Tolmetin

91 interactions 5 explained in plain English
Also sold as: Tolectin 600 Tolectin DS Tolectin® Tolectin® DS
About Tolmetin

Tolmetin is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Tolmetin is also used to relieve pain, tenderness, swelling, and stiffness cau… Read the full Tolmetin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Nasal Spray Ketorolac Injection Ketorolac Ophthalmic Apixaban Pemetrexed Injection
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Contraindicated

Tolmetin Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Tolmetin Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Tolmetin Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Tolmetin Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Tolmetin Amitriptyline Elavil Explained An increased risk of bleeding Details Tolmetin Sertraline Explained An increased risk of bleeding Details Tolmetin Apixaban Eliquis Explained An increased risk of bleeding Details Tolmetin Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Tolmetin Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Tolmetin Betrixaban Bevyxxa® An increased risk of bleeding Details Tolmetin Anagrelide Agrylin An increased risk of bleeding Details Tolmetin Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Tolmetin Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Tolmetin Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Tolmetin Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Tolmetin Clopidogrel Plavix An increased risk of bleeding Details Tolmetin Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Tolmetin Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Tolmetin Dabigatran Pradaxa® An increased risk of bleeding Details Tolmetin Dabigatran Etexilate An increased risk of bleeding Details Tolmetin Dalteparin Injection Fragmin An increased risk of bleeding Details Tolmetin Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Tolmetin Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Tolmetin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Tolmetin Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Tolmetin Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Tolmetin Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Tolmetin Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Tolmetin Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Tolmetin Dipyridamole Permole® An increased risk of bleeding Details Tolmetin Edoxaban Savaysa An increased risk of bleeding Details Tolmetin Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Tolmetin Enoxaparin Lovenox An increased risk of bleeding Details Tolmetin Enoxaparin Injection Lovenox An increased risk of bleeding Details Tolmetin Epoprostenol Flolan An increased risk of bleeding Details Tolmetin Etodolac Lodine Increased risk of bleeding Details Tolmetin Fenoprofen Fenopron Increased risk of bleeding Details Tolmetin Flurbiprofen Ansaid Increased risk of bleeding Details Tolmetin Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Tolmetin Fondaparinux Arixtra An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.