Tobramycin Injection

Generic name: Pronounced as (toe bra mye' sin)
Brand names
  • Nebcin®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 12/15/2015

Tobramycin may cause serious kidney problems. Kidney problems may occur more often in older people. Tell your doctor if you have or have ever had kidney disease. If you experience any of the following symptoms, call your doctor immediately: decreased urination; swelling of the face, arms, hands, feet, ankles, or lower legs; or unusual tiredness or weakness.

Tobramycin may cause serious hearing problems. Hearing problems may occur more often in older people. Hearing loss may be permanent in some cases. Tell your doctor if you have or have ever had dizziness, vertigo, hearing loss, or ringing in the ears. If you experience any of the following symptoms, call your doctor immediately: hearing loss, ringing in the ears, or dizziness.

Tobramycin may cause nerve problems. Tell your doctor if you have or have ever had burning or tingling in the hands, arms, feet, or legs; muscle twitching or weakness; or seizures.

The risk that you will develop serious kidney, hearing, or other problems is greater if you are taking certain medications. Tell your doctor and pharmacist if you are taking acyclovir (Zovirax, Sitavig); amphotericin (Abelcet, Ambisome, Amphotec); capreomycin (Capastat); certain cephalosporin antibiotics such as cefazolin (Ancef, Kefzol), cefixime (Suprax), or cephalexin (Keflex); cisplatin; colistin (Coly-Mycin S); cyclosporine (Gengraf, Neoral, Restasis, Sandimmune); diuretics ('water pills') such as bumetanide, ethacrynic acid (Edecrin), furosemide (Lasix), or torsemide (Demadex). other aminoglycoside antibiotics such as amikacin, gentamicin, kanamycin, neomycin (Neo-Fradin), and streptomycin; pentamidine (Nebupent, Pentam); polymyxin B; or vancomycin (Vanocin). Your doctor may not want you to receive tobramycin injection.

Tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while using tobramycin injection, call your doctor immediately. Tobramycin may harm the fetus.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests, including hearing tests, before and during treatment to check your body's response to tobramycin.

Tobramycin injection is used to treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract. Tobramycin injection is in a class of medications called aminoglycoside antibiotics. It works by killing bacteria.

Antibiotics such as tobramycin injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Tobramycin injection comes as a liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). When tobramycin is injected intravenously, it is usually infused (injected slowly) over a period of 20 to 60 minutes once every 6 or 8 hours. The length of your treatment depends on the type of infection you have.

You may receive tobramycin injection in a hospital or you may administer the medication at home. If you will be receiving tobramycin injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions.

You should begin to feel better during the first few days of treatment with tobramycin injection. If your symptoms do not improve or get worse, call your doctor.

Use tobramycin injection until you finish the prescription, even if you feel better. If you stop using tobramycin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using tobramycin,

  • tell your doctor and pharmacist if you are allergic to tobramycin injection; other aminoglycoside antibiotics such as amikacin, gentamicin, kanamycin, neomycin, or streptomycin; sulfites; any other medications; or any of the ingredients in tobramycin injection. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements, you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: other antibiotics such as amoxicillin (Amoxil, Larotid, Moxatag, in Augmentin, in Prevpac), ampicillin, or penicillin; dimenhydrinate (Dramamine); meclizine (Bonine); or nonsteroidal anti-inflammatory drugs such as indomethacin (Indocin, Tivorbex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with tobramycin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you are or have or have ever had cystic fibrosis (an inherited condition that affects the lungs and digestive system), problems with your muscles such as myasthenia gravis, or Parkinson's disease.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are using tobramycin injection.

Unless your doctor tells you otherwise, continue your normal diet.

  • Tobramycin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • diarrhea

    • pain at the injection site

    • headache

    • fever

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

    • rash

    • peeling or blistering of the skin

    • itching

    • hives

    • swelling of the eyes, face, throat, tongue, or lips

    • difficulty breathing or swallowing

    • hoarseness

  • Tobramycin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • hearing loss

  • ringing in the ears

  • dizziness

  • decreased urination

  • swelling of the face, arms, hands, feet, ankles, or lower legs

  • unusual tiredness or weakness

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Alendronate Alendronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Tobramycin is combined with Alendronic acid.
Cilostazol Cilostazol Tobramycin may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Tobramycin may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate Tobramycin may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine Tobramycin may decrease the excretion rate of Guanfacine which could result in a higher serum level.
Magnesium Gluconate Magnesium Gluconate The risk or severity of neuromuscular blockade can be increased when Tobramycin is combined with Magnesium gluconate.
Magnesium Hydroxide Magnesium Hydroxide Tobramycin may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium Oxide Magnesium Oxide The risk or severity of neuromuscular blockade can be increased when Tobramycin is combined with Magnesium oxide.
Mycophenolate Mycophenolate Tobramycin may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Potassium Potassium Tobramycin may decrease the excretion rate of Potassium cation which could result in a higher serum level.
Prednisone Prednisone Tobramycin may decrease the excretion rate of Prednisone which could result in a higher serum level.
Ranitidine Ranitidine Tobramycin may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine Reserpine Tobramycin may decrease the excretion rate of Reserpine which could result in a higher serum level.
Rizatriptan Rizatriptan Tobramycin may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan Tobramycin may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus Tobramycin may decrease the excretion rate of Tacrolimus which could result in a higher serum level.
Tiludronate Tiludronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Tobramycin is combined with Etidronic acid.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Tobramycin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Tobramycin may decrease the excretion rate of Fluconazole which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection The risk or severity of nephrotoxicity can be increased when Tobramycin is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection Tobramycin may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Tobramycin may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection Tobramycin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Metoclopramide Injection Metoclopramide Injection Tobramycin may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection Tobramycin may decrease the excretion rate of Pamidronic acid which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Tobramycin may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine Tobramycin may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Cefuroxime Cefuroxime Tobramycin may decrease the excretion rate of Cefuroxime which could result in a higher serum level.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Enoxaparin Injection Enoxaparin Injection The therapeutic efficacy of Tobramycin can be decreased when used in combination with Enoxaparin.
Torsemide Torsemide The serum concentration of Tobramycin can be increased when it is combined with Torasemide.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Pantoprazole Pantoprazole Tobramycin may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Risedronate Risedronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Tobramycin is combined with Risedronic acid.
Temozolomide Temozolomide Tobramycin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Tobramycin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Perindopril Perindopril Tobramycin may decrease the excretion rate of Perindopril which could result in a higher serum level.
Tenofovir Tenofovir Tobramycin may increase the nephrotoxic activities of Tenofovir.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Zonisamide Zonisamide Tobramycin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Atomoxetine Atomoxetine Tobramycin may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
Atazanavir Atazanavir Tobramycin may decrease the excretion rate of Atazanavir which could result in a higher serum level.
Almotriptan Almotriptan Tobramycin may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Emtricitabine Emtricitabine Tobramycin may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Tobramycin may decrease the excretion rate of Memantine which could result in a higher serum level.
Tadalafil Tadalafil Tobramycin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Duloxetine Duloxetine Tobramycin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Tinidazole Tinidazole Tobramycin may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Cefditoren Cefditoren Tobramycin may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Tobramycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Eszopiclone Eszopiclone Tobramycin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ganciclovir Ganciclovir Tobramycin may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Tobramycin may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Valganciclovir Valganciclovir Tobramycin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Zoledronic Acid Injection Zoledronic Acid Injection The risk or severity of nephrotoxicity and hypocalcemia can be increased when Tobramycin is combined with Zoledronic acid.
Adefovir Adefovir Tobramycin may decrease the excretion rate of Adefovir which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Tobramycin may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Ibandronate Ibandronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Tobramycin is combined with Ibandronate.
Ramelteon Ramelteon Tobramycin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Tobramycin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pregabalin Pregabalin Tobramycin may decrease the excretion rate of Pregabalin which could result in a higher serum level.
Ranolazine Ranolazine Tobramycin may decrease the excretion rate of Ranolazine which could result in a higher serum level.
Rasagiline Rasagiline Tobramycin may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Sitagliptin Sitagliptin Tobramycin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Tobramycin may decrease the excretion rate of Varenicline which could result in a higher serum level.
Albuterol Albuterol Tobramycin may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone Tobramycin may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Clofarabine Injection Clofarabine Injection Tobramycin may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone Lubiprostone Tobramycin may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Pemetrexed Injection Pemetrexed Injection Tobramycin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Sorafenib Sorafenib Tobramycin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Levocetirizine Levocetirizine Tobramycin may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Tobramycin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Tobramycin may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Lenalidomide Lenalidomide Tobramycin may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Budesonide Budesonide Tobramycin may decrease the excretion rate of Budesonide which could result in a higher serum level.
Desmopressin Desmopressin Tobramycin may decrease the excretion rate of Desmopressin which could result in a higher serum level.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Tobramycin is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Tobramycin is combined with Botulinum Toxin Type B.
Doripenem Injection Doripenem Injection Tobramycin may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Tobramycin may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine Tobramycin may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Cevimeline Cevimeline Tobramycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
Pilocarpine Pilocarpine The therapeutic efficacy of Pilocarpine can be decreased when used in combination with Tobramycin.
Certolizumab Injection Certolizumab Injection Tobramycin may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Daptomycin Injection Daptomycin Injection Tobramycin may decrease the excretion rate of Daptomycin which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Tobramycin may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Midazolam Midazolam Tobramycin may decrease the excretion rate of Midazolam which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Tobramycin may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Milnacipran Milnacipran Tobramycin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Plerixafor Injection Plerixafor Injection Tobramycin may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Tobramycin may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Prasugrel Prasugrel Tobramycin may decrease the excretion rate of Prasugrel which could result in a higher serum level.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Tobramycin is combined with Botulinum toxin type A.
Pralatrexate Injection Pralatrexate Injection Tobramycin may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Tobramycin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Saxagliptin Saxagliptin Tobramycin may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Tobramycin may decrease the excretion rate of Telavancin which could result in a higher serum level.
Topotecan Topotecan Tobramycin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Dalfampridine Dalfampridine Tobramycin may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Tobramycin is combined with Botulinum toxin type A.
Ceftaroline Injection Ceftaroline Injection Tobramycin may decrease the excretion rate of Ceftaroline fosamil which could result in a higher serum level.
Acetaminophen Injection Acetaminophen Injection Tobramycin may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Tobramycin may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Tobramycin may decrease the excretion rate of Aldesleukin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Tobramycin may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Roflumilast Roflumilast Tobramycin may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Rivaroxaban Rivaroxaban Tobramycin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib Ruxolitinib Tobramycin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Tobramycin may decrease the excretion rate of Clobazam which could result in a higher serum level.
Deferiprone Deferiprone Tobramycin may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Naloxone Injection Naloxone Injection Tobramycin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fondaparinux Injection Fondaparinux Injection Tobramycin may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Enzalutamide Enzalutamide Tobramycin may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Tobramycin may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Teduglutide Injection Teduglutide Injection Tobramycin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Tobramycin may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Pomalidomide Pomalidomide Tobramycin may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Canagliflozin Canagliflozin Tobramycin may decrease the excretion rate of Canagliflozin which could result in a higher serum level.
Trametinib Trametinib Tobramycin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran Tobramycin may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Ertapenem Injection Ertapenem Injection Tobramycin may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Tigecycline Injection Tigecycline Injection The risk or severity of neuromuscular blockade can be increased when Tigecycline is combined with Tobramycin.
Vortioxetine Vortioxetine Tobramycin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Sofosbuvir Sofosbuvir Tobramycin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Apremilast Apremilast Tobramycin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Tobramycin may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Testosterone Injection Testosterone Injection Tobramycin may decrease the excretion rate of Testosterone which could result in a higher serum level.
Edoxaban Edoxaban Tobramycin may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Methamphetamine Methamphetamine Tobramycin may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Tobramycin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Haloperidol Injection Haloperidol Injection Tobramycin may decrease the excretion rate of Haloperidol which could result in a higher serum level.
Macitentan Macitentan Tobramycin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Penicillin G Procaine Injection Penicillin G Procaine Injection Procaine benzylpenicillin may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Ixazomib Ixazomib Tobramycin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Tobramycin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection Tobramycin may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Furosemide Injection Furosemide Injection Furosemide may increase the ototoxic activities of Tobramycin.
Lixisenatide Injection Lixisenatide Injection Tobramycin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Tobramycin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Tobramycin may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Tobramycin may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Naldemedine Naldemedine Tobramycin may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Benznidazole Benznidazole Tobramycin may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Tobramycin may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Apalutamide Apalutamide Tobramycin may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib Baricitinib Tobramycin may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine Tobramycin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Tobramycin may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Stiripentol Stiripentol Tobramycin may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Prucalopride Prucalopride Tobramycin may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Magnesium Citrate Magnesium Citrate The risk or severity of neuromuscular blockade can be increased when Tobramycin is combined with Magnesium citrate.
Acyclovir Ophthalmic Acyclovir Ophthalmic Tobramycin may decrease the excretion rate of Acyclovir which could result in a higher serum level.
Solriamfetol Solriamfetol Tobramycin may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Pitolisant Pitolisant Tobramycin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Viloxazine Viloxazine Tobramycin may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Sucralfate Sucralfate Tobramycin may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Floxuridine Floxuridine Tobramycin may decrease the excretion rate of Floxuridine which could result in a higher serum level.
Metaxalone Metaxalone Tobramycin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection Tobramycin may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Chlorpromazine Chlorpromazine Tobramycin may decrease the excretion rate of Chlorpromazine which could result in a higher serum level.
Diazepam Diazepam Tobramycin may decrease the excretion rate of Diazepam which could result in a higher serum level.
Oxazepam Oxazepam Tobramycin may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Flurazepam Flurazepam Tobramycin may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate Clorazepate Tobramycin may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Tobramycin may decrease the excretion rate of Lorazepam which could result in a higher serum level.
Carmustine Carmustine Tobramycin may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine Amantadine Tobramycin may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine Tobramycin may decrease the excretion rate of Codeine which could result in a higher serum level.
Phenelzine Phenelzine Tobramycin may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Tetracycline Tetracycline Tobramycin may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Minocycline Minocycline The risk or severity of neuromuscular blockade can be increased when Tobramycin is combined with Minocycline.
Demeclocycline Demeclocycline The risk or severity of neuromuscular blockade can be increased when Demeclocycline is combined with Tobramycin.
Bleomycin Bleomycin Tobramycin may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Sulfadiazine Sulfadiazine Tobramycin may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Methadone Methadone Tobramycin may decrease the excretion rate of Methadone which could result in a higher serum level.
Benztropine Benztropine Tobramycin may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Maprotiline Maprotiline Tobramycin may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Azathioprine Azathioprine Tobramycin may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Methylphenidate Methylphenidate Tobramycin may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Phenazopyridine Phenazopyridine Tobramycin may decrease the excretion rate of Phenazopyridine which could result in a higher serum level.
Carbamazepine Carbamazepine Tobramycin may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa Tobramycin may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Hydralazine Hydralazine Tobramycin may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine Tobramycin may decrease the excretion rate of Cimetidine which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Tobramycin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Warfarin Warfarin Tobramycin may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam Clonazepam Tobramycin may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Promethazine Promethazine Tobramycin may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Tobramycin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Tobramycin may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Tobramycin may decrease the excretion rate of Chloroquine which could result in a higher serum level.
Quinine Quinine The risk or severity of neuromuscular blockade can be increased when Quinine is combined with Tobramycin.
Triamterene Triamterene Triamterene may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Tobramycin.
Metolazone Metolazone Tobramycin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Clindamycin Injection Clindamycin Injection The risk or severity of neuromuscular blockade can be increased when Tobramycin is combined with Clindamycin.
Secobarbital Secobarbital Tobramycin may decrease the excretion rate of Secobarbital which could result in a higher serum level.
Desipramine Desipramine Tobramycin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline Tobramycin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Imipramine Imipramine Tobramycin may decrease the excretion rate of Imipramine which could result in a higher serum level.
Probenecid Probenecid Tobramycin may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine Quinidine Tobramycin may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Tobramycin may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Tobramycin may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide Pyrazinamide Tobramycin may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Disopyramide Disopyramide Tobramycin may decrease the excretion rate of Disopyramide which could result in a higher serum level.
Butabarbital Butabarbital Tobramycin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Liothyronine Liothyronine Tobramycin may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole Methimazole Tobramycin may decrease the excretion rate of Methimazole which could result in a higher serum level.
Chlorpropamide Chlorpropamide Tobramycin may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Tolbutamide Tolbutamide Tobramycin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Tobramycin may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Baclofen Baclofen Tobramycin may decrease the excretion rate of Baclofen which could result in a higher serum level.
Ethambutol Ethambutol Tobramycin may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Hydrochlorothiazide Hydrochlorothiazide Tobramycin may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Dantrolene Dantrolene The risk or severity of neuromuscular blockade can be increased when Tobramycin is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone Tobramycin may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Pyridoxine Pyridoxine Tobramycin may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
Folic Acid Folic Acid Tobramycin may decrease the excretion rate of Folic acid which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Tobramycin may decrease the excretion rate of Propranolol which could result in a higher serum level.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Phytonadione Phytonadione Tobramycin may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Nadolol Nadolol Tobramycin may decrease the excretion rate of Nadolol which could result in a higher serum level.
Allopurinol Allopurinol Tobramycin may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Flavoxate Flavoxate Tobramycin may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Colchicine Colchicine Tobramycin may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Tobramycin may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cefadroxil Cefadroxil Tobramycin may decrease the excretion rate of Cefadroxil which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Tobramycin may decrease the excretion rate of Cefazolin which could result in a higher serum level.
Cephalexin Cephalexin Tobramycin may decrease the excretion rate of Cephalexin which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Tobramycin may decrease the excretion rate of Cefoxitin which could result in a higher serum level.
Dacarbazine Dacarbazine Tobramycin may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Tobramycin may decrease the excretion rate of Salmon calcitonin which could result in a higher serum level.
Pyrantel Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Tobramycin.
Bethanechol Bethanechol The therapeutic efficacy of Bethanechol can be decreased when used in combination with Tobramycin.
Ethacrynic Acid Ethacrynic Acid The serum concentration of Tobramycin can be increased when it is combined with Etacrynic acid.
Colistimethate Injection Colistimethate Injection Tobramycin may decrease the excretion rate of Colistimethate which could result in a higher serum level.
Metoprolol Metoprolol Tobramycin may decrease the excretion rate of Metoprolol which could result in a higher serum level.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Alprazolam Alprazolam Tobramycin may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Temazepam Temazepam Tobramycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam Triazolam Tobramycin may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Tobramycin may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Propantheline Propantheline Tobramycin may decrease the excretion rate of Propantheline which could result in a higher serum level.
Trimethoprim Trimethoprim Tobramycin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Nifedipine Nifedipine Tobramycin may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol Tobramycin may decrease the excretion rate of Timolol which could result in a higher serum level.
Verapamil Verapamil Tobramycin may decrease the excretion rate of Verapamil which could result in a higher serum level.
Pindolol Pindolol Tobramycin may decrease the excretion rate of Pindolol which could result in a higher serum level.
Cisplatin Injection Cisplatin Injection Tobramycin may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Bumetanide Bumetanide The serum concentration of Tobramycin can be increased when it is combined with Bumetanide.
Glipizide Glipizide Tobramycin may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Tobramycin may decrease the excretion rate of Indapamide which could result in a higher serum level.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Dicloxacillin Dicloxacillin The serum concentration of Tobramycin can be decreased when it is combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The serum concentration of Tobramycin can be decreased when it is combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Pentoxifylline Pentoxifylline Tobramycin may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Tobramycin may decrease the excretion rate of Pentamidine which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Tobramycin may decrease the excretion rate of Ceftriaxone which could result in a higher serum level.
Labetalol Labetalol Tobramycin may decrease the excretion rate of Labetalol which could result in a higher serum level.
Auranofin Auranofin Tobramycin may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Tobramycin may decrease the excretion rate of Leuprolide which could result in a higher serum level.
Gemfibrozil Gemfibrozil Tobramycin may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Tobramycin may decrease the excretion rate of Adefovir dipivoxil which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Tobramycin may decrease the excretion rate of Ceftazidime which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Tobramycin may decrease the excretion rate of Cefotetan which could result in a higher serum level.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Tobramycin may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone Tobramycin may decrease the excretion rate of Buspirone which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin Tobramycin may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Clozapine Clozapine Tobramycin may decrease the excretion rate of Clozapine which could result in a higher serum level.
Estazolam Estazolam Tobramycin may decrease the excretion rate of Estazolam which could result in a higher serum level.
Didanosine Didanosine Tobramycin may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Tobramycin may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Etodolac Etodolac Etodolac may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Fosinopril Fosinopril Tobramycin may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Lisinopril Lisinopril Tobramycin may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Bisoprolol Bisoprolol Tobramycin may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
Isradipine Isradipine Tobramycin may decrease the excretion rate of Isradipine which could result in a higher serum level.
Venlafaxine Venlafaxine Tobramycin may decrease the excretion rate of Venlafaxine which could result in a higher serum level.
Fluvoxamine Fluvoxamine Tobramycin may decrease the excretion rate of Fluvoxamine which could result in a higher serum level.
Nefazodone Nefazodone Tobramycin may decrease the excretion rate of Nefazodone which could result in a higher serum level.
Lamotrigine Lamotrigine Tobramycin may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
Valacyclovir Valacyclovir Tobramycin may decrease the excretion rate of Valaciclovir which could result in a higher serum level.
Tramadol Tramadol Tobramycin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection The risk or severity of ototoxicity and nephrotoxicity can be increased when Tobramycin is combined with Carboplatin.
Ifosfamide Injection Ifosfamide Injection Tobramycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Bupropion Bupropion Tobramycin may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine Tobramycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
Metformin Metformin Tobramycin may decrease the excretion rate of Metformin which could result in a higher serum level.
Dalteparin Injection Dalteparin Injection The therapeutic efficacy of Tobramycin can be decreased when used in combination with Dalteparin.
Nisoldipine Nisoldipine Tobramycin may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
Lamivudine Lamivudine Tobramycin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Acarbose Acarbose Tobramycin may decrease the excretion rate of Acarbose which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Tobramycin may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Cidofovir Injection Cidofovir Injection Tobramycin may decrease the excretion rate of Cidofovir which could result in a higher serum level.
Meropenem Injection Meropenem Injection Tobramycin may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine Tobramycin may decrease the excretion rate of Clomipramine which could result in a higher serum level.
Fosfomycin Fosfomycin Tobramycin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Topiramate Topiramate Tobramycin may decrease the excretion rate of Topiramate which could result in a higher serum level.
Pramipexole Pramipexole Tobramycin may decrease the excretion rate of Pramipexole which could result in a higher serum level.
Nilutamide Nilutamide Tobramycin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Tobramycin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tamsulosin Tamsulosin Tobramycin may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Quetiapine Quetiapine Tobramycin may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection Tobramycin may decrease the excretion rate of Cefepime which could result in a higher serum level.
Cefprozil Cefprozil Tobramycin may decrease the excretion rate of Cefprozil which could result in a higher serum level.
Cefpodoxime Cefpodoxime Tobramycin may decrease the excretion rate of Cefpodoxime which could result in a higher serum level.
Cetirizine Cetirizine Tobramycin may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Tolcapone Tolcapone Tobramycin may decrease the excretion rate of Tolcapone which could result in a higher serum level.
Capecitabine Capecitabine Tobramycin may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Abacavir Abacavir Tobramycin may decrease the excretion rate of Abacavir which could result in a higher serum level.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Rosiglitazone Rosiglitazone Tobramycin may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Tolterodine Tolterodine Tobramycin may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Oseltamivir Oseltamivir Tobramycin may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Nateglinide Nateglinide Tobramycin may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Rabeprazole Rabeprazole Tobramycin may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists