Sulindac

Generic name: Pronounced as (sul in' dak)
Brand names
  • Clinoril®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2021

People who take nonsteroidal anti-inflammatory medications (NSAIDs) (other than aspirin) such as sulindac may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as sulindac if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take sulindac right before or right after the surgery.

NSAIDs such as sulindac may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while you are taking sulindac. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as diflunisal, ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn), or oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking sulindac and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to sulindac. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with sulindac and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Sulindac is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine). Sulindac also is used to treat pain in the shoulder caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint) and tendinitis (inflammation of the tissue that connects muscle to bone). It is also used to relieve gouty arthritis (attacks of severe joint pain and swelling caused by a build-up of certain substances in the joints). Sulindac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

Sulindac comes as a tablet to take by mouth. It is usually taken with food twice a day. Take sulindac at around the same times each day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sulindac exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Sulindac helps control arthritis pain but does not cure arthritis. If you are taking sulindac to treat arthritis pain, it may take 1 week or longer before you feel the full benefit of sulindac.

Sulindac is also sometimes used to reduce the number of polyps (abnormal growths) in the colon (large intestine) and rectum in patients with familial adenomatous polyposis (a condition in which hundreds or thousands of polyps form in the colon and cancer may develop). Talk to your doctor about the risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking sulindac,

  • tell your doctor and pharmacist if you are allergic to sulindac, aspirin, or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), or any other medications. Ask your pharmacist for a list of the inactive ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin II receptor antagonists such as candesartan (Atacand , in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Twynsta), valsartan (in Exforge HCT); cyclosporine (Gengraf, Neoral, Sandimmune); medications by mouth for diabetes; diuretics ('water pills'); lithium (Lithobid);methotrexate (Otrexup, Rasuvo, Trexall); and probenecid (Probalan).

  • tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); heart failure; kidney stones; swelling of the hands, arms, feet, ankles, or lower legs; or liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant; or are breast-feeding. Sulindac may harm the fetus and cause problems with delivery if it is taken around 20 weeks or later during pregnancy. Do not take sulindac around or after 20 weeks of pregnancy, unless you are told to do so by your doctor. If you become pregnant while taking sulindac, call your doctor.

  • talk to your doctor about the risks and benefits of taking sulindac if you are 75 years of age or older. Do not take this medication for a longer period of time or at a higher dose than recommended by your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking sulindac.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Sulindac may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • dizziness

    • nervousness

    • diarrhea

    • constipation

    • gas

    • ringing in the ears

  • Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more sulindac until you speak to your doctor:

    • unexplained weight gain

    • shortness of breath or difficulty breathing

    • swelling of the abdomen, feet, ankles, or lower legs

    • fever

    • chills

    • cough

    • sweating

    • flushing

    • muscle or joint pain

    • chest pain

    • blisters

    • rash

    • itching

    • hives

    • swelling of the eyes, face, lips, tongue, throat, arms, or hands

    • difficulty swallowing

    • hoarseness

    • pale skin

    • fast heartbeat

    • excessive tiredness

    • unusual bleeding or bruising

    • lack of energy

    • upset stomach

    • loss of appetite

    • pain in the upper right part of the stomach

    • flu-like symptoms

    • yellowing of the skin or eyes

    • cloudy, discolored, or bloody urine

    • back pain

    • difficult or painful urination

    • blurred vision or other problems with sight

  • Sulindac may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • loss of consciousness

  • fainting

  • dizziness

  • blurred vision

  • upset stomach

  • decreased urination

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin Sulindac may increase the neuroexcitatory activities of Moxifloxacin.
Alendronate Alendronate The risk or severity of adverse effects can be increased when Sulindac is combined with Alendronic acid.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Sulindac is combined with Anagrelide.
Candesartan Candesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Candesartan is combined with Sulindac.
Cilostazol Cilostazol The risk or severity of bleeding can be increased when Sulindac is combined with Cilostazol.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Sulindac is combined with Clopidogrel.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Sulindac may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate Sulindac may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The therapeutic efficacy of Guanfacine can be decreased when used in combination with Sulindac.
Magnesium Hydroxide Magnesium Hydroxide Sulindac may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Sulindac.
Mycophenolate Mycophenolate Sulindac may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of hypertension can be increased when Sulindac is combined with Naratriptan.
Olsalazine Olsalazine The therapeutic efficacy of Olsalazine can be decreased when used in combination with Sulindac.
Penbutolol Penbutolol Sulindac may decrease the antihypertensive activities of Acebutolol.
Potassium Potassium Sulindac may decrease the excretion rate of Potassium cation which could result in a higher serum level.
Prednisone Prednisone The risk or severity of gastrointestinal irritation can be increased when Sulindac is combined with Prednisone.
Ranitidine Ranitidine Sulindac may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine Reserpine The therapeutic efficacy of Reserpine can be decreased when used in combination with Sulindac.
Rizatriptan Rizatriptan Sulindac may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan Sulindac may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The risk or severity of renal failure can be increased when Sulindac is combined with Tacrolimus.
Tiludronate Tiludronate The risk or severity of gastrointestinal bleeding can be increased when Sulindac is combined with Etidronic acid.
Triamcinolone Triamcinolone The risk or severity of gastrointestinal irritation can be increased when Triamcinolone is combined with Sulindac.
Zolmitriptan Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Sulindac.
Ampicillin Injection Ampicillin Injection Sulindac may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Sulindac may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Sulindac may decrease the excretion rate of Fluconazole which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection Sulindac may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Sulindac may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection Sulindac may decrease the excretion rate of Meperidine which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone is combined with Sulindac.
Metoclopramide Injection Metoclopramide Injection Sulindac may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection The risk or severity of gastrointestinal bleeding can be increased when Sulindac is combined with Pamidronic acid.
Vancomycin Injection Vancomycin Injection Sulindac may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The risk or severity of bleeding can be increased when Zidovudine is combined with Sulindac.
Altretamine Altretamine Sulindac may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Cefuroxime Cefuroxime The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefuroxime.
Cyclosporine Cyclosporine The risk or severity of renal failure and hypertension can be increased when Sulindac is combined with Cyclosporine.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Enoxaparin.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Sulindac.
Eprosartan Eprosartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Eprosartan is combined with Sulindac.
Meloxicam Meloxicam The risk or severity of adverse effects can be increased when Sulindac is combined with Meloxicam.
Pantoprazole Pantoprazole Sulindac may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Risedronate Risedronate The risk or severity of gastrointestinal bleeding can be increased when Sulindac is combined with Risedronic acid.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Sulindac resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Telmisartan is combined with Sulindac.
Temozolomide Temozolomide Sulindac may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Sulindac may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Linezolid Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Sulindac.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Pentosan polysulfate.
Trimipramine Trimipramine The risk or severity of hypertension can be increased when Sulindac is combined with Trimipramine.
Perindopril Perindopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Perindopril.
Tenofovir Tenofovir Sulindac may increase the nephrotoxic activities of Tenofovir.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of adverse effects can be increased when Sulindac is combined with Choline magnesium trisalicylate.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Sulindac is combined with Dutasteride.
Epinephrine Injection Epinephrine Injection The risk or severity of hypertension can be increased when Sulindac is combined with Epinephrine.
Eplerenone Eplerenone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Eplerenone.
Escitalopram Escitalopram The risk or severity of gastrointestinal bleeding can be increased when Escitalopram is combined with Sulindac.
Olmesartan Olmesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Olmesartan is combined with Sulindac.
Zonisamide Zonisamide Sulindac may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Aripiprazole Aripiprazole The risk or severity of hypertension can be increased when Sulindac is combined with Aripiprazole.
Atomoxetine Atomoxetine Sulindac may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
Dexmethylphenidate Dexmethylphenidate The risk or severity of hypertension can be increased when Sulindac is combined with Dexmethylphenidate.
Atazanavir Atazanavir The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Atazanavir.
Almotriptan Almotriptan Sulindac may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Eletriptan Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Sulindac.
Emtricitabine Emtricitabine Sulindac may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Sulindac may decrease the excretion rate of Memantine which could result in a higher serum level.
Tadalafil Tadalafil Sulindac may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan Frovatriptan The risk or severity of hypertension can be increased when Sulindac is combined with Frovatriptan.
Gemifloxacin Gemifloxacin Sulindac may increase the neuroexcitatory activities of Gemifloxacin.
Protriptyline Protriptyline The risk or severity of hypertension can be increased when Protriptyline is combined with Sulindac.
Duloxetine Duloxetine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Sulindac.
Tinidazole Tinidazole Sulindac may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan Bosentan The therapeutic efficacy of Bosentan can be decreased when used in combination with Sulindac.
Cefditoren Cefditoren Sulindac may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Sulindac may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Eszopiclone Eszopiclone Sulindac may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ganciclovir Ganciclovir Sulindac may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Sulindac may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of hypertension can be increased when Sulindac is combined with Solifenacin.
Valganciclovir Valganciclovir Sulindac may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Zoledronic Acid Injection Zoledronic Acid Injection The risk or severity of gastrointestinal bleeding can be increased when Sulindac is combined with Zoledronic acid.
Adefovir Adefovir The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Adefovir.
Dextroamphetamine Dextroamphetamine Sulindac may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Ibandronate Ibandronate The risk or severity of gastrointestinal bleeding can be increased when Sulindac is combined with Ibandronate.
Isocarboxazid Isocarboxazid The risk or severity of hypertension can be increased when Sulindac is combined with Isocarboxazid.
Ramelteon Ramelteon Sulindac may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Sulindac may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pregabalin Pregabalin Sulindac may decrease the excretion rate of Pregabalin which could result in a higher serum level.
Deferasirox Deferasirox The risk or severity of gastrointestinal bleeding and peptic ulcer can be increased when Sulindac is combined with Deferasirox.
Phenylephrine Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Sulindac.
Ranolazine Ranolazine Sulindac may decrease the excretion rate of Ranolazine which could result in a higher serum level.
Rasagiline Rasagiline Sulindac may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Sitagliptin Sitagliptin Sulindac may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Sulindac may decrease the excretion rate of Varenicline which could result in a higher serum level.
Albuterol Albuterol Sulindac may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone Sulindac may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Clofarabine Injection Clofarabine Injection Sulindac may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone Lubiprostone Sulindac may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Aliskiren Aliskiren The risk or severity of renal failure and hypertension can be increased when Sulindac is combined with Aliskiren.
Bismuth Subsalicylate Bismuth Subsalicylate The therapeutic efficacy of Bismuth subsalicylate can be decreased when used in combination with Sulindac.
Pemetrexed Injection Pemetrexed Injection Sulindac may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lisdexamfetamine Lisdexamfetamine The risk or severity of hypertension can be increased when Sulindac is combined with Lisdexamfetamine.
Sorafenib Sorafenib Sulindac may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Levocetirizine Levocetirizine Sulindac may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Sulindac may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Sulindac may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Lenalidomide Lenalidomide Sulindac may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Budesonide Budesonide The risk or severity of gastrointestinal irritation can be increased when Sulindac is combined with Budesonide.
Desmopressin Desmopressin The risk or severity of hypertension, hyponatremia, and water intoxication can be increased when Sulindac is combined with Desmopressin.
Doripenem Injection Doripenem Injection Sulindac may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Sulindac may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine The risk or severity of gastrointestinal bleeding can be increased when Desvenlafaxine is combined with Sulindac.
Cevimeline Cevimeline Sulindac may decrease the excretion rate of Cevimeline which could result in a higher serum level.
Nebivolol Nebivolol Sulindac may decrease the antihypertensive activities of Nebivolol.
Certolizumab Injection Certolizumab Injection Sulindac may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Daptomycin Injection Daptomycin Injection Sulindac may decrease the excretion rate of Daptomycin which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Sulindac may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Midazolam Midazolam Sulindac may decrease the excretion rate of Midazolam which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Sulindac may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Milnacipran Milnacipran The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Sulindac.
Plerixafor Injection Plerixafor Injection Sulindac may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The risk or severity of renal failure can be increased when Sodium phosphate, monobasic is combined with Sulindac.
Fesoterodine Fesoterodine Sulindac may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Betaxolol Betaxolol Sulindac may decrease the antihypertensive activities of Betaxolol.
Iloperidone Iloperidone The risk or severity of hypertension can be increased when Sulindac is combined with Iloperidone.
Prasugrel Prasugrel The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Prasugrel.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The risk or severity of hyperkalemia can be increased when Sulindac is combined with Tolvaptan.
Dronedarone Dronedarone The risk or severity of hypertension can be increased when Sulindac is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Sulindac may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Sulindac may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Saxagliptin Saxagliptin Sulindac may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Sulindac may decrease the excretion rate of Telavancin which could result in a higher serum level.
Topotecan Topotecan Sulindac may decrease the excretion rate of Topotecan which could result in a higher serum level.
Asenapine Asenapine The risk or severity of hypertension can be increased when Sulindac is combined with Asenapine.
Dabigatran Dabigatran The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Dabigatran.
Dalfampridine Dalfampridine Sulindac may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Ceftaroline Injection Ceftaroline Injection The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Ceftaroline fosamil.
Lurasidone Lurasidone The risk or severity of hypertension can be increased when Sulindac is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The risk or severity of adverse effects can be increased when Acetaminophen is combined with Sulindac.
Vilazodone Vilazodone The risk or severity of hypertension can be increased when Sulindac is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Sulindac may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Sulindac may decrease the excretion rate of Aldesleukin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Sulindac may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Azilsartan medoxomil is combined with Sulindac.
Roflumilast Roflumilast Sulindac may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Sulindac.
Rivaroxaban Rivaroxaban The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Rivaroxaban.
Ticagrelor Ticagrelor The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Ticagrelor.
Ruxolitinib Ruxolitinib Sulindac may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Sulindac may decrease the excretion rate of Clobazam which could result in a higher serum level.
Deferiprone Deferiprone Sulindac may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Cabergoline Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Sulindac.
Naloxone Injection Naloxone Injection Sulindac may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan Ambrisentan The therapeutic efficacy of Ambrisentan can be decreased when used in combination with Sulindac.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Fondaparinux.
Iloprost Iloprost The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Iloprost.
Enzalutamide Enzalutamide Sulindac may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Sulindac may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of gastrointestinal irritation can be increased when Corticotropin is combined with Sulindac.
Teduglutide Injection Teduglutide Injection Sulindac may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Sulindac is combined with Icosapent ethyl.
Alogliptin Alogliptin Sulindac may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Pomalidomide Pomalidomide Sulindac may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Apixaban Apixaban The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Apixaban.
Canagliflozin Canagliflozin Sulindac may decrease the excretion rate of Canagliflozin which could result in a higher serum level.
Trametinib Trametinib Sulindac may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The risk or severity of gastrointestinal bleeding can be increased when Levomilnacipran is combined with Sulindac.
Ertapenem Injection Ertapenem Injection Sulindac may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine Vortioxetine Sulindac may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ketorolac Injection Ketorolac Injection The risk or severity of adverse effects can be increased when Ketorolac is combined with Sulindac.
Sofosbuvir Sofosbuvir Sulindac may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Apremilast Apremilast Sulindac may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Sulindac may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Testosterone Injection Testosterone Injection Sulindac may decrease the excretion rate of Testosterone which could result in a higher serum level.
Vorapaxar Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Vorapaxar.
Edoxaban Edoxaban The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Edoxaban.
Methamphetamine Methamphetamine Sulindac may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Sulindac may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat The therapeutic efficacy of Riociguat can be decreased when used in combination with Sulindac.
Risperidone Injection Risperidone Injection The risk or severity of hypertension can be increased when Sulindac is combined with Risperidone.
Haloperidol Injection Haloperidol Injection The therapeutic efficacy of Haloperidol can be increased when used in combination with Sulindac.
Amiloride Amiloride The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Amiloride.
Macitentan Macitentan The therapeutic efficacy of Macitentan can be decreased when used in combination with Sulindac.
Flibanserin Flibanserin The risk or severity of hypertension can be increased when Sulindac is combined with Flibanserin.
Prednisolone Prednisolone The risk or severity of gastrointestinal irritation can be increased when Prednisolone is combined with Sulindac.
Brexpiprazole Brexpiprazole The risk or severity of hypertension can be increased when Sulindac is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of hypertension can be increased when Ziprasidone is combined with Sulindac.
Cariprazine Cariprazine The risk or severity of hypertension can be increased when Sulindac is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Sulindac may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Ixazomib Ixazomib Sulindac may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Sulindac may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The risk or severity of gastrointestinal irritation can be increased when Dexamethasone is combined with Sulindac.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Defibrotide.
Brivaracetam Injection Brivaracetam Injection Sulindac may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Midodrine Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Sulindac.
Selexipag Selexipag The therapeutic efficacy of Selexipag can be decreased when used in combination with Sulindac.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Sulindac.
Lixisenatide Injection Lixisenatide Injection Sulindac may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Sulindac may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Sulindac may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Sulindac may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of gastrointestinal irritation can be increased when Deflazacort is combined with Sulindac.
Safinamide Safinamide The risk or severity of hypertension can be increased when Sulindac is combined with Safinamide.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Sulindac.
Naldemedine Naldemedine Sulindac may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Benznidazole Benznidazole Sulindac may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Sulindac may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Sulindac.
Apalutamide Apalutamide Sulindac may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib Baricitinib Sulindac may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Sulindac.
Plazomicin Injection Plazomicin Injection Sulindac may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Cannabidiol Cannabidiol The risk or severity of hypertension can be increased when Sulindac is combined with Cannabidiol.
Stiripentol Stiripentol Sulindac may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Prucalopride Prucalopride Sulindac may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Siponimod Siponimod The risk or severity of hypertension can be increased when Sulindac is combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic Sulindac may decrease the excretion rate of Acyclovir which could result in a higher serum level.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Sulindac is combined with Caplacizumab.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Sulindac.
Pitolisant Pitolisant The risk or severity of adverse effects can be increased when Sulindac is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The serum concentration of Phenytoin can be increased when it is combined with Sulindac.
Selpercatinib Selpercatinib The risk or severity of hypertension can be increased when Sulindac is combined with Selpercatinib.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Sulindac is combined with Naxitamab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Sulindac is combined with Drospirenone.
Viloxazine Viloxazine Sulindac may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Sulindac may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Fenoprofen Fenoprofen The risk or severity of adverse effects can be increased when Fenoprofen is combined with Sulindac.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Sulindac.
Mefenamic Acid Mefenamic Acid The risk or severity of adverse effects can be increased when Sulindac is combined with Mefenamic acid.
Naproxen Naproxen The risk or severity of adverse effects can be increased when Sulindac is combined with Naproxen.
Tolmetin Tolmetin The risk or severity of adverse effects can be increased when Tolmetin is combined with Sulindac.
Trazodone Trazodone The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Sulindac.
Isotretinoin Isotretinoin Sulindac may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Sulindac may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Floxuridine Floxuridine Sulindac may decrease the excretion rate of Floxuridine which could result in a higher serum level.
Metaxalone Metaxalone Sulindac may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The serum concentration of Methotrexate can be increased when it is combined with Sulindac.
Methsuximide Methsuximide The risk or severity of hyperkalemia can be increased when Sulindac is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of hypertension can be increased when Sulindac is combined with Diethylpropion.
Chlorpromazine Chlorpromazine Sulindac may decrease the excretion rate of Chlorpromazine which could result in a higher serum level.
Diazepam Diazepam Sulindac may decrease the excretion rate of Diazepam which could result in a higher serum level.
Oxazepam Oxazepam Sulindac may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Flurazepam Flurazepam Sulindac may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate Clorazepate Sulindac may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Sulindac may decrease the excretion rate of Lorazepam which could result in a higher serum level.
Phenoxybenzamine Phenoxybenzamine The therapeutic efficacy of Phenoxybenzamine can be decreased when used in combination with Sulindac.
Carmustine Carmustine Sulindac may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine Amantadine Sulindac may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine Sulindac may decrease the excretion rate of Codeine which could result in a higher serum level.
Bromocriptine Bromocriptine The risk or severity of hypertension can be increased when Sulindac is combined with Bromocriptine.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Sulindac is combined with Orciprenaline.
Tranylcypromine Tranylcypromine The risk or severity of hypertension can be increased when Sulindac is combined with Tranylcypromine.
Phenelzine Phenelzine Sulindac may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of hypertension can be increased when Sulindac is combined with Ergoloid mesylate.
Tetracycline Tetracycline Sulindac may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Thioridazine Thioridazine The risk or severity of hypertension can be increased when Sulindac is combined with Thioridazine.
Trifluoperazine Trifluoperazine The risk or severity of hypertension can be increased when Sulindac is combined with Trifluoperazine.
Bleomycin Bleomycin Sulindac may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Sulfadiazine Sulfadiazine Sulindac may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Methadone Methadone Sulindac may decrease the excretion rate of Methadone which could result in a higher serum level.
Benztropine Benztropine Sulindac may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Sulindac resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline Sulindac may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen The risk or severity of adverse effects can be increased when Sulindac is combined with Ibuprofen.
Azathioprine Azathioprine Sulindac may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Phentermine Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Sulindac.
Methylphenidate Methylphenidate Sulindac may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine Amoxapine The risk or severity of hypertension can be increased when Amoxapine is combined with Sulindac.
Sulfasalazine Sulfasalazine The therapeutic efficacy of Sulfasalazine can be decreased when used in combination with Sulindac.
Hydrocortisone Hydrocortisone The risk or severity of gastrointestinal irritation can be increased when Hydrocortisone is combined with Sulindac.
Phenazopyridine Phenazopyridine The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Phenazopyridine.
Carbamazepine Carbamazepine Sulindac may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Sulindac.
Clonidine Clonidine The therapeutic efficacy of Clonidine can be decreased when used in combination with Sulindac.
Prazosin Prazosin The therapeutic efficacy of Prazosin can be decreased when used in combination with Sulindac.
Hydralazine Hydralazine Sulindac may decrease the antihypertensive activities of Hydralazine.
Cimetidine Cimetidine Sulindac may decrease the excretion rate of Cimetidine which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Sulindac may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Warfarin Warfarin The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Warfarin.
Clonazepam Clonazepam Sulindac may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide Loperamide The risk or severity of hyperkalemia can be increased when Sulindac is combined with Loperamide.
Promethazine Promethazine Sulindac may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate The risk or severity of adverse effects can be increased when Sulindac is combined with Meclofenamic acid.
Nitrofurantoin Nitrofurantoin Sulindac may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Sulindac may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Sulindac may decrease the excretion rate of Chloroquine which could result in a higher serum level.
Ethosuximide Ethosuximide The risk or severity of hyperkalemia can be increased when Ethosuximide is combined with Sulindac.
Triamterene Triamterene The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Sulindac is combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Sulindac.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Sulindac.
Metolazone Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Sulindac.
Secobarbital Secobarbital Sulindac may decrease the excretion rate of Secobarbital which could result in a higher serum level.
Desipramine Desipramine Sulindac may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline Amitriptyline may decrease the excretion rate of Sulindac which could result in a higher serum level.
Imipramine Imipramine Imipramine may decrease the excretion rate of Sulindac which could result in a higher serum level.
Probenecid Probenecid Probenecid may decrease the excretion rate of Sulindac which could result in a higher serum level.
Quinidine Quinidine Sulindac may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Sulindac may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Sulindac may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide Pyrazinamide Sulindac may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Disopyramide Disopyramide Sulindac may decrease the excretion rate of Disopyramide which could result in a higher serum level.
Valproic Acid Valproic Acid The protein binding of Valproic acid can be decreased when combined with Sulindac.
Butabarbital Butabarbital Sulindac may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Liothyronine Liothyronine Sulindac may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole Methimazole Sulindac may decrease the excretion rate of Methimazole which could result in a higher serum level.
Chlorpropamide Chlorpropamide The protein binding of Chlorpropamide can be decreased when combined with Sulindac.
Tolbutamide Tolbutamide The protein binding of Tolbutamide can be decreased when combined with Sulindac.
Tolazamide Tolazamide The protein binding of Tolazamide can be decreased when combined with Sulindac.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Sulindac.
Baclofen Baclofen Sulindac may decrease the excretion rate of Baclofen which could result in a higher serum level.
Ethambutol Ethambutol Sulindac may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Sulindac.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Sulindac is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone Sulindac may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Pyridoxine Pyridoxine Sulindac may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
Folic Acid Folic Acid Sulindac may decrease the excretion rate of Folic acid which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Sulindac may decrease the antihypertensive activities of Propranolol.
Minoxidil Minoxidil The therapeutic efficacy of Minoxidil can be decreased when used in combination with Sulindac.
Pseudoephedrine Pseudoephedrine The risk or severity of hypertension can be increased when Sulindac is combined with Pseudoephedrine.
Nortriptyline Nortriptyline The risk or severity of hypertension can be increased when Nortriptyline is combined with Sulindac.
Spironolactone Spironolactone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Amphotericin B.
Phytonadione Phytonadione Sulindac may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Sulindac may decrease the excretion rate of Amikacin which could result in a higher serum level.
Nadolol Nadolol Sulindac may decrease the antihypertensive activities of Nadolol.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Sulindac resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol Sulindac may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Flavoxate Flavoxate Sulindac may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Colchicine Colchicine Sulindac may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Sulindac may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cefadroxil Cefadroxil Sulindac may decrease the excretion rate of Cefadroxil which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefazolin.
Cephalexin Cephalexin Sulindac may decrease the excretion rate of Cephalexin which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefoxitin.
Dacarbazine Dacarbazine Sulindac may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Cefotaxime Injection Cefotaxime Injection The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Sulindac.
Calcitonin Salmon Injection Calcitonin Salmon Injection Sulindac may decrease the excretion rate of Salmon calcitonin which could result in a higher serum level.
Ketoconazole Ketoconazole The risk or severity of hyperkalemia can be increased when Sulindac is combined with Ketoconazole.
Pyrantel Pyrantel Sulindac may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Captopril Captopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Captopril.
Dipyridamole Dipyridamole The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Dipyridamole.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Sulindac is combined with Isoxsuprine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Sulindac.
Colistimethate Injection Colistimethate Injection The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Colistimethate.
Metoprolol Metoprolol Sulindac may decrease the antihypertensive activities of Metoprolol.
Aspirin Aspirin The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Sulindac.
Salsalate Salsalate The risk or severity of adverse effects can be increased when Sulindac is combined with Salsalate.
Alprazolam Alprazolam Sulindac may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Temazepam Temazepam Sulindac may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam Triazolam Sulindac may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Sulindac may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Propantheline Propantheline Sulindac may decrease the excretion rate of Propantheline which could result in a higher serum level.
Trimethoprim Trimethoprim Sulindac may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Diltiazem Diltiazem The therapeutic efficacy of Diltiazem can be decreased when used in combination with Sulindac.
Nifedipine Nifedipine Sulindac may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol Sulindac may decrease the antihypertensive activities of Timolol.
Verapamil Verapamil Sulindac may decrease the excretion rate of Verapamil which could result in a higher serum level.
Atenolol Atenolol Sulindac may decrease the antihypertensive activities of Atenolol.
Pindolol Pindolol Sulindac may decrease the antihypertensive activities of Pindolol.
Cisplatin Injection Cisplatin Injection Sulindac may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The therapeutic efficacy of Diflunisal can be decreased when used in combination with Sulindac.
Piroxicam Piroxicam The risk or severity of adverse effects can be increased when Piroxicam is combined with Sulindac.
Bumetanide Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Sulindac.
Glyburide Glyburide The protein binding of Glyburide can be decreased when combined with Sulindac.
Glipizide Glipizide The protein binding of Glipizide can be decreased when combined with Sulindac.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Sulindac.
Amoxicillin Amoxicillin Sulindac may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Sulindac may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Sulindac is combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection Sulindac may decrease the excretion rate of Ceftriaxone which could result in a higher serum level.
Labetalol Labetalol Sulindac may decrease the antihypertensive activities of Labetalol.
Auranofin Auranofin Sulindac may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Sulindac may decrease the excretion rate of Leuprolide which could result in a higher serum level.
Gemfibrozil Gemfibrozil Sulindac may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Guanabenz Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Sulindac.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Adefovir dipivoxil.
Ceftazidime Injection Ceftazidime Injection Sulindac may decrease the excretion rate of Ceftazidime which could result in a higher serum level.
Ketoprofen Ketoprofen The risk or severity of adverse effects can be increased when Sulindac is combined with Ketoprofen.
Cefotetan Injection Cefotetan Injection Sulindac may decrease the excretion rate of Cefotetan which could result in a higher serum level.
Enalapril Enalapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Enalapril.
Flurbiprofen Flurbiprofen The risk or severity of adverse effects can be increased when Flurbiprofen is combined with Sulindac.
Amiodarone Amiodarone The risk or severity of hyperkalemia can be increased when Sulindac is combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Sulindac may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone Sulindac may decrease the excretion rate of Buspirone which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin Sulindac may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Mesalamine Mesalamine The therapeutic efficacy of Mesalazine can be decreased when used in combination with Sulindac.
Diclofenac Diclofenac The risk or severity of adverse effects can be increased when Diclofenac is combined with Sulindac.
Fluoxetine Fluoxetine The risk or severity of gastrointestinal bleeding can be increased when Fluoxetine is combined with Sulindac.
Nimodipine Nimodipine The therapeutic efficacy of Nimodipine can be decreased when used in combination with Sulindac.
Clozapine Clozapine Sulindac may decrease the excretion rate of Clozapine which could result in a higher serum level.
Estazolam Estazolam Sulindac may decrease the excretion rate of Estazolam which could result in a higher serum level.
Ofloxacin Ofloxacin Sulindac may increase the neuroexcitatory activities of Ofloxacin.
Didanosine Didanosine Sulindac may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Sulindac may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Benazepril Benazepril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Benazepril.
Etodolac Etodolac The risk or severity of adverse effects can be increased when Sulindac is combined with Etodolac.
Felodipine Felodipine The therapeutic efficacy of Felodipine can be decreased when used in combination with Sulindac.
Fosinopril Fosinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Fosinopril.
Nabumetone Nabumetone The risk or severity of adverse effects can be increased when Nabumetone is combined with Sulindac.
Quinapril Quinapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Quinapril.
Ramipril Ramipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Ramipril.
Amlodipine Amlodipine Sulindac may decrease the antihypertensive activities of Amlodipine.
Itraconazole Itraconazole The risk or severity of hyperkalemia can be increased when Sulindac is combined with Itraconazole.
Lisinopril Lisinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Lisinopril.
Oxaprozin Oxaprozin The risk or severity of adverse effects can be increased when Sulindac is combined with Oxaprozin.
Sotalol Sotalol Sulindac may decrease the antihypertensive activities of Sotalol.
Bisoprolol Bisoprolol Sulindac may decrease the antihypertensive activities of Bisoprolol.
Doxazosin Doxazosin The therapeutic efficacy of Doxazosin can be decreased when used in combination with Sulindac.
Terazosin Terazosin The therapeutic efficacy of Terazosin can be decreased when used in combination with Sulindac.
Isradipine Isradipine The therapeutic efficacy of Isradipine can be decreased when used in combination with Sulindac.
Venlafaxine Venlafaxine Venlafaxine may increase the antiplatelet activities of Sulindac.
Stavudine Stavudine The excretion of Stavudine can be decreased when combined with Sulindac.
Fluvoxamine Fluvoxamine The risk or severity of gastrointestinal bleeding can be increased when Sulindac is combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of gastrointestinal bleeding can be increased when Sulindac is combined with Nefazodone.
Lamotrigine Lamotrigine Sulindac may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
Losartan Losartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Losartan is combined with Sulindac.
Valacyclovir Valacyclovir Sulindac may decrease the excretion rate of Valaciclovir which could result in a higher serum level.
Tramadol Tramadol Sulindac may decrease the excretion rate of Tramadol which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Sulindac may decrease the excretion rate of Carboplatin which could result in a higher serum level.
Moexipril Moexipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Moexipril.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Sulindac.
Ifosfamide Injection Ifosfamide Injection Sulindac may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine Nicardipine The therapeutic efficacy of Nicardipine can be decreased when used in combination with Sulindac.
Bupropion Bupropion Sulindac may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine The risk or severity of bleeding can be increased when Sulindac is combined with Ticlopidine.
Metformin Metformin Sulindac may decrease the excretion rate of Metformin which could result in a higher serum level.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Dalteparin.
Nisoldipine Nisoldipine The therapeutic efficacy of Nisoldipine can be decreased when used in combination with Sulindac.
Lamivudine Lamivudine Sulindac may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Acarbose Acarbose Sulindac may decrease the excretion rate of Acarbose which could result in a higher serum level.
Glimepiride Glimepiride The protein binding of Glimepiride can be decreased when combined with Sulindac.
Gemcitabine Injection Gemcitabine Injection Sulindac may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Cidofovir Injection Cidofovir Injection Sulindac may decrease the excretion rate of Cidofovir which could result in a higher serum level.
Meropenem Injection Meropenem Injection Sulindac may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine Sulindac may decrease the excretion rate of Clomipramine which could result in a higher serum level.
Fosfomycin Fosfomycin Sulindac may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Sulindac.
Trandolapril Trandolapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Trandolapril.
Topiramate Topiramate Sulindac may decrease the excretion rate of Topiramate which could result in a higher serum level.
Valsartan Valsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Valsartan is combined with Sulindac.
Pramipexole Pramipexole Sulindac may decrease the excretion rate of Pramipexole which could result in a higher serum level.
Carvedilol Carvedilol Sulindac may decrease the antihypertensive activities of Carvedilol.
Nilutamide Nilutamide Sulindac may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Sulindac may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline The risk or severity of hypertension can be increased when Sulindac is combined with Selegiline.
Sertraline Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Sulindac.
Propafenone Propafenone Sulindac may decrease the antihypertensive activities of Propafenone.
Irbesartan Irbesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Sulindac.
Tamsulosin Tamsulosin Sulindac may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Finasteride Finasteride The risk or severity of hypertension can be increased when Sulindac is combined with Finasteride.
Quetiapine Quetiapine Sulindac may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefepime.
Cefprozil Cefprozil The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefprozil.
Cefpodoxime Cefpodoxime The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefpodoxime.
Cetirizine Cetirizine Sulindac may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Sulindac.
Tolcapone Tolcapone Sulindac may decrease the excretion rate of Tolcapone which could result in a higher serum level.
Citalopram Citalopram The risk or severity of gastrointestinal bleeding can be increased when Citalopram is combined with Sulindac.
Capecitabine Capecitabine Sulindac may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Abacavir Abacavir Sulindac may decrease the excretion rate of Abacavir which could result in a higher serum level.
Celecoxib Celecoxib The risk or severity of adverse effects can be increased when Celecoxib is combined with Sulindac.
Rosiglitazone Rosiglitazone Sulindac may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Tolterodine Tolterodine Sulindac may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Oseltamivir Oseltamivir Sulindac may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Sulindac resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The therapeutic efficacy of Balsalazide can be decreased when used in combination with Sulindac.
Nateglinide Nateglinide Sulindac may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Rabeprazole Rabeprazole Sulindac may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists