Montelukast

Generic name: Pronounced as (mon te loo' kast)
Brand names
  • Singulair®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 12/15/2021

Montelukast may cause serious or life-threatening mental health changes while you are taking this medication or after treatment has stopped. Tell your doctor if you have or have ever had any type of mental illness. However, you should know that it is possible to develop these changes in mental health and behavior even if you have never had any mental health problems in the past. You should call your doctor right away and stop taking montelukast if you experience any of the following symptoms: agitation, aggressive behavior, anxiety, irritability, difficulty paying attention, memory loss or forgetfulness, confusion, unusual dreams, hallucinations (seeing things or hearing voices that do not exist), repeating thoughts that you cannot control, depression, difficulty falling asleep or staying asleep, restlessness, sleep walking, suicidal thoughts or actions (thinking about harming or killing yourself or planning or trying to do so), or tremor (uncontrollable shaking of a part of the body). Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

Montelukast is used to prevent wheezing, difficulty breathing, chest tightness, and coughing caused by asthma in adults and children 12 months of age and older. Montelukast is also used to prevent bronchospasm (breathing difficulties) during exercise in adults and children 6 years of age and older. Montelukast is also used to treat the symptoms of seasonal (occurs only at certain times of the year), allergic rhinitis (a condition associated with sneezing and stuffy, runny or itchy nose) in adults and children 2 years of age and older, and perennial (occurs all year round) allergic rhinitis in adults and children 6 months of age and older. Montelukast should be used to treat seasonal or perennial allergic rhinitis only in adults and children who cannot be treated with other medications. Montelukast is in a class of medications called leukotriene receptor antagonists (LTRAs). It works by blocking the action of substances in the body that cause the symptoms of asthma and allergic rhinitis.

Montelukast comes as a tablet, a chewable tablet, and granules to take by mouth. Montelukast is usually taken once a day with or without food. When montelukast is used to treat asthma, it should be taken in the evening. When montelukast is used to prevent breathing difficulties during exercise, it should be taken at least 2 hours before exercise. If you are taking montelukast once a day on a regular basis, or if you have taken a dose of montelukast within the past 24 hours, you should not take an additional dose before exercising. When montelukast is used to treat allergic rhinitis, it may be taken at any time of day. Take montelukast at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take montelukast exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are giving the granules to your child, you should not open the foil pouch until your child is ready to take the medication. There are several ways that you can give the granules to your child, so choose the one that works best for you and your child. You may pour all of the granules directly from the packet into your child's mouth to be swallowed immediately. You may also pour the entire packet of granules onto a clean spoon and place the spoonful of medication in your child's mouth. If you prefer, you may mix the entire packet of granules in 1 teaspoon (5 mL) of cold or room temperature baby formula, breast milk, applesauce, soft carrots, ice cream, or rice. You should not mix the granules with any other foods or liquids, but your child may drink any liquid right after he or she takes the granules. If you mix the granules with one of the allowed foods or drinks, use the mixtures within 15 minutes. Do not store unused mixtures of food, formula, or breast milk and the medication.

Do not use montelukast to treat a sudden attack of asthma symptoms. Your doctor will prescribe a short-acting inhaler to use during attacks. Talk to your doctor about how to treat symptoms of a sudden asthma attack. If your asthma symptoms get worse or if you have asthma attacks more often, be sure to call your doctor.

If you are taking montelukast to treat asthma, continue to take or use all other medications that your doctor has prescribed to treat your asthma. Do not stop taking any of your medications or change the doses of any of your medications unless your doctor tells you that you should. If your asthma is made worse by aspirin, do not take aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) during your treatment with montelukast.

Montelukast controls the symptoms of asthma and allergic rhinitis but does not cure these conditions. Continue to take montelukast even if you feel well. Do not stop taking montelukast without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking montelukast,

  • tell your doctor and pharmacist if you are allergic to montelukast or any other medications, or any of the ingredients in montelukast tablet, chewable tablet, or granules.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention gemfibrozil (Lopid), phenobarbital and rifampin (Rifadin, Rimactane, in Rifamate, Rifater). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.

  • tell your doctor if you have or have ever had liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking montelukast, call your doctor.

  • if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability), you should know that the chewable tablets contain aspartame that forms phenylalanine.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Do not take more than one dose of montelukast in a 24 hour period.

  • Montelukast may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • heartburn

    • stomach pain

    • tiredness

    • diarrhea

  • Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNINGS or SPECIAL PRECAUTIONS section, call your doctor immediately:

    • difficulty breathing or swallowing; swelling of the face, throat, tongue, lips, or eyes; hoarseness; itching; rash; hives

    • blistering, peeling, or shedding skin

    • flu-like symptoms, rash, pins and needles or numbness in the arms or legs, pain and swelling of the sinuses

    • ear pain, fever (in children)

  • Montelukast may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light and excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • stomach pain

  • sleepiness

  • thirst

  • headache

  • vomiting

  • restlessness or agitation

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Montelukast.
Leflunomide Leflunomide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Montelukast can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Montelukast can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Montelukast.
Alendronate Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Alendronic acid.
Candesartan Candesartan The metabolism of Montelukast can be decreased when combined with Candesartan.
Clopidogrel Clopidogrel The metabolism of Montelukast can be decreased when combined with Clopidogrel.
Fenofibrate Fenofibrate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Fenofibrate.
Nafarelin Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Nafarelin.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Montelukast.
Prednisone Prednisone The metabolism of Montelukast can be increased when combined with Prednisone.
Ranitidine Ranitidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Ranitidine.
Tacrolimus Tacrolimus The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Tacrolimus.
Triamcinolone Triamcinolone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Triamcinolone.
Fluconazole Injection Fluconazole Injection The metabolism of Montelukast can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Montelukast can be decreased when combined with Hydromorphone.
Metoclopramide Injection Metoclopramide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Montelukast can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Montelukast.
Pamidronate Injection Pamidronate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pamidronic acid is combined with Montelukast.
Zidovudine Injection Zidovudine Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Zidovudine.
Altretamine Altretamine The metabolism of Montelukast can be decreased when combined with Amphetamine.
Cyclosporine Cyclosporine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Cyclosporine is combined with Montelukast.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Montelukast.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Montelukast.
Olanzapine Olanzapine The metabolism of Montelukast can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Montelukast.
Eprosartan Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Eprosartan.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Montelukast.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Montelukast.
Risedronate Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Risedronic acid.
Anakinra Anakinra The metabolism of Montelukast can be increased when combined with Anakinra.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Montelukast.
Etanercept Injection Etanercept Injection The metabolism of Montelukast can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Montelukast can be decreased when combined with Armodafinil.
Epinephrine Injection Epinephrine Injection The metabolism of Montelukast can be decreased when combined with Epinephrine.
Adalimumab Injection Adalimumab Injection The metabolism of Montelukast can be increased when combined with Adalimumab.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Montelukast.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Montelukast.
Eletriptan Eletriptan The metabolism of Montelukast can be increased when combined with Eletriptan.
Mefloquine Mefloquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Mefloquine is combined with Montelukast.
Rosuvastatin Rosuvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Rosuvastatin.
Aprepitant Aprepitant The metabolism of Montelukast can be decreased when combined with Aprepitant.
Memantine Memantine The metabolism of Montelukast can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Montelukast can be decreased when combined with Tegaserod.
Progesterone Progesterone The metabolism of Montelukast can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Montelukast.
Infliximab Injection Infliximab Injection The metabolism of Montelukast can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Montelukast can be decreased when combined with Oxandrolone.
Rifaximin Rifaximin The metabolism of Montelukast can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Montelukast.
Bosentan Bosentan The metabolism of Montelukast can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Montelukast.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Montelukast.
Ganciclovir Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Ganciclovir.
Voriconazole Voriconazole The metabolism of Montelukast can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The metabolism of Montelukast can be decreased when combined with Amphetamine.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Montelukast can be increased when combined with Peginterferon alfa-2b.
Ibandronate Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Ibandronate.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Montelukast.
Deferasirox Deferasirox The metabolism of Montelukast can be decreased when combined with Deferasirox.
Felbamate Felbamate The metabolism of Montelukast can be decreased when combined with Felbamate.
Abatacept Injection Abatacept Injection The metabolism of Montelukast can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Montelukast can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Montelukast.
Gefitinib Gefitinib The metabolism of Montelukast can be decreased when combined with Gefitinib.
Bortezomib Bortezomib The metabolism of Montelukast can be decreased when combined with Bortezomib.
Nabilone Nabilone The metabolism of Montelukast can be decreased when combined with Nabilone.
Sorafenib Sorafenib The metabolism of Montelukast can be decreased when combined with Sorafenib.
Dronabinol Dronabinol The metabolism of Montelukast can be decreased when combined with Dronabinol.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Montelukast.
Armodafinil Armodafinil The metabolism of Montelukast can be decreased when combined with Armodafinil.
Ivermectin Ivermectin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Ivermectin.
Nilotinib Nilotinib The metabolism of Montelukast can be decreased when combined with Nilotinib.
Raltegravir Raltegravir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Raltegravir.
Bexarotene Bexarotene The metabolism of Montelukast can be decreased when combined with Bexarotene.
Etravirine Etravirine The metabolism of Montelukast can be decreased when combined with Etravirine.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Montelukast.
Pilocarpine Pilocarpine The metabolism of Montelukast can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Montelukast can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Montelukast can be increased when combined with Certolizumab pegol.
Daptomycin Injection Daptomycin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Montelukast.
Naltrexone Injection Naltrexone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Naltrexone.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Montelukast.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Montelukast.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Montelukast.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Montelukast.
Golimumab Injection Golimumab Injection The metabolism of Montelukast can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Montelukast.
Pitavastatin Pitavastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Pitavastatin.
Tocilizumab Injection Tocilizumab Injection The metabolism of Montelukast can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Montelukast.
Acetaminophen Injection Acetaminophen Injection The metabolism of Montelukast can be decreased when combined with Acetaminophen.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Montelukast.
Abiraterone Abiraterone The metabolism of Montelukast can be decreased when combined with Abiraterone.
Ticagrelor Ticagrelor The metabolism of Montelukast can be decreased when combined with Ticagrelor.
Vemurafenib Vemurafenib The metabolism of Montelukast can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Montelukast can be decreased when combined with Vismodegib.
Iloprost Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Iloprost.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Montelukast.
Regorafenib Regorafenib The metabolism of Montelukast can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Montelukast can be decreased when combined with Bosutinib.
Teriflunomide Teriflunomide The metabolism of Montelukast can be decreased when combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Montelukast.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Montelukast.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Montelukast.
Dabrafenib Dabrafenib The metabolism of Montelukast can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Montelukast.
Trametinib Trametinib The metabolism of Montelukast can be decreased when combined with Trametinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Montelukast.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Montelukast.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Montelukast.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Montelukast.
Apremilast Apremilast The metabolism of Montelukast can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Montelukast can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Montelukast can be increased when combined with Siltuximab.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be decreased when combined with Montelukast.
Oritavancin Injection Oritavancin Injection The metabolism of Montelukast can be decreased when combined with Oritavancin.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Montelukast.
Secukinumab Injection Secukinumab Injection The metabolism of Montelukast can be increased when combined with Secukinumab.
Lenvatinib Lenvatinib The metabolism of Montelukast can be decreased when combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Montelukast.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Montelukast.
Rifapentine Rifapentine The metabolism of Montelukast can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Montelukast.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Montelukast can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Montelukast.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Montelukast.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Montelukast.
Rucaparib Rucaparib The metabolism of Montelukast can be decreased when combined with Rucaparib.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Montelukast.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Montelukast.
Safinamide Safinamide The metabolism of Montelukast can be decreased when combined with Safinamide.
Midostaurin Midostaurin The metabolism of Montelukast can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Montelukast.
Delafloxacin Delafloxacin The metabolism of Montelukast can be increased when combined with Delafloxacin.
Letermovir Letermovir The metabolism of Montelukast can be decreased when combined with Letermovir.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Montelukast.
Apalutamide Apalutamide The metabolism of Apalutamide can be decreased when combined with Montelukast.
Penicillamine Penicillamine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Penicillamine.
Avatrombopag Avatrombopag The metabolism of Montelukast can be increased when combined with Avatrombopag.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Montelukast.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Montelukast.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Montelukast.
Stiripentol Stiripentol The metabolism of Montelukast can be decreased when combined with Stiripentol.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Montelukast.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Montelukast.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Montelukast.
Rifamycin Rifamycin The metabolism of Montelukast can be decreased when combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Montelukast can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Montelukast.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Montelukast.
Alpelisib Alpelisib The serum concentration of Montelukast can be decreased when it is combined with Alpelisib.
Cladribine Cladribine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Cladribine is combined with Montelukast.
Triclabendazole Triclabendazole The metabolism of Montelukast can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Montelukast.
Pitolisant Pitolisant The serum concentration of Montelukast can be decreased when it is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Montelukast.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Montelukast.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Montelukast.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Montelukast.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Montelukast.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Montelukast.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Montelukast.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Montelukast.
Selpercatinib Selpercatinib The serum concentration of Montelukast can be increased when it is combined with Selpercatinib.
Pralsetinib Pralsetinib The metabolism of Montelukast can be decreased when combined with Pralsetinib.
Opicapone Opicapone The metabolism of Montelukast can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Montelukast can be decreased when it is combined with Satralizumab.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Montelukast.
Indomethacin Indomethacin The metabolism of Montelukast can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Montelukast.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Montelukast.
Isotretinoin Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Isotretinoin.
Floxuridine Floxuridine The metabolism of Montelukast can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Montelukast.
Methotrexate Injection Methotrexate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Methotrexate.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Montelukast.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Montelukast.
Flurazepam Flurazepam The metabolism of Flurazepam can be decreased when combined with Montelukast.
Tranylcypromine Tranylcypromine The metabolism of Montelukast can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Montelukast can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Procarbazine.
Minocycline Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Minocycline.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Montelukast.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Montelukast.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Montelukast.
Oxybutynin Oxybutynin The metabolism of Montelukast can be decreased when combined with Oxybutynin.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Montelukast.
Hydrocortisone Hydrocortisone The metabolism of Montelukast can be increased when combined with Hydrocortisone.
Cytarabine Cytarabine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Cytarabine.
Methyldopa Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Methyldopa.
Cimetidine Cimetidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Cimetidine.
Warfarin Warfarin The metabolism of Warfarin can be decreased when combined with Montelukast.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Montelukast.
Promethazine Promethazine The metabolism of Montelukast can be decreased when combined with Promethazine.
Griseofulvin Griseofulvin The metabolism of Montelukast can be increased when combined with Griseofulvin.
Loxapine Loxapine The therapeutic efficacy of Montelukast can be decreased when used in combination with Loxapine.
Chloroquine Chloroquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Chloroquine.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Montelukast.
Sulfinpyrazone Sulfinpyrazone The metabolism of Montelukast can be decreased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Montelukast can be increased when combined with Secobarbital.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Montelukast.
Probenecid Probenecid The metabolism of Montelukast can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Montelukast can be decreased when combined with Quinidine.
Procainamide Procainamide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Procainamide.
Isoniazid Isoniazid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Isoniazid.
Rifampin Rifampin The metabolism of Montelukast can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Montelukast can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Montelukast.
Levothyroxine Levothyroxine The metabolism of Montelukast can be decreased when combined with Levothyroxine.
Methimazole Methimazole The metabolism of Montelukast can be decreased when combined with Methimazole.
Propylthiouracil Propylthiouracil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Propylthiouracil.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Montelukast.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Montelukast.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Montelukast.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Montelukast.
Niacin Niacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Niacin.
Baclofen Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Baclofen is combined with Montelukast.
Chlorzoxazone Chlorzoxazone The metabolism of Montelukast can be decreased when combined with Chlorzoxazone.
Spironolactone Spironolactone The metabolism of Montelukast can be decreased when combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Amphotericin B.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Montelukast.
Colchicine Colchicine The metabolism of Montelukast can be decreased when combined with Colchicine.
Ketoconazole Ketoconazole The metabolism of Montelukast can be decreased when combined with Ketoconazole.
Vincristine Injection Vincristine Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Vincristine.
Captopril Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Captopril.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Montelukast.
Triazolam Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Triazolam.
Trimethoprim Trimethoprim The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Montelukast.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Montelukast.
Nifedipine Nifedipine The metabolism of Montelukast can be decreased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Montelukast.
Cisplatin Injection Cisplatin Injection The metabolism of Montelukast can be decreased when combined with Cisplatin.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Montelukast.
Bumetanide Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Bumetanide.
Glyburide Glyburide The metabolism of Montelukast can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Montelukast.
Leuprolide Injection Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Montelukast.
Gemfibrozil Gemfibrozil The metabolism of Montelukast can be decreased when combined with Gemfibrozil.
Ketoprofen Ketoprofen The metabolism of Montelukast can be decreased when combined with Ketoprofen.
Enalapril Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Enalapril.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Montelukast.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Montelukast.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Montelukast.
Ciprofloxacin Ciprofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Montelukast.
Fluoxetine Fluoxetine The metabolism of Montelukast can be decreased when combined with Fluoxetine.
Clozapine Clozapine The metabolism of Clozapine can be decreased when combined with Montelukast.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Montelukast.
Ofloxacin Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Ofloxacin.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Montelukast.
Felodipine Felodipine The metabolism of Montelukast can be decreased when combined with Felodipine.
Nabumetone Nabumetone The metabolism of Montelukast can be decreased when combined with Nabumetone.
Pravastatin Pravastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Montelukast.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Montelukast.
Teniposide Injection Teniposide Injection The metabolism of Montelukast can be decreased when combined with Teniposide.
Atovaquone Atovaquone The metabolism of Montelukast can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Montelukast can be increased when combined with Rifabutin.
Zolpidem Zolpidem The metabolism of Montelukast can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Montelukast.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Montelukast.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Montelukast.
Fluvastatin Fluvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Montelukast can be decreased when combined with Venlafaxine.
Nizatidine Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Nizatidine.
Stavudine Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Stavudine.
Fluvoxamine Fluvoxamine The metabolism of Montelukast can be decreased when combined with Fluvoxamine.
Losartan Losartan The metabolism of Montelukast can be decreased when combined with Losartan.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Montelukast.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Montelukast.
Nicardipine Nicardipine The metabolism of Montelukast can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Montelukast.
Ticlopidine Ticlopidine The metabolism of Montelukast can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Montelukast can be decreased when combined with Saquinavir.
Lamivudine Lamivudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Lamivudine.
Glimepiride Glimepiride The metabolism of Montelukast can be decreased when combined with Glimepiride.
Anastrozole Anastrozole The metabolism of Montelukast can be decreased when combined with Anastrozole.
Indinavir Indinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Indinavir is combined with Montelukast.
Ritonavir Ritonavir The serum concentration of Montelukast can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Docetaxel.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Montelukast.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Montelukast.
Valsartan Valsartan The metabolism of Montelukast can be decreased when combined with Valsartan.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Montelukast.
Nelfinavir Nelfinavir The metabolism of Montelukast can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Montelukast can be decreased when combined with Azithromycin.
Loratadine Loratadine The metabolism of Montelukast can be decreased when combined with Loratadine.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Montelukast.
Nilutamide Nilutamide The metabolism of Montelukast can be decreased when combined with Nilutamide.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Montelukast.
Bicalutamide Bicalutamide The metabolism of Montelukast can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Montelukast can be decreased when combined with Sertraline.
Letrozole Letrozole The metabolism of Montelukast can be decreased when combined with Letrozole.
Raloxifene Raloxifene The metabolism of Montelukast can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Montelukast.
Ropinirole Ropinirole The metabolism of Ropinirole can be increased when combined with Montelukast.
Paroxetine Paroxetine The metabolism of Montelukast can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Montelukast can be decreased when combined with Tolcapone.
Capecitabine Capecitabine The metabolism of Montelukast can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Montelukast can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Montelukast.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Montelukast.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Montelukast.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Montelukast.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Montelukast.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Montelukast.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Montelukast.
Rabeprazole Rabeprazole The metabolism of Montelukast can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists