Diflunisal

Generic name: Pronounced as (dye floo' ni sal)
Brand names
  • Dolobid®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2021

People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as diflunisal may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as diflunisal if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take diflunisal right before or right after the surgery.

NSAIDs such as diflunisal may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while you are taking diflunisal. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking diflunisal and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to diflunisal. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with diflunisal and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

Diflunisal is used to relieve pain, tenderness, swelling and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Diflunisal is also used to relieve mild to moderate pain from other causes. Diflunisal is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

Diflunisal comes as a tablet to take by mouth. It usually is taken with water, milk, or food every 8 to 12 hours. Take diflunisal at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take diflunisal exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

It may take several days or longer for you to feel the full benefit of diflunisal. Continue to take diflunisal until your doctor tells you that you should stop taking the medication.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking diflunisal,

  • tell your doctor and pharmacist if you are allergic to diflunisal, aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), or any other medications. Ask your doctor or pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: acetaminophen (Tylenol); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin II receptor antagonists such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); antacids; cyclosporine (Gengraf, Neoral, Sandimmune); diuretics ('water pills'); indomethacin (Indocin, Tivorbex); lithium (Lithobid); methotrexate (Otrexup, Rasuvo, Trexall); and sulindac. Your doctor may need to change the dose of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); heart failure; swelling of the hands, feet, ankles, or lower legs; or liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant; or are breast-feeding. Diflunisal may harm the fetus and cause problems with delivery if it is taken around 20 weeks or later during pregnancy. Do not take diflunisal around or after 20 weeks of pregnancy, unless you are told to do so by your doctor. If you become pregnant while taking diflunisal, call your doctor.

  • talk to your doctor about the risks and benefits of taking diflunisal if you are 75 years of age or older. Do not take this medication for a longer period of time or at a higher dose than recommended by your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking diflunisal.

  • call your doctor if you think you may have a virus, such as chicken pox or the flu. Do not take diflunisal if you have a virus, and do not give diflunisal to a child who has a virus.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Diflunisal may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • vomiting

    • diarrhea

    • constipation

    • gas

    • headache

    • dizziness

    • ringing in the ears

    • problems with vision

  • Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more diflunisal until you speak to your doctor.

    • upset stomach

    • shortness of breath or difficulty breathing

    • swelling of the abdomen, feet, ankles, or lower legs

    • excessive tiredness

    • unusual bleeding or bruising

    • itching

    • lack of energy

    • loss of appetite

    • pain in the upper right part of the stomach

    • yellowing of the skin or eyes

    • flu-like symptoms

    • rash

    • blisters

    • fever or chills

    • pale skin

    • fast heartbeat

    • easy bruising or bleeding

    • muscle or joint pain

    • unexplained weight gain

    • back pain

    • cloudy, discolored, or bloody urine

    • difficult or painful urination

    • frequent urination, especially at night

    • swelling of the face, throat, tongue, lips, eyes, or hands

    • hoarseness

    • difficulty swallowing

  • Diflunisal may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • drowsiness

  • vomiting

  • upset stomach

  • diarrhea

  • decreased urination

  • fast breathing

  • fast heartbeat

  • sweating

  • ringing in the ears

  • confusion

  • coma (loss of consciousness for a period of time)

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking diflunisal.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin Diflunisal may increase the neuroexcitatory activities of Moxifloxacin.
Repaglinide Repaglinide Diflunisal may increase the hypoglycemic activities of Repaglinide.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection Diflunisal may increase the hypoglycemic activities of Insulin glargine.
Alendronate Alendronate The risk or severity of adverse effects can be increased when Diflunisal is combined with Alendronic acid.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Diflunisal.
Candesartan Candesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Candesartan is combined with Diflunisal.
Cilostazol Cilostazol The risk or severity of bleeding can be increased when Diflunisal is combined with Cilostazol.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Diflunisal is combined with Clopidogrel.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Diflunisal may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate Diflunisal may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The therapeutic efficacy of Guanfacine can be decreased when used in combination with Diflunisal.
Magnesium Hydroxide Magnesium Hydroxide Diflunisal may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Diflunisal.
Miglitol Miglitol Diflunisal may increase the hypoglycemic activities of Miglitol.
Mycophenolate Mycophenolate The metabolism of Mycophenolic acid can be decreased when combined with Diflunisal.
Naratriptan Naratriptan The risk or severity of hypertension can be increased when Diflunisal is combined with Naratriptan.
Olsalazine Olsalazine The therapeutic efficacy of Olsalazine can be decreased when used in combination with Diflunisal.
Penbutolol Penbutolol Diflunisal may decrease the antihypertensive activities of Acebutolol.
Potassium Potassium Diflunisal may decrease the excretion rate of Potassium cation which could result in a higher serum level.
Prednisone Prednisone The risk or severity of gastrointestinal irritation can be increased when Diflunisal is combined with Prednisone.
Ranitidine Ranitidine Diflunisal may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine Reserpine The therapeutic efficacy of Reserpine can be decreased when used in combination with Diflunisal.
Rizatriptan Rizatriptan Diflunisal may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan Diflunisal may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The risk or severity of renal failure can be increased when Diflunisal is combined with Tacrolimus.
Tiludronate Tiludronate The risk or severity of gastrointestinal bleeding can be increased when Diflunisal is combined with Etidronic acid.
Triamcinolone Triamcinolone The risk or severity of gastrointestinal irritation can be increased when Diflunisal is combined with Triamcinolone.
Zolmitriptan Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Diflunisal.
Ampicillin Injection Ampicillin Injection Diflunisal may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Diflunisal may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Diflunisal may decrease the excretion rate of Fluconazole which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection The risk or severity of nephrotoxicity can be increased when Diflunisal is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection Diflunisal may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Diflunisal may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection Diflunisal may decrease the excretion rate of Meperidine which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of gastrointestinal irritation can be increased when Diflunisal is combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection Diflunisal may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection The risk or severity of gastrointestinal bleeding can be increased when Diflunisal is combined with Pamidronic acid.
Vancomycin Injection Vancomycin Injection Diflunisal may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The risk or severity of bleeding can be increased when Zidovudine is combined with Diflunisal.
Altretamine Altretamine Diflunisal may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Cyclosporine Cyclosporine The risk or severity of renal failure and hypertension can be increased when Diflunisal is combined with Cyclosporine.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Enoxaparin.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Diflunisal.
Entacapone Entacapone The metabolism of Entacapone can be decreased when combined with Diflunisal.
Eprosartan Eprosartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Eprosartan is combined with Diflunisal.
Meloxicam Meloxicam The therapeutic efficacy of Diflunisal can be decreased when used in combination with Meloxicam.
Pantoprazole Pantoprazole Diflunisal may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Risedronate Risedronate The risk or severity of gastrointestinal bleeding can be increased when Diflunisal is combined with Risedronic acid.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Diflunisal resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Telmisartan is combined with Diflunisal.
Temozolomide Temozolomide Diflunisal may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Diflunisal may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Linezolid Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Diflunisal.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Pentosan polysulfate.
Trimipramine Trimipramine The risk or severity of hypertension can be increased when Trimipramine is combined with Diflunisal.
Perindopril Perindopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Perindopril.
Tenofovir Tenofovir Diflunisal may increase the nephrotoxic activities of Tenofovir.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The therapeutic efficacy of Diflunisal can be decreased when used in combination with Choline magnesium trisalicylate.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Diflunisal is combined with Dutasteride.
Epinephrine Injection Epinephrine Injection The risk or severity of hypertension can be increased when Epinephrine is combined with Diflunisal.
Eplerenone Eplerenone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Eplerenone.
Escitalopram Escitalopram The risk or severity of gastrointestinal bleeding can be increased when Escitalopram is combined with Diflunisal.
Olmesartan Olmesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Olmesartan is combined with Diflunisal.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Diflunisal is combined with Zonisamide.
Aripiprazole Aripiprazole The risk or severity of hypertension can be increased when Diflunisal is combined with Aripiprazole.
Atomoxetine Atomoxetine Diflunisal may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
Dexmethylphenidate Dexmethylphenidate The risk or severity of hypertension can be increased when Diflunisal is combined with Dexmethylphenidate.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Almotriptan Almotriptan Diflunisal may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Eletriptan Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Diflunisal.
Emtricitabine Emtricitabine Diflunisal may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Diflunisal may decrease the excretion rate of Memantine which could result in a higher serum level.
Tadalafil Tadalafil Diflunisal may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan Frovatriptan The risk or severity of hypertension can be increased when Diflunisal is combined with Frovatriptan.
Gemifloxacin Gemifloxacin Diflunisal may increase the neuroexcitatory activities of Gemifloxacin.
Protriptyline Protriptyline The risk or severity of hypertension can be increased when Protriptyline is combined with Diflunisal.
Duloxetine Duloxetine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Diflunisal.
Tinidazole Tinidazole Diflunisal may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan Bosentan The therapeutic efficacy of Bosentan can be decreased when used in combination with Diflunisal.
Cefditoren Cefditoren Diflunisal may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Diflunisal may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Eszopiclone Eszopiclone Diflunisal may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ganciclovir Ganciclovir Diflunisal may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection Diflunisal may increase the hypoglycemic activities of Insulin aspart.
Ribavirin Ribavirin Diflunisal may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of hypertension can be increased when Diflunisal is combined with Solifenacin.
Valganciclovir Valganciclovir Diflunisal may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Zoledronic Acid Injection Zoledronic Acid Injection The risk or severity of gastrointestinal bleeding can be increased when Diflunisal is combined with Zoledronic acid.
Adefovir Adefovir Adefovir may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Diflunisal may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Pramlintide Injection Pramlintide Injection Diflunisal may increase the hypoglycemic activities of Pramlintide.
Exenatide Injection Exenatide Injection Diflunisal may increase the hypoglycemic activities of Exenatide.
Ibandronate Ibandronate The risk or severity of gastrointestinal bleeding can be increased when Diflunisal is combined with Ibandronate.
Isocarboxazid Isocarboxazid The risk or severity of hypertension can be increased when Diflunisal is combined with Isocarboxazid.
Ramelteon Ramelteon Diflunisal may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Fentanyl may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Pregabalin Pregabalin Diflunisal may decrease the excretion rate of Pregabalin which could result in a higher serum level.
Deferasirox Deferasirox The risk or severity of gastrointestinal bleeding and peptic ulcer can be increased when Diflunisal is combined with Deferasirox.
Phenylephrine Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Diflunisal.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection Diflunisal may increase the hypoglycemic activities of Insulin detemir.
Ranolazine Ranolazine Diflunisal may decrease the excretion rate of Ranolazine which could result in a higher serum level.
Rasagiline Rasagiline Diflunisal may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Sitagliptin Sitagliptin Diflunisal may increase the hypoglycemic activities of Sitagliptin.
Varenicline Varenicline Diflunisal may decrease the excretion rate of Varenicline which could result in a higher serum level.
Albuterol Albuterol Diflunisal may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone Diflunisal may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Clofarabine Injection Clofarabine Injection Diflunisal may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of adverse effects can be increased when Diflunisal is combined with Varicella Zoster Vaccine (Live/attenuated).
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection Diflunisal may increase the hypoglycemic activities of Insulin glulisine.
Lubiprostone Lubiprostone Diflunisal may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Aliskiren Aliskiren The risk or severity of renal failure and hypertension can be increased when Diflunisal is combined with Aliskiren.
Bismuth Subsalicylate Bismuth Subsalicylate The therapeutic efficacy of Bismuth subsalicylate can be decreased when used in combination with Diflunisal.
Pemetrexed Injection Pemetrexed Injection Diflunisal may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lisdexamfetamine Lisdexamfetamine The risk or severity of hypertension can be increased when Diflunisal is combined with Lisdexamfetamine.
Sorafenib Sorafenib The metabolism of Sorafenib can be decreased when combined with Diflunisal.
Sunitinib Sunitinib Diflunisal may increase the hypoglycemic activities of Sunitinib.
Levocetirizine Levocetirizine Diflunisal may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Diflunisal may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Diflunisal may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Lenalidomide Lenalidomide Diflunisal may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Budesonide Budesonide The risk or severity of gastrointestinal irritation can be increased when Diflunisal is combined with Budesonide.
Desmopressin Desmopressin The risk or severity of hypertension, hyponatremia, and water intoxication can be increased when Diflunisal is combined with Desmopressin.
Doripenem Injection Doripenem Injection Diflunisal may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Diflunisal may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine The risk or severity of gastrointestinal bleeding can be increased when Desvenlafaxine is combined with Diflunisal.
Cevimeline Cevimeline Diflunisal may decrease the excretion rate of Cevimeline which could result in a higher serum level.
Nebivolol Nebivolol Diflunisal may decrease the antihypertensive activities of Nebivolol.
Certolizumab Injection Certolizumab Injection Diflunisal may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Diflunisal.
Daptomycin Injection Daptomycin Injection Diflunisal may decrease the excretion rate of Daptomycin which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Diflunisal may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Midazolam Midazolam Diflunisal may decrease the excretion rate of Midazolam which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Diflunisal may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Milnacipran Milnacipran The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Diflunisal.
Plerixafor Injection Plerixafor Injection Diflunisal may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The risk or severity of renal failure can be increased when Sodium phosphate, monobasic is combined with Diflunisal.
Fesoterodine Fesoterodine Diflunisal may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Betaxolol Betaxolol Diflunisal may decrease the antihypertensive activities of Betaxolol.
Iloperidone Iloperidone The risk or severity of hypertension can be increased when Diflunisal is combined with Iloperidone.
Prasugrel Prasugrel The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Prasugrel.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Diflunisal may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone The risk or severity of hypertension can be increased when Diflunisal is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection The serum concentration of Pralatrexate can be increased when it is combined with Diflunisal.
Palonosetron Injection Palonosetron Injection Diflunisal may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Saxagliptin Saxagliptin Diflunisal may increase the hypoglycemic activities of Saxagliptin.
Telavancin Injection Telavancin Injection Diflunisal may decrease the excretion rate of Telavancin which could result in a higher serum level.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Diflunisal.
Topotecan Topotecan Diflunisal may decrease the excretion rate of Topotecan which could result in a higher serum level.
Asenapine Asenapine The risk or severity of hypertension can be increased when Diflunisal is combined with Asenapine.
Dabigatran Dabigatran The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Dabigatran.
Liraglutide Injection Liraglutide Injection Diflunisal may increase the hypoglycemic activities of Liraglutide.
Dalfampridine Dalfampridine Diflunisal may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of hypertension can be increased when Diflunisal is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The serum concentration of Acetaminophen can be increased when it is combined with Diflunisal.
Vilazodone Vilazodone The risk or severity of hypertension can be increased when Diflunisal is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Diflunisal may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Diflunisal may decrease the excretion rate of Aldesleukin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Diflunisal may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Azilsartan medoxomil is combined with Diflunisal.
Roflumilast Roflumilast Diflunisal may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin Diflunisal may increase the hypoglycemic activities of Linagliptin.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Diflunisal.
Rivaroxaban Rivaroxaban The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Rivaroxaban.
Ticagrelor Ticagrelor The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Ticagrelor.
Ruxolitinib Ruxolitinib Diflunisal may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Diflunisal may decrease the excretion rate of Clobazam which could result in a higher serum level.
Deferiprone Deferiprone Diflunisal may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Cabergoline Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Diflunisal.
Naloxone Injection Naloxone Injection Diflunisal may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Diflunisal.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Fondaparinux.
Iloprost Iloprost The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Iloprost.
Enzalutamide Enzalutamide Diflunisal may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Diflunisal may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Regorafenib can be decreased when combined with Diflunisal.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of gastrointestinal irritation can be increased when Diflunisal is combined with Corticotropin.
Lorcaserin Lorcaserin Diflunisal may increase the hypoglycemic activities of Mecasermin.
Teduglutide Injection Teduglutide Injection Diflunisal may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Diflunisal is combined with Icosapent ethyl.
Alogliptin Alogliptin Diflunisal may increase the hypoglycemic activities of Alogliptin.
Pomalidomide Pomalidomide Diflunisal may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Apixaban Apixaban The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Apixaban.
Canagliflozin Canagliflozin The metabolism of Canagliflozin can be decreased when combined with Diflunisal.
Methazolamide Methazolamide The risk or severity of adverse effects can be increased when Diflunisal is combined with Methazolamide.
Trametinib Trametinib Diflunisal may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dolutegravir Dolutegravir The metabolism of Dolutegravir can be decreased when combined with Diflunisal.
Levomilnacipran Levomilnacipran The risk or severity of gastrointestinal bleeding can be increased when Levomilnacipran is combined with Diflunisal.
Ertapenem Injection Ertapenem Injection Diflunisal may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine Vortioxetine Diflunisal may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ketorolac Injection Ketorolac Injection The risk or severity of adverse effects can be increased when Ketorolac is combined with Diflunisal.
Sofosbuvir Sofosbuvir Diflunisal may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Diflunisal.
Apremilast Apremilast Diflunisal may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Diflunisal may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Albiglutide Injection Albiglutide Injection Diflunisal may increase the hypoglycemic activities of Albiglutide.
Testosterone Injection Testosterone Injection Diflunisal may decrease the excretion rate of Testosterone which could result in a higher serum level.
Empagliflozin Empagliflozin Diflunisal may increase the hypoglycemic activities of Empagliflozin.
Vorapaxar Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Vorapaxar.
Dulaglutide Injection Dulaglutide Injection Diflunisal may increase the hypoglycemic activities of Dulaglutide.
Edoxaban Edoxaban The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Edoxaban.
Methamphetamine Methamphetamine Diflunisal may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Diflunisal may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat The therapeutic efficacy of Riociguat can be decreased when used in combination with Diflunisal.
Risperidone Injection Risperidone Injection The risk or severity of hypertension can be increased when Risperidone is combined with Diflunisal.
Insulin Human Inhalation Insulin Human Inhalation Diflunisal may increase the hypoglycemic activities of Insulin human.
Haloperidol Injection Haloperidol Injection The therapeutic efficacy of Haloperidol can be increased when used in combination with Diflunisal.
Amiloride Amiloride The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Amiloride.
Macitentan Macitentan The therapeutic efficacy of Macitentan can be decreased when used in combination with Diflunisal.
Flibanserin Flibanserin The risk or severity of hypertension can be increased when Diflunisal is combined with Flibanserin.
Prednisolone Prednisolone The risk or severity of gastrointestinal irritation can be increased when Diflunisal is combined with Prednisolone.
Brexpiprazole Brexpiprazole The risk or severity of hypertension can be increased when Diflunisal is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of hypertension can be increased when Ziprasidone is combined with Diflunisal.
Cariprazine Cariprazine The risk or severity of hypertension can be increased when Diflunisal is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Diflunisal may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection Diflunisal may increase the hypoglycemic activities of Insulin degludec.
Ixazomib Ixazomib Diflunisal may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Diflunisal may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The risk or severity of gastrointestinal irritation can be increased when Diflunisal is combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Defibrotide.
Brivaracetam Injection Brivaracetam Injection Diflunisal may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Midodrine Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Diflunisal.
Selexipag Selexipag The therapeutic efficacy of Selexipag can be decreased when used in combination with Diflunisal.
Furosemide Injection Furosemide Injection The risk or severity of adverse effects can be increased when Diflunisal is combined with Furosemide.
Lixisenatide Injection Lixisenatide Injection Diflunisal may increase the hypoglycemic activities of Lixisenatide.
Doxepin (Insomnia) Doxepin (Insomnia) Diflunisal may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Diflunisal may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Diflunisal may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of gastrointestinal irritation can be increased when Diflunisal is combined with Deflazacort.
Safinamide Safinamide The risk or severity of hypertension can be increased when Diflunisal is combined with Safinamide.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Diflunisal.
Naldemedine Naldemedine Diflunisal may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Diflunisal.
Benznidazole Benznidazole Diflunisal may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Diflunisal may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Diflunisal.
Semaglutide Injection Semaglutide Injection Diflunisal may increase the hypoglycemic activities of Semaglutide.
Ertugliflozin Ertugliflozin The metabolism of Ertugliflozin can be decreased when combined with Diflunisal.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Diflunisal.
Apalutamide Apalutamide Diflunisal may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Fostamatinib Fostamatinib The metabolism of Fostamatinib can be decreased when combined with Diflunisal.
Baricitinib Baricitinib Diflunisal may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Diflunisal.
Plazomicin Injection Plazomicin Injection Diflunisal may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Cannabidiol Cannabidiol The risk or severity of hypertension can be increased when Diflunisal is combined with Cannabidiol.
Stiripentol Stiripentol Diflunisal may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Diflunisal.
Prucalopride Prucalopride Diflunisal may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Siponimod Siponimod The risk or severity of hypertension can be increased when Diflunisal is combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Diflunisal is combined with Caplacizumab.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Diflunisal.
Darolutamide Darolutamide The metabolism of Darolutamide can be decreased when combined with Diflunisal.
Pitolisant Pitolisant The risk or severity of adverse effects can be increased when Diflunisal is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The serum concentration of Phenytoin can be increased when it is combined with Diflunisal.
Fosphenytoin Injection Fosphenytoin Injection The protein binding of Fosphenytoin can be decreased when combined with Diflunisal.
Selpercatinib Selpercatinib The risk or severity of hypertension can be increased when Diflunisal is combined with Selpercatinib.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Diflunisal is combined with Naxitamab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Diflunisal is combined with Drospirenone.
Viloxazine Viloxazine Diflunisal may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Diflunisal may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Fenoprofen Fenoprofen The therapeutic efficacy of Diflunisal can be decreased when used in combination with Fenoprofen.
Indomethacin Indomethacin The therapeutic efficacy of Diflunisal can be decreased when used in combination with Indomethacin.
Mefenamic Acid Mefenamic Acid The therapeutic efficacy of Diflunisal can be decreased when used in combination with Mefenamic acid.
Naproxen Naproxen The therapeutic efficacy of Diflunisal can be decreased when used in combination with Naproxen.
Tolmetin Tolmetin The therapeutic efficacy of Diflunisal can be decreased when used in combination with Tolmetin.
Sulindac Sulindac The therapeutic efficacy of Diflunisal can be decreased when used in combination with Sulindac.
Trazodone Trazodone The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Diflunisal.
Isotretinoin Isotretinoin Diflunisal may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Diflunisal may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Floxuridine Floxuridine Diflunisal may decrease the excretion rate of Floxuridine which could result in a higher serum level.
Metaxalone Metaxalone Diflunisal may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The serum concentration of Methotrexate can be increased when it is combined with Diflunisal.
Methsuximide Methsuximide The risk or severity of hyperkalemia can be increased when Diflunisal is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of hypertension can be increased when Diflunisal is combined with Diethylpropion.
Chlorpromazine Chlorpromazine Diflunisal may decrease the excretion rate of Chlorpromazine which could result in a higher serum level.
Diazepam Diazepam Diflunisal may decrease the excretion rate of Diazepam which could result in a higher serum level.
Oxazepam Oxazepam The metabolism of Oxazepam can be decreased when combined with Diflunisal.
Flurazepam Flurazepam Diflunisal may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate Clorazepate Diflunisal may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Diflunisal may decrease the excretion rate of Lorazepam which could result in a higher serum level.
Phenoxybenzamine Phenoxybenzamine The therapeutic efficacy of Phenoxybenzamine can be decreased when used in combination with Diflunisal.
Carmustine Carmustine Diflunisal may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine Amantadine Diflunisal may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine Diflunisal may decrease the excretion rate of Codeine which could result in a higher serum level.
Bromocriptine Bromocriptine Diflunisal may increase the hypoglycemic activities of Bromocriptine.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Orciprenaline is combined with Diflunisal.
Tranylcypromine Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Diflunisal.
Phenelzine Phenelzine Diflunisal may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of hypertension can be increased when Diflunisal is combined with Ergoloid mesylate.
Tetracycline Tetracycline Diflunisal may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Thioguanine Thioguanine The metabolism of Tioguanine can be decreased when combined with Diflunisal.
Thioridazine Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Diflunisal.
Trifluoperazine Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Diflunisal.
Bleomycin Bleomycin Diflunisal may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Sulfadiazine Sulfadiazine Diflunisal may increase the hypoglycemic activities of Sulfadiazine.
Methadone Methadone Diflunisal may decrease the excretion rate of Methadone which could result in a higher serum level.
Benztropine Benztropine Diflunisal may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Diflunisal resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline Diflunisal may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen The risk or severity of adverse effects can be increased when Diflunisal is combined with Ibuprofen.
Azathioprine Azathioprine Diflunisal may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Phentermine Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Diflunisal.
Methylphenidate Methylphenidate Diflunisal may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine Amoxapine The risk or severity of hypertension can be increased when Amoxapine is combined with Diflunisal.
Sulfasalazine Sulfasalazine The therapeutic efficacy of Diflunisal can be decreased when used in combination with Sulfasalazine.
Hydrocortisone Hydrocortisone The risk or severity of gastrointestinal irritation can be increased when Diflunisal is combined with Hydrocortisone.
Phenazopyridine Phenazopyridine The risk or severity of nephrotoxicity can be increased when Diflunisal is combined with Phenazopyridine.
Carbamazepine Carbamazepine Diflunisal may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Diflunisal.
Clonidine Clonidine The therapeutic efficacy of Clonidine can be decreased when used in combination with Diflunisal.
Prazosin Prazosin The therapeutic efficacy of Prazosin can be decreased when used in combination with Diflunisal.
Hydralazine Hydralazine Diflunisal may decrease the antihypertensive activities of Hydralazine.
Cimetidine Cimetidine Diflunisal may decrease the excretion rate of Cimetidine which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Diflunisal may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Warfarin Warfarin The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Warfarin.
Clonazepam Clonazepam Diflunisal may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide Loperamide The risk or severity of hyperkalemia can be increased when Loperamide is combined with Diflunisal.
Promethazine Promethazine Diflunisal may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate The therapeutic efficacy of Diflunisal can be decreased when used in combination with Meclofenamic acid.
Nitrofurantoin Nitrofurantoin Diflunisal may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Diflunisal may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Diflunisal may decrease the excretion rate of Chloroquine which could result in a higher serum level.
Quinine Quinine Diflunisal may increase the hypoglycemic activities of Quinine.
Ethosuximide Ethosuximide The risk or severity of hyperkalemia can be increased when Ethosuximide is combined with Diflunisal.
Triamterene Triamterene The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Diflunisal is combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Diflunisal.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Diflunisal.
Metolazone Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Diflunisal.
Isosorbide Isosorbide Diflunisal may increase the excretion rate of Isosorbide which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital Diflunisal may decrease the excretion rate of Secobarbital which could result in a higher serum level.
Desipramine Desipramine Diflunisal may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline Amitriptyline may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Imipramine Imipramine Imipramine may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Probenecid Probenecid Probenecid may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Quinidine Quinidine Diflunisal may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Diflunisal may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Diflunisal may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide Pyrazinamide Diflunisal may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Disopyramide Disopyramide Diflunisal may increase the hypoglycemic activities of Disopyramide.
Valproic Acid Valproic Acid The serum concentration of Valproic acid can be increased when it is combined with Diflunisal.
Butabarbital Butabarbital Diflunisal may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be increased when used in combination with Diflunisal.
Liothyronine Liothyronine Diflunisal may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole Methimazole Diflunisal may decrease the excretion rate of Methimazole which could result in a higher serum level.
Chlorpropamide Chlorpropamide Diflunisal may increase the hypoglycemic activities of Chlorpropamide.
Tolbutamide Tolbutamide Diflunisal may increase the hypoglycemic activities of Tolbutamide.
Tolazamide Tolazamide Diflunisal may increase the hypoglycemic activities of Tolazamide.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Diflunisal.
Baclofen Baclofen Diflunisal may decrease the excretion rate of Baclofen which could result in a higher serum level.
Ethambutol Ethambutol Diflunisal may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Diflunisal.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Diflunisal.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Diflunisal is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone Diflunisal may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Pyridoxine Pyridoxine Diflunisal may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
Folic Acid Folic Acid Diflunisal may decrease the excretion rate of Folic acid which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Diflunisal may decrease the antihypertensive activities of Propranolol.
Minoxidil Minoxidil The therapeutic efficacy of Minoxidil can be decreased when used in combination with Diflunisal.
Pseudoephedrine Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Diflunisal.
Nortriptyline Nortriptyline The risk or severity of hypertension can be increased when Nortriptyline is combined with Diflunisal.
Spironolactone Spironolactone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Mercaptopurine Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Diflunisal.
Phytonadione Phytonadione Diflunisal may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Diflunisal may decrease the excretion rate of Amikacin which could result in a higher serum level.
Nadolol Nadolol Diflunisal may decrease the antihypertensive activities of Nadolol.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Diflunisal resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol Diflunisal may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Flavoxate Flavoxate Diflunisal may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Colchicine Colchicine Diflunisal may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Cefadroxil Cefadroxil Diflunisal may decrease the excretion rate of Cefadroxil which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Dacarbazine Dacarbazine Diflunisal may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Diflunisal is combined with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Diflunisal may decrease the excretion rate of Salmon calcitonin which could result in a higher serum level.
Ketoconazole Ketoconazole The risk or severity of hyperkalemia can be increased when Diflunisal is combined with Ketoconazole.
Pyrantel Pyrantel Diflunisal may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Captopril Captopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Captopril.
Dipyridamole Dipyridamole The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Dipyridamole.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Diflunisal is combined with Isoxsuprine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Diflunisal.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Metoprolol Metoprolol Diflunisal may decrease the antihypertensive activities of Metoprolol.
Aspirin Aspirin The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Diflunisal.
Salsalate Salsalate The therapeutic efficacy of Diflunisal can be decreased when used in combination with Salsalate.
Alprazolam Alprazolam Diflunisal may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Temazepam Temazepam Diflunisal may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam Triazolam Diflunisal may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Diflunisal may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Propantheline Propantheline Diflunisal may decrease the excretion rate of Propantheline which could result in a higher serum level.
Trimethoprim Trimethoprim Diflunisal may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Diltiazem Diltiazem The risk or severity of bleeding can be increased when Diltiazem is combined with Diflunisal.
Nifedipine Nifedipine Diflunisal may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol Diflunisal may decrease the antihypertensive activities of Timolol.
Verapamil Verapamil The risk or severity of bleeding can be increased when Verapamil is combined with Diflunisal.
Atenolol Atenolol Diflunisal may decrease the antihypertensive activities of Atenolol.
Pindolol Pindolol Diflunisal may decrease the antihypertensive activities of Pindolol.
Cisplatin Injection Cisplatin Injection Diflunisal may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Piroxicam Piroxicam The therapeutic efficacy of Diflunisal can be decreased when used in combination with Piroxicam.
Bumetanide Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Diflunisal.
Glyburide Glyburide Diflunisal may increase the hypoglycemic activities of Glyburide.
Glipizide Glipizide Diflunisal may increase the hypoglycemic activities of Glipizide.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Diflunisal.
Amoxicillin Amoxicillin Diflunisal may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Diflunisal may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Diflunisal is combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection Diflunisal may increase the hypoglycemic activities of Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection Diflunisal may decrease the excretion rate of Ceftriaxone which could result in a higher serum level.
Labetalol Labetalol Diflunisal may decrease the antihypertensive activities of Labetalol.
Auranofin Auranofin Diflunisal may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Diflunisal may decrease the excretion rate of Leuprolide which could result in a higher serum level.
Gemfibrozil Gemfibrozil Diflunisal may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Guanabenz Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Diflunisal.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Ketoprofen Ketoprofen The risk or severity of bleeding and gastrointestinal bleeding can be increased when Diflunisal is combined with Ketoprofen.
Cefotetan Injection Cefotetan Injection Diflunisal may decrease the excretion rate of Cefotetan which could result in a higher serum level.
Enalapril Enalapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Enalapril.
Flurbiprofen Flurbiprofen The therapeutic efficacy of Diflunisal can be decreased when used in combination with Flurbiprofen.
Amiodarone Amiodarone The risk or severity of hyperkalemia can be increased when Diflunisal is combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Diflunisal may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone Diflunisal may decrease the excretion rate of Buspirone which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin Diflunisal may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Mesalamine Mesalamine The therapeutic efficacy of Diflunisal can be decreased when used in combination with Mesalazine.
Diclofenac Diclofenac The therapeutic efficacy of Diflunisal can be decreased when used in combination with Diclofenac.
Fluoxetine Fluoxetine The risk or severity of gastrointestinal bleeding can be increased when Fluoxetine is combined with Diflunisal.
Nimodipine Nimodipine The therapeutic efficacy of Nimodipine can be decreased when used in combination with Diflunisal.
Clozapine Clozapine Diflunisal may decrease the excretion rate of Clozapine which could result in a higher serum level.
Estazolam Estazolam Diflunisal may decrease the excretion rate of Estazolam which could result in a higher serum level.
Ofloxacin Ofloxacin Diflunisal may increase the neuroexcitatory activities of Ofloxacin.
Didanosine Didanosine Diflunisal may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Diflunisal may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Benazepril Benazepril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Benazepril.
Etodolac Etodolac The therapeutic efficacy of Diflunisal can be decreased when used in combination with Etodolac.
Felodipine Felodipine The therapeutic efficacy of Felodipine can be decreased when used in combination with Diflunisal.
Fosinopril Fosinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Fosinopril.
Nabumetone Nabumetone The therapeutic efficacy of Diflunisal can be decreased when used in combination with Nabumetone.
Quinapril Quinapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Quinapril.
Ramipril Ramipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Ramipril.
Amlodipine Amlodipine Diflunisal may decrease the antihypertensive activities of Amlodipine.
Itraconazole Itraconazole The risk or severity of hyperkalemia can be increased when Diflunisal is combined with Itraconazole.
Lisinopril Lisinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Lisinopril.
Oxaprozin Oxaprozin The therapeutic efficacy of Diflunisal can be decreased when used in combination with Oxaprozin.
Sotalol Sotalol Diflunisal may decrease the antihypertensive activities of Sotalol.
Bisoprolol Bisoprolol Diflunisal may decrease the antihypertensive activities of Bisoprolol.
Doxazosin Doxazosin The therapeutic efficacy of Doxazosin can be decreased when used in combination with Diflunisal.
Terazosin Terazosin The therapeutic efficacy of Terazosin can be decreased when used in combination with Diflunisal.
Isradipine Isradipine Diflunisal may decrease the excretion rate of Isradipine which could result in a higher serum level.
Venlafaxine Venlafaxine Venlafaxine may increase the antiplatelet activities of Diflunisal.
Stavudine Stavudine The excretion of Stavudine can be decreased when combined with Diflunisal.
Fluvoxamine Fluvoxamine The risk or severity of gastrointestinal bleeding can be increased when Diflunisal is combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of gastrointestinal bleeding can be increased when Diflunisal is combined with Nefazodone.
Lamotrigine Lamotrigine Diflunisal may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
Losartan Losartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Losartan is combined with Diflunisal.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Tramadol Tramadol Diflunisal may decrease the excretion rate of Tramadol which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Diflunisal may decrease the excretion rate of Carboplatin which could result in a higher serum level.
Moexipril Moexipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Moexipril.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Diflunisal.
Ifosfamide Injection Ifosfamide Injection Diflunisal may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine Nicardipine The therapeutic efficacy of Nicardipine can be decreased when used in combination with Diflunisal.
Bupropion Bupropion Diflunisal may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine The risk or severity of bleeding can be increased when Diflunisal is combined with Ticlopidine.
Metformin Metformin Diflunisal may increase the hypoglycemic activities of Metformin.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Dalteparin.
Nisoldipine Nisoldipine Diflunisal may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
Lamivudine Lamivudine Diflunisal may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Acarbose Acarbose Diflunisal may increase the hypoglycemic activities of Acarbose.
Glimepiride Glimepiride Diflunisal may increase the hypoglycemic activities of Glimepiride.
Gemcitabine Injection Gemcitabine Injection Diflunisal may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Meropenem Injection Meropenem Injection Diflunisal may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine Diflunisal may decrease the excretion rate of Clomipramine which could result in a higher serum level.
Fosfomycin Fosfomycin Diflunisal may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Diflunisal.
Trandolapril Trandolapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Trandolapril.
Topiramate Topiramate Diflunisal may decrease the excretion rate of Topiramate which could result in a higher serum level.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Diflunisal.
Valsartan Valsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Valsartan is combined with Diflunisal.
Insulin Lispro Injection Insulin Lispro Injection Diflunisal may increase the hypoglycemic activities of Insulin lispro.
Pramipexole Pramipexole Diflunisal may decrease the excretion rate of Pramipexole which could result in a higher serum level.
Carvedilol Carvedilol Diflunisal may decrease the antihypertensive activities of Carvedilol.
Nilutamide Nilutamide Diflunisal may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Diflunisal may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline The risk or severity of hypertension can be increased when Diflunisal is combined with Selegiline.
Sertraline Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Diflunisal.
Propafenone Propafenone Diflunisal may decrease the antihypertensive activities of Propafenone.
Irbesartan Irbesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Diflunisal.
Tamsulosin Tamsulosin Diflunisal may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Finasteride Finasteride The risk or severity of hypertension can be increased when Diflunisal is combined with Finasteride.
Quetiapine Quetiapine Diflunisal may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Cetirizine Cetirizine Diflunisal may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Diflunisal.
Tolcapone Tolcapone Diflunisal may decrease the excretion rate of Tolcapone which could result in a higher serum level.
Citalopram Citalopram The risk or severity of gastrointestinal bleeding can be increased when Citalopram is combined with Diflunisal.
Capecitabine Capecitabine Diflunisal may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Abacavir Abacavir Diflunisal may decrease the excretion rate of Abacavir which could result in a higher serum level.
Pioglitazone Pioglitazone Diflunisal may increase the hypoglycemic activities of Pioglitazone.
Celecoxib Celecoxib The risk or severity of adverse effects can be increased when Celecoxib is combined with Diflunisal.
Rosiglitazone Rosiglitazone Diflunisal may increase the hypoglycemic activities of Rosiglitazone.
Tolterodine Tolterodine Diflunisal may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Oseltamivir Oseltamivir Diflunisal may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Diflunisal resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The therapeutic efficacy of Balsalazide can be decreased when used in combination with Diflunisal.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Diflunisal.
Rabeprazole Rabeprazole Diflunisal may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

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