Diclofenac Interactions
Diclofenac capsules (Zipsor, Zorvolex) and tablets (Cataflam) are used to relieve mild to moderate pain. Diclofenac extended-release tablets (Voltaren XR), tablets (Cataflam), and delayed-release tablets (available generically) are used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Diclofenac extended-release tablets and delayed-release tablets are also used to treat ankylosing spondylitis (arthritis that mainly affects the spine). Diclofenac tablets (Cataflam) are also used to treat painful menstrual periods. Diclofenac solution (Cambia) is used to treat migraine headaches in adults, but cannot be used to prevent migraines or to treat other types of headaches. Diclofenac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.
Brand Names Associated with Diclofenac
- Cambia®
- Cataflam®
- Diclofenac
- Voltaren XR®
- Zipsor®
- Zorvolex®
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- Contraindicated
- Major
- Prednisone
- Apixaban
- Warfarin
- Hydrochlorothiazide
- Sertraline
- Ticagrelor
- Escitalopram
- Furosemide
- Trazodone
- Fluoxetine
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- Eplerenone
- Epoprostenol
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- Iloprost
- Imipramine
- Indapamide
- Inotersen
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- Lepirudin
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- Lornoxicam
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- Nortriptyline
- Olsalazine
- Opipramol
- Oxaprozin
- Oxyphenbutazone
- Paramethasone
- Parecoxib
- Parnaparin
- Paroxetine
- Pemetrexed
- Pentosan Polysulfate Sodium
- Pentoxifylline
- Phenindione
- Phenprocoumon
- Phenylbutazone
- Phenyl Salicylate
- Piketoprofen
- Piretanide
- Piroxicam
- Polythiazide
- Potassium Citrate
- Prasugrel
- Prednisolone
- Proglumetacin
- Propyphenazone
- Proquazone
- Protein C
- Protriptyline
- Quinethazone
- Reviparin
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- Rofecoxib
- Salicylamide
- Salicylic Acid
- Salsalate
- Selexipag
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- Sodium Salicylate
- Sparsentan
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- Sulfinpyrazone
- Sulindac
- Sulodexide
- Tacrolimus
- Tenofovir Alafenamide
- Tenofovir Disoproxil Fumarate
- Tenoxicam
- Tianeptine
- Tiaprofenic Acid
- Ticlopidine
- Tinzaparin
- Tirofiban
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- Trimipramine
- Trolamine Salicylate
- Valdecoxib
- Vilazodone
- Vorapaxar
- Vortioxetine
- Xipamide
- Moderate
- Metoprolol
- Losartan
- Sacubitril; Valsartan
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- Atenolol
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- Amiodarone
- Aprepitant
- Azilsartan
- Azilsartan Medoxomil
- Benazepril
- Betaxolol
- Bisoprolol
- Bosentan
- Candesartan
- Captopril
- Carbamazepine
- Carteolol
- Celiprolol
- Cholestyramine
- Ciprofloxacin
- Colestipol
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What Do The Severity Ratings Mean?
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Drug interaction information is compilated from several drug compendia, including:
- Gold Standard Drug Database
- Micromedix
- Lexicomp
- PubMed
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.