Ibuprofen

Generic name: Pronounced as (eye byoo' proe fen)
Brand names
  • Addaprin®
  • Advil®
  • Cedaprin®
  • I-Prin®
  • Midol®
  • Motrin®
  • Motrin® IB
  • NeoProfen®
  • Profen IB®
  • Proprinal®
  • Ultraprin®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2022

People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as ibuprofen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as ibuprofen if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke; if you smoke; and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take ibuprofen right before or right after the surgery.

NSAIDs such as ibuprofen may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or who drink three or more alcoholic drinks per day while taking ibuprofen. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ketoprofen and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking ibuprofen and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to ibuprofen. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with prescription ibuprofen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Prescription ibuprofen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period). Nonprescription ibuprofen is used to reduce fever and to relieve minor aches and pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Ibuprofen is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

Prescription ibuprofen comes as a tablet to take by mouth. It is usually taken three or four times a day for arthritis or every 4 to 6 hours as needed for pain. Nonprescription ibuprofen comes as a tablet, chewable tablet, suspension (liquid), and drops (concentrated liquid). Adults and children older than 12 years of age may usually take nonprescription ibuprofen every 4 to 6 hours as needed for pain or fever. Children and infants may usually be given nonprescription ibuprofen every 6 to 8 hours as needed for pain or fever, but should not be given more than 4 doses in 24 hours. Ibuprofen may be taken with food or milk to prevent stomach upset. If you are taking ibuprofen on a regular basis, you should take it at the same time(s) every day. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ibuprofen exactly as directed. Do not take more or less of it or take it more often than directed by the package label or prescribed by your doctor.

Ibuprofen comes alone and in combination with other medications. Some of these combination products are available by prescription only, and some of these combination products are available without a prescription and are used to treat cough and cold symptoms and other conditions. If your doctor has prescribed a medication that contains ibuprofen, you should be careful not to take any nonprescription medications that also contain ibuprofen.

Swallow the tablet whole; do not chew or crush it.

If you are selecting a product to treat cough or cold symptoms, ask your doctor or pharmacist for advice on which product is best for you. Check nonprescription product labels carefully before using two or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose. This is especially important if you will be giving cough and cold medications to a child.

Nonprescription cough and cold combination products, including products that contain ibuprofen, can cause serious side effects or death in young children. Do not give these products to children younger than 4 years of age. If you give these products to children 4 to 11 years of age, use caution and follow the package directions carefully.

If you are giving ibuprofen or a combination product that contains ibuprofen to a child, read the package label carefully to be sure that it is the right product for a child of that age. Do not give ibuprofen products that are made for adults to children.

Before you give an ibuprofen product to a child, check the package label to find out how much medication the child should receive. Give the dose that matches the child's age on the chart. Ask the child's doctor if you don't know how much medication to give the child.

Shake the suspension and drops well before each use to mix the medication evenly. Use the measuring cup provided to measure each dose of the suspension, and use the dosing device provided to measure each dose of the drops.

The chewable tablets may cause a burning feeling in the mouth or throat. Take the chewable tablets with food or water.

Stop taking nonprescription ibuprofen and call your doctor if your symptoms get worse, you develop new or unexpected symptoms, the part of your body that was painful becomes red or swollen, your pain lasts for more than 10 days, or your fever lasts more than 3 days. Stop giving nonprescription ibuprofen to your child and call your child's doctor if your child does not start to feel better during the first 24 hours of treatment. Also stop giving nonprescription ibuprofen to your child and call your child's doctor if your child develops new symptoms, including redness or swelling on the painful part of his body, or if your child's pain or fever get worse or lasts longer than 3 days.

Do not give nonprescription ibuprofen to a child who has a sore throat that is severe or does not go away, or that comes along with fever, headache, nausea, or vomiting. Call the child's doctor right away, because these symptoms may be signs of a more serious condition.

Ibuprofen is also sometimes used to treat ankylosing spondylitis (arthritis that mainly affects the spine), gouty arthritis (joint pain caused by a build-up of certain substances in the joints), and psoriatic arthritis (arthritis that occurs with a long-lasting skin disease that causes scaling and swelling). Talk to your doctor about the risks of using this drug for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking ibuprofen,

  • tell your doctor and pharmacist if you are allergic to ibuprofen, aspirin or other NSAIDs such as ketoprofen and naproxen (Aleve, Naprosyn), any other medications, or any of the inactive ingredients in the type of ibuprofen you plan to take. Ask your pharmacist or check the label on the package for a list of the inactive ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); diuretics ('water pills'); lithium (Lithobid); and methotrexate (Otrexup, Rasuvo, Trexall). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.

  • do not take nonprescription ibuprofen with any other medication for pain unless your doctor tells you that you should.

  • tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the inside of the nose); heart failure; swelling of the hands, arms, feet, ankles, or lower legs; lupus (a condition in which the body attacks many of its own tissues and organs, often including the skin, joints, blood, and kidneys); or liver or kidney disease. If you are giving ibuprofen to a child, tell the child's doctor if the child has not been drinking fluids or has lost a large amount of fluid from repeated vomiting or diarrhea.

  • tell your doctor if you are pregnant, plan to become pregnant; or are breast-feeding. Ibuprofen may harm the fetus and cause problems with delivery if it is taken around 20 weeks or later during pregnancy. Do not take ibuprofen around or after 20 weeks of pregnancy, unless you are told to do so by your doctor. If you become pregnant while taking ibuprofen, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking ibuprofen.

  • talk to your doctor about the risks and benefits of taking ibuprofen if you are 75 years of age or older. Do not take this medication for a longer period of time or at a higher dose than recommended on the product label or by your doctor.

  • if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability), read the package label carefully before taking nonprescription ibuprofen. Some types of nonprescription ibuprofen may be sweetened with aspartame, a source of phenylalanine.

Unless your doctor tells you otherwise, continue your normal diet.

If you are taking ibuprofen on a regular basis, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Ibuprofen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • constipation

    • diarrhea

    • gas or bloating

    • dizziness

    • nervousness

    • ringing in the ears

  • Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more ibuprofen until you speak to your doctor.

    • unexplained weight gain

    • shortness of breath or difficulty breathing

    • swelling of the abdomen, feet, ankles, or lower legs

    • fever

    • blisters

    • rash

    • itching

    • hives

    • swelling of the eyes, face, throat, arms, or hands

    • difficulty breathing or swallowing

    • hoarseness

    • excessive tiredness

    • pain in the upper right part of the stomach

    • nausea

    • loss of appetite

    • yellowing of the skin or eyes

    • flu-like symptoms

    • pale skin

    • fast heartbeat

    • cloudy, discolored, or bloody urine

    • back pain

    • difficult or painful urination

    • blurred vision, changes in color vision, or other vision problems

    • red or painful eyes

    • stiff neck

    • headache

    • confusion

    • aggression

  • Ibuprofen may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdosage may include:

  • dizziness

  • fast eye movements that you cannot control

  • slow breathing or short periods of time without breathing

  • blue color around the lips, mouth, and nose

If you are taking prescription ibuprofen, do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Advil® PM (containing Diphenhydramine, Ibuprofen)
  • Combunox® (containing Ibuprofen, Oxycodone)
  • Duexis® (containing Famotidine, Ibuprofen)
  • Ibudone® (containing Hydrocodone, Ibuprofen)
  • Reprexain® (containing Hydrocodone, Ibuprofen)
  • Vicoprofen® (containing Hydrocodone, Ibuprofen)

Drug Interaction
Moxifloxacin Moxifloxacin Ibuprofen may increase the neuroexcitatory activities of Moxifloxacin.
Repaglinide Repaglinide The metabolism of Ibuprofen can be decreased when combined with Repaglinide.
Montelukast Montelukast The metabolism of Ibuprofen can be decreased when combined with Montelukast.
Leflunomide Leflunomide The metabolism of Ibuprofen can be decreased when combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Ibuprofen can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Ibuprofen can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Ibuprofen.
Alendronate Alendronate The risk or severity of adverse effects can be increased when Ibuprofen is combined with Alendronic acid.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Ibuprofen is combined with Anagrelide.
Candesartan Candesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Candesartan is combined with Ibuprofen.
Cilostazol Cilostazol The risk or severity of bleeding can be increased when Ibuprofen is combined with Cilostazol.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Ibuprofen is combined with Clopidogrel.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The excretion of Conjugated estrogens can be decreased when combined with Ibuprofen.
Fenofibrate Fenofibrate The metabolism of Ibuprofen can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine The therapeutic efficacy of Guanfacine can be decreased when used in combination with Ibuprofen.
Magnesium Hydroxide Magnesium Hydroxide Ibuprofen may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Ibuprofen.
Mycophenolate Mycophenolate Ibuprofen may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Ibuprofen.
Olsalazine Olsalazine The risk or severity of adverse effects can be increased when Ibuprofen is combined with Olsalazine.
Paregoric Paregoric The metabolism of Ibuprofen can be decreased when combined with Morphine.
Penbutolol Penbutolol Ibuprofen may decrease the antihypertensive activities of Acebutolol.
Potassium Potassium Ibuprofen may decrease the excretion rate of Potassium cation which could result in a higher serum level.
Prednisone Prednisone The risk or severity of gastrointestinal irritation can be increased when Prednisone is combined with Ibuprofen.
Ranitidine Ranitidine The excretion of Ranitidine can be decreased when combined with Ibuprofen.
Reserpine Reserpine Ibuprofen may decrease the excretion rate of Reserpine which could result in a higher serum level.
Rizatriptan Rizatriptan Ibuprofen may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan Sumatriptan may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Tacrolimus Tacrolimus The risk or severity of renal failure can be increased when Ibuprofen is combined with Tacrolimus.
Tiludronate Tiludronate The risk or severity of gastrointestinal bleeding can be increased when Ibuprofen is combined with Etidronic acid.
Triamcinolone Triamcinolone The risk or severity of gastrointestinal irritation can be increased when Triamcinolone is combined with Ibuprofen.
Zolmitriptan Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Ibuprofen.
Ampicillin Injection Ampicillin Injection Ibuprofen may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection The metabolism of Ibuprofen can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection The risk or severity of nephrotoxicity can be increased when Ibuprofen is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Ibuprofen may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection Ibuprofen may decrease the excretion rate of Meperidine which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone is combined with Ibuprofen.
Metoclopramide Injection Metoclopramide Injection Ibuprofen may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Metronidazole Injection Metronidazole Injection The metabolism of Ibuprofen can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Ibuprofen can be decreased when combined with Morphine.
Pamidronate Injection Pamidronate Injection The risk or severity of gastrointestinal bleeding can be increased when Ibuprofen is combined with Pamidronic acid.
Vancomycin Injection Vancomycin Injection Ibuprofen may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The risk or severity of bleeding can be increased when Zidovudine is combined with Ibuprofen.
Altretamine Altretamine Ibuprofen may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Cyclosporine Cyclosporine The risk or severity of renal failure and hypertension can be increased when Ibuprofen is combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Ibuprofen can be decreased when combined with Ondansetron.
Enoxaparin Injection Enoxaparin Injection The risk or severity of hyperkalemia can be increased when Ibuprofen is combined with Enoxaparin.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Ibuprofen.
Olanzapine Olanzapine The metabolism of Ibuprofen can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Ibuprofen can be decreased when combined with Alosetron.
Eprosartan Eprosartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Eprosartan is combined with Ibuprofen.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Ibuprofen.
Meloxicam Meloxicam The risk or severity of adverse effects can be increased when Meloxicam is combined with Ibuprofen.
Pantoprazole Pantoprazole Ibuprofen may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Risedronate Risedronate The risk or severity of gastrointestinal bleeding can be increased when Ibuprofen is combined with Risedronic acid.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Ibuprofen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Telmisartan is combined with Ibuprofen.
Temozolomide Temozolomide Ibuprofen may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Ibuprofen may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Anakinra Anakinra The metabolism of Ibuprofen can be increased when combined with Anakinra.
Linezolid Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Ibuprofen.
Trimipramine Trimipramine The metabolism of Ibuprofen can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Ibuprofen can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Ibuprofen can be decreased when combined with Modafinil.
Perindopril Perindopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Perindopril.
Tenofovir Tenofovir Ibuprofen may increase the nephrotoxic activities of Tenofovir.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of adverse effects can be increased when Ibuprofen is combined with Choline magnesium trisalicylate.
Sirolimus Sirolimus The risk or severity of angioedema can be increased when Sirolimus is combined with Ibuprofen.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Ibuprofen is combined with Dutasteride.
Epinephrine Injection Epinephrine Injection The metabolism of Ibuprofen can be decreased when combined with Epinephrine.
Eplerenone Eplerenone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Ibuprofen.
Escitalopram Escitalopram The risk or severity of gastrointestinal bleeding can be increased when Escitalopram is combined with Ibuprofen.
Olmesartan Olmesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Olmesartan is combined with Ibuprofen.
Zonisamide Zonisamide Ibuprofen may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Adalimumab Injection Adalimumab Injection The metabolism of Ibuprofen can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of hypertension can be increased when Ibuprofen is combined with Aripiprazole.
Atomoxetine Atomoxetine Ibuprofen may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
Dexmethylphenidate Dexmethylphenidate The risk or severity of hypertension can be increased when Ibuprofen is combined with Dexmethylphenidate.
Atazanavir Atazanavir The metabolism of Ibuprofen can be decreased when combined with Atazanavir.
Almotriptan Almotriptan Ibuprofen may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Eletriptan Eletriptan The metabolism of Ibuprofen can be decreased when combined with Eletriptan.
Rosuvastatin Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Ibuprofen.
Aprepitant Aprepitant The metabolism of Ibuprofen can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Ibuprofen may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Ibuprofen may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod Tegaserod The metabolism of Ibuprofen can be decreased when combined with Tegaserod.
Tadalafil Tadalafil The therapeutic efficacy of Tadalafil can be decreased when used in combination with Ibuprofen.
Frovatriptan Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Ibuprofen.
Gemifloxacin Gemifloxacin Ibuprofen may increase the neuroexcitatory activities of Gemifloxacin.
Progesterone Progesterone The metabolism of Ibuprofen can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Ibuprofen can be decreased when combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Ibuprofen can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Ibuprofen can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The risk or severity of hypertension can be increased when Protriptyline is combined with Ibuprofen.
Rifaximin Rifaximin The metabolism of Ibuprofen can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Ibuprofen.
Tinidazole Tinidazole Ibuprofen may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan Bosentan The therapeutic efficacy of Bosentan can be decreased when used in combination with Ibuprofen.
Cefditoren Cefditoren The excretion of Cefdinir can be decreased when combined with Ibuprofen.
Cyanocobalamin Injection Cyanocobalamin Injection Ibuprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Ibuprofen can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone Ibuprofen may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ganciclovir Ganciclovir Ibuprofen may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Ibuprofen may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of hypertension can be increased when Ibuprofen is combined with Solifenacin.
Valganciclovir Valganciclovir Ibuprofen may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The serum concentration of Ibuprofen can be increased when it is combined with Voriconazole.
Zoledronic Acid Injection Zoledronic Acid Injection The risk or severity of gastrointestinal bleeding can be increased when Ibuprofen is combined with Zoledronic acid.
Adefovir Adefovir Adefovir may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Ibuprofen may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Ibuprofen can be increased when combined with Peginterferon alfa-2b.
Ibandronate Ibandronate The risk or severity of gastrointestinal bleeding can be increased when Ibuprofen is combined with Ibandronate.
Isocarboxazid Isocarboxazid The risk or severity of hypertension can be increased when Ibuprofen is combined with Isocarboxazid.
Ramelteon Ramelteon Ibuprofen may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Fentanyl may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Pregabalin Pregabalin Ibuprofen may decrease the excretion rate of Pregabalin which could result in a higher serum level.
Deferasirox Deferasirox The risk or severity of gastrointestinal bleeding and peptic ulcer can be increased when Ibuprofen is combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Ibuprofen can be increased when combined with Tipranavir.
Felbamate Felbamate The metabolism of Ibuprofen can be decreased when combined with Felbamate.
Ranolazine Ranolazine Ibuprofen may decrease the excretion rate of Ranolazine which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Ibuprofen can be increased when combined with Abatacept.
Rasagiline Rasagiline Ibuprofen may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Imatinib Imatinib The serum concentration of Imatinib can be decreased when it is combined with Ibuprofen.
Sitagliptin Sitagliptin The excretion of Sitagliptin can be decreased when combined with Ibuprofen.
Varenicline Varenicline Ibuprofen may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Ibuprofen can be decreased when combined with Gefitinib.
Albuterol Albuterol Ibuprofen may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone Ibuprofen may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Bortezomib Bortezomib The metabolism of Ibuprofen can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The excretion of Clofarabine can be decreased when combined with Ibuprofen.
Lubiprostone Lubiprostone Ibuprofen may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Aliskiren Aliskiren The risk or severity of renal failure and hypertension can be increased when Ibuprofen is combined with Aliskiren.
Pemetrexed Injection Pemetrexed Injection Ibuprofen may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lisdexamfetamine Lisdexamfetamine The risk or severity of hypertension can be increased when Ibuprofen is combined with Lisdexamfetamine.
Nabilone Nabilone The metabolism of Ibuprofen can be decreased when combined with Nabilone.
Sorafenib Sorafenib The metabolism of Ibuprofen can be decreased when combined with Sorafenib.
Lapatinib Lapatinib The metabolism of Ibuprofen can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine Ibuprofen may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Ibuprofen may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Armodafinil Armodafinil The metabolism of Ibuprofen can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Ibuprofen may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Temsirolimus Temsirolimus The risk or severity of angioedema can be increased when Ibuprofen is combined with Temsirolimus.
Lenalidomide Lenalidomide Ibuprofen may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Ibuprofen can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Ibuprofen can be decreased when combined with Bexarotene.
Budesonide Budesonide The risk or severity of gastrointestinal irritation can be increased when Budesonide is combined with Ibuprofen.
Desmopressin Desmopressin The risk or severity of hypertension, hyponatremia, and water intoxication can be increased when Ibuprofen is combined with Desmopressin.
Doripenem Injection Doripenem Injection Ibuprofen may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Ibuprofen can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Ibuprofen may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine The risk or severity of gastrointestinal bleeding can be increased when Ibuprofen is combined with Desvenlafaxine.
Cevimeline Cevimeline Ibuprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
Nebivolol Nebivolol Ibuprofen may decrease the antihypertensive activities of Nebivolol.
Tretinoin Tretinoin The metabolism of Ibuprofen can be decreased when combined with Tretinoin.
Leucovorin Injection Leucovorin Injection The excretion of Leucovorin can be decreased when combined with Ibuprofen.
Flecainide Flecainide The metabolism of Ibuprofen can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Ibuprofen can be increased when combined with Certolizumab pegol.
Daptomycin Injection Daptomycin Injection Ibuprofen may decrease the excretion rate of Daptomycin which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Ibuprofen may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Midazolam Midazolam Ibuprofen may decrease the excretion rate of Midazolam which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Ibuprofen may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Ibuprofen can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of gastrointestinal bleeding can be increased when Ibuprofen is combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Ibuprofen may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The risk or severity of renal failure can be increased when Sodium phosphate, monobasic is combined with Ibuprofen.
Fesoterodine Fesoterodine Ibuprofen may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Betaxolol Betaxolol Ibuprofen may decrease the antihypertensive activities of Betaxolol.
Iloperidone Iloperidone The risk or severity of hypertension can be increased when Ibuprofen is combined with Iloperidone.
Prasugrel Prasugrel The risk or severity of bleeding can be increased when Ibuprofen is combined with Prasugrel.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Ibuprofen.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Ibuprofen which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone The risk or severity of hypertension can be increased when Ibuprofen is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Ibuprofen may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Ibuprofen may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Saxagliptin Saxagliptin Ibuprofen may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Ibuprofen may decrease the excretion rate of Telavancin which could result in a higher serum level.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Ibuprofen.
Topotecan Topotecan Ibuprofen may decrease the excretion rate of Topotecan which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Ibuprofen can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Ibuprofen can be decreased when combined with Pazopanib.
Asenapine Asenapine The risk or severity of hypertension can be increased when Ibuprofen is combined with Asenapine.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Ibuprofen.
Tocilizumab Injection Tocilizumab Injection The metabolism of Ibuprofen can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Ibuprofen may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Ibuprofen.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of hypertension can be increased when Ibuprofen is combined with Lurasidone.
Vilazodone Vilazodone The risk or severity of hypertension can be increased when Ibuprofen is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Ibuprofen may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Ibuprofen may decrease the excretion rate of Aldesleukin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Ibuprofen may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Azilsartan medoxomil is combined with Ibuprofen.
Roflumilast Roflumilast Ibuprofen may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin The risk or severity of angioedema can be increased when Ibuprofen is combined with Linagliptin.
Telaprevir Telaprevir The metabolism of Ibuprofen can be decreased when combined with Glecaprevir.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Ibuprofen.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Ibuprofen can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Ibuprofen can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Ibuprofen may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The risk or severity of bleeding can be increased when Ibuprofen is combined with Ticagrelor.
Ruxolitinib Ruxolitinib Ibuprofen may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Ibuprofen may decrease the excretion rate of Clobazam which could result in a higher serum level.
Vemurafenib Vemurafenib The metabolism of Ibuprofen can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Ibuprofen can be decreased when combined with Vismodegib.
Deferiprone Deferiprone Ibuprofen may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Cabergoline Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Ibuprofen.
Naloxone Injection Naloxone Injection Ibuprofen may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan Ambrisentan The therapeutic efficacy of Ambrisentan can be decreased when used in combination with Ibuprofen.
Fondaparinux Injection Fondaparinux Injection Ibuprofen may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Iloprost Iloprost The risk or severity of bleeding can be increased when Ibuprofen is combined with Iloprost.
Enzalutamide Enzalutamide The metabolism of Ibuprofen can be increased when combined with Enzalutamide.
Mirabegron Mirabegron Ibuprofen may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Ibuprofen can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Ibuprofen can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of gastrointestinal irritation can be increased when Corticotropin is combined with Ibuprofen.
Teriflunomide Teriflunomide The metabolism of Ibuprofen can be decreased when combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Ibuprofen.
Teduglutide Injection Teduglutide Injection Ibuprofen may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Ibuprofen is combined with Icosapent ethyl.
Alogliptin Alogliptin Ibuprofen may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ibuprofen can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide Ibuprofen may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Apixaban Apixaban The risk or severity of bleeding and gastrointestinal bleeding can be increased when Ibuprofen is combined with Apixaban.
Canagliflozin Canagliflozin Ibuprofen may decrease the excretion rate of Canagliflozin which could result in a higher serum level.
Methazolamide Methazolamide Ibuprofen may increase the excretion rate of Methazolamide which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The metabolism of Ibuprofen can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Ibuprofen.
Trametinib Trametinib The metabolism of Ibuprofen can be decreased when combined with Trametinib.
Levomilnacipran Levomilnacipran The risk or severity of gastrointestinal bleeding can be increased when Ibuprofen is combined with Levomilnacipran.
Ertapenem Injection Ertapenem Injection Ibuprofen may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine Vortioxetine Ibuprofen may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ketorolac Injection Ketorolac Injection The risk or severity of adverse effects can be increased when Ketorolac is combined with Ibuprofen.
Sofosbuvir Sofosbuvir Ibuprofen may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Ibuprofen may increase the excretion rate of Dapagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast The metabolism of Ibuprofen can be increased when combined with Apremilast.
Droxidopa Droxidopa Ibuprofen may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ibuprofen can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Ibuprofen can be increased when combined with Siltuximab.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Oritavancin Injection Oritavancin Injection The metabolism of Ibuprofen can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The risk or severity of bleeding can be increased when Ibuprofen is combined with Vorapaxar.
Edoxaban Edoxaban Ibuprofen may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Methamphetamine Methamphetamine Ibuprofen may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Ibuprofen may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat The therapeutic efficacy of Riociguat can be decreased when used in combination with Ibuprofen.
Secukinumab Injection Secukinumab Injection The metabolism of Ibuprofen can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of hypertension can be increased when Risperidone is combined with Ibuprofen.
Lenvatinib Lenvatinib The metabolism of Ibuprofen can be decreased when combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Ibuprofen.
Amiloride Amiloride The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Amiloride.
Macitentan Macitentan The therapeutic efficacy of Macitentan can be decreased when used in combination with Ibuprofen.
Flibanserin Flibanserin The risk or severity of hypertension can be increased when Ibuprofen is combined with Flibanserin.
Prednisolone Prednisolone The risk or severity of gastrointestinal irritation can be increased when Prednisolone is combined with Ibuprofen.
Brexpiprazole Brexpiprazole The risk or severity of hypertension can be increased when Ibuprofen is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of hypertension can be increased when Ziprasidone is combined with Ibuprofen.
Cariprazine Cariprazine The risk or severity of hypertension can be increased when Ibuprofen is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Ibuprofen may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The excretion of Eluxadoline can be decreased when combined with Ibuprofen.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Ibuprofen.
Ixazomib Ixazomib Ibuprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Ibuprofen can be increased when combined with Rifapentine.
Lesinurad Lesinurad Ibuprofen may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The risk or severity of gastrointestinal irritation can be increased when Ibuprofen is combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Ibuprofen is combined with Defibrotide.
Brivaracetam Injection Brivaracetam Injection Ibuprofen may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Midodrine Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Ibuprofen.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Ibuprofen.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Ibuprofen.
Rucaparib Rucaparib The metabolism of Ibuprofen can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Ibuprofen may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Ibuprofen.
Doxepin (Insomnia) Doxepin (Insomnia) Ibuprofen may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Ibuprofen may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Ibuprofen may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of gastrointestinal irritation can be increased when Deflazacort is combined with Ibuprofen.
Safinamide Safinamide The metabolism of Ibuprofen can be decreased when combined with Safinamide.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Ibuprofen.
Naldemedine Naldemedine Ibuprofen may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Ibuprofen can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Ibuprofen can be decreased when combined with Enasidenib.
Benznidazole Benznidazole Ibuprofen may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Ibuprofen may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Ibuprofen.
Letermovir Letermovir The metabolism of Ibuprofen can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The metabolism of Ibuprofen can be decreased when combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The metabolism of Ibuprofen can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Ibuprofen can be decreased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Ibuprofen can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The metabolism of Ibuprofen can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The excretion of Baricitinib can be decreased when combined with Ibuprofen.
Lofexidine Lofexidine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Ibuprofen.
Plazomicin Injection Plazomicin Injection Ibuprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Ibuprofen.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Ibuprofen.
Dacomitinib Dacomitinib The metabolism of Ibuprofen can be decreased when combined with Dacomitinib.
Stiripentol Stiripentol The metabolism of Ibuprofen can be decreased when combined with Stiripentol.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Ibuprofen.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Ibuprofen.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Ibuprofen.
Rifamycin Rifamycin The metabolism of Ibuprofen can be decreased when combined with Rifamycin.
Prucalopride Prucalopride Ibuprofen may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Ibuprofen can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Ibuprofen.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Ibuprofen is combined with Caplacizumab.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Ibuprofen.
Alpelisib Alpelisib The serum concentration of Ibuprofen can be decreased when it is combined with Alpelisib.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Ibuprofen.
Triclabendazole Triclabendazole The metabolism of Ibuprofen can be decreased when combined with Triclabendazole.
Pexidartinib Pexidartinib The metabolism of Ibuprofen can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Ibuprofen.
Pitolisant Pitolisant The risk or severity of adverse effects can be increased when Ibuprofen is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The serum concentration of Phenytoin can be increased when it is combined with Ibuprofen.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Ibuprofen.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Ibuprofen.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Ibuprofen.
Cenobamate Cenobamate The serum concentration of Ibuprofen can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Ibuprofen.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Ibuprofen.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Ibuprofen.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Ibuprofen.
Pralsetinib Pralsetinib The metabolism of Ibuprofen can be decreased when combined with Pralsetinib.
Opicapone Opicapone The metabolism of Ibuprofen can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Ibuprofen can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Ibuprofen is combined with Naxitamab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Ibuprofen is combined with Drospirenone.
Viloxazine Viloxazine Ibuprofen may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Ibuprofen may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Theophylline Theophylline The metabolism of Ibuprofen can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen The risk or severity of adverse effects can be increased when Fenoprofen is combined with Ibuprofen.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Ibuprofen.
Mefenamic Acid Mefenamic Acid The risk or severity of adverse effects can be increased when Mefenamic acid is combined with Ibuprofen.
Naproxen Naproxen The risk or severity of adverse effects can be increased when Naproxen is combined with Ibuprofen.
Tolmetin Tolmetin The risk or severity of adverse effects can be increased when Tolmetin is combined with Ibuprofen.
Sulindac Sulindac The risk or severity of adverse effects can be increased when Sulindac is combined with Ibuprofen.
Trazodone Trazodone The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Ibuprofen.
Isotretinoin Isotretinoin Ibuprofen may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Ibuprofen may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Floxuridine Floxuridine The metabolism of Ibuprofen can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Ibuprofen can be decreased when combined with Phenobarbital.
Metaxalone Metaxalone Ibuprofen may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The serum concentration of Methotrexate can be increased when it is combined with Ibuprofen.
Primidone Primidone The metabolism of Ibuprofen can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of hyperkalemia can be increased when Ibuprofen is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Ibuprofen.
Chlorpromazine Chlorpromazine Chlorpromazine may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Diazepam Diazepam Diazepam may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Oxazepam Oxazepam Ibuprofen may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Flurazepam Flurazepam Ibuprofen may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate Clorazepate Ibuprofen may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Ibuprofen may decrease the excretion rate of Lorazepam which could result in a higher serum level.
Phenoxybenzamine Phenoxybenzamine The therapeutic efficacy of Phenoxybenzamine can be decreased when used in combination with Ibuprofen.
Carmustine Carmustine Ibuprofen may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine Amantadine Ibuprofen may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine Ibuprofen may decrease the excretion rate of Codeine which could result in a higher serum level.
Bromocriptine Bromocriptine The risk or severity of hypertension can be increased when Ibuprofen is combined with Bromocriptine.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Orciprenaline is combined with Ibuprofen.
Tranylcypromine Tranylcypromine The metabolism of Ibuprofen can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine Ibuprofen may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Ibuprofen.
Tetracycline Tetracycline The excretion of Tetracycline can be decreased when combined with Ibuprofen.
Thioridazine Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Ibuprofen.
Trifluoperazine Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Ibuprofen.
Bleomycin Bleomycin Ibuprofen may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Dapsone Dapsone The metabolism of Ibuprofen can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine Ibuprofen may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Methadone Methadone The metabolism of Ibuprofen can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Ibuprofen can be decreased when combined with Oxybutynin.
Benztropine Benztropine Ibuprofen may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Ibuprofen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline Ibuprofen may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Azathioprine Azathioprine Ibuprofen may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Phentermine Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Ibuprofen.
Methylphenidate Methylphenidate Ibuprofen may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine Amoxapine The risk or severity of hypertension can be increased when Amoxapine is combined with Ibuprofen.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Ibuprofen.
Hydrocortisone Hydrocortisone The risk or severity of gastrointestinal irritation can be increased when Ibuprofen is combined with Hydrocortisone.
Phenazopyridine Phenazopyridine The risk or severity of nephrotoxicity can be increased when Ibuprofen is combined with Phenazopyridine.
Carbamazepine Carbamazepine Ibuprofen may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Ibuprofen.
Clonidine Clonidine The therapeutic efficacy of Clonidine can be decreased when used in combination with Ibuprofen.
Prazosin Prazosin The therapeutic efficacy of Prazosin can be decreased when used in combination with Ibuprofen.
Hydralazine Hydralazine Ibuprofen may decrease the antihypertensive activities of Hydralazine.
Cimetidine Cimetidine The excretion of Cimetidine can be decreased when combined with Ibuprofen.
Gentamicin Injection Gentamicin Injection Ibuprofen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Warfarin Warfarin The metabolism of Warfarin can be decreased when combined with Ibuprofen.
Clonazepam Clonazepam Ibuprofen may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide Loperamide The metabolism of Ibuprofen can be decreased when combined with Loperamide.
Promethazine Promethazine The metabolism of Ibuprofen can be decreased when combined with Promethazine.
Meclofenamate Meclofenamate The risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Ibuprofen.
Nitrofurantoin Nitrofurantoin Ibuprofen may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Ibuprofen can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Ibuprofen.
Chloroquine Chloroquine The metabolism of Ibuprofen can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Ibuprofen can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of hyperkalemia can be increased when Ethosuximide is combined with Ibuprofen.
Triamterene Triamterene The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Ibuprofen is combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Ibuprofen.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Ibuprofen.
Metolazone Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Ibuprofen.
Isosorbide Isosorbide Ibuprofen may increase the excretion rate of Isosorbide which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The metabolism of Ibuprofen can be increased when combined with Secobarbital.
Desipramine Desipramine Ibuprofen may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline The metabolism of Ibuprofen can be decreased when combined with Amitriptyline.
Imipramine Imipramine Imipramine may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Probenecid Probenecid Probenecid may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Quinidine Quinidine Quinidine may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Procainamide Procainamide Ibuprofen may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Ibuprofen may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide Pyrazinamide Ibuprofen may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Rifampin Rifampin The metabolism of Ibuprofen can be increased when combined with Rifampicin.
Disopyramide Disopyramide Ibuprofen may decrease the excretion rate of Disopyramide which could result in a higher serum level.
Valproic Acid Valproic Acid The protein binding of Valproic acid can be decreased when combined with Ibuprofen.
Tamoxifen Tamoxifen The metabolism of Ibuprofen can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Ibuprofen may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Levothyroxine Levothyroxine The metabolism of Ibuprofen can be decreased when combined with Levothyroxine.
Liothyronine Liothyronine Ibuprofen may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole Methimazole The metabolism of Ibuprofen can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The protein binding of Chlorpropamide can be decreased when combined with Ibuprofen.
Tolbutamide Tolbutamide The protein binding of Tolbutamide can be decreased when combined with Ibuprofen.
Tolazamide Tolazamide The protein binding of Tolazamide can be decreased when combined with Ibuprofen.
Dextromethorphan Dextromethorphan The metabolism of Ibuprofen can be decreased when combined with Dextromethorphan.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Ibuprofen.
Baclofen Baclofen Ibuprofen may decrease the excretion rate of Baclofen which could result in a higher serum level.
Ethambutol Ethambutol Ibuprofen may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Ibuprofen.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Ibuprofen.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Ibuprofen is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone Ibuprofen may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Pyridoxine Pyridoxine Ibuprofen may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
Folic Acid Folic Acid Ibuprofen may decrease the excretion rate of Folic acid which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Ibuprofen may decrease the antihypertensive activities of Propranolol.
Minoxidil Minoxidil The therapeutic efficacy of Minoxidil can be decreased when used in combination with Ibuprofen.
Nortriptyline Nortriptyline The risk or severity of hypertension can be increased when Nortriptyline is combined with Ibuprofen.
Spironolactone Spironolactone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Mercaptopurine Mercaptopurine The excretion of Mercaptopurine can be decreased when combined with Ibuprofen.
Phytonadione Phytonadione Ibuprofen may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Ibuprofen may decrease the excretion rate of Amikacin which could result in a higher serum level.
Nadolol Nadolol Ibuprofen may decrease the antihypertensive activities of Nadolol.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Ibuprofen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol Ibuprofen may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Flavoxate Flavoxate Ibuprofen may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Ibuprofen can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Ibuprofen can be decreased when combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Cefadroxil Cefadroxil Ibuprofen may decrease the excretion rate of Cefadroxil which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Dacarbazine Dacarbazine Ibuprofen may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Ibuprofen which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Ibuprofen may decrease the excretion rate of Salmon calcitonin which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Ibuprofen can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel Ibuprofen may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Captopril Captopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Captopril.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Ibuprofen is combined with Dipyridamole.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Ibuprofen is combined with Isoxsuprine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Ibuprofen.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Metoprolol Metoprolol Ibuprofen may decrease the antihypertensive activities of Metoprolol.
Aspirin Aspirin Ibuprofen may decrease the antiplatelet activities of Acetylsalicylic acid.
Salsalate Salsalate The risk or severity of adverse effects can be increased when Ibuprofen is combined with Salsalate.
Alprazolam Alprazolam Ibuprofen may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Temazepam Temazepam Ibuprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam Triazolam Ibuprofen may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Ibuprofen may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Propantheline Propantheline Ibuprofen may decrease the excretion rate of Propantheline which could result in a higher serum level.
Trimethoprim Trimethoprim The metabolism of Ibuprofen can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The therapeutic efficacy of Diltiazem can be decreased when used in combination with Ibuprofen.
Nifedipine Nifedipine The metabolism of Ibuprofen can be decreased when combined with Nifedipine.
Timolol Timolol Ibuprofen may decrease the antihypertensive activities of Timolol.
Verapamil Verapamil The metabolism of Ibuprofen can be decreased when combined with Verapamil.
Atenolol Atenolol Ibuprofen may decrease the antihypertensive activities of Atenolol.
Pindolol Pindolol Ibuprofen may decrease the antihypertensive activities of Pindolol.
Cisplatin Injection Cisplatin Injection Ibuprofen may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The risk or severity of adverse effects can be increased when Diflunisal is combined with Ibuprofen.
Piroxicam Piroxicam The risk or severity of adverse effects can be increased when Piroxicam is combined with Ibuprofen.
Bumetanide Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Ibuprofen.
Glyburide Glyburide The metabolism of Ibuprofen can be decreased when combined with Glyburide.
Glipizide Glipizide The protein binding of Glipizide can be decreased when combined with Ibuprofen.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Ibuprofen.
Amoxicillin Amoxicillin Ibuprofen may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Ibuprofen may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Ibuprofen is combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ibuprofen may decrease the excretion rate of Ceftriaxone which could result in a higher serum level.
Labetalol Labetalol Ibuprofen may decrease the antihypertensive activities of Labetalol.
Auranofin Auranofin Ibuprofen may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Ibuprofen may decrease the excretion rate of Leuprolide which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Ibuprofen can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Ibuprofen.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Ketoprofen Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Ibuprofen.
Cefotetan Injection Cefotetan Injection Ibuprofen may decrease the excretion rate of Cefotetan which could result in a higher serum level.
Enalapril Enalapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Enalapril.
Flurbiprofen Flurbiprofen The risk or severity of adverse effects can be increased when Flurbiprofen is combined with Ibuprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Ibuprofen.
Aztreonam Injection Aztreonam Injection Ibuprofen may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Ibuprofen can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin Ibuprofen may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Mesalamine Mesalamine The risk or severity of adverse effects can be increased when Ibuprofen is combined with Mesalazine.
Diclofenac Diclofenac The risk or severity of adverse effects can be increased when Diclofenac is combined with Ibuprofen.
Fluoxetine Fluoxetine The risk or severity of gastrointestinal bleeding can be increased when Fluoxetine is combined with Ibuprofen.
Nimodipine Nimodipine The therapeutic efficacy of Nimodipine can be decreased when used in combination with Ibuprofen.
Clozapine Clozapine Clozapine may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Estazolam Estazolam Ibuprofen may decrease the excretion rate of Estazolam which could result in a higher serum level.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Ibuprofen.
Ofloxacin Ofloxacin Ibuprofen may increase the neuroexcitatory activities of Ofloxacin.
Didanosine Didanosine Ibuprofen may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Ibuprofen may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Benazepril Benazepril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Benazepril.
Etodolac Etodolac The risk or severity of adverse effects can be increased when Etodolac is combined with Ibuprofen.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Ibuprofen.
Fosinopril Fosinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Fosinopril.
Nabumetone Nabumetone The risk or severity of adverse effects can be increased when Nabumetone is combined with Ibuprofen.
Pravastatin Pravastatin The excretion of Pravastatin can be decreased when combined with Ibuprofen.
Quinapril Quinapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Quinapril.
Ramipril Ramipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Ramipril.
Simvastatin Simvastatin The metabolism of Ibuprofen can be decreased when combined with Simvastatin.
Amlodipine Amlodipine Ibuprofen may decrease the antihypertensive activities of Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Ibuprofen can be decreased when combined with Teniposide.
Itraconazole Itraconazole The risk or severity of hyperkalemia can be increased when Ibuprofen is combined with Itraconazole.
Lisinopril Lisinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Lisinopril.
Oxaprozin Oxaprozin The risk or severity of adverse effects can be increased when Oxaprozin is combined with Ibuprofen.
Atovaquone Atovaquone The metabolism of Ibuprofen can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Ibuprofen can be increased when combined with Rifabutin.
Sotalol Sotalol Ibuprofen may decrease the antihypertensive activities of Sotalol.
Bisoprolol Bisoprolol Ibuprofen may decrease the antihypertensive activities of Bisoprolol.
Zolpidem Zolpidem The metabolism of Ibuprofen can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The therapeutic efficacy of Ibuprofen can be decreased when used in combination with Doxazosin.
Terazosin Terazosin The therapeutic efficacy of Terazosin can be decreased when used in combination with Ibuprofen.
Isradipine Isradipine Ibuprofen may decrease the excretion rate of Isradipine which could result in a higher serum level.
Omeprazole Omeprazole The metabolism of Ibuprofen can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Ibuprofen can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Ibuprofen can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Stavudine Stavudine The excretion of Stavudine can be decreased when combined with Ibuprofen.
Fluvoxamine Fluvoxamine The risk or severity of gastrointestinal bleeding can be increased when Fluvoxamine is combined with Ibuprofen.
Nefazodone Nefazodone The risk or severity of gastrointestinal bleeding can be increased when Ibuprofen is combined with Nefazodone.
Lamotrigine Lamotrigine The metabolism of Ibuprofen can be increased when combined with Lamotrigine.
Losartan Losartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Losartan is combined with Ibuprofen.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Tramadol Tramadol Ibuprofen may decrease the excretion rate of Tramadol which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Moexipril Moexipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Moexipril.
Lansoprazole Lansoprazole The metabolism of Ibuprofen can be decreased when combined with Lansoprazole.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Ibuprofen.
Ifosfamide Injection Ifosfamide Injection Ibuprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine Nicardipine The metabolism of Ibuprofen can be decreased when combined with Nicardipine.
Bupropion Bupropion Ibuprofen may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine The risk or severity of bleeding can be increased when Ibuprofen is combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Ibuprofen can be decreased when combined with Saquinavir.
Metformin Metformin Ibuprofen may decrease the excretion rate of Metformin which could result in a higher serum level.
Dalteparin Injection Dalteparin Injection The risk or severity of hyperkalemia can be increased when Ibuprofen is combined with Dalteparin.
Nisoldipine Nisoldipine Ibuprofen may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
Lamivudine Lamivudine Ibuprofen may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Acarbose Acarbose Ibuprofen may decrease the excretion rate of Acarbose which could result in a higher serum level.
Glimepiride Glimepiride The protein binding of Glimepiride can be decreased when combined with Ibuprofen.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Ibuprofen.
Gemcitabine Injection Gemcitabine Injection Ibuprofen may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Indinavir Indinavir The metabolism of Ibuprofen can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Ibuprofen can be increased when it is combined with Ritonavir.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Meropenem Injection Meropenem Injection Ibuprofen may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine Ibuprofen may decrease the excretion rate of Clomipramine which could result in a higher serum level.
Zafirlukast Zafirlukast The metabolism of Ibuprofen can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Ibuprofen may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Ibuprofen.
Trandolapril Trandolapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Trandolapril.
Topiramate Topiramate Ibuprofen may decrease the excretion rate of Topiramate which could result in a higher serum level.
Zileuton Zileuton The metabolism of Ibuprofen can be decreased when combined with Zileuton.
Valsartan Valsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Valsartan is combined with Ibuprofen.
Pramipexole Pramipexole Ibuprofen may decrease the excretion rate of Pramipexole which could result in a higher serum level.
Donepezil Donepezil The metabolism of Ibuprofen can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Ibuprofen can be increased when combined with Nelfinavir.
Fexofenadine Fexofenadine The excretion of Fexofenadine can be decreased when combined with Ibuprofen.
Loratadine Loratadine The metabolism of Ibuprofen can be decreased when combined with Loratadine.
Carvedilol Carvedilol Ibuprofen may decrease the antihypertensive activities of Carvedilol.
Nilutamide Nilutamide Ibuprofen may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Ibuprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline The metabolism of Ibuprofen can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Ibuprofen can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Ibuprofen.
Propafenone Propafenone Ibuprofen may decrease the antihypertensive activities of Propafenone.
Raloxifene Raloxifene The metabolism of Ibuprofen can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Ibuprofen.
Tamsulosin Tamsulosin Ibuprofen may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Finasteride Finasteride The risk or severity of hypertension can be increased when Ibuprofen is combined with Finasteride.
Quetiapine Quetiapine Ibuprofen may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Ibuprofen which could result in a higher serum level.
Cetirizine Cetirizine Ibuprofen may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Ibuprofen.
Tolcapone Tolcapone Ibuprofen may decrease the excretion rate of Tolcapone which could result in a higher serum level.
Citalopram Citalopram The risk or severity of gastrointestinal bleeding can be increased when Citalopram is combined with Ibuprofen.
Capecitabine Capecitabine The metabolism of Ibuprofen can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Ibuprofen can be decreased when combined with Efavirenz.
Abacavir Abacavir Ibuprofen may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Ibuprofen can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Ibuprofen can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The risk or severity of adverse effects can be increased when Celecoxib is combined with Ibuprofen.
Rosiglitazone Rosiglitazone The metabolism of Ibuprofen can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Ibuprofen may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide Thalidomide The metabolism of Ibuprofen can be decreased when combined with Thalidomide.
Oseltamivir Oseltamivir Ibuprofen may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Ibuprofen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The risk or severity of adverse effects can be increased when Balsalazide is combined with Ibuprofen.
Nateglinide Nateglinide Ibuprofen may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Rabeprazole Rabeprazole The metabolism of Ibuprofen can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Ibuprofen can be decreased when combined with Terbinafine.

* This branded product is no longer on the market. Generic alternatives may be available.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists