Insulin Glulisine (rDNA origin) Injection

Generic name: Pronounced as (in' su lin) (gloo' lis een)
Brand names
  • Apidra®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 08/15/2016

Insulin glulisine is used to treat type 1 diabetes (condition in which the body does not make insulin and therefore cannot control the amount of sugar in the blood). It is also used to treat people with type 2 diabetes (condition in which the blood sugar is too high because the body does not produce or use insulin normally) who need insulin to control their diabetes. In patients with type 1 diabetes, insulin glulisine is usually used with another type of insulin, unless it is used in an external insulin pump. In patients with type 2 diabetes, insulin glulisine also may be used with another type of insulin or with oral medication(s) for diabetes. Insulin glulisine is a short-acting, man-made version of human insulin. Insulin glulisine works by replacing the insulin that is normally produced by the body and by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar.

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

Insulin glulisine comes as a solution (liquid) to inject subcutaneously (under the skin). It is usually injected up to 15 minutes before a meal or within 20 minutes after starting a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use insulin glulisine exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Never use insulin glulisine when you have symptoms of hypoglycemia (low blood sugar) or if you have checked your blood sugar and found it to be low. Do not inject insulin into a skin area that is red, swollen, itchy, or thickened.

Insulin glulisine controls diabetes but does not cure it. Continue to use insulin glulisine even if you feel well. Do not stop using insulin glulisine without talking to your doctor. Do not switch to another brand or type of insulin or change the dose of any type of insulin you are using without talking to your doctor. Always check the insulin label to make sure you received the right type of insulin from the pharmacy.

Insulin glulisine comes in vials and in dosing pens that contain cartridges of medication. Be sure you know what type of container your insulin glulisine comes in and what other supplies, such as needles, syringes, or pens, you will need to inject your medication.

If your insulin glulisine comes in vials, you will need to use syringes to inject your dose. Ask your doctor or pharmacist to show you how to inject insulin glulisine using a syringe. Ask your doctor or pharmacist if you have questions about the type of syringe you should use.

If your insulin glargine comes in pens, be sure to read and understand the manufacturer's instructions. Ask your doctor or pharmacist to show you how to use the pen. Follow the directions carefully, and always perform the safety test before use.

Never reuse needles or syringes and never share needles, syringes, or pens. If you are using an insulin pen, always remove the needle right after you inject your dose. Dispose of needles and syringes in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture-resistant container.

Your doctor may tell you to mix your insulin glulisine with another type of insulin (NPH insulin [Novolin N, Humulin N]) in the same syringe. Do not mix or dilute insulin glulisine with any other type of insulin. If you mix insulin glulisine with NPH insulin, draw insulin glulisine into the syringe first, then draw the NPH insulin into the syringe and inject the solution immediately after mixing.

You can inject your insulin glulisine in your thighs, stomach, or upper arms. Never inject insulin glulisine into a vein or muscle. Change (rotate) the injection site within the chosen area with each dose; try to avoid injecting the same site more often than once every 1 to 2 weeks.

Always look at your insulin glulisine before you inject it. It should be clear and colorless. Do not use your insulin glulisine if it is colored, cloudy, or contains solid particles, or if the expiration date on the bottle has passed.

Insulin glulisine also can be used with an external insulin pump. Before using insulin glulisine in a pump system, read the pump label to make sure the pump can be used for continuous delivery of fast-acting insulin. Read the pump manual for recommended reservoir and tubing sets, and ask your doctor or pharmacist to show you how to use the insulin pump. Do not dilute insulin glulisine or mix it with any other type of insulin when using it in an external insulin pump. Insulin glulisine used in an external insulin pump should be infused into your stomach area. When using insulin glulisine in an external insulin pump, replace the insulin in the reservoir and change the tubing, needle, and infusion site (spot where the pump is attached to the body) at least every 48 hours. If the infusion site is red, itchy, or thickened, tell your doctor and use a different infusion site.

When using insulin glulisine in an external insulin pump, high blood sugar may occur quickly if the pump stops working properly or if the insulin in the pump reservoir is exposed to direct sunlight or temperatures greater than 98.6°F (37°C). High blood sugar may also occur if the tubing leaks or becomes blocked, disconnected, or kinks. You may need to change the infusion set and insulin in the pump or infusion site if you have high blood sugar, the pump alarm sounds, or the insulin flow is blocked. If the problem cannot be found quickly and corrected, call your doctor right away. You may need to temporarily use insulin by subcutaneous injection (using syringes or an insulin pen). Make sure you have back-up insulin and any necessary supplies on hand, and ask your doctor or pharmacist to show you how to use them.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using insulin glulisine,

  • tell your doctor and pharmacist if you are allergic to insulin (Humulin, Novolin, others), any of the ingredients of insulin glulisine, or any other medications. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); certain cholesterol-lowering medications such as fenofibrate (Antara, Lofibra, TriCor, Triglide), gemfibrozil (Lopid), and niacin (Niacor, Niaspan, in Advicor); clonidine (Catapres, Catapres-TTS, in Clorpres); danazol; disopyramide (Norpace); diuretics ('water pills'); fluoxetine (Prozac, Sarafem, in Symbyax); glucagon (Glucagen); hormone replacement therapy; isoniazid (INH, Nydrazid); lithium (Eskalith, Lithobid); medications for asthma and colds; certain medications for human immunodeficiency virus (HIV) including amprenavir (Agenerase), atazanavir (Reyataz), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (in Kaletra, Norvir), saquinavir (Invirase), and tipranavir (Aptivus); medications for mental illness and nausea; monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); hormonal contraceptives (birth control pills, patches, rings, injections, or implants); octreotide (Sandostatin); oral medications for diabetes; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); pentamidine (NebuPent, Pentam); pentoxifylline (Pentoxil, Trental); pramlintide (Symlin); reserpine; salicylate pain relievers such as aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan's, others), and salsalate (Argesic, Disalcid, Salgesic); somatropin (Nutropin, Serostem, others); sulfa antibiotics; and thyroid medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had nerve damage caused by your diabetes or any other medical conditions, including kidney or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using insulin glulisine, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are using insulin glulisine.

  • alcohol may cause a change in blood sugar. Ask your doctor about the safe use of alcoholic beverages while you are using insulin glulisine.

  • ask your doctor what to do if you get sick, experience unusual stress, or change your exercise and activity level. These changes can affect your blood sugar and the amount of insulin you may need.

  • ask your doctor how often you should check your blood sugar. Be aware that hypoglycemia may affect your ability to perform tasks such as driving and ask your doctor if you need to check your blood sugar before driving or operating machinery.

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthful diet and to eat about the same amounts of the same kinds of food at about the same times each day. Skipping or delaying meals or changing the amount or kind of food you eat can cause problems with your blood sugar control.

Insulin glulisine must be injected up to 15 minutes before or within 20 minutes after starting a meal. If some time has passed since your meal, follow the instructions provided by your doctor or call your doctor to find out whether you should inject the missed dose. Do not inject a double dose to make up for a missed one.

Insulin glulisine may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

  • Insulin glulisine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • redness, swelling, or itching at the site of the injection

    • changes in the feel of your skin, skin thickening (fat build-up), or a little indentation in the skin (fat breakdown)

    • swelling of the hands and feet

    • weight gain

    • constipation

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency treatment:

    • rash and/or itching over the whole body

    • shortness of breath

    • wheezing

    • dizziness

    • blurred vision

    • fast heartbeat

    • sweating

    • lightheadedness/fainting

    • difficulty breathing or swallowing

    • weakness

    • muscle cramps

    • abnormal heartbeat

  • Insulin glulisine may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

Store unopened insulin glulisine vials and pens in the refrigerator away from light. Never allow insulin glulisine to freeze; do not use insulin glulisine that has been frozen and thawed. Opened insulin glulisine vials may be refrigerated or may be stored at room temperature, away from direct sunlight and heat, for up to 28 days. Prefilled pens that have not been used may be refrigerated or may be stored at room temperature, away from direct heat and sunlight, for up to 28 days. Prefilled pens that have been used should not be refrigerated; they should be stored at room temperature for up to 28 days after the first use. Dispose of opened insulin glulisine vials and pens after 28 days. Dispose of unopened, refrigerated insulin glulisine after the expiration date printed on the label has passed. Dispose of any insulin glulisine that has been frozen or exposed to extreme heat.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Insulin glulisine overdose can occur if you use too much insulin glulisine or if you use the right amount of insulin glulisine but eat less than usual or exercise more than usual. Insulin glulisine overdose can cause hypoglycemia. If you have symptoms of hypoglycemia, follow your doctor's instructions for what you should do if you develop hypoglycemia. Other symptoms of overdose may include:

  • loss of consciousness

  • seizures

Keep all appointments with your doctor and the laboratory. Your blood sugar and glycosylated hemoglobin (HbA1c) should be checked regularly to determine your response to insulin glulisine. Your doctor will also tell you how to check your response to insulin by measuring your blood sugar levels at home. Follow these instructions carefully.

You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Moxifloxacin.
Repaglinide Repaglinide The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Insulin glulisine.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Insulin glargine is combined with Insulin glulisine.
Leflunomide Leflunomide The metabolism of Leflunomide can be increased when combined with Insulin glulisine.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Insulin glulisine.
Anagrelide Anagrelide The metabolism of Anagrelide can be increased when combined with Insulin glulisine.
Cilostazol Cilostazol The metabolism of Cilostazol can be increased when combined with Insulin glulisine.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be increased when combined with Insulin glulisine.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Conjugated estrogens can be increased when combined with Insulin glulisine.
Miglitol Miglitol The risk or severity of hypoglycemia can be increased when Miglitol is combined with Insulin glulisine.
Olsalazine Olsalazine Olsalazine may increase the hypoglycemic activities of Insulin glulisine.
Penbutolol Penbutolol The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Acebutolol.
Prednisone Prednisone The risk or severity of hyperglycemia can be increased when Prednisone is combined with Insulin glulisine.
Ranitidine Ranitidine The metabolism of Ranitidine can be increased when combined with Insulin glulisine.
Sumatriptan Sumatriptan The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Sumatriptan.
Tacrolimus Tacrolimus The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Tacrolimus.
Tizanidine Tizanidine The metabolism of Tizanidine can be increased when combined with Insulin glulisine.
Triamcinolone Triamcinolone The risk or severity of hyperglycemia can be increased when Triamcinolone is combined with Insulin glulisine.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be increased when combined with Insulin glulisine.
Fluconazole Injection Fluconazole Injection The risk or severity of hypoglycemia can be increased when Insulin glulisine is combined with Fluconazole.
Levofloxacin Injection Levofloxacin Injection The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Levofloxacin.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of hyperglycemia can be increased when Methylprednisolone is combined with Insulin glulisine.
Metoclopramide Injection Metoclopramide Injection The therapeutic efficacy of Metoclopramide can be increased when used in combination with Insulin glulisine.
Altretamine Altretamine Amphetamine may increase the hypoglycemic activities of Insulin glulisine.
Torsemide Torsemide The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Torasemide.
Olanzapine Olanzapine The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Olanzapine.
Alosetron Alosetron The metabolism of Alosetron can be increased when combined with Insulin glulisine.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Hydroxychloroquine.
Linezolid Linezolid Linezolid may increase the hypoglycemic activities of Insulin glulisine.
Trimipramine Trimipramine Trimipramine may decrease the hypoglycemic activities of Insulin glulisine.
Sirolimus Sirolimus The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Sirolimus.
Epinephrine Injection Epinephrine Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Epinephrine.
Escitalopram Escitalopram The risk or severity of hypoglycemia can be increased when Escitalopram is combined with Insulin glulisine.
Zonisamide Zonisamide The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Zonisamide.
Aripiprazole Aripiprazole The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Aripiprazole.
Atazanavir Atazanavir The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Atazanavir.
Rosuvastatin Rosuvastatin The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Rosuvastatin.
Fosamprenavir Fosamprenavir The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Fosamprenavir.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be increased when combined with Insulin glulisine.
Gemifloxacin Gemifloxacin The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Gemifloxacin.
Progesterone Progesterone The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Progesterone.
Oxandrolone Oxandrolone Oxandrolone may increase the hypoglycemic activities of Insulin glulisine.
Protriptyline Protriptyline Protriptyline may decrease the hypoglycemic activities of Insulin glulisine.
Duloxetine Duloxetine The metabolism of Duloxetine can be increased when combined with Insulin glulisine.
Norethindrone Norethindrone The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Norethisterone.
Bosentan Bosentan The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Bosentan.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be increased when combined with Insulin glulisine.
Erlotinib Erlotinib The metabolism of Erlotinib can be increased when combined with Insulin glulisine.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Insulin aspart is combined with Insulin glulisine.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the hypoglycemic activities of Insulin glulisine.
Entecavir Entecavir The metabolism of Entecavir can be increased when combined with Insulin glulisine.
Pramlintide Injection Pramlintide Injection Pramlintide may increase the hypoglycemic activities of Insulin glulisine.
Exenatide Injection Exenatide Injection Exenatide may increase the hypoglycemic activities of Insulin glulisine.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypoglycemic activities of Insulin glulisine.
Ramelteon Ramelteon The metabolism of Ramelteon can be increased when combined with Insulin glulisine.
Pregabalin Pregabalin The risk or severity of hypoglycemia can be increased when Pregabalin is combined with Insulin glulisine.
Tipranavir Tipranavir The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Tipranavir.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Insulin detemir is combined with Insulin glulisine.
Rasagiline Rasagiline The metabolism of Rasagiline can be increased when combined with Insulin glulisine.
Imatinib Imatinib The metabolism of Imatinib can be increased when combined with Insulin glulisine.
Sitagliptin Sitagliptin Sitagliptin may increase the hypoglycemic activities of Insulin glulisine.
Paliperidone Paliperidone The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Paliperidone.
Bortezomib Bortezomib The metabolism of Bortezomib can be increased when combined with Insulin glulisine.
Primaquine Primaquine The metabolism of Primaquine can be increased when combined with Insulin glulisine.
Bismuth Subsalicylate Bismuth Subsalicylate Bismuth subsalicylate may increase the hypoglycemic activities of Insulin glulisine.
Darunavir Darunavir The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Darunavir.
Pemetrexed Injection Pemetrexed Injection The metabolism of Pemetrexed can be increased when combined with Insulin glulisine.
Vorinostat Vorinostat The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Vorinostat.
Sorafenib Sorafenib The metabolism of Sorafenib can be increased when combined with Insulin glulisine.
Sunitinib Sunitinib The risk or severity of hypoglycemia can be increased when Sunitinib is combined with Insulin glulisine.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Insulin glulisine.
Mexiletine Mexiletine The metabolism of Mexiletine can be increased when combined with Insulin glulisine.
Temsirolimus Temsirolimus The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Temsirolimus.
Nilotinib Nilotinib The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Nilotinib.
Budesonide Budesonide The risk or severity of hyperglycemia can be increased when Budesonide is combined with Insulin glulisine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The risk or severity of hypoglycemia can be increased when Insulin glulisine is combined with Desvenlafaxine.
Nebivolol Nebivolol The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Nebivolol.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be increased when combined with Insulin glulisine.
Flecainide Flecainide The metabolism of Flecainide can be increased when combined with Insulin glulisine.
Praziquantel Praziquantel The metabolism of Praziquantel can be increased when combined with Insulin glulisine.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be increased when combined with Insulin glulisine.
Milnacipran Milnacipran The risk or severity of hypoglycemia can be increased when Insulin glulisine is combined with Milnacipran.
Betaxolol Betaxolol The therapeutic efficacy of Betaxolol can be increased when used in combination with Insulin glulisine.
Iloperidone Iloperidone The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Iloperidone.
Everolimus Everolimus The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Everolimus.
Saxagliptin Saxagliptin Saxagliptin may increase the hypoglycemic activities of Insulin glulisine.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Insulin glulisine.
Asenapine Asenapine The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Asenapine.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Insulin glulisine.
Levonorgestrel Levonorgestrel The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Levonorgestrel.
Liraglutide Injection Liraglutide Injection Liraglutide may increase the hypoglycemic activities of Insulin glulisine.
Lurasidone Lurasidone The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Insulin glulisine.
Linagliptin Linagliptin Linagliptin may increase the hypoglycemic activities of Insulin glulisine.
Triptorelin Injection Triptorelin Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Triptorelin.
Vemurafenib Vemurafenib The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Vemurafenib.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Insulin glulisine.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of hyperglycemia can be increased when Corticotropin is combined with Insulin glulisine.
Lorcaserin Lorcaserin The risk or severity of hypoglycemia can be increased when Mecasermin is combined with Insulin glulisine.
Alogliptin Alogliptin Alogliptin may increase the hypoglycemic activities of Insulin glulisine.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Insulin glulisine.
Canagliflozin Canagliflozin Canagliflozin may increase the hypoglycemic activities of Insulin glulisine.
Methazolamide Methazolamide The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Methazolamide.
Dabrafenib Dabrafenib The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Dabrafenib.
Levomilnacipran Levomilnacipran The risk or severity of hypoglycemia can be increased when Insulin glulisine is combined with Levomilnacipran.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Insulin glulisine.
Simeprevir Simeprevir The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Simeprevir.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the hypoglycemic activities of Insulin glulisine.
Apremilast Apremilast The metabolism of Apremilast can be increased when combined with Insulin glulisine.
Ceritinib Ceritinib The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Ceritinib.
Albiglutide Injection Albiglutide Injection Albiglutide may increase the hypoglycemic activities of Insulin glulisine.
Testosterone Injection Testosterone Injection Testosterone may increase the hypoglycemic activities of Insulin glulisine.
Empagliflozin Empagliflozin The risk or severity of hypoglycemia can be increased when Insulin glulisine is combined with Empagliflozin.
Dulaglutide Injection Dulaglutide Injection Dulaglutide may increase the hypoglycemic activities of Insulin glulisine.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Insulin glulisine.
Lanreotide Injection Lanreotide Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Lanreotide.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be increased when combined with Insulin glulisine.
Risperidone Injection Risperidone Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Risperidone.
Insulin Human Inhalation Insulin Human Inhalation The risk or severity of hypoglycemia can be increased when Insulin human is combined with Insulin glulisine.
Haloperidol Injection Haloperidol Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Haloperidol.
Prednisolone Prednisolone The risk or severity of hyperglycemia can be increased when Prednisolone is combined with Insulin glulisine.
Brexpiprazole Brexpiprazole The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Ziprasidone.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Insulin glulisine is combined with Insulin degludec.
Dexamethasone Injection Dexamethasone Injection The risk or severity of hyperglycemia can be increased when Dexamethasone is combined with Insulin glulisine.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Furosemide.
Rucaparib Rucaparib The metabolism of Rucaparib can be increased when combined with Insulin glulisine.
Lixisenatide Injection Lixisenatide Injection Lixisenatide may increase the hypoglycemic activities of Insulin glulisine.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be increased when combined with Insulin glulisine.
Deflazacort Deflazacort The risk or severity of hyperglycemia can be increased when Deflazacort is combined with Insulin glulisine.
Safinamide Safinamide Safinamide may increase the hypoglycemic activities of Insulin glulisine.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Insulin glulisine.
Delafloxacin Delafloxacin The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Delafloxacin.
Semaglutide Injection Semaglutide Injection Semaglutide may increase the hypoglycemic activities of Insulin glulisine.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Ertugliflozin.
Lofexidine Lofexidine The metabolism of Lofexidine can be increased when combined with Insulin glulisine.
Binimetinib Binimetinib The metabolism of Binimetinib can be increased when combined with Insulin glulisine.
Stiripentol Stiripentol The metabolism of Stiripentol can be increased when combined with Insulin glulisine.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Acyclovir can be increased when combined with Insulin glulisine.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be increased when combined with Insulin glulisine.
Istradefylline Istradefylline The metabolism of Istradefylline can be increased when combined with Insulin glulisine.
Teprotumumab-trbw Injection Teprotumumab-trbw Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Teprotumumab.
Selumetinib Selumetinib The metabolism of Selumetinib can be increased when combined with Insulin glulisine.
Octreotide Octreotide The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Octreotide.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Drospirenone.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Insulin glulisine.
Indomethacin Indomethacin The risk or severity of hypoglycemia can be increased when Indomethacin is combined with Insulin glulisine.
Naproxen Naproxen The metabolism of Naproxen can be increased when combined with Insulin glulisine.
Methsuximide Methsuximide The risk or severity of hypoglycemia can be increased when Methsuximide is combined with Insulin glulisine.
Chlorpromazine Chlorpromazine The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Chlorpromazine.
Carmustine Carmustine The metabolism of Carmustine can be increased when combined with Insulin glulisine.
Bromocriptine Bromocriptine The risk or severity of hypoglycemia can be increased when Bromocriptine is combined with Insulin glulisine.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypoglycemic activities of Insulin glulisine.
Phenelzine Phenelzine Phenelzine may increase the hypoglycemic activities of Insulin glulisine.
Procarbazine Procarbazine Procarbazine may increase the hypoglycemic activities of Insulin glulisine.
Trifluoperazine Trifluoperazine The metabolism of Trifluoperazine can be increased when combined with Insulin glulisine.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Sulfadiazine.
Maprotiline Maprotiline The metabolism of Maprotiline can be increased when combined with Insulin glulisine.
Perphenazine Perphenazine The metabolism of Perphenazine can be increased when combined with Insulin glulisine.
Azathioprine Azathioprine The metabolism of Azathioprine can be increased when combined with Insulin glulisine.
Phentermine Phentermine The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Phentermine.
Amoxapine Amoxapine Amoxapine may decrease the hypoglycemic activities of Insulin glulisine.
Sulfasalazine Sulfasalazine Sulfasalazine may increase the hypoglycemic activities of Insulin glulisine.
Hydrocortisone Hydrocortisone The risk or severity of hyperglycemia can be increased when Hydrocortisone is combined with Insulin glulisine.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Insulin glulisine.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Insulin glulisine.
Loperamide Loperamide The risk or severity of hypoglycemia can be increased when Loperamide is combined with Insulin glulisine.
Quinine Quinine The risk or severity of hypoglycemia can be increased when Quinine is combined with Insulin glulisine.
Ethosuximide Ethosuximide The risk or severity of hypoglycemia can be increased when Ethosuximide is combined with Insulin glulisine.
Triamterene Triamterene The metabolism of Triamterene can be increased when combined with Insulin glulisine.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Chlorthalidone.
Metolazone Metolazone The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Metolazone.
Desipramine Desipramine Desipramine may decrease the hypoglycemic activities of Insulin glulisine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be increased when combined with Insulin glulisine.
Imipramine Imipramine The metabolism of Imipramine can be increased when combined with Insulin glulisine.
Probenecid Probenecid The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Probenecid.
Disopyramide Disopyramide The risk or severity of hypoglycemia can be increased when Disopyramide is combined with Insulin glulisine.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Insulin glulisine.
Levothyroxine Levothyroxine The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Levothyroxine.
Liothyronine Liothyronine The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Liothyronine.
Chlorpropamide Chlorpropamide The risk or severity of hypoglycemia can be increased when Chlorpropamide is combined with Insulin glulisine.
Glucagon Injection Glucagon Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Glucagon.
Tolbutamide Tolbutamide The risk or severity of hypoglycemia can be increased when Tolbutamide is combined with Insulin glulisine.
Tolazamide Tolazamide The risk or severity of hypoglycemia can be increased when Tolazamide is combined with Insulin glulisine.
Cyclobenzaprine Cyclobenzaprine The metabolism of Cyclobenzaprine can be increased when combined with Insulin glulisine.
Niacin Niacin The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Niacin.
Baclofen Baclofen The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Baclofen.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Hydrochlorothiazide.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be increased when combined with Insulin glulisine.
Danazol Danazol The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The therapeutic efficacy of Propranolol can be increased when used in combination with Insulin glulisine.
Pseudoephedrine Pseudoephedrine The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Pseudoephedrine.
Nortriptyline Nortriptyline Nortriptyline may decrease the hypoglycemic activities of Insulin glulisine.
Nadolol Nadolol The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Nadolol.
Fluoxymesterone Fluoxymesterone Fluoxymesterone may increase the hypoglycemic activities of Insulin glulisine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be increased when combined with Insulin glulisine.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be increased when combined with Insulin glulisine.
Acetazolamide Acetazolamide The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Acetazolamide.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Etacrynic acid.
Metoprolol Metoprolol The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Metoprolol.
Thiothixene Thiothixene The metabolism of Thiothixene can be increased when combined with Insulin glulisine.
Aspirin Aspirin The risk or severity of hypoglycemia can be increased when Acetylsalicylic acid is combined with Insulin glulisine.
Diltiazem Diltiazem The risk or severity of hypoglycemia can be increased when Diltiazem is combined with Insulin glulisine.
Nifedipine Nifedipine The metabolism of Nifedipine can be increased when combined with Insulin glulisine.
Timolol Timolol The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Timolol.
Verapamil Verapamil The metabolism of Verapamil can be increased when combined with Insulin glulisine.
Atenolol Atenolol The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Atenolol.
Pindolol Pindolol The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Pindolol.
Diflunisal Diflunisal Diflunisal may increase the hypoglycemic activities of Insulin glulisine.
Bumetanide Bumetanide The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Bumetanide.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Insulin glulisine.
Glyburide Glyburide The risk or severity of hypoglycemia can be increased when Glyburide is combined with Insulin glulisine.
Glipizide Glipizide The risk or severity of hypoglycemia can be increased when Glipizide is combined with Insulin glulisine.
Indapamide Indapamide The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Indapamide.
Pentoxifylline Pentoxifylline The metabolism of Pentoxifylline can be increased when combined with Insulin glulisine.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Pentamidine.
Labetalol Labetalol The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Labetalol.
Leuprolide Injection Leuprolide Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Leuprolide.
Guanabenz Guanabenz The metabolism of Guanabenz can be increased when combined with Insulin glulisine.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Insulin glulisine.
Amiodarone Amiodarone The risk or severity of hypoglycemia can be increased when Amiodarone is combined with Insulin glulisine.
Ciprofloxacin Ciprofloxacin The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may increase the hypoglycemic activities of Insulin glulisine.
Diclofenac Diclofenac The metabolism of Diclofenac can be increased when combined with Insulin glulisine.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be increased when combined with Insulin glulisine.
Nimodipine Nimodipine The risk or severity of hypoglycemia can be increased when Nimodipine is combined with Insulin glulisine.
Clozapine Clozapine The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Clozapine.
Ofloxacin Ofloxacin The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Ofloxacin.
Benazepril Benazepril The risk or severity of hypoglycemia can be increased when Benazepril is combined with Insulin glulisine.
Felodipine Felodipine The risk or severity of hypoglycemia can be increased when Felodipine is combined with Insulin glulisine.
Nabumetone Nabumetone The metabolism of Nabumetone can be increased when combined with Insulin glulisine.
Amlodipine Amlodipine The risk or severity of hypoglycemia can be increased when Amlodipine is combined with Insulin glulisine.
Sotalol Sotalol The risk or severity of hypoglycemia can be increased when Sotalol is combined with Insulin glulisine.
Bisoprolol Bisoprolol The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Bisoprolol.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Insulin glulisine.
Isradipine Isradipine The risk or severity of hypoglycemia can be increased when Isradipine is combined with Insulin glulisine.
Venlafaxine Venlafaxine The risk or severity of hypoglycemia can be increased when Venlafaxine is combined with Insulin glulisine.
Fluvoxamine Fluvoxamine The metabolism of Fluvoxamine can be increased when combined with Insulin glulisine.
Nefazodone Nefazodone The risk or severity of hypoglycemia can be increased when Nefazodone is combined with Insulin glulisine.
Lamotrigine Lamotrigine The risk or severity of hypoglycemia can be increased when Lamotrigine is combined with Insulin glulisine.
Nicardipine Nicardipine The risk or severity of hypoglycemia can be increased when Nicardipine is combined with Insulin glulisine.
Saquinavir Saquinavir The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Saquinavir.
Metformin Metformin The risk or severity of adverse effects can be increased when Insulin glulisine is combined with Metformin.
Nisoldipine Nisoldipine The risk or severity of hypoglycemia can be increased when Nisoldipine is combined with Insulin glulisine.
Riluzole Riluzole The metabolism of Riluzole can be increased when combined with Insulin glulisine.
Acarbose Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Insulin glulisine.
Glimepiride Glimepiride The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Insulin glulisine.
Indinavir Indinavir The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Indinavir.
Ritonavir Ritonavir The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Ritonavir.
Clomipramine Clomipramine The metabolism of Clomipramine can be increased when combined with Insulin glulisine.
Mirtazapine Mirtazapine The metabolism of Mirtazapine can be increased when combined with Insulin glulisine.
Zileuton Zileuton The metabolism of Zileuton can be increased when combined with Insulin glulisine.
Insulin Lispro Injection Insulin Lispro Injection The risk or severity of hypoglycemia can be increased when Insulin lispro is combined with Insulin glulisine.
Nelfinavir Nelfinavir The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Nelfinavir.
Carvedilol Carvedilol The therapeutic efficacy of Carvedilol can be increased when used in combination with Insulin glulisine.
Flutamide Flutamide The metabolism of Flutamide can be increased when combined with Insulin glulisine.
Selegiline Selegiline The metabolism of Selegiline can be increased when combined with Insulin glulisine.
Sertraline Sertraline The risk or severity of hypoglycemia can be increased when Sertraline is combined with Insulin glulisine.
Propafenone Propafenone The therapeutic efficacy of Propafenone can be increased when used in combination with Insulin glulisine.
Tamsulosin Tamsulosin The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Tamsulosin.
Ropinirole Ropinirole The metabolism of Ropinirole can be increased when combined with Insulin glulisine.
Quetiapine Quetiapine The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Quetiapine.
Paroxetine Paroxetine The metabolism of Paroxetine can be increased when combined with Insulin glulisine.
Citalopram Citalopram The risk or severity of hypoglycemia can be increased when Citalopram is combined with Insulin glulisine.
Efavirenz Efavirenz The metabolism of Efavirenz can be increased when combined with Insulin glulisine.
Pioglitazone Pioglitazone The risk or severity of adverse effects can be increased when Pioglitazone is combined with Insulin glulisine.
Celecoxib Celecoxib The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Celecoxib.
Rosiglitazone Rosiglitazone The risk or severity of congestive heart failure can be increased when Insulin glulisine is combined with Rosiglitazone.
Balsalazide Balsalazide Balsalazide may increase the hypoglycemic activities of Insulin glulisine.
Nateglinide Nateglinide The risk or severity of hypoglycemia can be increased when Nateglinide is combined with Insulin glulisine.
Terbinafine Terbinafine The metabolism of Terbinafine can be increased when combined with Insulin glulisine.

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