Skip to the answer

Celecoxib

Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used for arthritis (osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis), acute pain, primary dysmenorrhea (painful periods), and, in one liquid product, acute migraine.

Brand names CelebrexElyxybVyscoxaELYXYB - celecoxib
Drug class Nonsteroidal Anti-inflammatory Drug
Rx Forms 3
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 159 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 4, 2026 🚨Recall on record · 2
Celecoxib at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID), on the market since about 1998 and available generically, that eases pain and inflammation mainly by blocking an enzyme called COX-2; it is a familiar choice for osteoarthritis, rheumatoid arthritis (adult and juvenile) and ankylosing spondylitis (arthritis of the spine), and some forms also treat acute pain, painful periods or migraine attacks. Most people tolerate it well, and it is often gentler on the stomach than ibuprofen or naproxen, though indigestion, diarrhea and leg swelling still happen. Its boxed warning covers heart attack, stroke and silent stomach bleeding, all of which can be fatal, so use the lowest dose for the shortest time.

Clinical pearls

  • Skip ibuprofen, naproxen and other NSAIDs while on celecoxib, since stacking them adds stomach risk with no extra relief.
  • Celecoxib does not replace low-dose aspirin for heart protection, and taking the two together raises stomach bleeding risk.
  • A sulfa drug allergy rules celecoxib out, as does asthma or hives triggered by aspirin or another NSAID.
  • Vyscoxa liquid must be taken on an empty stomach, at least 2 hours before or 1 hour after food.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Celecoxib and other NSAIDs can raise your risk of heart attack and stroke, which can be fatal. This risk can start early in treatment and may grow the longer you take it. Celecoxib must not be used around CABG heart surgery.

NSAIDs can also cause bleeding, ulcers or holes (perforation) in the stomach or intestines, which can be fatal. These can happen at any time and without warning symptoms. Older adults and people who have had stomach ulcers or GI bleeding are at greater risk.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asCapsule, Oral solution, Oral suspension
Earliest FDA record1998
Companies listing it with the FDA60
FDA label last updatedNov 22, 2024
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Celecoxib, written from its FDA label.

What Celecoxib is used for

▾

Celecoxib is used for several kinds of pain and inflammation, depending on the product.

  • Celebrex and generic celecoxib capsules: osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and juvenile rheumatoid arthritis in children 2 years and older.
  • Celebrex and generic celecoxib capsules: acute pain in adults and primary dysmenorrhea.
  • Vyscoxa oral suspension: osteoarthritis, rheumatoid arthritis and ankylosing spondylitis in adults, and juvenile rheumatoid arthritis in children 2 years and older. It is not for acute pain or primary dysmenorrhea.
  • ELYXYB oral solution: acute treatment of migraine with or without aura in adults. It is not for migraine prevention.

How Celecoxib works

▾

Celecoxib is believed to work by blocking prostaglandin production, mainly through the COX-2 enzyme. Prostaglandins make nerves more sensitive to pain and drive inflammation. With fewer prostaglandins in the tissues, pain and inflammation ease. It also has fever-reducing properties.

Celecoxib dosage

▾

Celecoxib is taken by mouth. Capsules are usually taken once or twice daily, and usual doses can be taken with or without food. Higher doses should be taken with food. Capsule contents can also be sprinkled on applesauce.

  • Vyscoxa suspension is taken on an empty stomach, at least 2 hours before or 1 hour after food.
  • ELYXYB is taken as needed for a migraine, with or without food, using a calibrated measuring device.

Follow your prescriber and the label for dose and timing.

Dosing details from the FDA-approved label

From the Celecoxib prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Osteoarthritis (OA)
    • 200 mg per day administered as a single dose or as 100 mg twice daily
    • Celebrex/generic capsules can be given without regard to timing of meals; Vyscoxa suspension (200 mg = 20 mL; 100 mg = 10 mL) must be taken on an empty stomach at least 2 hours before or 1 hour after food
  • Rheumatoid Arthritis (RA)
    • 100 mg to 200 mg twice daily
    • Vyscoxa suspension: 100 mg (10 mL) to 200 mg (20 mL) twice daily, taken on an empty stomach
  • Juvenile Rheumatoid Arthritis (JRA), patients 10 kg to 25 kg (age 2 years and older)
    • 50 mg twice daily
    • Capsule contents can be added to applesauce for patients who have difficulty swallowing capsules; Vyscoxa suspension dose is 50 mg (5 mL) twice daily
  • Juvenile Rheumatoid Arthritis (JRA), patients more than 25 kg (age 2 years and older)
    • 100 mg twice daily
    • Vyscoxa suspension dose is 100 mg (10 mL) twice daily
  • Ankylosing Spondylitis (AS)
    • 200 mg daily in single (once per day) or divided (twice per day) doses
    • If no effect is observed after 6 weeks, a trial of 400 mg daily may be worthwhile
    • Maximum: Vyscoxa suspension: not recommended at a single dose greater than 200 mg (20 mL)
    • If no effect after 6 weeks on 400 mg daily, a response is not likely. Vyscoxa suspension: 200 mg (20 mL) once daily or 100 mg (10 mL) twice daily; if no effect after 6 weeks, 200 mg (20 mL) twice daily may be worthwhile
  • Management of Acute Pain and Treatment of Primary Dysmenorrhea (capsules)
    • 400 mg initially, followed by an additional 200 mg dose if needed on the first day
    • On subsequent days 200 mg twice daily as needed
  • Moderate hepatic impairment (Child-Pugh Class B)
    • Reduce the dose by 50%
    • Use in severe hepatic impairment is not recommended
  • Known or suspected CYP2C9 poor metabolizers (adults)
    • Initiate treatment with half of the lowest recommended dose
    • In patients with JRA, consider using alternative treatments
Read the label’s full dosing text

2. DOSAGE AND ADMINISTRATION • Use the lowest effective dosage for shortest duration consistent with individual patient treatment goals. ( Error! Hyperlink reference not valid. ) • OA: 200 mg once daily or 100 mg twice daily. ( Error! Hyperlink reference not valid. , Error! Hyperlink reference not valid. ) • RA: 100 mg to 200 mg twice daily. ( Error! Hyperlink reference not valid. , Error! Hyperlink reference not valid. ) • JRA: 50 mg twice daily in patients 10 kg to 25 kg. 100 mg twice daily in patients more than 25 kg. ( Error! Hyperlink reference not valid. , Error! Hyperlink reference not valid. ) • AS: 200 mg once daily single dose or 100 mg twice daily. If no effect is observed after 6 weeks, a trial of 400 mg (single or divided doses) may be of benefit. ( Error! Hyperlink reference not valid. , Error! Hyperlink reference not valid. ) • AP and PD: 400 mg initially, followed by 200 mg dose if needed on first day. On subsequent days, 200 mg twice daily as needed. ( Error! Hyperlink reference not valid. , Error! Hyperlink reference not valid. ) Hepatic Impairment: Reduce daily dose by 50% in patients with moderate hepatic impairment (Child-Pugh Class B). ( Error! Hyperlink reference not valid. , Error! Hyperlink reference not valid. , Error! Hyperlink reference not valid. ) Poor Metabolizers of CYP2C9 Substrates: Consider a dose reduction by 50% (or alternative management for JRA) in patients who are known or suspected to be CYP2C9 poor metabolizers. ( Error! Hyperlink reference not valid. , Error! Hyperlink reference not valid. , Error! Hyperlink reference not valid. ) 2.1 General Dosing Instructions Carefully consider the potential benefits and risks of celecoxib and other treatment options before deciding to use celecoxib. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [ see Error! Hyperlink reference not valid. ]. These doses can be given without regard to timing of meals. 2.2 Osteoarthritis For OA, the dosage is 200 mg per day administered as a single dose or as 100 mg twice daily. 2.3 Rheumatoid Arthritis For RA, the dosage is 100 mg to 200 mg twice daily. 2.4 Juvenile Rheumatoid Arthritis For JRA, the dosage for pediatric patients (age 2 years and older) is based on weight. For patients ≥ 10 kg to ≤ 25 kg the recommended dose is 50 mg twice daily.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Celecoxib side effects

▾

Most side effects in arthritis trials were mild and involved the stomach or the nose and throat.

Common side effects

  • Stomach pain
  • Indigestion (dyspepsia)
  • Diarrhea
  • Gas (flatulence)
  • Nausea
  • Swelling in the legs or hands (peripheral edema)
  • Dizziness
  • Cold-like symptoms, such as sore throat, runny nose or sinus infection
  • Sore throat, runny nose, sinus or upper respiratory infections

When to get medical help

  • Chest pain, shortness of breath, weakness on one side of the body or slurred speech: these can be signs of a heart attack or stroke. Get emergency help.
  • Black or bloody stools, vomiting blood, or severe stomach pain: these can be signs of stomach or intestinal bleeding, ulcer or perforation. These can happen without warning.
  • Yellow skin or eyes, itching, nausea, unusual tiredness, right upper belly tenderness or flu-like symptoms: these can be signs of liver problems.
  • Skin rash, blistering or other allergic signs: stop the medicine and call your doctor right away.
  • Swelling of the face or throat, or trouble breathing: these can be signs of a serious allergic reaction. Get emergency help.
  • Sudden weight gain, swelling or worsening heart failure symptoms: tell your doctor.
  • Signs of anemia, such as unusual paleness or tiredness: tell your doctor, who may check your blood counts.

Celecoxib warnings and precautions

▾

Celecoxib can raise the risk of heart attack, stroke and serious stomach or intestinal bleeding. These risks can begin early and may rise with longer use or higher doses. Older adults and people with past ulcers or GI bleeding are at greater risk.

  • It can raise blood pressure and cause fluid retention. Use caution in severe heart failure.
  • It can harm the kidneys, especially with dehydration, heart failure, or liver or kidney disease.
  • It can cause liver injury, serious skin reactions and allergic reactions.
  • Celecoxib is not a substitute for low-dose aspirin for heart protection.
  • Avoid in people with a recent heart attack unless the benefits outweigh the risks.

Celecoxib interactions

▾

Celecoxib can clash with several common medicines.

  • Warfarin, aspirin, SSRIs, SNRIs and corticosteroids: more bleeding or ulcer risk.
  • Other NSAIDs and salicylates: more stomach toxicity with no added benefit.
  • ACE inhibitors, ARBs, beta-blockers and diuretics: weaker blood pressure effects and possible kidney strain.
  • Digoxin and lithium: blood levels can rise.
  • Methotrexate, cyclosporine and pemetrexed: higher toxicity risk.
  • Fluconazole, rifampin and CYP2D6 drugs such as atomoxetine: celecoxib or the other drug may need adjustment.
  • Aluminum- and magnesium-containing antacids: may lower celecoxib levels.

Interactions listed in the FDA-approved label

From the Celecoxib prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Drugs that interfere with hemostasis (anticoagulants such as warfarin, antiplatelet drugs, SSRIs, SNRIs): Celecoxib and anticoagulants have a synergistic effect on bleeding, and concomitant use increases the risk of serious bleeding compared to either drug alone. Monitor patients for signs of bleeding.
  • Aspirin: Concomitant use of NSAIDs and analgesic doses of aspirin produces no greater therapeutic effect than the NSAID alone and was associated with a significantly increased incidence of GI adverse reactions. Concomitant use with analgesic doses of aspirin is not generally recommended; celecoxib is not a substitute for low dose aspirin for cardiovascular protection.
  • ACE inhibitors, angiotensin receptor blockers, and beta-blockers: NSAIDs may diminish the antihypertensive effect of these drugs; in elderly, volume-depleted or renally impaired patients, ACE inhibitors or ARBs with an NSAID may result in deterioration of renal function, including possible acute renal failure. Monitor blood pressure; monitor for signs of worsening renal function in high-risk patients; keep patients adequately hydrated and assess renal function at the beginning of concomitant treatment and periodically thereafter.
  • Diuretics (loop diuretics such as furosemide, and thiazide diuretics): NSAIDs reduced the natriuretic effect of loop and thiazide diuretics in some patients. Observe patients for signs of worsening renal function and assure diuretic efficacy including antihypertensive effects.
  • Digoxin: Concomitant use with celecoxib has been reported to increase the serum concentration and prolong the half-life of digoxin. Monitor serum digoxin levels.
  • Lithium: NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance; the mean minimum lithium concentration increased 15%, and renal clearance decreased by approximately 20%. Monitor patients for signs of lithium toxicity.
  • Methotrexate: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction); celecoxib has no effect on methotrexate pharmacokinetics. Monitor patients for methotrexate toxicity.
  • Cyclosporine: Concomitant use may increase cyclosporine's nephrotoxicity. Monitor patients for signs of worsening renal function.
  • Other NSAIDs or salicylates (e.g., diflunisal, salsalate): Concomitant use increases the risk of GI toxicity, with little or no increase in efficacy. Concomitant use is not recommended.
  • Pemetrexed: Concomitant use may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity. In patients with creatinine clearance 45 to 79 mL/min, monitor for myelosuppression, renal and GI toxicity; avoid short half-life NSAIDs for two days before, the day of, and two days following pemetrexed; for longer half-life NSAIDs, interrupt dosing for at least five days before, the day of, and two days following pemetrexed.
Read the label’s full interactions text

7. DRUG INTERACTIONS See Table 3 for clinically significant drug interactions with celecoxib. Table 3: Clinically Significant Drug Interactions with Celecoxib Drugs That Interfere with Hemostasis Clinical Impact: • Celecoxib and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of celecoxib and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. • Serotonin release by platelets plays an important role in hemostasis. Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone. Intervention: Monitor patients with concomitant use of celecoxib with anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin), SSRIs, and SNRIs for signs of bleeding [ see Error! Hyperlink reference not valid. ]. Aspirin Clinical Impact: Controlled clinical studies showed that the concomitant use of NSAIDs and analgesic doses of aspirin does not produce any greater therapeutic effect than the use of NSAIDs alone. In a clinical study, the concomitant use of an NSAID and aspirin was associated with a significantly increased incidence of GI adverse reactions as compared to use of the NSAID alone [ see Error! Hyperlink reference not valid. ]. In two studies in healthy volunteers, and in patients with osteoarthritis and established heart disease respectively, celecoxib (200 mg to 400 mg daily) has demonstrated a lack of interference with the cardioprotective antiplatelet effect of aspirin (100 mg to 325 mg). Intervention: Concomitant use of celecoxib and analgesic doses of aspirin is not generally recommended because of the increased risk of bleeding [ see Error! Hyperlink reference not valid. ]. Celecoxib is not a substitute for low dose aspirin for cardiovascular protection.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿117 supplements and herbs with documented Celecoxib interactions, ranked by severity Check Celecoxib against a supplement or herb →

Before taking Celecoxib

▾
  • Do not use if allergic to celecoxib or sulfonamides, or if aspirin or NSAIDs have caused asthma, hives or allergic reactions.
  • Do not use around CABG surgery.
  • Tell your doctor about heart disease, high blood pressure, heart failure, past ulcers or bleeding, and kidney or liver disease.
  • Pregnancy: limit use between about 20 and 30 weeks and avoid from about 30 weeks.
  • Breastfeeding: low levels pass into milk, so discuss with your doctor.
  • May delay ovulation and affect fertility in some women.
  • Children: for juvenile rheumatoid arthritis ages 2 and older, with long-term safety not studied.
  • Moderate liver impairment or known CYP2C9 poor metabolizers may need a lower dose.

Celecoxib overdose

▾

Too much celecoxib can cause sleepiness, nausea, vomiting and upper stomach pain. GI bleeding can occur. High blood pressure, acute kidney failure, slowed breathing and coma were rare. There is no specific antidote, and treatment is supportive. Call poison control at 1-800-222-1222.

What Celecoxib does in the body

▾

In healthy volunteers, celecoxib did not reduce platelet clumping or lengthen bleeding time, even at doses above those recommended. For that reason it is not a substitute for aspirin for heart protection. By lowering prostaglandins, it may also cause the body to retain sodium and water.

How your body processes Celecoxib

▾

Celecoxib levels peak about 3 hours after an oral dose. It is mostly broken down by the liver enzyme CYP2C9, and its half-life is about 11 hours. Steady levels are reached within about 5 days of regular dosing. Very little leaves the body unchanged, and the inactive breakdown products leave in feces and urine. Older adults had higher drug levels than younger adults.

How to store Celecoxib

▾

Store at room temperature 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) . Dispense in tight (USP), child resistant containers.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

117

Supplements & herbs that interact with Celecoxib

117 supplements and herbal products have documented interactions with Celecoxib in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 5
  • Moderate · 84
  • Minor · 28
ACTIVATED CHARCOAL Major ASARABACCA Major BEER Major SIBERIAN COCKLEBUR Major WINE Major ADRAFINIL Moderate AFRICAN WILD POTATO Moderate ALFALFA Moderate +109 more
Every supplement checked against Celecoxib — ranked by severity The full interaction hub: 5 major · 84 moderate · 28 minor · every one linked to its full report. Check Celecoxib against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Celecoxib has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

FOLIC ACID Insufficient Evidence
See the full Celecoxib nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Celecoxib: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Celecoxib — the kind of thing our pharmacy team would talk through with you at the counter.

What is celecoxib used for?

▾
It depends on the product. Celebrex and generic capsules are used for several types of arthritis, acute pain and painful periods. Vyscoxa liquid is for certain arthritis types. ELYXYB liquid is for treating a migraine attack once it starts.

Should I take it with food?

▾
For capsules, usual doses can be taken with or without food, but higher doses are taken with food. Vyscoxa suspension must be taken on an empty stomach, at least 2 hours before or 1 hour after food. ELYXYB can be taken with or without food.

What side effects should I expect?

▾
The most common ones are stomach upset, indigestion, diarrhea, gas, swelling, dizziness, cold-like symptoms and rash. Call your doctor if they bother you or don't go away.

When should I call my doctor or get emergency help?

▾
Get emergency help for chest pain, shortness of breath, weakness on one side, slurred speech, black or bloody stools, vomiting blood, or swelling of the face or throat. Stop it and call right away for a rash or signs of liver trouble such as yellow skin or eyes.

Can I take it with other pain relievers or my blood pressure pills?

▾
Avoid other NSAIDs and aspirin at pain-relief doses unless your doctor says otherwise, since stomach bleeding risk goes up. It can also weaken some blood pressure medicines and add to bleeding risk with blood thinners. Check with me or your doctor before combining it with anything.

Is celecoxib safe in pregnancy?

▾
Use between about 20 and 30 weeks should be limited, and it should be avoided from about 30 weeks on. It can affect the baby's kidneys and a key blood vessel in the heart. Tell your doctor if you are pregnant, planning pregnancy or having trouble conceiving.

Is Celecoxib available over the counter?

▾
No. Celecoxib is a prescription medicine: every Celecoxib product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Celecoxib first available?

▾
The earliest FDA record we hold for Celecoxib is from 1998: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Celecoxib was first used.

Who makes Celecoxib?

▾
60 companies currently list Celecoxib products in the FDA's NDC Directory, including Bryant Ranch Prepack, Proficient Rx LP, A-S Medication Solutions. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Celecoxib on HelloPharmacist

📊Celecoxib supplement interactions117 checked — ranked by severity 🌿Drug & Supplement CheckerCelecoxib vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Celecoxib NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Celecoxib Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Celecoxib forms and strengths (how it comes)

Celecoxib is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Capsule

By mouth
Brands Celebrex
How this form is used
What it may be used for
  • Celebrex and generic celecoxib capsules are used for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis (ages 2 and older) and ankylosing spondylitis.
  • Celebrex and generic celecoxib capsules are also used for acute pain in adults and primary dysmenorrhea.
Important instructions
  • Celebrex and generic celecoxib capsule labels say the usual doses can be taken without regard to timing of meals.
  • Celecoxib capsule labels say higher doses should be taken with food to improve absorption.
Available strengths 4 strengths
50 mg 100 mg 200 mg 400 mg
483 FDA-listed product records ⓘ

Oral solution

By mouth
Brands ELYXYB - celecoxib
How this form is used
What it may be used for
  • ELYXYB is used for the acute treatment of migraine with or without aura in adults.
  • ELYXYB is not for preventing migraine.
Important instructions
  • ELYXYB is taken by mouth, with or without food.
  • ELYXYB should be used for the fewest number of days per month, as needed.
  • ELYXYB labeling recommends a calibrated measuring device, not a household spoon.
Available strengths 1 strength
120 mg/4.8 mL
2 FDA-listed product records ⓘ

Oral suspension

By mouth
Brands Vyscoxa
How this form is used
What it may be used for
  • Vyscoxa is used for osteoarthritis, rheumatoid arthritis and ankylosing spondylitis in adults.
  • Vyscoxa is also used for juvenile rheumatoid arthritis in children 2 years and older.
  • Vyscoxa is not for acute pain or primary dysmenorrhea.
Important instructions
  • Vyscoxa must be taken on an empty stomach, at least 2 hours before or 1 hour after food.
  • Taking Vyscoxa with food can raise celecoxib exposure by up to 50%.
  • If you cannot tolerate Vyscoxa on an empty stomach, it should be stopped.
Available strengths 1 strength
10 mg/mL
1 FDA-listed product record ⓘ

Celecoxib on the U.S. market: products, makers and brands

How Celecoxib appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

60 companies list 238 Celecoxib product records with the FDA, mostly as capsule, oral solution, oral suspension; the earliest marketing or approval year on record is 1998. Brand names on the directory include Celebrex, Elyxyb, Vyscoxa and 1 more; the rest are generics.

3
Dose forms ⓘ
60
Labelers (makers, repackagers, distributors)
5
Brand names
238
FDA-listed product records ⓘ
1998
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (24) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack6%
Proficient Rx LP5%
A-S Medication Solutions4%
Asclemed USA, Inc.4%
Remedyrepack Inc.4%
Hawaii Repack, Inc.3%
Other makers74%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Celecoxib is used (Medicaid data)

A general measure of how commonly Celecoxib is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Celecoxib is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

1,204,360
Medicaid prescriptions filled (Q1–Q4 2025)
$38M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Celecoxib prescribed? Of the 1,601 medications we measure, Celecoxib ranks #148 by Medicaid prescriptions — more than 91% of them.

Where Celecoxib ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #148 of 1,601
#143 Dexamethasone Injectio... 1,290,031 Rx #144 Ketorolac Injection 1,259,288 Rx #145 Dicyclomine 1,233,412 Rx #146 Albuterol and Ipratrop... 1,217,671 Rx #147 Diazepam 1,216,820 Rx #148 Celecoxib 1,204,360 Rx #149 Ofloxacin 1,194,981 Rx #150 Nicotine Transdermal P... 1,178,062 Rx #151 Hydrochlorothiazide /... 1,175,772 Rx #152 Senna 1,155,349 Rx #153 Medroxyprogesterone 1,134,727 Rx

Utilization by Celecoxib product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 200 mg oral capsule is the most-dispensed Celecoxib product — about 69% of these Medicaid prescriptions.

celecoxib 200 MG Oral Capsule Most dispensed

833,732 Medicaid prescriptions (Q1–Q4 2025) 69% of Celecoxib prescriptions shown $26.5M gross reimbursement (before rebates) ≈ $32 per prescription (gross)

Summed across the 39 of 507 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 205323

celecoxib 100 MG Oral Capsule

346,250 Medicaid prescriptions (Q1–Q4 2025) 29% of Celecoxib prescriptions shown $9.1M gross reimbursement (before rebates) ≈ $26 per prescription (gross)

Summed across the 32 of 309 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 205322

celecoxib 50 MG Oral Capsule

11,701 Medicaid prescriptions (Q1–Q4 2025) <1% of Celecoxib prescriptions shown $276,731 gross reimbursement (before rebates) ≈ $24 per prescription (gross)

Summed across the 9 of 94 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 686379

celecoxib 400 MG Oral Capsule

11,102 Medicaid prescriptions (Q1–Q4 2025) <1% of Celecoxib prescriptions shown $583,086 gross reimbursement (before rebates) ≈ $53 per prescription (gross)

Summed across the 9 of 109 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 349514

celecoxib 25 MG/ML Oral Solution

1,575 Medicaid prescriptions (Q1–Q4 2025) <1% of Celecoxib prescriptions shown $1.4M gross reimbursement (before rebates) ≈ $919 per prescription (gross)

Summed across the 1 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2373454

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Celecoxib, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 90 of 1,025 listed Celecoxib NDCs with Medicaid activity.

Compare Celecoxib products

A representative set of FDA-listed product records for Celecoxib — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 96 of 238 products — FDA National Drug Code Directory. See every product, package size and price: browse all 238 Celecoxib NDCs →

Celecoxib recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 2 Celecoxib recalls since July 2021. Both are still ongoing or began in the last six months. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II May 13, 2025 · AvKARE
Presence of Foreign Tablets/Capsules: manufacturer recalled because one tadalafil 5mg tablet was found in 500 count bottle of Celecoxib 200 mg capsules
  • Celecoxib Capsules, 200 mg, 50 Capsules (5x10) Unit Dose per carton, Rx Only, Manufactured for: AvKARE, Pulaski, TN 38478. NDC 50268-169-15 Lots: Lot #47881, Exp 05/31/2026 FDA record D-0460-2025 →
Ongoing Class II May 9, 2025 · Alembic Pharmaceuticals Limited
Presence of Foreign Tablets/Capsules; customer complaint found one Tadalafil 5mg tablet inside a sealed 500-count bottle of Celecoxib 200mg capsule
  • Celecoxib Capsules, 200 mg, 500-count bottle, Rx only, Manufactured by: Alembic Pharmaceuticals Limited (Formulation Division), Panelav 389350, Gujarat, India, Manufactured for: Alembic Pharmaceutica… Lots: Batch 2405014780, Exp. Date: Sep. 30, 2027 FDA record D-0459-2025 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Celecoxib RxCUI 140587 4 dose forms · 7 strengths
  1. Dose form (SCDF) Oral Capsule RxCUI 371343 In current FDA listings
    Clinical drug / strength (SCD) 50 MG RxCUI 686379 100 MG RxCUI 205322 200 MG RxCUI 205323 400 MG RxCUI 349514
  2. Dose form (SCDF) Oral Solution RxCUI 2373453 In current FDA listings
    Clinical drug / strength (SCD) 25 MG/ML RxCUI 2373454
  3. Dose form (SCDF) Oral Suspension RxCUI 2721528 In current FDA listings
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 2721529
  4. Dose form (SCDF) Oral Tablet RxCUI 438395 No current FDA listing
    Clinical drug / strength (SCD) 200 MG RxCUI 430890

Look up RxCUI 140587 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Celecoxib costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Capsule · Oral 200 mg $0.076 per capsule NDC details & price history
Capsule · Oral 100 mg $0.061 per capsule NDC details & price history
Capsule · Oral 50 mg $0.091 per capsule NDC details & price history
Capsule · Oral 400 mg $0.248 per capsule NDC details & price history
Capsule 400 mg $0.284 per capsule NDC details & price history
Capsule 200 mg $0.076 per capsule NDC details & price history
Capsule 100 mg $0.061 per capsule NDC details & price history
Capsule 50 mg $0.091 per capsule NDC details & price history
Liquid · Oral 120 mg/4.8 mL $30.54 per mL NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Celecoxib brand names

Celecoxib is sold under 4 brand names in the FDA directory — Celebrex, Elyxyb, Vyscoxa, ELYXYB - celecoxib. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Celebrex Elyxyb Vyscoxa ELYXYB - celecoxib

Who makes Celecoxib: manufacturers and labelers

60 companies list Celecoxib products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Proficient Rx LP, A-S Medication Solutions. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 15 Proficient Rx LP 11 A-S Medication Solutions 10 Asclemed USA, Inc. 10 Remedyrepack Inc. 9 Hawaii Repack, Inc. 8 Advanced Rx Pharmacy of Tennessee, LLC 7 Northwind Health Company, LLC 6 St. Mary's Medical Park Pharmacy 6 PD-Rx Pharmaceuticals, Inc. 5 Preferred Pharmaceuticals, Inc. 5 Actavis Pharma, Inc. 4 Advanced Rx of Tennessee, LLC 4 AiPing Pharmaceutical, Inc. 4 Alembic Pharmaceuticals Inc. 4 Alembic Pharmaceuticals Limited 4 Aurobindo Pharma Limited 4 Avet Pharmaceuticals Inc. 4 Cadila Pharmaceuticals Limited 4 Cipla USA Inc. 4 Direct_Rx 4 Epic Pharma, Llc 4 Lupin Pharmaceuticals, Inc. 4 Macleods Pharmaceuticals Limited 4

…and 36 more on the FDA NDC directory.

Celecoxib drug class (RxNorm)

Celecoxib belongs to the Nonsteroidal Anti-inflammatory Drug class.

Pharmacologic class Nonsteroidal Anti-inflammatory Drug
Drug family (ATC) Other antineoplastic agents, Coxibs, Dihydropyridine derivatives
How it works Cyclooxygenase Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Celecoxib page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Nov 22, 2024
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Celecoxib.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Celecoxib after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
159
Finished products in the current FDA directory
238
Companies listing them (makers, repackagers, distributors)
60
FDA labeler codes behind them ⓘ
63
Linked representative label ⓘ
Viatris Specialty LLC
Linked label effective
Nov 22, 2024
Composite sections available
25
Linked SPL Set ID
2d6675e4-5859-4be2-8037-a20ce9f707aa
Linked SPL Document ID
0c321a7b-89e4-48cc-ab0b-1bd7620d7799
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Viatris Specialty LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →