Tolmetin

Generic name: Pronounced as (tole' met in)
Brand names
  • Tolectin®
  • Tolectin® DS
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2021

People who take nonsteroidal anti-inflammatory medications (NSAIDs) (other than aspirin) such as tolmetin may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as tolmetin if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke,and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take tolmetin right before or right after the surgery.

NSAIDs such as tolmetin may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while taking tolmetin. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking tolmetin and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to tolmetin. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with tolmetin and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

Tolmetin is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Tolmetin is also used to relieve pain, tenderness, swelling, and stiffness caused by juvenile rheumatoid arthritis in children 2 years of age and older. Tolmetin is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

Tolmetin comes as a tablet and a capsule to take by mouth. Adults usually take tolmetin three times a day on an empty stomach, and children older than 2 years of age usually take tolmetin three or four times a day on an empty stomach. Take tolmetin at around the same times every day. It is best to take the first dose of the day just after waking in the morning and to take the last dose of the day at bedtime. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tolmetin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Tell your doctor if tolmetin upsets your stomach. Your doctor may tell you to take tolmetin with an antacid to prevent stomach upset. Your doctor will tell you which antacids are safe to take with tolmetin.

Tolmetin may help to control your symptoms but will not cure your condition. Your symptoms may improve within one week after you start to take tolmetin, but it may take several weeks or longer for you to feel the full benefit of the medication. Talk to your doctor about how tolmetin is working for you.

Tolmetin is also used to treat ankylosing spondylitis (arthritis that mainly affects the spine). It is also sometimes used to treat certain conditions that cause muscle strain or swelling in the shoulder or elbow and injuries such as recent sprains.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tolmetin,

  • tell your doctor and pharmacist if you are allergic to tolmetin, aspirin, or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), any other medications, or any of the inactive ingredients in tolmetin tablets or capsules. Ask your pharmacist for a list of the inactive ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); diuretics ('water pills'); lithium (Lithobid); and methotrexate (Otrexup, Rasuvo, Trexall). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); heart failure; swelling of the hands, feet, ankles, or lower legs; or liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant; or are breast-feeding. Tolmetin may harm the fetus and cause problems with delivery if it is taken around 20 weeks or later during pregnancy. Do not take tolmetin around or after 20 weeks of pregnancy, unless you are told to do so by your doctor. If you become pregnant while taking tolmetin, call your doctor.

  • talk to your doctor about the risks and benefits of taking tolmetin if you are 75 years of age or older. Do not take this medication for a longer period of time or at a higher dose than recommended by your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tolmetin.

  • you should know that this drug may make you dizzy. Do not drive a car or operate machinery until you know how this drug affects you.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Tolmetin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • constipation

    • gas

    • weight gain or loss

    • headache

    • depression

    • skin irritation

    • ringing in the ears

  • Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more tolmetin until you speak to your doctor:

    • changes in vision

    • unexplained weight gain

    • shortness of breath or difficulty breathing

    • swelling of the stomach, feet, ankles, or lower legs

    • fever

    • blisters

    • rash

    • itching

    • hives

    • swelling of the eyes, face, lips, tongue, throat, arms, or hands

    • difficulty swallowing

    • hoarseness

    • yellowing of the skin or eyes

    • excessive tiredness

    • unusual bleeding or bruising

    • lack of energy

    • upset stomach

    • loss of appetite

    • pain in the upper right part of the stomach

    • flu-like symptoms

    • pale skin

    • fast heartbeat

    • cloudy, discolored, or bloody urine

    • back pain

    • difficult or painful urination

  • Tolmetin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking tolmetin.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin Tolmetin may increase the neuroexcitatory activities of Moxifloxacin.
Alendronate Alendronate The risk or severity of adverse effects can be increased when Tolmetin is combined with Alendronic acid.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Tolmetin is combined with Anagrelide.
Candesartan Candesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Candesartan is combined with Tolmetin.
Cilostazol Cilostazol The risk or severity of bleeding can be increased when Tolmetin is combined with Cilostazol.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Tolmetin is combined with Clopidogrel.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Tolmetin may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate Tolmetin may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The therapeutic efficacy of Guanfacine can be decreased when used in combination with Tolmetin.
Magnesium Hydroxide Magnesium Hydroxide Tolmetin may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Tolmetin.
Mycophenolate Mycophenolate Tolmetin may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of hypertension can be increased when Tolmetin is combined with Naratriptan.
Olsalazine Olsalazine The therapeutic efficacy of Olsalazine can be decreased when used in combination with Tolmetin.
Penbutolol Penbutolol Tolmetin may decrease the antihypertensive activities of Acebutolol.
Potassium Potassium Tolmetin may decrease the excretion rate of Potassium cation which could result in a higher serum level.
Prednisone Prednisone The risk or severity of gastrointestinal irritation can be increased when Tolmetin is combined with Prednisone.
Ranitidine Ranitidine Tolmetin may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine Reserpine The therapeutic efficacy of Reserpine can be decreased when used in combination with Tolmetin.
Rizatriptan Rizatriptan Tolmetin may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan Tolmetin may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The risk or severity of renal failure can be increased when Tolmetin is combined with Tacrolimus.
Tiludronate Tiludronate The risk or severity of gastrointestinal bleeding can be increased when Tolmetin is combined with Etidronic acid.
Triamcinolone Triamcinolone The risk or severity of gastrointestinal irritation can be increased when Triamcinolone is combined with Tolmetin.
Zolmitriptan Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Tolmetin.
Ampicillin Injection Ampicillin Injection Tolmetin may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Tolmetin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Tolmetin may decrease the excretion rate of Fluconazole which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection Tolmetin may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Tolmetin may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection Tolmetin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone is combined with Tolmetin.
Metoclopramide Injection Metoclopramide Injection Tolmetin may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection The risk or severity of gastrointestinal bleeding can be increased when Tolmetin is combined with Pamidronic acid.
Vancomycin Injection Vancomycin Injection Tolmetin may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The risk or severity of bleeding can be increased when Zidovudine is combined with Tolmetin.
Altretamine Altretamine Tolmetin may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Cefuroxime Cefuroxime The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefuroxime.
Cyclosporine Cyclosporine The risk or severity of renal failure and hypertension can be increased when Tolmetin is combined with Cyclosporine.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Enoxaparin.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Tolmetin.
Eprosartan Eprosartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Eprosartan is combined with Tolmetin.
Meloxicam Meloxicam The risk or severity of adverse effects can be increased when Tolmetin is combined with Meloxicam.
Pantoprazole Pantoprazole Tolmetin may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Risedronate Risedronate The risk or severity of gastrointestinal bleeding can be increased when Tolmetin is combined with Risedronic acid.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Tolmetin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Telmisartan is combined with Tolmetin.
Temozolomide Temozolomide Tolmetin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Tolmetin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Linezolid Linezolid The risk or severity of hypertension can be increased when Tolmetin is combined with Linezolid.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Pentosan polysulfate.
Trimipramine Trimipramine The risk or severity of hypertension can be increased when Tolmetin is combined with Trimipramine.
Perindopril Perindopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Perindopril.
Tenofovir Tenofovir Tolmetin may increase the nephrotoxic activities of Tenofovir.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of adverse effects can be increased when Tolmetin is combined with Choline magnesium trisalicylate.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Tolmetin is combined with Dutasteride.
Epinephrine Injection Epinephrine Injection The risk or severity of hypertension can be increased when Tolmetin is combined with Epinephrine.
Eplerenone Eplerenone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Eplerenone.
Escitalopram Escitalopram The risk or severity of gastrointestinal bleeding can be increased when Escitalopram is combined with Tolmetin.
Olmesartan Olmesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Olmesartan is combined with Tolmetin.
Zonisamide Zonisamide Tolmetin may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Aripiprazole Aripiprazole The risk or severity of hypertension can be increased when Tolmetin is combined with Aripiprazole.
Atomoxetine Atomoxetine Tolmetin may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
Dexmethylphenidate Dexmethylphenidate The risk or severity of hypertension can be increased when Tolmetin is combined with Dexmethylphenidate.
Atazanavir Atazanavir The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Atazanavir.
Almotriptan Almotriptan Tolmetin may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Eletriptan Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Tolmetin.
Emtricitabine Emtricitabine Tolmetin may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Tolmetin may decrease the excretion rate of Memantine which could result in a higher serum level.
Tadalafil Tadalafil Tolmetin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan Frovatriptan The risk or severity of hypertension can be increased when Tolmetin is combined with Frovatriptan.
Gemifloxacin Gemifloxacin Tolmetin may increase the neuroexcitatory activities of Gemifloxacin.
Protriptyline Protriptyline The risk or severity of hypertension can be increased when Protriptyline is combined with Tolmetin.
Duloxetine Duloxetine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Tolmetin.
Tinidazole Tinidazole Tolmetin may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan Bosentan The therapeutic efficacy of Bosentan can be decreased when used in combination with Tolmetin.
Cefditoren Cefditoren Tolmetin may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Tolmetin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Eszopiclone Eszopiclone Tolmetin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ganciclovir Ganciclovir Tolmetin may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Tolmetin may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of hypertension can be increased when Tolmetin is combined with Solifenacin.
Valganciclovir Valganciclovir Tolmetin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Zoledronic Acid Injection Zoledronic Acid Injection The risk or severity of gastrointestinal bleeding can be increased when Tolmetin is combined with Zoledronic acid.
Adefovir Adefovir The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Adefovir.
Dextroamphetamine Dextroamphetamine Tolmetin may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Ibandronate Ibandronate The risk or severity of gastrointestinal bleeding can be increased when Tolmetin is combined with Ibandronate.
Isocarboxazid Isocarboxazid The risk or severity of hypertension can be increased when Tolmetin is combined with Isocarboxazid.
Ramelteon Ramelteon Tolmetin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Tolmetin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pregabalin Pregabalin Tolmetin may decrease the excretion rate of Pregabalin which could result in a higher serum level.
Deferasirox Deferasirox The risk or severity of gastrointestinal bleeding and peptic ulcer can be increased when Tolmetin is combined with Deferasirox.
Phenylephrine Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Tolmetin.
Ranolazine Ranolazine Tolmetin may decrease the excretion rate of Ranolazine which could result in a higher serum level.
Rasagiline Rasagiline Tolmetin may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Sitagliptin Sitagliptin Tolmetin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Tolmetin may decrease the excretion rate of Varenicline which could result in a higher serum level.
Albuterol Albuterol Tolmetin may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone Tolmetin may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Clofarabine Injection Clofarabine Injection Tolmetin may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone Lubiprostone Tolmetin may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Aliskiren Aliskiren The risk or severity of renal failure and hypertension can be increased when Tolmetin is combined with Aliskiren.
Bismuth Subsalicylate Bismuth Subsalicylate The therapeutic efficacy of Bismuth subsalicylate can be decreased when used in combination with Tolmetin.
Pemetrexed Injection Pemetrexed Injection Tolmetin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lisdexamfetamine Lisdexamfetamine The risk or severity of hypertension can be increased when Tolmetin is combined with Lisdexamfetamine.
Sorafenib Sorafenib Tolmetin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Levocetirizine Levocetirizine Tolmetin may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Tolmetin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Tolmetin may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Lenalidomide Lenalidomide Tolmetin may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Budesonide Budesonide The risk or severity of gastrointestinal irritation can be increased when Tolmetin is combined with Budesonide.
Desmopressin Desmopressin The risk or severity of hypertension, hyponatremia, and water intoxication can be increased when Tolmetin is combined with Desmopressin.
Doripenem Injection Doripenem Injection Tolmetin may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Tolmetin may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine The risk or severity of gastrointestinal bleeding can be increased when Desvenlafaxine is combined with Tolmetin.
Cevimeline Cevimeline Tolmetin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
Nebivolol Nebivolol Tolmetin may decrease the antihypertensive activities of Nebivolol.
Certolizumab Injection Certolizumab Injection Tolmetin may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Daptomycin Injection Daptomycin Injection Tolmetin may decrease the excretion rate of Daptomycin which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Tolmetin may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Midazolam Midazolam Tolmetin may decrease the excretion rate of Midazolam which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Tolmetin may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Milnacipran Milnacipran The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Tolmetin.
Plerixafor Injection Plerixafor Injection Tolmetin may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The risk or severity of renal failure can be increased when Sodium phosphate, monobasic is combined with Tolmetin.
Fesoterodine Fesoterodine Tolmetin may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Betaxolol Betaxolol Tolmetin may decrease the antihypertensive activities of Betaxolol.
Iloperidone Iloperidone The risk or severity of hypertension can be increased when Tolmetin is combined with Iloperidone.
Prasugrel Prasugrel The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Prasugrel.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Tolvaptan.
Dronedarone Dronedarone The risk or severity of hypertension can be increased when Tolmetin is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Tolmetin may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Tolmetin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Saxagliptin Saxagliptin Tolmetin may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Tolmetin may decrease the excretion rate of Telavancin which could result in a higher serum level.
Topotecan Topotecan Tolmetin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Asenapine Asenapine The risk or severity of hypertension can be increased when Tolmetin is combined with Asenapine.
Dabigatran Dabigatran The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Dabigatran.
Dalfampridine Dalfampridine Tolmetin may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Ceftaroline Injection Ceftaroline Injection The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Ceftaroline fosamil.
Lurasidone Lurasidone The risk or severity of hypertension can be increased when Tolmetin is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The risk or severity of adverse effects can be increased when Acetaminophen is combined with Tolmetin.
Vilazodone Vilazodone The risk or severity of hypertension can be increased when Tolmetin is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Tolmetin may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Tolmetin may decrease the excretion rate of Aldesleukin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Tolmetin may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Azilsartan medoxomil is combined with Tolmetin.
Roflumilast Roflumilast Tolmetin may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Tolmetin.
Rivaroxaban Rivaroxaban The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Rivaroxaban.
Ticagrelor Ticagrelor The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Ticagrelor.
Ruxolitinib Ruxolitinib Tolmetin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Tolmetin may decrease the excretion rate of Clobazam which could result in a higher serum level.
Deferiprone Deferiprone Tolmetin may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Cabergoline Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Tolmetin.
Naloxone Injection Naloxone Injection Tolmetin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan Ambrisentan The therapeutic efficacy of Ambrisentan can be decreased when used in combination with Tolmetin.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Fondaparinux.
Iloprost Iloprost The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Iloprost.
Enzalutamide Enzalutamide Tolmetin may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Tolmetin may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of gastrointestinal irritation can be increased when Corticotropin is combined with Tolmetin.
Teduglutide Injection Teduglutide Injection Tolmetin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Tolmetin is combined with Icosapent ethyl.
Alogliptin Alogliptin Tolmetin may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Pomalidomide Pomalidomide Tolmetin may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Apixaban Apixaban The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Apixaban.
Canagliflozin Canagliflozin Tolmetin may decrease the excretion rate of Canagliflozin which could result in a higher serum level.
Trametinib Trametinib Tolmetin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The risk or severity of gastrointestinal bleeding can be increased when Levomilnacipran is combined with Tolmetin.
Ertapenem Injection Ertapenem Injection Tolmetin may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine Vortioxetine Tolmetin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ketorolac Injection Ketorolac Injection The risk or severity of adverse effects can be increased when Ketorolac is combined with Tolmetin.
Sofosbuvir Sofosbuvir Tolmetin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Apremilast Apremilast Tolmetin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Tolmetin may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Testosterone Injection Testosterone Injection Tolmetin may decrease the excretion rate of Testosterone which could result in a higher serum level.
Vorapaxar Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Vorapaxar.
Edoxaban Edoxaban The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Edoxaban.
Methamphetamine Methamphetamine Tolmetin may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Tolmetin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat The therapeutic efficacy of Riociguat can be decreased when used in combination with Tolmetin.
Risperidone Injection Risperidone Injection The risk or severity of hypertension can be increased when Tolmetin is combined with Risperidone.
Haloperidol Injection Haloperidol Injection The therapeutic efficacy of Haloperidol can be increased when used in combination with Tolmetin.
Amiloride Amiloride The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Amiloride.
Macitentan Macitentan The therapeutic efficacy of Macitentan can be decreased when used in combination with Tolmetin.
Flibanserin Flibanserin The risk or severity of hypertension can be increased when Tolmetin is combined with Flibanserin.
Prednisolone Prednisolone The risk or severity of gastrointestinal irritation can be increased when Prednisolone is combined with Tolmetin.
Brexpiprazole Brexpiprazole The risk or severity of hypertension can be increased when Tolmetin is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of hypertension can be increased when Ziprasidone is combined with Tolmetin.
Cariprazine Cariprazine The risk or severity of hypertension can be increased when Tolmetin is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Tolmetin may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Ixazomib Ixazomib Tolmetin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Tolmetin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The risk or severity of gastrointestinal irritation can be increased when Dexamethasone is combined with Tolmetin.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Defibrotide.
Brivaracetam Injection Brivaracetam Injection Tolmetin may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Midodrine Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Tolmetin.
Selexipag Selexipag The therapeutic efficacy of Selexipag can be decreased when used in combination with Tolmetin.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Tolmetin.
Lixisenatide Injection Lixisenatide Injection Tolmetin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Tolmetin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Tolmetin may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Tolmetin may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of gastrointestinal irritation can be increased when Deflazacort is combined with Tolmetin.
Safinamide Safinamide The risk or severity of hypertension can be increased when Tolmetin is combined with Safinamide.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Tolmetin.
Naldemedine Naldemedine Tolmetin may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Benznidazole Benznidazole Tolmetin may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Tolmetin may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Tolmetin.
Apalutamide Apalutamide Tolmetin may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib Baricitinib Tolmetin may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Tolmetin.
Plazomicin Injection Plazomicin Injection Tolmetin may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Cannabidiol Cannabidiol The risk or severity of hypertension can be increased when Tolmetin is combined with Cannabidiol.
Stiripentol Stiripentol Tolmetin may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Prucalopride Prucalopride Tolmetin may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Siponimod Siponimod The risk or severity of hypertension can be increased when Tolmetin is combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic Tolmetin may decrease the excretion rate of Acyclovir which could result in a higher serum level.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Tolmetin is combined with Caplacizumab.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Tolmetin.
Pitolisant Pitolisant The risk or severity of adverse effects can be increased when Tolmetin is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The serum concentration of Phenytoin can be increased when it is combined with Tolmetin.
Selpercatinib Selpercatinib The risk or severity of hypertension can be increased when Tolmetin is combined with Selpercatinib.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Tolmetin is combined with Naxitamab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Drospirenone.
Viloxazine Viloxazine Tolmetin may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tolmetin may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Fenoprofen Fenoprofen The risk or severity of adverse effects can be increased when Tolmetin is combined with Fenoprofen.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Tolmetin.
Mefenamic Acid Mefenamic Acid The risk or severity of adverse effects can be increased when Tolmetin is combined with Mefenamic acid.
Naproxen Naproxen The risk or severity of adverse effects can be increased when Tolmetin is combined with Naproxen.
Sulindac Sulindac The risk or severity of adverse effects can be increased when Tolmetin is combined with Sulindac.
Trazodone Trazodone The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Tolmetin.
Isotretinoin Isotretinoin Tolmetin may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Tolmetin may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Floxuridine Floxuridine Tolmetin may decrease the excretion rate of Floxuridine which could result in a higher serum level.
Metaxalone Metaxalone Tolmetin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The serum concentration of Methotrexate can be increased when it is combined with Tolmetin.
Methsuximide Methsuximide The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of hypertension can be increased when Tolmetin is combined with Diethylpropion.
Chlorpromazine Chlorpromazine Tolmetin may decrease the excretion rate of Chlorpromazine which could result in a higher serum level.
Diazepam Diazepam Tolmetin may decrease the excretion rate of Diazepam which could result in a higher serum level.
Oxazepam Oxazepam Tolmetin may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Flurazepam Flurazepam Tolmetin may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate Clorazepate Tolmetin may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Tolmetin may decrease the excretion rate of Lorazepam which could result in a higher serum level.
Phenoxybenzamine Phenoxybenzamine The therapeutic efficacy of Phenoxybenzamine can be decreased when used in combination with Tolmetin.
Carmustine Carmustine Tolmetin may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine Amantadine Tolmetin may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine Tolmetin may decrease the excretion rate of Codeine which could result in a higher serum level.
Bromocriptine Bromocriptine The risk or severity of hypertension can be increased when Tolmetin is combined with Bromocriptine.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Tolmetin is combined with Orciprenaline.
Tranylcypromine Tranylcypromine The risk or severity of hypertension can be increased when Tolmetin is combined with Tranylcypromine.
Phenelzine Phenelzine Tolmetin may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of hypertension can be increased when Tolmetin is combined with Ergoloid mesylate.
Tetracycline Tetracycline Tolmetin may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Thioridazine Thioridazine The risk or severity of hypertension can be increased when Tolmetin is combined with Thioridazine.
Trifluoperazine Trifluoperazine The risk or severity of hypertension can be increased when Tolmetin is combined with Trifluoperazine.
Bleomycin Bleomycin Tolmetin may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Sulfadiazine Sulfadiazine Tolmetin may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Methadone Methadone Tolmetin may decrease the excretion rate of Methadone which could result in a higher serum level.
Benztropine Benztropine Tolmetin may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Tolmetin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline Tolmetin may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen The risk or severity of adverse effects can be increased when Tolmetin is combined with Ibuprofen.
Azathioprine Azathioprine Tolmetin may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Phentermine Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Tolmetin.
Methylphenidate Methylphenidate Tolmetin may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine Amoxapine The risk or severity of hypertension can be increased when Tolmetin is combined with Amoxapine.
Sulfasalazine Sulfasalazine The therapeutic efficacy of Sulfasalazine can be decreased when used in combination with Tolmetin.
Hydrocortisone Hydrocortisone The risk or severity of gastrointestinal irritation can be increased when Hydrocortisone is combined with Tolmetin.
Phenazopyridine Phenazopyridine The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Phenazopyridine.
Carbamazepine Carbamazepine Tolmetin may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Tolmetin.
Clonidine Clonidine The therapeutic efficacy of Clonidine can be decreased when used in combination with Tolmetin.
Prazosin Prazosin The therapeutic efficacy of Prazosin can be decreased when used in combination with Tolmetin.
Hydralazine Hydralazine Tolmetin may decrease the antihypertensive activities of Hydralazine.
Cimetidine Cimetidine Tolmetin may decrease the excretion rate of Cimetidine which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Tolmetin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Warfarin Warfarin The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Warfarin.
Clonazepam Clonazepam Tolmetin may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide Loperamide The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Loperamide.
Promethazine Promethazine Tolmetin may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate The risk or severity of adverse effects can be increased when Tolmetin is combined with Meclofenamic acid.
Nitrofurantoin Nitrofurantoin Tolmetin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Tolmetin may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Tolmetin may decrease the excretion rate of Chloroquine which could result in a higher serum level.
Ethosuximide Ethosuximide The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Ethosuximide.
Triamterene Triamterene The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Tolmetin is combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Tolmetin.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tolmetin.
Metolazone Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Tolmetin.
Secobarbital Secobarbital Tolmetin may decrease the excretion rate of Secobarbital which could result in a higher serum level.
Desipramine Desipramine Tolmetin may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline Amitriptyline may decrease the excretion rate of Tolmetin which could result in a higher serum level.
Imipramine Imipramine Imipramine may decrease the excretion rate of Tolmetin which could result in a higher serum level.
Probenecid Probenecid Probenecid may decrease the excretion rate of Tolmetin which could result in a higher serum level.
Quinidine Quinidine Tolmetin may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Tolmetin may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Tolmetin may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide Pyrazinamide Tolmetin may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Disopyramide Disopyramide Tolmetin may decrease the excretion rate of Disopyramide which could result in a higher serum level.
Valproic Acid Valproic Acid The protein binding of Valproic acid can be decreased when combined with Tolmetin.
Butabarbital Butabarbital Tolmetin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Liothyronine Liothyronine Tolmetin may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole Methimazole Tolmetin may decrease the excretion rate of Methimazole which could result in a higher serum level.
Chlorpropamide Chlorpropamide The protein binding of Chlorpropamide can be decreased when combined with Tolmetin.
Tolbutamide Tolbutamide The protein binding of Tolbutamide can be decreased when combined with Tolmetin.
Tolazamide Tolazamide The protein binding of Tolazamide can be decreased when combined with Tolmetin.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Tolmetin.
Baclofen Baclofen Tolmetin may decrease the excretion rate of Baclofen which could result in a higher serum level.
Ethambutol Ethambutol Tolmetin may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Tolmetin.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Tolmetin.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone Tolmetin may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Pyridoxine Pyridoxine Tolmetin may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
Folic Acid Folic Acid Tolmetin may decrease the excretion rate of Folic acid which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Tolmetin may decrease the antihypertensive activities of Propranolol.
Minoxidil Minoxidil The therapeutic efficacy of Minoxidil can be decreased when used in combination with Tolmetin.
Pseudoephedrine Pseudoephedrine The risk or severity of hypertension can be increased when Tolmetin is combined with Pseudoephedrine.
Nortriptyline Nortriptyline The risk or severity of hypertension can be increased when Tolmetin is combined with Nortriptyline.
Spironolactone Spironolactone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Amphotericin B.
Phytonadione Phytonadione Tolmetin may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Tolmetin may decrease the excretion rate of Amikacin which could result in a higher serum level.
Nadolol Nadolol Tolmetin may decrease the antihypertensive activities of Nadolol.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Tolmetin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol Tolmetin may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Flavoxate Flavoxate Tolmetin may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Colchicine Colchicine Tolmetin may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Tolmetin may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cefadroxil Cefadroxil Tolmetin may decrease the excretion rate of Cefadroxil which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefazolin.
Cephalexin Cephalexin Tolmetin may decrease the excretion rate of Cephalexin which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefoxitin.
Dacarbazine Dacarbazine Tolmetin may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Cefotaxime Injection Cefotaxime Injection The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Tolmetin.
Calcitonin Salmon Injection Calcitonin Salmon Injection Tolmetin may decrease the excretion rate of Salmon calcitonin which could result in a higher serum level.
Ketoconazole Ketoconazole The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Ketoconazole.
Pyrantel Pyrantel Tolmetin may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Captopril Captopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Captopril.
Dipyridamole Dipyridamole The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Dipyridamole.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Tolmetin is combined with Isoxsuprine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Tolmetin.
Colistimethate Injection Colistimethate Injection The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Colistimethate.
Metoprolol Metoprolol Tolmetin may decrease the antihypertensive activities of Metoprolol.
Aspirin Aspirin The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Tolmetin.
Salsalate Salsalate The risk or severity of adverse effects can be increased when Tolmetin is combined with Salsalate.
Alprazolam Alprazolam Tolmetin may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Temazepam Temazepam Tolmetin may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam Triazolam Tolmetin may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Tolmetin may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Propantheline Propantheline Tolmetin may decrease the excretion rate of Propantheline which could result in a higher serum level.
Trimethoprim Trimethoprim Tolmetin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Diltiazem Diltiazem The therapeutic efficacy of Diltiazem can be decreased when used in combination with Tolmetin.
Nifedipine Nifedipine Tolmetin may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol Tolmetin may decrease the antihypertensive activities of Timolol.
Verapamil Verapamil Tolmetin may decrease the excretion rate of Verapamil which could result in a higher serum level.
Atenolol Atenolol Tolmetin may decrease the antihypertensive activities of Atenolol.
Pindolol Pindolol Tolmetin may decrease the antihypertensive activities of Pindolol.
Cisplatin Injection Cisplatin Injection Tolmetin may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The therapeutic efficacy of Diflunisal can be decreased when used in combination with Tolmetin.
Piroxicam Piroxicam The risk or severity of adverse effects can be increased when Tolmetin is combined with Piroxicam.
Bumetanide Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Tolmetin.
Glyburide Glyburide The protein binding of Glyburide can be decreased when combined with Tolmetin.
Glipizide Glipizide The protein binding of Glipizide can be decreased when combined with Tolmetin.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Tolmetin.
Amoxicillin Amoxicillin Tolmetin may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Tolmetin may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Tolmetin is combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection Tolmetin may decrease the excretion rate of Ceftriaxone which could result in a higher serum level.
Labetalol Labetalol Tolmetin may decrease the antihypertensive activities of Labetalol.
Auranofin Auranofin Tolmetin may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Tolmetin may decrease the excretion rate of Leuprolide which could result in a higher serum level.
Gemfibrozil Gemfibrozil Tolmetin may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Guanabenz Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Tolmetin.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Adefovir dipivoxil.
Ceftazidime Injection Ceftazidime Injection Tolmetin may decrease the excretion rate of Ceftazidime which could result in a higher serum level.
Ketoprofen Ketoprofen The risk or severity of adverse effects can be increased when Tolmetin is combined with Ketoprofen.
Cefotetan Injection Cefotetan Injection Tolmetin may decrease the excretion rate of Cefotetan which could result in a higher serum level.
Enalapril Enalapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Enalapril.
Flurbiprofen Flurbiprofen The risk or severity of adverse effects can be increased when Flurbiprofen is combined with Tolmetin.
Amiodarone Amiodarone The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Tolmetin may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone Tolmetin may decrease the excretion rate of Buspirone which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin Tolmetin may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Mesalamine Mesalamine The therapeutic efficacy of Mesalazine can be decreased when used in combination with Tolmetin.
Diclofenac Diclofenac The risk or severity of adverse effects can be increased when Diclofenac is combined with Tolmetin.
Fluoxetine Fluoxetine The risk or severity of gastrointestinal bleeding can be increased when Fluoxetine is combined with Tolmetin.
Nimodipine Nimodipine The therapeutic efficacy of Nimodipine can be decreased when used in combination with Tolmetin.
Clozapine Clozapine Tolmetin may decrease the excretion rate of Clozapine which could result in a higher serum level.
Estazolam Estazolam Tolmetin may decrease the excretion rate of Estazolam which could result in a higher serum level.
Ofloxacin Ofloxacin Tolmetin may increase the neuroexcitatory activities of Ofloxacin.
Didanosine Didanosine Tolmetin may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Tolmetin may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Benazepril Benazepril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Benazepril.
Etodolac Etodolac The risk or severity of adverse effects can be increased when Tolmetin is combined with Etodolac.
Felodipine Felodipine The therapeutic efficacy of Felodipine can be decreased when used in combination with Tolmetin.
Fosinopril Fosinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Fosinopril.
Nabumetone Nabumetone The risk or severity of adverse effects can be increased when Nabumetone is combined with Tolmetin.
Quinapril Quinapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Quinapril.
Ramipril Ramipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Ramipril.
Amlodipine Amlodipine Tolmetin may decrease the antihypertensive activities of Amlodipine.
Itraconazole Itraconazole The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Itraconazole.
Lisinopril Lisinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Lisinopril.
Oxaprozin Oxaprozin The risk or severity of adverse effects can be increased when Tolmetin is combined with Oxaprozin.
Sotalol Sotalol Tolmetin may decrease the antihypertensive activities of Sotalol.
Bisoprolol Bisoprolol Tolmetin may decrease the antihypertensive activities of Bisoprolol.
Doxazosin Doxazosin The therapeutic efficacy of Doxazosin can be decreased when used in combination with Tolmetin.
Terazosin Terazosin The therapeutic efficacy of Terazosin can be decreased when used in combination with Tolmetin.
Isradipine Isradipine The therapeutic efficacy of Isradipine can be decreased when used in combination with Tolmetin.
Venlafaxine Venlafaxine Venlafaxine may increase the antiplatelet activities of Tolmetin.
Stavudine Stavudine The excretion of Stavudine can be decreased when combined with Tolmetin.
Fluvoxamine Fluvoxamine The risk or severity of gastrointestinal bleeding can be increased when Tolmetin is combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of gastrointestinal bleeding can be increased when Tolmetin is combined with Nefazodone.
Lamotrigine Lamotrigine Tolmetin may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
Losartan Losartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Losartan is combined with Tolmetin.
Valacyclovir Valacyclovir Tolmetin may decrease the excretion rate of Valaciclovir which could result in a higher serum level.
Tramadol Tramadol Tolmetin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Tolmetin may decrease the excretion rate of Carboplatin which could result in a higher serum level.
Moexipril Moexipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Moexipril.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Tolmetin.
Ifosfamide Injection Ifosfamide Injection Tolmetin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine Nicardipine The therapeutic efficacy of Nicardipine can be decreased when used in combination with Tolmetin.
Bupropion Bupropion Tolmetin may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine The risk or severity of bleeding can be increased when Tolmetin is combined with Ticlopidine.
Metformin Metformin Tolmetin may decrease the excretion rate of Metformin which could result in a higher serum level.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Dalteparin.
Nisoldipine Nisoldipine The therapeutic efficacy of Nisoldipine can be decreased when used in combination with Tolmetin.
Lamivudine Lamivudine Tolmetin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Acarbose Acarbose Tolmetin may decrease the excretion rate of Acarbose which could result in a higher serum level.
Glimepiride Glimepiride The protein binding of Glimepiride can be decreased when combined with Tolmetin.
Gemcitabine Injection Gemcitabine Injection Tolmetin may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Cidofovir Injection Cidofovir Injection Tolmetin may decrease the excretion rate of Cidofovir which could result in a higher serum level.
Meropenem Injection Meropenem Injection Tolmetin may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine Tolmetin may decrease the excretion rate of Clomipramine which could result in a higher serum level.
Fosfomycin Fosfomycin Tolmetin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Tolmetin.
Trandolapril Trandolapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Trandolapril.
Topiramate Topiramate Tolmetin may decrease the excretion rate of Topiramate which could result in a higher serum level.
Valsartan Valsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Valsartan is combined with Tolmetin.
Pramipexole Pramipexole Tolmetin may decrease the excretion rate of Pramipexole which could result in a higher serum level.
Carvedilol Carvedilol Tolmetin may decrease the antihypertensive activities of Carvedilol.
Nilutamide Nilutamide Tolmetin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Tolmetin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline The risk or severity of hypertension can be increased when Tolmetin is combined with Selegiline.
Sertraline Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Tolmetin.
Propafenone Propafenone Tolmetin may decrease the antihypertensive activities of Propafenone.
Irbesartan Irbesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Tolmetin.
Tamsulosin Tamsulosin Tolmetin may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Finasteride Finasteride The risk or severity of hypertension can be increased when Tolmetin is combined with Finasteride.
Quetiapine Quetiapine Tolmetin may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefepime.
Cefprozil Cefprozil The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefprozil.
Cefpodoxime Cefpodoxime The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefpodoxime.
Cetirizine Cetirizine Tolmetin may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Tolmetin.
Tolcapone Tolcapone Tolmetin may decrease the excretion rate of Tolcapone which could result in a higher serum level.
Citalopram Citalopram The risk or severity of gastrointestinal bleeding can be increased when Citalopram is combined with Tolmetin.
Capecitabine Capecitabine Tolmetin may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Abacavir Abacavir Tolmetin may decrease the excretion rate of Abacavir which could result in a higher serum level.
Celecoxib Celecoxib The risk or severity of adverse effects can be increased when Celecoxib is combined with Tolmetin.
Rosiglitazone Rosiglitazone Tolmetin may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Tolterodine Tolterodine Tolmetin may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Oseltamivir Oseltamivir Tolmetin may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Tolmetin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The therapeutic efficacy of Balsalazide can be decreased when used in combination with Tolmetin.
Nateglinide Nateglinide Tolmetin may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Rabeprazole Rabeprazole Tolmetin may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists