Can You Take DayQuil With Tamiflu?

In our latest question and answer, the pharmacist discusses whether or not DayQuil can safely be taken with Tamiflu (oseltamivir phosphate).


I am currently on Tamiflu after testing positive for the flu. While I feel a little better, I need something else for the symptoms. Can I take DayQuil safely?

Asked by Dave On Oct 28, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Oct 28, 2022
Last updated Jun 14, 2024

Key points

  • There is no known drug interaction between Tamiflu and DayQuil. They are considered safe to take together.


There is no reported interaction between DayQuil and Tamiflu and they can be safely taken together. DayQuil is a combination ingredient cough/cold product that contains the following ingredients:

  • Acetaminophen (analgesic/fever reducer)
  • Dextromethorphan (cough suppressant)
  • Phenylephrine (nasal decongestant)

Taking DayQuil With Tamiflu

Each ingredient contained in DayQuil is considered to be safe to take with Tamiflu due to the absence of drug interactions. In fact, per the prescribing information for Tamiflu, most drugs are safe to take with it as the medication has very few drug interactions.

One of the only reported interactions is with probenecid. Even with that interaction, no dosage adjustments are recommended for Tamiflu and it is considered to have a wide window of safety.

As Tamiflu is used to treat infection from the flu virus, it is common to need over-the-counter medication for the relief of flu-related symptoms such as headache, fever, and muscle aches. DayQuil is a good option for symptom relief and fortunately, Tamiflu is safe to take with it.

Drug Information

If you are looking for additional information on the drugs mentioned in this question, you can visit our drug detail pages, or contact one of our pharmacists directly!

Final Words

Thanks for reaching out to us! Please do so again anytime.


About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

Recent Questions