Doxycycline Injection

Generic name: Pronounced as (dox i sye' kleen)
Brand names
  • Doxy 100®
  • Doxy 200®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 09/15/2017

Doxycycline injection is used to treat or prevent bacterial infections, including pneumonia and other respiratory tract infections. It is also used to treat certain skin, genital, intestine, and urinary system infections. Doxycycline injection may be used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to anthrax in the air. Doxycycline injection is in a class of medications called tetracycline antibiotics. It works by killing bacteria that cause infections.

Antibiotics such as doxycycline injection will not work for colds, flu, or other viral infections. Taking or using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Doxycycline injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein). It is usually given every 12 or 24 hours over a period of 1 to 4 hours. The length of your treatment depends on the type of infection you have and how your body responds to the medication.

You may receive doxycycline injection in a hospital or you may administer the medication at home. If you will be receiving doxycycline injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions.

You should begin to feel better during the first few days of treatment with doxycycline injection. If your symptoms do not improve or get worse, call your doctor. If you still have symptoms of infection after you finish doxycycline injection, tell your doctor.

Use doxycycline injection until you finish the prescription, even if you feel better. If you stop using doxycycline injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving doxycycline injection,

  • tell your doctor and pharmacist if you are allergic to doxycycline, minocycline (Dynacin, Minocin, Solodyn), tetracycline (Achromycin V), any other medications, or any of the ingredients in doxycycline injection. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven) or penicillin (Bicillin, PfizerPen). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had lupus (a disease in which the body attacks many of its own organs).

  • you should know that doxycycline injection may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections). Talk to your doctor about using another form of birth control.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving doxycycline injection, call your doctor.

  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Doxycycline injection may make your skin sensitive to sunlight.

  • you should know that when doxycycline is used during pregnancy or in babies or children up to age 8, it can cause the teeth to become permanently stained. Doxycycline injection should not be used in children under age 8 unless your doctor decides it is needed.

Unless your doctor tells you otherwise, continue your normal diet.

  • Doxycycline injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • loss of appetite

    • vomiting

    • diarrhea

    • difficulty or pain when swallowing

    • swollen tongue

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • severe diarrhea (watery or bloody stools) that may occur up to 2 months or more after your treatment

    • headache

    • blurred vision

    • stomach cramps

    • fever

    • rash

    • hives

    • itching

    • swelling of the face, eyes, mouth, throat, tongue, or lips

    • difficulty breathing or swallowing

  • Doxycycline injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep all appointments with your doctor. Your doctor may order certain lab tests to check your body's response to doxycycline injection.

Ask your pharmacist any questions you have about doxycycline injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Doxycycline may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The excretion of Zidovudine can be decreased when combined with Doxycycline.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Tinidazole Tinidazole Doxycycline may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Rasagiline Rasagiline Doxycycline may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Doxycycline may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Doripenem Injection Doripenem Injection Doxycycline may decrease the excretion rate of Doripenem which could result in a higher serum level.
Tretinoin Tretinoin The risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Tretinoin is combined with Doxycycline.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Doxycycline.
Ulipristal Ulipristal The serum concentration of Ulipristal can be decreased when it is combined with Doxycycline.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Doxycycline is combined with Botulinum toxin type A.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Doxycycline may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Doxycycline may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Doxycycline.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Doxycycline.
Rivaroxaban Rivaroxaban The risk or severity of bleeding can be increased when Doxycycline is combined with Rivaroxaban.
Ticagrelor Ticagrelor The risk or severity of bleeding can be increased when Doxycycline is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Doxycycline.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Doxycycline.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Doxycycline.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be decreased when combined with Doxycycline.
Deferiprone Deferiprone Doxycycline may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Doxycycline.
Crizotinib Crizotinib The metabolism of Crizotinib can be decreased when combined with Doxycycline.
Enzalutamide Enzalutamide Doxycycline may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Doxycycline may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Regorafenib can be decreased when combined with Doxycycline.
Bosutinib Bosutinib The metabolism of Bosutinib can be decreased when combined with Doxycycline.
Teduglutide Injection Teduglutide Injection Doxycycline may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Mipomersen Injection Mipomersen Injection Doxycycline may increase the hepatotoxic activities of Mipomersen.
Alogliptin Alogliptin Doxycycline may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Doxycycline.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Doxycycline.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Doxycycline.
Apixaban Apixaban The risk or severity of bleeding can be increased when Doxycycline is combined with Apixaban.
Canagliflozin Canagliflozin Doxycycline may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be decreased when combined with Doxycycline.
Trametinib Trametinib Doxycycline may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran Doxycycline may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Vortioxetine Vortioxetine Doxycycline may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Doxycycline.
Sofosbuvir Sofosbuvir Doxycycline may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast Doxycycline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Doxycycline may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Doxycycline.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Doxycycline.
Testosterone Injection Testosterone Injection Doxycycline may decrease the excretion rate of Testosterone which could result in a higher serum level.
Vorapaxar Vorapaxar The risk or severity of bleeding can be increased when Doxycycline is combined with Vorapaxar.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Doxycycline.
Macitentan Macitentan Doxycycline may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Doxycycline.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Doxycycline is combined with Defibrotide.
Lixisenatide Injection Lixisenatide Injection Doxycycline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The serum concentration of Drospirenone can be decreased when it is combined with Doxycycline.
Viloxazine Viloxazine Doxycycline may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Doxycycline.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tetracycline Tetracycline Doxycycline may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Sulfadiazine Sulfadiazine Doxycycline may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Azathioprine Azathioprine Doxycycline may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Warfarin Warfarin The risk or severity of bleeding can be increased when Doxycycline is combined with Warfarin.
Triamterene Triamterene Triamterene may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Doxycycline.
Liothyronine Liothyronine Doxycycline may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Tolbutamide Tolbutamide Doxycycline may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Doxycycline may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Baclofen Baclofen Baclofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Doxycycline.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Doxycycline.
Vinblastine Vinblastine The metabolism of Vinblastine can be decreased when combined with Doxycycline.
Aspirin Aspirin The risk or severity of bleeding can be increased when Doxycycline is combined with Acetylsalicylic acid.
Temazepam Temazepam Temazepam may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Triazolam Triazolam Doxycycline may decrease the excretion rate of Triazolam which could result in a higher serum level.
Trimethoprim Trimethoprim Doxycycline may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Timolol Timolol Doxycycline may decrease the excretion rate of Timolol which could result in a higher serum level.
Verapamil Verapamil Doxycycline may decrease the excretion rate of Verapamil which could result in a higher serum level.
Auranofin Auranofin Doxycycline may decrease the excretion rate of Auranofin which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Doxycycline may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Doxycycline.
Tramadol Tramadol Tramadol may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ticlopidine Ticlopidine The metabolism of Doxycycline can be decreased when combined with Ticlopidine.
Gemcitabine Injection Gemcitabine Injection Doxycycline may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Zafirlukast Zafirlukast The metabolism of Doxycycline can be decreased when combined with Zafirlukast.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Tolterodine Tolterodine Doxycycline may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rabeprazole Rabeprazole Doxycycline may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists