yeast overgrowth, such as vaginal candidiasis (yeast infection) or thrush
  • Depression, anxiety, suicidal thoughts or hallucinations

Common side effects include:

  • Diarrhea
  • Nausea and vomiting
  • Loss of appetite
  • Stomach pain
  • Nasopharyngitis and sinusitis
  • Rash
  • Higher blood pressure
  • Easy sunburn

Seek care for severe diarrhea, severe skin reactions, vision changes or allergic reactions.

Doxycycline warnings and precautions

▾
  • C. difficile diarrhea can range from mild to fatal colitis and can occur over two months after treatment.
  • Teeth can be permanently discolored and bone growth slowed during the second and third trimesters of pregnancy and up to age 8.
  • Pseudotumor cerebri can cause headache, blurred vision and permanent vision loss.
  • Sun sensitivity can cause exaggerated sunburn, so limit sun exposure and tanning beds.
  • Severe skin reactions, autoimmune syndromes and tissue pigmentation have been reported.
  • Kidney impairment may require dose changes.
  • Overgrowth of fungi, such as vaginal candidiasis, can occur.

Doxycycline interactions

▾

Several medicines and supplements can change how doxycycline works.

  • Antacids with aluminum, calcium or magnesium, iron and bismuth subsalicylate reduce absorption.
  • Anticoagulants may need dose reduction.
  • Penicillin may be less effective.
  • Barbiturates, carbamazepine and phenytoin shorten doxycycline's half-life.
  • Isotretinoin raises the risk of pseudotumor cerebri.
  • Methoxyflurane has caused fatal kidney toxicity with tetracycline.
  • Oral contraceptives may be less effective.

Interactions listed in the FDA-approved label

From the Doxycycline prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Anticoagulants: Tetracyclines have been shown to depress plasma prothrombin activity. Patients on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
  • Penicillin: Bacteriostatic drugs may interfere with the bactericidal action of penicillin. It is advisable to avoid giving tetracyclines in conjunction with penicillin.
  • Antacids containing aluminum, calcium, or magnesium, and iron-containing preparations: Absorption of tetracyclines is impaired.
  • Bismuth subsalicylate: Absorption of tetracyclines is impaired.
  • Barbiturates, carbamazepine, and phenytoin: They decrease the half-life of doxycycline.
  • Penthrane (methoxyflurane): Concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.
  • Oral contraceptives: Concurrent use of tetracycline may render oral contraceptives less effective.
  • Urinary catecholamine laboratory test: False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.
Read the label’s full interactions text

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin. Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations. Absorption of tetracyclines is impaired by bismuth subsalicylate. Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. The concurrent use of tetracycline and Penthrane ® (methoxyflurane) has been reported to result in fatal renal toxicity. Concurrent use of tetracycline may render oral contraceptives less effective. Drug/Laboratory Test Interactions False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test. Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term studies in animals to evaluate carcinogenic potential of doxycycline have not been conducted. However, there has been evidence of oncogenic activity in rats in studies with the related antibacterial drugs, oxytetracycline (adrenal and pituitary tumors), and minocycline (thyroid tumors). Likewise, although mutagenicity studies of doxycycline have not been conducted, positive results in in vitro mammalian cell assays have been reported for related antibacterial drugs (tetracycline, oxytetracycline). Doxycycline administered orally at dosage levels as high as 250 mg/kg/day had no apparent effect on the fertility of female rats. Effect on male fertility has not been studied. Pregnancy Teratogenic Effects There are no adequate and well-controlled studies on the use of doxycycline in pregnant women. The vast majority of reported experience with doxycycline during human pregnancy is short-term, first trimester exposure.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿166 supplements and herbs with documented Doxycycline interactions, ranked by severity Check Doxycycline against a supplement or herb →

Before taking Doxycycline

▾
  • Do not use it if you are allergic to any tetracycline.
  • Tell your doctor if you are pregnant or breastfeeding.
  • Children 8 and younger should take it only for severe or life-threatening conditions.
  • Tell your doctor about kidney problems, history of raised pressure in the head, or stomach surgery.
  • Tell your doctor about a history of yeast infections.
  • Older adults: studies had too few people aged 65 and over to know if they respond differently.

Doxycycline overdose

▾

If too much is taken, stop the medicine and get medical help. Treatment is symptom-based and supportive. Dialysis does not change how long doxycycline stays in the blood, so it would not help.

What Doxycycline does in the body

▾

Doxycycline slows bacterial growth by blocking protein production at the 30S ribosomal subunit. It acts against a broad range of Gram-positive and Gram-negative bacteria, and some parasites. Cross-resistance with other tetracyclines is common.

How your body processes Doxycycline

▾

Doxycycline is almost completely absorbed after oral use, and it is more than 90% bound to plasma proteins. It is cleared in urine and feces as unchanged drug, and its half-life is roughly 16 to 22 hours. Kidney impairment does not significantly change its half-life, and hemodialysis does not change it either. Food and dairy can lower absorption of some products, and enzyme inducers shorten its half-life.

How to store Doxycycline

▾

Store at 20° to 25°C (68° to 77°F) excursions permitted to 15° to 30°C (59° to 86°F) . Protect from light and moisture. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

166

Supplements & herbs that interact with Doxycycline

166 supplements and herbal products have documented interactions with Doxycycline in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 7
  • Moderate · 139
  • Minor · 20
ACTIVATED CHARCOAL Major ASARABACCA Major BEER Major OLEANDER Major SIBERIAN COCKLEBUR Major ST. JOHN'S WORT Major WINE Major ALFALFA Moderate +158 more
Every supplement checked against Doxycycline — ranked by severity The full interaction hub: 7 major · 139 moderate · 20 minor · every one linked to its full report. Check Doxycycline against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

7

Nutrient depletion considerations

Doxycycline has been associated with lower levels of 7 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 6
  • Moderate · 1
BIOTIN Insignificant Depletion FOLIC ACID Insignificant Depletion RIBOFLAVIN Insignificant Depletion THIAMINE Insignificant Depletion VITAMIN B12 Insignificant Depletion VITAMIN B6 Insignificant Depletion VITAMIN K Moderate Depletion
See the full Doxycycline nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Doxycycline: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Doxycycline — the kind of thing our pharmacy team would talk through with you at the counter.

What is doxycycline used for?

▾
It is an antibiotic for bacterial infections such as rickettsial infections, sexually transmitted infections, respiratory tract infections and eye infections. Some products are also used for anthrax after exposure, malaria prevention, severe acne or rosacea. It will not work on viruses like colds or flu.

How should I take it?

▾
Take it exactly as your prescriber and label say. Swallow capsules with a full glass of water and avoid taking them right before lying down. For one capsule product, take it at least an hour before or two hours after meals. Some products can be broken or must be swallowed whole, so check yours.

What side effects should I expect?

▾
Diarrhea, nausea, vomiting, stomach upset and loss of appetite are the most common. You may also sunburn much more easily, so cover up and avoid tanning beds. Call me or your doctor if symptoms are severe.

When should I call my doctor?

▾
Call right away for severe or watery diarrhea, a blistering or peeling rash, headache with vision changes, trouble swallowing, or signs of an allergic reaction. Diarrhea can show up even weeks after you finish.

Can I take it with antacids, iron or other medicines?

▾
Antacids with calcium, magnesium or aluminum, iron products and bismuth subsalicylate can keep doxycycline from being absorbed. Blood thinners, penicillin, seizure medicines and isotretinoin can also interact. Tell me about everything you take, and ask how to space doses.

Is it safe in pregnancy or for kids?

▾
Doxycycline can harm a developing baby's bones and teeth, so tell your doctor if you are or may be pregnant. In children 8 and younger it can permanently stain teeth, so it is used only for severe or life-threatening infections. It also passes into breast milk, so talk with your doctor if you are nursing.

Is Doxycycline available over the counter?

▾
No. Doxycycline is a prescription medicine: every Doxycycline product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Doxycycline first available?

▾
The earliest FDA record we hold for Doxycycline is from 1967: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Doxycycline was first used.

Who makes Doxycycline?

▾
142 companies list Doxycycline products in the FDA's NDC Directory, including Remedyrepack Inc., Bryant Ranch Prepack, A-S Medication Solutions. That count includes repackagers and distributors as well as manufacturers, so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Doxycycline on HelloPharmacist

📊Doxycycline supplement interactions166 checked — ranked by severity 🌿Drug & Supplement CheckerDoxycycline vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Doxycycline NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Doxycycline Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Doxycycline forms and strengths (how it comes)

Doxycycline is available in 8 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Capsule

By mouth
Brands Acticlate Oracea
How this form is used
What it may be used for
  • Acticlate and Acticlate Cap are used for rickettsial, sexually transmitted, respiratory tract and eye infections, anthrax after exposure, and malaria prevention.
  • Doxycycline monohydrate capsules are used for infections such as Rocky Mountain spotted fever and respiratory tract infections caused by Mycoplasma pneumoniae.
Important instructions
  • Acticlate Cap capsules should be swallowed whole, not broken, opened, crushed, dissolved or chewed.
Available strengths 5 strengths
40 mg 50 mg 75 mg 100 mg 150 mg
466 FDA-listed product records ⓘ

Tablet

By mouth
Brands Acticlate Targadox
How this form is used
What it may be used for
  • Targadox is used for rickettsial infections, respiratory tract infections caused by Mycoplasma pneumoniae, lymphogranuloma venereum and trachoma.
Important instructions
  • Acticlate 150 mg tablets can be broken into two-thirds or one-third pieces.
  • Doxycycline hyclate 150 mg tablets can be broken into two-thirds or one-third pieces.
Available strengths 5 strengths
20 mg 50 mg 75 mg 100 mg 150 mg
356 FDA-listed product records ⓘ

Delayed-release tablet

By mouth
Brands Doryx Doryx Mpc
How this form is used
What it may be used for
  • Doryx Mpc is used for rickettsial, sexually transmitted and respiratory tract infections, anthrax after exposure, and malaria prevention.
Important instructions
  • Doryx Mpc cannot be swapped milligram for milligram with other oral doxycyclines.
  • Doryx Mpc tablets should not be chewed or crushed.
Available strengths 8 strengths
50 mg 60 mg 75 mg 80 mg 100 mg 120 mg
Show 2 more strengths Show fewer strengths
150 mg 200 mg
70 FDA-listed product records ⓘ

Injection

Into a vein
Brands Doxy 100 doxycycline hyclate
How this form is used
What it may be used for
  • Doxy 100 (Doxycycline for Injection) is used for infections caused by rickettsiae, Mycoplasma pneumoniae and other listed microorganisms.
Important instructions
  • Doxy 100 should not be given quickly through the vein.
  • Doxy 100 is used only when oral therapy is not appropriate, and oral therapy should start as soon as possible.
  • Doxy 100 given over a long period may cause thrombophlebitis (vein inflammation).
Available strengths 4 strengths
100 mg 100 mg/10 mL 100 mg/100 mg 200 mg/20 mL
43 FDA-listed product records ⓘ

Oral suspension

By mouth
Available strengths 2 strengths
25 mg/5 mL 1 kg/kg
13 FDA-listed product records ⓘ

Oral solution

By mouth
Available strengths 1 strength
50 mg/5 mL
2 FDA-listed product records ⓘ

Delayed-release capsule

By mouth
Available strengths 1 strength
40 mg
1 FDA-listed product record ⓘ

Topical cream, ointment or gel

By mouth
Available strengths 1 strength
2.5 g
1 FDA-listed product record ⓘ

Doxycycline on the U.S. market: products, makers and brands

How Doxycycline appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

142 companies list 971 Doxycycline product records with the FDA, mostly as capsule, tablet, delayed-release tablet; the earliest marketing or approval year on record is 1967. Brand names on the directory include Acticlate, Doryx Mpc, Doryx and 13 more; the rest are generics.

8
Dose forms ⓘ
142
Labelers (makers, repackagers, distributors)
17
Brand names
971
FDA-listed product records ⓘ
1967
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (19) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Remedyrepack Inc.8%
Bryant Ranch Prepack8%
A-S Medication Solutions8%
PD-Rx Pharmaceuticals, Inc.6%
NuCare Pharmaceuticals,Inc.5%
Alembic Pharmaceuticals Inc.4%
Other makers61%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Doxycycline is used (Medicaid data)

A general measure of how commonly Doxycycline is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Doxycycline is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

3,416,939
Medicaid prescriptions filled (Q1–Q4 2025)
$50.3M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Doxycycline prescribed? Of the 1,601 medications we measure, Doxycycline ranks #60 by Medicaid prescriptions — more than 96% of them.

Where Doxycycline ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #60 of 1,601
#55 Rosuvastatin 3,856,155 Rx #56 Insulin Glargine (rDNA... 3,731,821 Rx #57 Clonazepam 3,602,972 Rx #58 Fluconazole 3,462,620 Rx #59 Polyethylene Glycol 33... 3,441,581 Rx #60 Doxycycline 3,416,939 Rx #61 Risperidone 3,411,596 Rx #62 Lidocaine 3,379,243 Rx #63 Budesonide / Formotero... 3,326,951 Rx #64 Meloxicam 3,321,801 Rx #65 Folic Acid 3,298,551 Rx

Utilization by Doxycycline product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 100 mg oral capsule is the most-dispensed Doxycycline product — about 50% of these Medicaid prescriptions.

doxycycline hyclate 100 MG Oral Capsule Most dispensed

1,721,212 Medicaid prescriptions (Q1–Q4 2025) 50% of Doxycycline prescriptions shown $18.1M gross reimbursement (before rebates) ≈ $11 per prescription (gross)

Summed across the 16 of 332 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649988

doxycycline hyclate 100 MG Oral Tablet

681,304 Medicaid prescriptions (Q1–Q4 2025) 20% of Doxycycline prescriptions shown $8.2M gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 25 of 342 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1650143

doxycycline monohydrate 100 MG Oral Capsule

569,572 Medicaid prescriptions (Q1–Q4 2025) 17% of Doxycycline prescriptions shown $7.3M gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 9 of 177 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649990

doxycycline monohydrate 100 MG Oral Tablet

236,640 Medicaid prescriptions (Q1–Q4 2025) 7% of Doxycycline prescriptions shown $4.4M gross reimbursement (before rebates) ≈ $19 per prescription (gross)

Summed across the 6 of 46 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1650142

doxycycline hyclate 50 MG Oral Capsule

81,505 Medicaid prescriptions (Q1–Q4 2025) 2% of Doxycycline prescriptions shown $1.3M gross reimbursement (before rebates) ≈ $15 per prescription (gross)

Summed across the 6 of 79 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649405

doxycycline monohydrate 50 MG Oral Capsule

32,531 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $441,962 gross reimbursement (before rebates) ≈ $14 per prescription (gross)

Summed across the 4 of 40 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649401

doxycycline hyclate 20 MG Oral Tablet

28,975 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $449,486 gross reimbursement (before rebates) ≈ $16 per prescription (gross)

Summed across the 3 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 283535

doxycycline monohydrate 5 MG/ML Oral Suspension

27,690 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $1.4M gross reimbursement (before rebates) ≈ $52 per prescription (gross)

Summed across the 3 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1650030

doxycycline hyclate 50 MG Oral Tablet

13,140 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $4.4M gross reimbursement (before rebates) ≈ $336 per prescription (gross)

Summed across the 2 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1652674

doxycycline monohydrate 50 MG Oral Tablet

12,984 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $232,803 gross reimbursement (before rebates) ≈ $18 per prescription (gross)

Summed across the 3 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1652673

doxycycline hyclate 100 MG Injection

2,893 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $204,726 gross reimbursement (before rebates) ≈ $71 per prescription (gross)

Summed across the 11 of 43 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310027

doxycycline anhydrous 40 MG Delayed Release Oral Capsule

2,750 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $1.2M gross reimbursement (before rebates) ≈ $442 per prescription (gross)

Summed across the 6 of 21 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 901399

doxycycline monohydrate 75 MG Oral Capsule

2,090 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $1.9M gross reimbursement (before rebates) ≈ $889 per prescription (gross)

Summed across the 1 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 700408

doxycycline hyclate 100 MG Delayed Release Oral Tablet

1,215 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $76,220 gross reimbursement (before rebates) ≈ $63 per prescription (gross)

Summed across the 2 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 434018

doxycycline monohydrate 75 MG Oral Tablet

648 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $16,673 gross reimbursement (before rebates) ≈ $26 per prescription (gross)

Summed across the 2 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649429

doxycycline hyclate 60 MG Delayed Release Oral Tablet

589 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $618,493 gross reimbursement (before rebates) ≈ $1,050 per prescription (gross)

Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1801142

doxycycline hyclate 75 MG Oral Tablet

493 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $15,688 gross reimbursement (before rebates) ≈ $32 per prescription (gross)

Summed across the 2 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649425

doxycycline hyclate 150 MG Oral Tablet

342 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $13,145 gross reimbursement (before rebates) ≈ $38 per prescription (gross)

Summed across the 1 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1650446

doxycycline hyclate 200 MG Delayed Release Oral Tablet

289 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $23,193 gross reimbursement (before rebates) ≈ $80 per prescription (gross)

Summed across the 3 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1423080

doxycycline monohydrate 150 MG Oral Tablet

62 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $2,725 gross reimbursement (before rebates) ≈ $44 per prescription (gross)

Summed across the 1 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1650444

doxycycline hyclate 150 MG Delayed Release Oral Tablet

15 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $1,331 gross reimbursement (before rebates) ≈ $89 per prescription (gross)

Summed across the 1 of 19 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 799048

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Doxycycline, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 108 of 1,268 listed Doxycycline NDCs with Medicaid activity.

Compare Doxycycline products

A representative set of FDA-listed product records for Doxycycline — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 971 products — FDA National Drug Code Directory. See every product, package size and price: browse all 971 Doxycycline NDCs →

Doxycycline side effects reported to the FDA (FAERS)

After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Doxycycline — a signal of what to watch for, not proof the drug caused it.

The effects most often named in FDA reports that mention Doxycycline are nausea, fatigue, rash; about 72% of the reports were classed as serious. These are voluntary reports, so they show what people report, not how often it happens.

69,566
Reports mentioning it
72%
Reported as serious
12
Distinct effects shown
Most reported effects
Nausea
5,167
Fatigue
4,818
Rash
4,268
Diarrhoea
4,165
Dyspnoea
4,136
Pain
4,083
Headache
4,045
Vomiting
3,951
Drug Hypersensitivity
3,811
Malaise
3,090
Age groups
Adult · 6,762Elderly · 4,230Adolescent · 252Child · 85Neonate · 43Infant · 15

Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Doxycycline in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.

Doxycycline FDA approval history

How Doxycycline went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.

Doxycycline was first approved by the FDA in 1967 (Brand: VIBRAMYCIN · Pfizer); the first generic version was approved in 1973. It remains available in U.S. pharmacies today.

1967
Brand approved
Brand: VIBRAMYCIN · Pfizer
1973
First generic approved
Lower-cost ANDA competition begins
2026
Available today
Active in U.S. pharmacies

Source: Drugs@FDA.

Doxycycline recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 3 Doxycycline recalls since July 2021, covering 4 product listings. One of them is still ongoing and is listed first. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II Sep 29, 2025 · Acella Pharmaceuticals, LLC
Failed dissolution specifications: Stability testing found that the lot did not meet dissolution specifications.
  • Doxycycline Hyclate Tablets, USP 100 mg*, 500-count bottle, Rx Only, Distributed by: Acella Pharmaceuticals, LLC, Alpharetta, GA 30005, NDC 42192-501-05. Lots: Lot #: P24ZLK1, Exp 5/31/2027 FDA record D-0014-2026 →
Class II Apr 13, 2022 · Terminated · Mckesson Medical-Surgical Inc. Corporate Office
cGMP deviations: Temperature abuse
  • Doxycycline Hyclate Tablets, USP, 100 mg, 50-count carton (10 tablets each blister pack x 5), Rx only, MFG: Major Pharma, NDC 0904-0430-06 Lots: McKesson Medical-Surgical (MMS) is not able to identify the particular lot number received by a particular consignee for the recalled prescription products. Each letter includes the date it was distributed to customers and the dates that i… FDA record D-1054-2022 →
  • Doxycycline Capsules, USP, 100 mg, 50-count bottle, Rx only, Distributed by: Sun Pharmaceuticals, NDC 63304-616-50 Lots: McKesson Medical-Surgical (MMS) is not able to identify the particular lot number received by a particular consignee for the recalled prescription products. Each letter includes the date it was distributed to customers and the dates that i… FDA record D-1032-2022 →
Class II Jan 26, 2022 · Terminated · CARDINAL HEALTHCARE
CGMP Deviations: Products were exposed to temperatures outside of the products labeled storage conditions.
  • Doxycycline Capsules, USP 100 mg, 50 Capsules, Rx Only, Manufactured for: Lupin Pharmaceuticals, Inc., Baltimore, Maryland 21202 Unite States; Manufactured by: Lupin Limited, Nagpur - 441 108, INDIA.… Lots: Batch G104819 FDA record D-0178-2024 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Doxycycline RxCUI 3640 8 dose forms · 32 strengths
  1. Dose form (SCDF) Delayed Release Oral Capsule RxCUI 378209 In current FDA listings
    Clinical drug / strength (SCD) anhydrous 40 MG RxCUI 901399 hyclate 100 MG RxCUI 348869
  3. Dose form (SCDF) Disintegrating Oral Tablet RxCUI 597519 In current FDA listings
    Clinical drug / strength (SCD) 75 MG RxCUI 597521
  4. Dose form (SCDF) Extended Release Oral Capsule RxCUI 578681 No current FDA listing
  5. Dose form (SCDF) Injection RxCUI 1652652 In current FDA listings
    Clinical drug / strength (SCD) hyclate 100 MG RxCUI 310027 hyclate 200 MG RxCUI 1998483
  7. Dose form (SCDF) Oral Suspension RxCUI 371964 In current FDA listings
    Clinical drug / strength (SCD) calcium 10 MG/ML RxCUI 310026 monohydrate 5 MG/ML RxCUI 1650030

Look up RxCUI 3640 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

Doxycycline supply and shortage status

Whether Doxycycline is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.

Doxycycline is not in shortage right now; the FDA has 4 past shortage records for it.

✅No current shortage of Doxycycline on record
To be discontinued Doxycycline Hyclate, Tablet, Delayed Release, 200 mg (NDC 0591-4575-60)
Teva Pharmaceuticals USA, Inc. · Since 07/30/2026 · Updated 07/30/2026
To be discontinued Doxycycline Hyclate, Tablet, Delayed Release, 50 mg (NDC 0591-4550-22)
Teva Pharmaceuticals USA, Inc. · Since 07/30/2026 · Updated 07/30/2026
To be discontinued Doxycycline Hyclate, Tablet, 100 mg (NDC 0378-0167-13)
Mylan Pharmaceuticals Inc., a Viatris Company · Since 01/12/2026 · Updated 01/12/2026
To be discontinued Doxycycline Hyclate, Tablet, 100 mg (NDC 0378-0167-02)
Mylan Pharmaceuticals Inc., a Viatris Company · Since 01/12/2026 · Updated 01/12/2026

Source: openFDA, from the FDA Drug Shortages database.

Doxycycline brand names

Doxycycline is sold under 16 brand names in the FDA directory — Acticlate, Doryx Mpc, Doryx, Monodox and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Acticlate Doryx Mpc Doryx Monodox Oracea Vibramycin Acticlate CAP Doxychel Periostat Vibra-Tabs Morgidox Mondoxyne Targadox Okebo Adoxa Doxy

Who makes Doxycycline: manufacturers and labelers

40 companies list Doxycycline products with the FDA. By number of product records, the largest are Remedyrepack Inc., Bryant Ranch Prepack, A-S Medication Solutions. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Remedyrepack Inc. 62 Bryant Ranch Prepack 62 A-S Medication Solutions 59 PD-Rx Pharmaceuticals, Inc. 42 NuCare Pharmaceuticals,Inc. 35 Alembic Pharmaceuticals Inc. 33 Zydus Pharmaceuticals USA Inc. 27 Proficient Rx LP 27 Alembic Pharmaceuticals Limited 27 Zydus Lifesciences Limited 25 Strides Pharma Science Limited 23 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 20 RedPharm Drug, Inc. 18 Sun Pharmaceutical Industries, Inc. 17 Chartwell RX LLC 16 Denton Pharma, Inc. DBA Northwind Pharmaceuticals 15 AvPAK 15 Chartwell Governmental & Specialty RX, LLC 15 American Health Packaging 14 Chartwell RX, LLC. 14 Mayne Pharma Commercial LLC 13 Amneal Pharmaceuticals NY LLC 12 Direct Rx 12 Chartwell RX, LLC 12

…and 16 more on the FDA NDC directory.

Doxycycline drug class (RxNorm)

Doxycycline belongs to the Tetracycline-class Drug class.

Pharmacologic class Tetracycline-class Drug
Drug family (ATC) Antiinfectives and antiseptics for local oral treatment, Tetracyclines

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Doxycycline page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Apr 15, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Doxycycline.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Doxycycline after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
251
NDC products indexed
971
Distinct labelers/manufacturers represented
142
Linked representative label ⓘ
Mayne Pharma Inc.
Linked label effective
Apr 15, 2025
Composite sections available
25
Linked SPL Set ID
0e6b3e17-aeee-4910-8e94-c7ac925b9cca
Linked SPL Document ID
4600dc6a-950d-4d84-aed9-da01fbd0db8b
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Mayne Pharma Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →