Irbesartan

Generic name: Pronounced as (ir be sar' tan)
Brand names
  • Avapro®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2018

Tell your doctor if you are pregnant or plan to become pregnant. Do not take irbesartan if you are pregnant. If you become pregnant while you are taking irbesartan, stop taking irbesartan and call your doctor immediately. Irbesartan may cause death or serious injury to the fetus when taken in the last 6 months of pregnancy.

Irbesartan is used alone or in combination with other medications to treat high blood pressure. It is also used to treat kidney disease caused by diabetes in patients with type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood) and high blood pressure. Irbesartan is in a class of medications called angiotensin II receptor antagonists. It works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more efficiently.

High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Irbesartan comes as a tablet to take by mouth. It is usually taken once a day with or without food. To help you remember to take irbesartan, take it at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take irbesartan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of irbesartan and gradually increase your dose.

Irbesartan controls high blood pressure but does not cure it. It may take 2 weeks for you to notice the full benefit of irbesartan. Continue to take irbesartan even if you feel well. Do not stop taking irbesartan without talking to your doctor.

Irbesartan is also used sometimes to treat heart failure (condition in which the heart is unable to pump enough blood to the rest of the body). Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking irbesartan,

  • tell your doctor and pharmacist if you are allergic to irbesartan, any other medications, or any of the ingredients in irbesartan tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor if you have diabetes (high blood sugar) and you are taking aliskiren (Tekturna, in Amturnide, Tekamlo, Tekturna HCT). Your doctor will probably tell you not to take irbesartan if you have diabetes and you are also taking aliskiren.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten, in Capozide), enalapril (Vasotec), fosinopril, lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), and selective COX-2 inhibitors such as celecoxib (Celebrex); diuretics ('water pills'); and potassium supplements.. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had heart failure, or kidney disease.

  • tell your doctor if you are breastfeeding.

  • you should know that irbesartan may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking irbesartan. To help avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

  • you should know that diarrhea, vomiting, not drinking enough fluids, and sweating a lot can cause a drop in blood pressure, which may cause lightheadedness and fainting. Tell your doctor if you have any of these problems or develop them during your treatment.

Do not use salt substitutes containing potassium without talking to your doctor. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Irbesartan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • heartburn

    • excessive tiredness

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately:

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • hoarseness

    • difficulty breathing or swallowing

  • Irbesartan may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • dizziness

  • fainting

  • fast or slow heartbeat

Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to irbesartan.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Avalide® (containing Hydrochlorothiazide, Irbesartan)

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Irbesartan.
Montelukast Montelukast The metabolism of Irbesartan can be decreased when combined with Montelukast.
Leflunomide Leflunomide The metabolism of Irbesartan can be decreased when combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Irbesartan can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Irbesartan can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Irbesartan.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Irbesartan.
Candesartan Candesartan The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Irbesartan is combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Irbesartan.
Clopidogrel Clopidogrel The metabolism of Irbesartan can be decreased when combined with Clopidogrel.
Fenofibrate Fenofibrate The metabolism of Irbesartan can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine Guanfacine may decrease the antihypertensive activities of Irbesartan.
Methylergonovine Methylergonovine Methylergometrine may decrease the antihypertensive activities of Irbesartan.
Naratriptan Naratriptan Naratriptan may decrease the antihypertensive activities of Irbesartan.
Olsalazine Olsalazine The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Olsalazine.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Irbesartan.
Penbutolol Penbutolol The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Acebutolol.
Potassium Potassium Irbesartan may increase the hyperkalemic activities of Potassium cation.
Reserpine Reserpine Reserpine may increase the hypotensive activities of Irbesartan.
Rizatriptan Rizatriptan Rizatriptan may decrease the antihypertensive activities of Irbesartan.
Sumatriptan Sumatriptan Sumatriptan may decrease the antihypertensive activities of Irbesartan.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Irbesartan.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Irbesartan.
Zolmitriptan Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Irbesartan.
Fluconazole Injection Fluconazole Injection The metabolism of Irbesartan can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Irbesartan can be decreased when combined with Hydromorphone.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be decreased when combined with Irbesartan.
Metronidazole Injection Metronidazole Injection The metabolism of Irbesartan can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Irbesartan.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Irbesartan.
Altretamine Altretamine Amphetamine may increase the hypotensive activities of Irbesartan.
Cyclosporine Cyclosporine The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Irbesartan can be decreased when combined with Ondansetron.
Enoxaparin Injection Enoxaparin Injection The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Enoxaparin.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Irbesartan.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Irbesartan.
Alosetron Alosetron The metabolism of Irbesartan can be decreased when combined with Alosetron.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Irbesartan.
Eprosartan Eprosartan The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Eprosartan is combined with Irbesartan.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Irbesartan.
Meloxicam Meloxicam The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Meloxicam.
Telmisartan Telmisartan The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Telmisartan is combined with Irbesartan.
Anakinra Anakinra The metabolism of Irbesartan can be increased when combined with Anakinra.
Linezolid Linezolid Linezolid may increase the hypotensive activities of Irbesartan.
Trimipramine Trimipramine The metabolism of Irbesartan can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Irbesartan can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Irbesartan can be decreased when combined with Modafinil.
Perindopril Perindopril The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Perindopril is combined with Irbesartan.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Irbesartan.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Choline magnesium trisalicylate.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Irbesartan.
Dutasteride Dutasteride Dutasteride may decrease the antihypertensive activities of Irbesartan.
Epinephrine Injection Epinephrine Injection The metabolism of Irbesartan can be decreased when combined with Epinephrine.
Eplerenone Eplerenone The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Irbesartan.
Olmesartan Olmesartan The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Olmesartan is combined with Irbesartan.
Zonisamide Zonisamide The risk or severity of hyperkalemia can be increased when Zonisamide is combined with Irbesartan.
Adalimumab Injection Adalimumab Injection The metabolism of Irbesartan can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Irbesartan.
Atomoxetine Atomoxetine Atomoxetine may decrease the antihypertensive activities of Irbesartan.
Dexmethylphenidate Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Irbesartan.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Irbesartan.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Irbesartan.
Eletriptan Eletriptan Eletriptan may decrease the antihypertensive activities of Irbesartan.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Irbesartan.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Irbesartan.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Irbesartan.
Aprepitant Aprepitant The metabolism of Irbesartan can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The metabolism of Irbesartan can be decreased when combined with Tegaserod.
Tadalafil Tadalafil Irbesartan may increase the antihypertensive activities of Tadalafil.
Frovatriptan Frovatriptan Frovatriptan may decrease the antihypertensive activities of Irbesartan.
Progesterone Progesterone The metabolism of Irbesartan can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Irbesartan can be decreased when combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Irbesartan can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Irbesartan can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline Protriptyline may decrease the antihypertensive activities of Irbesartan.
Rifaximin Rifaximin The metabolism of Irbesartan can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Irbesartan is combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Irbesartan.
Bosentan Bosentan The metabolism of Irbesartan can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Irbesartan can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Irbesartan.
Solifenacin Solifenacin Solifenacin may decrease the antihypertensive activities of Irbesartan.
Voriconazole Voriconazole The metabolism of Irbesartan can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the hypotensive activities of Irbesartan.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Irbesartan can be increased when combined with Peginterferon alfa-2b.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypotensive activities of Irbesartan.
Ramelteon Ramelteon The metabolism of Irbesartan can be decreased when combined with Ramelteon.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Irbesartan.
Deferasirox Deferasirox The metabolism of Irbesartan can be decreased when combined with Deferasirox.
Phenylephrine Phenylephrine Phenylephrine may decrease the antihypertensive activities of Irbesartan.
Felbamate Felbamate The metabolism of Irbesartan can be decreased when combined with Felbamate.
Abatacept Injection Abatacept Injection The metabolism of Irbesartan can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may increase the hypotensive activities of Irbesartan.
Imatinib Imatinib The metabolism of Irbesartan can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Irbesartan.
Gefitinib Gefitinib The metabolism of Irbesartan can be decreased when combined with Gefitinib.
Albuterol Albuterol Salbutamol may decrease the antihypertensive activities of Irbesartan.
Paliperidone Paliperidone Paliperidone may decrease the antihypertensive activities of Irbesartan.
Bortezomib Bortezomib The metabolism of Irbesartan can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Irbesartan.
Rituximab Injection Rituximab Injection Irbesartan may increase the hypotensive activities of Rituximab.
Aliskiren Aliskiren The risk or severity of hyperkalemia can be increased when Aliskiren is combined with Irbesartan.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Irbesartan.
Nabilone Nabilone The metabolism of Irbesartan can be decreased when combined with Nabilone.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Irbesartan.
Sorafenib Sorafenib The metabolism of Irbesartan can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Irbesartan.
Dronabinol Dronabinol The metabolism of Irbesartan can be decreased when combined with Dronabinol.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Irbesartan.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Irbesartan.
Armodafinil Armodafinil The metabolism of Irbesartan can be decreased when combined with Armodafinil.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Irbesartan.
Nilotinib Nilotinib The metabolism of Irbesartan can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Irbesartan can be decreased when combined with Bexarotene.
Desmopressin Desmopressin Desmopressin may decrease the antihypertensive activities of Irbesartan.
Etravirine Etravirine The metabolism of Irbesartan can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Irbesartan.
Nebivolol Nebivolol The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Nebivolol.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Irbesartan.
Flecainide Flecainide The metabolism of Irbesartan can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Irbesartan can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Irbesartan.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Irbesartan.
Rufinamide Rufinamide The metabolism of Rufinamide can be decreased when combined with Irbesartan.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Irbesartan.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Irbesartan.
Sodium Phosphate Sodium Phosphate The risk or severity of nephrotoxicity can be increased when Irbesartan is combined with Sodium phosphate, monobasic.
Betaxolol Betaxolol The risk or severity of hyperkalemia can be increased when Betaxolol is combined with Irbesartan.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Irbesartan.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Irbesartan.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Irbesartan.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Irbesartan.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Irbesartan.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Irbesartan.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Irbesartan.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Irbesartan.
Golimumab Injection Golimumab Injection The metabolism of Irbesartan can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Irbesartan.
Asenapine Asenapine Asenapine may decrease the antihypertensive activities of Irbesartan.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Irbesartan.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Irbesartan.
Tocilizumab Injection Tocilizumab Injection The metabolism of Irbesartan can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Irbesartan.
Lurasidone Lurasidone Lurasidone may decrease the antihypertensive activities of Irbesartan.
Vilazodone Vilazodone Vilazodone may decrease the antihypertensive activities of Irbesartan.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Irbesartan.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the antihypertensive activities of Irbesartan.
Azilsartan Azilsartan The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Irbesartan is combined with Azilsartan medoxomil.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Irbesartan.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Irbesartan.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Irbesartan.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Irbesartan.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Irbesartan.
Abiraterone Abiraterone The metabolism of Irbesartan can be decreased when combined with Abiraterone.
Ticagrelor Ticagrelor The metabolism of Irbesartan can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Irbesartan.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Irbesartan.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Irbesartan.
Vemurafenib Vemurafenib The metabolism of Irbesartan can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Irbesartan can be decreased when combined with Vismodegib.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Irbesartan.
Crizotinib Crizotinib The metabolism of Crizotinib can be decreased when combined with Irbesartan.
Cabergoline Cabergoline The metabolism of Irbesartan can be decreased when combined with Cabergoline.
Ambrisentan Ambrisentan Irbesartan may increase the hypotensive activities of Ambrisentan.
Iloprost Iloprost Iloprost may increase the hypotensive activities of Irbesartan.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Irbesartan.
Mirabegron Mirabegron Mirabegron may decrease the antihypertensive activities of Irbesartan.
Regorafenib Regorafenib The metabolism of Irbesartan can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Irbesartan can be decreased when combined with Bosutinib.
Teriflunomide Teriflunomide The metabolism of Irbesartan can be decreased when combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Irbesartan.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Irbesartan.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Irbesartan.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Irbesartan.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Irbesartan.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Irbesartan.
Canagliflozin Canagliflozin The risk or severity of hypotension, hyperkalemia, and reduced intravascular volume can be increased when Canagliflozin is combined with Irbesartan.
Methazolamide Methazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Irbesartan.
Dabrafenib Dabrafenib The metabolism of Irbesartan can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Irbesartan.
Trametinib Trametinib The metabolism of Irbesartan can be decreased when combined with Trametinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Irbesartan.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Irbesartan.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Irbesartan.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Irbesartan.
Avanafil Avanafil Avanafil may increase the antihypertensive activities of Irbesartan.
Ketorolac Injection Ketorolac Injection The therapeutic efficacy of Irbesartan can be decreased when used in combination with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection Irbesartan may increase the hypotensive activities of Obinutuzumab.
Dapagliflozin Dapagliflozin The risk or severity of adverse effects can be increased when Dapagliflozin is combined with Irbesartan.
Apremilast Apremilast The metabolism of Irbesartan can be increased when combined with Apremilast.
Droxidopa Droxidopa Droxidopa may decrease the antihypertensive activities of Irbesartan.
Ceritinib Ceritinib The metabolism of Irbesartan can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Irbesartan can be increased when combined with Siltuximab.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Irbesartan.
Testosterone Injection Testosterone Injection The metabolism of Irbesartan can be decreased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Irbesartan can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin The risk or severity of adverse effects can be increased when Empagliflozin is combined with Irbesartan.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Irbesartan.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Irbesartan.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Irbesartan.
Methamphetamine Methamphetamine Metamfetamine may decrease the antihypertensive activities of Irbesartan.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Irbesartan.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Irbesartan.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Irbesartan.
Secukinumab Injection Secukinumab Injection The metabolism of Irbesartan can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection Irbesartan may increase the hypotensive activities of Risperidone.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Irbesartan.
Lenvatinib Lenvatinib The metabolism of Irbesartan can be decreased when combined with Lenvatinib.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Irbesartan.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Irbesartan.
Haloperidol Injection Haloperidol Injection The serum concentration of Irbesartan can be increased when it is combined with Haloperidol.
Amiloride Amiloride The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Amiloride.
Macitentan Macitentan Irbesartan may increase the hypotensive activities of Macitentan.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Irbesartan.
Flibanserin Flibanserin Flibanserin may decrease the antihypertensive activities of Irbesartan.
Brexpiprazole Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Irbesartan.
Ziprasidone Injection Ziprasidone Injection Irbesartan may increase the antihypertensive activities of Ziprasidone.
Cariprazine Cariprazine Cariprazine may decrease the antihypertensive activities of Irbesartan.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Irbesartan.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Irbesartan.
Osimertinib Osimertinib The metabolism of Osimertinib can be decreased when combined with Irbesartan.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Irbesartan.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Irbesartan.
Rifapentine Rifapentine The metabolism of Irbesartan can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Irbesartan.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Irbesartan.
Dexamethasone Injection Dexamethasone Injection The metabolism of Irbesartan can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Irbesartan.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Irbesartan.
Midodrine Midodrine Midodrine may decrease the antihypertensive activities of Irbesartan.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Irbesartan.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Irbesartan.
Furosemide Injection Furosemide Injection The risk or severity of renal failure and hypotension can be increased when Furosemide is combined with Irbesartan.
Rucaparib Rucaparib The metabolism of Irbesartan can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Irbesartan.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Irbesartan.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Irbesartan.
Safinamide Safinamide Safinamide may increase the hypotensive activities of Irbesartan.
Midostaurin Midostaurin The metabolism of Irbesartan can be decreased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Irbesartan.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Irbesartan.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Irbesartan.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Irbesartan.
Delafloxacin Delafloxacin The metabolism of Irbesartan can be increased when combined with Delafloxacin.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Irbesartan.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Irbesartan.
Letermovir Letermovir The metabolism of Irbesartan can be decreased when combined with Letermovir.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Irbesartan.
Apalutamide Apalutamide The metabolism of Apalutamide can be decreased when combined with Irbesartan.
Fostamatinib Fostamatinib Fostamatinib may increase the antihypertensive activities of Irbesartan.
Avatrombopag Avatrombopag The metabolism of Irbesartan can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Irbesartan.
Lofexidine Lofexidine Irbesartan may decrease the antihypertensive activities of Lofexidine.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Irbesartan.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Irbesartan.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Irbesartan.
Cannabidiol Cannabidiol Cannabidiol may decrease the antihypertensive activities of Irbesartan.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Irbesartan.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Irbesartan.
Stiripentol Stiripentol The metabolism of Irbesartan can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Irbesartan.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Irbesartan.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Irbesartan.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Irbesartan.
Rifamycin Rifamycin The metabolism of Irbesartan can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Irbesartan.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Irbesartan can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Irbesartan can be decreased when combined with Siponimod.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Irbesartan.
Alpelisib Alpelisib The serum concentration of Irbesartan can be decreased when it is combined with Alpelisib.
Solriamfetol Solriamfetol Solriamfetol may decrease the antihypertensive activities of Irbesartan.
Triclabendazole Triclabendazole The metabolism of Irbesartan can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Irbesartan.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Irbesartan.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Irbesartan.
Lefamulin Lefamulin The metabolism of Lefamulin can be decreased when combined with Irbesartan.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Irbesartan.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Irbesartan.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Irbesartan.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Irbesartan.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Irbesartan.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Irbesartan.
Cenobamate Cenobamate The metabolism of Irbesartan can be increased when combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Irbesartan.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Irbesartan.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Irbesartan.
Selpercatinib Selpercatinib The serum concentration of Irbesartan can be increased when it is combined with Selpercatinib.
Pralsetinib Pralsetinib The metabolism of Irbesartan can be decreased when combined with Pralsetinib.
Opicapone Opicapone The metabolism of Irbesartan can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Irbesartan can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Irbesartan.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Drospirenone.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Irbesartan.
Fenoprofen Fenoprofen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Fenoprofen.
Indomethacin Indomethacin The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Mefenamic acid.
Naproxen Naproxen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Naproxen.
Tolmetin Tolmetin The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Tolmetin.
Sulindac Sulindac The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Sulindac.
Trazodone Trazodone Trazodone may decrease the antihypertensive activities of Irbesartan.
Floxuridine Floxuridine The metabolism of Irbesartan can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Irbesartan can be decreased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Irbesartan.
Primidone Primidone Primidone may increase the hypotensive activities of Irbesartan.
Methsuximide Methsuximide The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Methsuximide.
Diethylpropion Diethylpropion Diethylpropion may decrease the antihypertensive activities of Irbesartan.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Irbesartan.
Diazepam Diazepam The metabolism of Irbesartan can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Irbesartan.
Phenoxybenzamine Phenoxybenzamine Phenoxybenzamine may decrease the antihypertensive activities of Irbesartan.
Bromocriptine Bromocriptine Bromocriptine may decrease the antihypertensive activities of Irbesartan.
Metaproterenol Metaproterenol Orciprenaline may decrease the antihypertensive activities of Irbesartan.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypotensive activities of Irbesartan.
Phenelzine Phenelzine Phenelzine may increase the hypotensive activities of Irbesartan.
Procarbazine Procarbazine Procarbazine may increase the hypotensive activities of Irbesartan.
Ergoloid Mesylates Ergoloid Mesylates Ergoloid mesylate may decrease the antihypertensive activities of Irbesartan.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Irbesartan.
Thioridazine Thioridazine Thioridazine may decrease the antihypertensive activities of Irbesartan.
Trifluoperazine Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Irbesartan.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Irbesartan.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Irbesartan.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Irbesartan.
Oxybutynin Oxybutynin The metabolism of Irbesartan can be decreased when combined with Oxybutynin.
Ibuprofen Ibuprofen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Ibuprofen.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Irbesartan.
Methylphenidate Methylphenidate Methylphenidate may decrease the antihypertensive activities of Irbesartan.
Amoxapine Amoxapine Amoxapine may decrease the antihypertensive activities of Irbesartan.
Sulfasalazine Sulfasalazine The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Sulfasalazine.
Hydrocortisone Hydrocortisone The metabolism of Irbesartan can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Irbesartan.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Irbesartan.
Methyldopa Methyldopa Methyldopa may increase the hypotensive activities of Irbesartan.
Clonidine Clonidine The risk or severity of hypotension can be increased when Clonidine is combined with Irbesartan.
Prazosin Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Irbesartan.
Hydralazine Hydralazine Irbesartan may increase the hypotensive activities of Hydralazine.
Cimetidine Cimetidine The metabolism of Irbesartan can be decreased when combined with Cimetidine.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Irbesartan.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Irbesartan.
Promethazine Promethazine The metabolism of Irbesartan can be decreased when combined with Promethazine.
Meclofenamate Meclofenamate The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Meclofenamic acid.
Nitrofurantoin Nitrofurantoin The risk or severity of hyperkalemia can be increased when Nitrofurantoin is combined with Irbesartan.
Griseofulvin Griseofulvin The metabolism of Irbesartan can be increased when combined with Griseofulvin.
Digoxin Digoxin The risk or severity of hyperkalemia can be increased when Digoxin is combined with Irbesartan.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Irbesartan.
Quinine Quinine The metabolism of Irbesartan can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of hyperkalemia can be increased when Ethosuximide is combined with Irbesartan.
Triamterene Triamterene The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone The metabolism of Irbesartan can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Irbesartan can be increased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the hypotensive activities of Irbesartan.
Metolazone Metolazone Metolazone may increase the hypotensive activities of Irbesartan.
Secobarbital Secobarbital The metabolism of Irbesartan can be increased when combined with Secobarbital.
Desipramine Desipramine Desipramine may decrease the antihypertensive activities of Irbesartan.
Amitriptyline Amitriptyline The metabolism of Irbesartan can be decreased when combined with Amitriptyline.
Imipramine Imipramine Imipramine may decrease the antihypertensive activities of Irbesartan.
Probenecid Probenecid The metabolism of Irbesartan can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Irbesartan can be decreased when combined with Quinidine.
Isoniazid Isoniazid The metabolism of Irbesartan can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Irbesartan can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Irbesartan can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Irbesartan can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Butabarbital may increase the hypotensive activities of Irbesartan.
Levothyroxine Levothyroxine The metabolism of Irbesartan can be decreased when combined with Levothyroxine.
Methimazole Methimazole The metabolism of Irbesartan can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The metabolism of Irbesartan can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Irbesartan.
Tolazamide Tolazamide The metabolism of Irbesartan can be decreased when combined with Tolazamide.
Dextromethorphan Dextromethorphan The metabolism of Irbesartan can be decreased when combined with Dextromethorphan.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Irbesartan.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Irbesartan can be increased when used in combination with Methyclothiazide.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Dantrolene.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The risk or severity of hyperkalemia can be increased when Propranolol is combined with Irbesartan.
Minoxidil Minoxidil Minoxidil may increase the hypotensive activities of Irbesartan.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Irbesartan.
Nortriptyline Nortriptyline The metabolism of Irbesartan can be decreased when combined with Nortriptyline.
Spironolactone Spironolactone The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of adverse effects can be increased when Amphotericin B is combined with Irbesartan.
Nadolol Nadolol The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Nadolol.
Papaverine Papaverine The risk or severity of adverse effects can be increased when Papaverine is combined with Irbesartan.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Irbesartan.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Irbesartan.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Irbesartan.
Ketoconazole Ketoconazole The metabolism of Irbesartan can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Irbesartan.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Irbesartan.
Captopril Captopril The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Captopril is combined with Irbesartan.
Dipyridamole Dipyridamole Dipyridamole may increase the antihypertensive activities of Irbesartan.
Isoxsuprine Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Irbesartan.
Vinblastine Vinblastine The metabolism of Vinblastine can be decreased when combined with Irbesartan.
Ethacrynic Acid Ethacrynic Acid The risk or severity of adverse effects can be increased when Etacrynic acid is combined with Irbesartan.
Metoprolol Metoprolol The metabolism of Irbesartan can be decreased when combined with Metoprolol.
Aspirin Aspirin The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Acetylsalicylic acid.
Salsalate Salsalate The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Salsalate.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Irbesartan.
Trimethoprim Trimethoprim The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Irbesartan.
Diltiazem Diltiazem The metabolism of Irbesartan can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The serum concentration of the active metabolites of Irbesartan can be increased when Irbesartan is used in combination with Nifedipine.
Timolol Timolol The risk or severity of hyperkalemia can be increased when Timolol is combined with Irbesartan.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Irbesartan.
Atenolol Atenolol The risk or severity of hyperkalemia can be increased when Atenolol is combined with Irbesartan.
Pindolol Pindolol The risk or severity of hyperkalemia can be increased when Pindolol is combined with Irbesartan.
Cisplatin Injection Cisplatin Injection The metabolism of Irbesartan can be decreased when combined with Cisplatin.
Diflunisal Diflunisal The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Diflunisal.
Piroxicam Piroxicam The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Piroxicam.
Bumetanide Bumetanide The risk or severity of adverse effects can be increased when Bumetanide is combined with Irbesartan.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Irbesartan.
Glyburide Glyburide The metabolism of Irbesartan can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Irbesartan.
Indapamide Indapamide The therapeutic efficacy of Irbesartan can be increased when used in combination with Indapamide.
Pentoxifylline Pentoxifylline Pentoxifylline may increase the hypotensive activities of Irbesartan.
Pentamidine Injection Pentamidine Injection The risk or severity of hyperkalemia can be increased when Pentamidine is combined with Irbesartan.
Labetalol Labetalol The risk or severity of hyperkalemia can be increased when Labetalol is combined with Irbesartan.
Gemfibrozil Gemfibrozil The metabolism of Irbesartan can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz Irbesartan may decrease the antihypertensive activities of Guanabenz.
Ketoprofen Ketoprofen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Ketoprofen.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Irbesartan.
Enalapril Enalapril The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Enalapril is combined with Irbesartan.
Flurbiprofen Flurbiprofen The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Irbesartan.
Buspirone Buspirone Buspirone may decrease the antihypertensive activities of Irbesartan.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Irbesartan.
Ciprofloxacin Ciprofloxacin The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Ciprofloxacin.
Mesalamine Mesalamine The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Mesalazine.
Diclofenac Diclofenac The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Diclofenac.
Fluoxetine Fluoxetine The metabolism of Irbesartan can be decreased when combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of hyperkalemia can be increased when Nimodipine is combined with Irbesartan.
Clozapine Clozapine Clozapine may decrease the antihypertensive activities of Irbesartan.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Irbesartan.
Benazepril Benazepril The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Benazepril is combined with Irbesartan.
Etodolac Etodolac The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Etodolac.
Felodipine Felodipine The metabolism of Irbesartan can be decreased when combined with Felodipine.
Fosinopril Fosinopril The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Fosinopril is combined with Irbesartan.
Nabumetone Nabumetone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Nabumetone.
Quinapril Quinapril The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Quinapril is combined with Irbesartan.
Ramipril Ramipril The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Ramipril is combined with Irbesartan.
Simvastatin Simvastatin The metabolism of Irbesartan can be decreased when combined with Simvastatin.
Amlodipine Amlodipine Amlodipine may increase the hypotensive activities of Irbesartan.
Teniposide Injection Teniposide Injection The metabolism of Irbesartan can be decreased when combined with Teniposide.
Itraconazole Itraconazole The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Itraconazole.
Lisinopril Lisinopril The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Lisinopril is combined with Irbesartan.
Oxaprozin Oxaprozin The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Oxaprozin.
Atovaquone Atovaquone The metabolism of Irbesartan can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Irbesartan can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of hyperkalemia can be increased when Sotalol is combined with Irbesartan.
Bisoprolol Bisoprolol The risk or severity of hyperkalemia can be increased when Bisoprolol is combined with Irbesartan.
Zolpidem Zolpidem The metabolism of Irbesartan can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Irbesartan.
Terazosin Terazosin Irbesartan may increase the hypotensive activities of Terazosin.
Isradipine Isradipine The risk or severity of hyperkalemia can be increased when Isradipine is combined with Irbesartan.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Irbesartan.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Irbesartan.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Irbesartan.
Venlafaxine Venlafaxine The metabolism of Irbesartan can be decreased when combined with Venlafaxine.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Irbesartan.
Fluvoxamine Fluvoxamine The metabolism of Irbesartan can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone Nefazodone may decrease the antihypertensive activities of Irbesartan.
Lamotrigine Lamotrigine The risk or severity of hyperkalemia can be increased when Lamotrigine is combined with Irbesartan.
Losartan Losartan The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Losartan is combined with Irbesartan.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Irbesartan.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Irbesartan.
Moexipril Moexipril The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Moexipril is combined with Irbesartan.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Irbesartan.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Irbesartan.
Nicardipine Nicardipine The metabolism of Irbesartan can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Irbesartan.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Irbesartan.
Saquinavir Saquinavir The metabolism of Irbesartan can be decreased when combined with Saquinavir.
Dalteparin Injection Dalteparin Injection The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Dalteparin.
Nisoldipine Nisoldipine Nisoldipine may increase the hypotensive activities of Irbesartan.
Amifostine Injection Amifostine Injection Irbesartan may increase the hypotensive activities of Amifostine.
Glimepiride Glimepiride The metabolism of Irbesartan can be decreased when combined with Glimepiride.
Anastrozole Anastrozole The metabolism of Irbesartan can be decreased when combined with Anastrozole.
Ritonavir Ritonavir The metabolism of Irbesartan can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Irbesartan.
Clomipramine Clomipramine The metabolism of Irbesartan can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Irbesartan can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine Mirtazapine may decrease the antihypertensive activities of Irbesartan.
Trandolapril Trandolapril The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Trandolapril is combined with Irbesartan.
Zileuton Zileuton The metabolism of Irbesartan can be decreased when combined with Zileuton.
Valsartan Valsartan The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Valsartan is combined with Irbesartan.
Pramipexole Pramipexole The risk or severity of adverse effects can be increased when Pramipexole is combined with Irbesartan.
Donepezil Donepezil The metabolism of Irbesartan can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Irbesartan can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Irbesartan.
Loratadine Loratadine The metabolism of Irbesartan can be decreased when combined with Loratadine.
Carvedilol Carvedilol The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Irbesartan can be decreased when combined with Nilutamide.
Selegiline Selegiline Selegiline may increase the hypotensive activities of Irbesartan.
Bicalutamide Bicalutamide The metabolism of Irbesartan can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Irbesartan can be decreased when combined with Sertraline.
Propafenone Propafenone The risk or severity of hyperkalemia can be increased when Propafenone is combined with Irbesartan.
Raloxifene Raloxifene The metabolism of Irbesartan can be decreased when combined with Raloxifene.
Tamsulosin Tamsulosin The risk or severity of adverse effects can be increased when Tamsulosin is combined with Irbesartan.
Ropinirole Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Irbesartan.
Finasteride Finasteride Finasteride may decrease the antihypertensive activities of Irbesartan.
Quetiapine Quetiapine Irbesartan may increase the hypotensive activities of Quetiapine.
Paroxetine Paroxetine The metabolism of Irbesartan can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Irbesartan can be decreased when combined with Tolcapone.
Capecitabine Capecitabine The metabolism of Irbesartan can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Irbesartan can be decreased when combined with Efavirenz.
Sildenafil Sildenafil Sildenafil may increase the antihypertensive activities of Irbesartan.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Irbesartan.
Celecoxib Celecoxib The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Irbesartan can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Irbesartan.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Irbesartan.
Balsalazide Balsalazide The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Balsalazide.
Nateglinide Nateglinide The metabolism of Irbesartan can be decreased when combined with Nateglinide.
Rabeprazole Rabeprazole The metabolism of Irbesartan can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Irbesartan.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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