Diclofenac

99 interactions 5 explained in plain English
Also sold as: Aleve Arthritis Pain Cambia Cambia® Cataflam Cataflam® Flector Licart Lofena Pennsaid Surpass Anti-Inflammatory Voltaren Voltaren XR® Xiclo Zipsor Zipsor® Zorvolex Zorvolex®
About Diclofenac

Diclofenac is an NSAID pain reliever used to treat mild to moderate pain, arthritis, and migraines. Read the full Diclofenac drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Nasal Spray Ketorolac Injection Ketorolac Ophthalmic Dabigatran Etexilate Cyclosporine Ophthalmic
4 Contraindicated 60 Major 35 Moderate
All (99) Contraindicated (4) Major (60) Moderate (35)

Contraindicated

Diclofenac Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Diclofenac Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Diclofenac Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Diclofenac Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Diclofenac Amitriptyline Elavil Explained An increased risk of bleeding Details Diclofenac Sertraline Explained An increased risk of bleeding Details Diclofenac Apixaban Eliquis Explained An increased risk of bleeding Details Diclofenac Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Diclofenac Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Diclofenac Azathioprine Azasan An increased risk of hepatotoxicity Details Diclofenac Betrixaban Bevyxxa® An increased risk of bleeding Details Diclofenac Anagrelide Agrylin An increased risk of bleeding Details Diclofenac Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Clopidogrel Plavix An increased risk of bleeding Details Diclofenac Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Diclofenac Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Diclofenac Dabigatran Pradaxa® An increased risk of bleeding Details Diclofenac Dabigatran Etexilate An increased risk of bleeding Details Diclofenac Dalteparin Injection Fragmin An increased risk of bleeding Details Diclofenac Deferiprone Ferriprox Decreased deferiprone clearance and increased deferiprone plasma concentrations Details Diclofenac Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Dipyridamole Permole® An increased risk of bleeding Details Diclofenac Edoxaban Savaysa An increased risk of bleeding Details Diclofenac Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Diclofenac Enoxaparin Lovenox An increased risk of bleeding Details Diclofenac Enoxaparin Injection Lovenox An increased risk of bleeding Details Diclofenac Epoprostenol Flolan An increased risk of bleeding Details Diclofenac Etodolac Lodine Increased risk of bleeding Details Diclofenac Fenoprofen Fenopron Increased risk of bleeding Details Diclofenac Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Fluorouracil Topical Carac Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Flurbiprofen Ansaid Increased risk of bleeding Details Diclofenac Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Diclofenac Fondaparinux Arixtra An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.