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Digoxin

Digoxin is a cardiac glycoside (a heart medicine) used to treat mild to moderate heart failure and to control heart rate in chronic atrial fibrillation.

Brand names CardoxinDigitekLanoxicapsLanoxinDigox
Drug class Cardiac Glycoside
Rx Forms 3
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 35 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026
Digoxin at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Digoxin is an older standby for mild to moderate heart failure and for controlling heart rate in chronic atrial fibrillation (an irregular heartbeat), helping the heart squeeze harder and beat slower; on the market since about 1954 and available as a generic, it is now usually an add-on rather than a first choice. At the right level most people feel little from it beyond occasional tiredness or dizziness. The one thing to watch for is toxicity, since the helpful and harmful levels sit close together, so call your prescriber promptly about nausea, poor appetite, blurred or yellow-green vision, or a slow or irregular heartbeat.

Clinical pearls

  • Clarithromycin, erythromycin, amiodarone and verapamil are among the drugs that raise digoxin levels, sometimes enough to need a lower dose.
  • Antacids, cholestyramine and high-bran meals can lower how much digoxin you absorb, so do not take them together with it.
  • Water pills and steroids can lower potassium, which raises toxicity risk, so keep your potassium, kidney and digoxin blood tests.
  • Siberian ginseng, Asian ginseng and ashwagandha can distort digoxin blood test readings, giving a misleading picture of your level.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asTablet, Injection, Oral solution
Earliest FDA record1954
Companies listing it with the FDA30
FDA label last updatedMay 8, 2019
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Digoxin, written from its FDA label.

What Digoxin is used for

▾

Digoxin is a heart medicine with these supported uses:

  • Mild to moderate heart failure in adults (tablet, oral solution and injection products).
  • Increasing the heart’s pumping strength in children with heart failure (tablet, oral solution, Lanoxin injection and most Digoxin injection products).
  • Control of resting heart rate in adults with chronic atrial fibrillation (all products).
  • Digoxin Oral Solution should not be used for multifocal atrial tachycardia.

How Digoxin works

▾

Digoxin blocks the “sodium pump” enzyme (NaK-ATPase) in heart cells. This raises calcium inside the cells, so the heart contracts more forcefully. It also slows electrical conduction through the AV node and slows the heart rate.

It also lowers activity of the sympathetic nervous system and the renin-angiotensin system, two stress-hormone systems that strain the heart in heart failure.

Digoxin dosage

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Digoxin comes as tablets, an oral solution and an injection. Doses are individualized by your prescriber using your age, lean body weight, kidney function and other medicines.

  • Tablets: can be taken with or after meals. Meals high in bran fiber may lower absorption.
  • Oral solution: used to get the right dose in infants, young children or people with very low body weight.
  • Injection: given by a healthcare professional, preferably into a vein. It is used when a quick effect is urgent or when you cannot take it by mouth.

Follow your prescriber and label for timing and for what to do about a missed dose.

Dosing details from the FDA-approved label

From the Digoxin prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Adults and pediatric patients over 10 years - IV loading dose (Lanoxin Injection)
    • Total IV loading dose 8-12 mcg/kg
    • Administer half the total loading dose initially, then 1/4 the loading dose every 6-8 hours twice
    • Administer over 5 minutes or longer; avoid bolus administration
  • Adults and pediatric patients over 10 years - oral loading dose (Lanoxin Tablet)
    • Total oral loading dose 10-15 mcg/kg
    • Administer half the total loading dose initially, then 1/4 the loading dose every 6 to 8 hours twice
    • Careful assessment of clinical response and toxicity before each dose
  • Adults and pediatric patients over 10 years - IV maintenance dose
    • 2.4-3.6 mcg/kg/day given once daily
    • May be increased every 2 weeks according to clinical response, serum drug levels, and toxicity
    • Based on lean body weight, renal function, age, and concomitant products; assumes normal renal function
  • Adults and pediatric patients over 10 years - oral maintenance dose
    • 3.4-5.1 mcg/kg/day given once daily
    • May be increased every 2 weeks according to clinical response, serum drug levels, and toxicity
    • Based on lean body weight, renal function, age, and concomitant products; assumes normal renal function
  • Premature - IV loading dose
    • 15-25 mcg/kg total IV loading dose
    • Half initially, then 1/4 every 6-8 hours twice
  • Full-Term - IV loading dose
    • 20-30 mcg/kg total IV loading dose
    • Half initially, then 1/4 every 6-8 hours twice
  • 1-24 Months - IV loading dose
    • 30-50 mcg/kg total IV loading dose
    • Half initially, then 1/4 every 6-8 hours twice
  • 2-5 Years - IV loading dose
    • 25-35 mcg/kg total IV loading dose
    • Half initially, then 1/4 every 6-8 hours twice
  • 5-10 Years - IV loading dose
    • 15-30 mcg/kg total IV loading dose
    • Half initially, then 1/4 every 6-8 hours twice
  • Pediatric patients less than 10 years old - IV maintenance dose
    • Given twice daily, mcg/kg/dose: Premature 1.9-3.1
    • Full-Term 3-4.5
    • 1-24 Months 4.5-7.5
    • 2-5 Years 3.8-5.3
    • 5-10 Years 2.3-4.5
    • Assumes normal renal function; based on lean body weight, renal function, age, and concomitant products
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION Toxic levels of digoxin are only slightly higher than therapeutic levels. The pharmacokinetics of digoxin are complex and dose determination should take into account patient-specific factors (age, lean body weight, renal function, etc.). ( 2.4 , 2.5 ) Patients should be monitored for toxicity and therapeutic effect and doses should be adjusted, accordingly. ( 2.2 ) 2.1 General Dosing Considerations The dose of digoxin should be based on clinical assessment but individual patient factors should be taken into consideration. Those factors are: • Lean body weight • Renal function • Patient age • Concurrent disease [see Warnings and Precautions (5) ] • Concomitant medication [see Drug Interactions (7) ] Because the pharmacokinetics of digoxin are complex, and because toxic levels of digoxin are only slightly higher than therapeutic levels, digoxin dosing can be difficult. The recommended approach is to: • estimate the patient’s daily maintenance dose • adjust the estimate to account for patient-specific factors • choose a dosing regimen • decide whether to initiate therapy with a loading dose • monitor the patient for toxicity and for therapeutic effect • adjust the dose Dose titration may be accomplished by either of two general approaches that differ in dosage and frequency of administration, but reach the same total amount of digoxin accumulated in the body. • If rapid titration is considered medically appropriate, administer a loading dose based upon projected peak digoxin body stores. Maintenance dose can be calculated as a percentage of the loading dose. • More gradual titration may be obtained by beginning an appropriate maintenance dose, thus allowing digoxin body stores to accumulate slowly. Steady-state serum digoxin concentrations will be achieved in approximately five half-lives of the drug for the individual patient. Depending upon the patient’s renal function, this will take between 1 and 3 weeks. 2.2 Serum Digoxin Concentrations In general, the dose of digoxin used should be determined on clinical grounds. However, measurement of serum digoxin concentrations can be helpful to the clinician in determining the adequacy of digoxin therapy and in assigning certain probabilities to the likelihood of digoxin intoxication.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Digoxin side effects

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Side effects depend on your dose and your other health conditions. Overall, adverse reactions are reported in about 5% to 20% of people. Common ones include:

Common side effects

  • Loss of appetite
  • Nausea and vomiting
  • Diarrhea
  • Abdominal pain
  • Headache
  • Dizziness
  • Weakness or fatigue
  • Blurred vision or yellow-green color changes

When to get medical help

  • Call your doctor right away if you have nausea, vomiting, loss of appetite, unusual tiredness or vision changes. These can be early signs of digoxin toxicity.
  • Get urgent help for a very slow, very fast or irregular heartbeat, fainting or chest symptoms.
  • Seek help for confusion, hallucinations, severe depression or delirium.
  • Get emergency care for swelling of the mouth, lips or throat, trouble breathing or an unexplained rash. These may be signs of an allergic reaction.
  • Report severe or persistent abdominal pain.
  • In a child taking digoxin, any new heart rhythm problem or slow heart rate should be checked promptly for digoxin toxicity.

Digoxin warnings and precautions

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  • Toxicity: The toxic level is only slightly above the helpful level. Early signs are nausea, vomiting, poor appetite, tiredness and vision changes.
  • Kidney problems: Digoxin is cleared by the kidneys, so lower doses are needed and toxicity lasts longer.
  • Electrolytes: Low potassium or magnesium and high calcium raise the risk of toxicity.
  • Heart rhythm: It can cause a very slow heartbeat or heart block. It can be dangerous in Wolff-Parkinson-White syndrome with atrial fibrillation.
  • Other heart conditions: It may not help hypertrophic cardiomyopathy, constrictive pericarditis or restrictive cardiomyopathy. It should be avoided in myocarditis. It may be unhelpful during an acute heart attack.
  • Thyroid: Dose needs change with thyroid disease, and overactive thyroid arrhythmias respond poorly to digoxin.

Digoxin interactions

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Digoxin has a narrow safety margin, so many interactions matter. Your levels should be checked when interacting medicines are started, changed or stopped.

  • Raise digoxin levels: amiodarone, verapamil, quinidine, propafenone, dronedarone, clarithromycin, erythromycin, tetracycline, gentamicin, itraconazole and others.
  • Lower digoxin levels: antacids, cholestyramine, colestipol, rifampin, phenytoin, St. John’s Wort, sucralfate and high-bran meals.
  • Lower potassium (raising toxicity risk): diuretics and corticosteroids.
  • Add to heart-slowing effects: beta-blockers, calcium channel blockers and ivabradine.
  • Raise arrhythmia risk: dofetilide, sotalol and epinephrine, norepinephrine or dopamine.
  • Can affect kidney clearance: ACE inhibitors, ARBs and NSAIDs.
  • Can interfere with digoxin blood tests: some herbal products such as Siberian ginseng, Asian ginseng and ashwagandha.

Interactions listed in the FDA-approved label

From the Digoxin prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Amiodarone, captopril, clarithromycin, dronedarone, gentamicin, erythromycin, itraconazole, lapatinib, propafenone, quinidine, ranolazine, ritonavir, telaprevir, tetracycline, verapamil: Digoxin concentrations increased greater than 50%. Measure serum digoxin concentrations before initiating concomitant drugs. Reduce digoxin dose by approximately 30 to 50% or modify the dosing frequency and continue monitoring.
  • Atorvastatin, carvedilol, conivaptan, diltiazem, indomethacin, mirabegron, nefazodone, nifedipine, propantheline, quinine, rabeprazole, saquinavir, spironolactone, telmisartan, ticagrelor, tolvaptan, trimethoprim: Digoxin concentrations increased less than 50%. Measure serum digoxin concentrations before initiating concomitant drugs. Reduce digoxin dose by approximately 15 to 30% or modify the dosing frequency and continue monitoring.
  • Alprazolam, azithromycin, cyclosporine, diclofenac, diphenoxylate, epoprostenol, esomeprazole, ibuprofen, ketoconazole, lansoprazole, metformin, omeprazole: Digoxin concentrations increased, but magnitude is unclear. Measure serum digoxin concentrations before initiating concomitant drugs. Continue monitoring and reduce digoxin dose as necessary.
  • Acarbose, activated charcoal, albuterol, antacids, certain cancer chemotherapy or radiation therapy, cholestyramine, colestipol, exenatide, kaolin-pectin, meals high in bran, metoclopramide, miglitol, neomycin, penicillamine, phenytoin, rifampin, St. John's Wort, sucralfate, sulfasalazine: Digoxin concentrations decreased. Measure serum digoxin concentrations before initiating concomitant drugs. Continue monitoring and increase digoxin dose by approximately 20 to 40% as necessary.
  • P-glycoprotein (PGP) inducers/inhibitors: Drugs that induce or inhibit P-glycoprotein have the potential to alter digoxin pharmacokinetics. Increased monitoring of serum digoxin concentrations and signs of toxicity when initiating, adjusting, or discontinuing interacting drugs.
  • ACE inhibitors, angiotensin receptor blockers, NSAIDs, COX-2 inhibitors: A decline in GFR or tubular secretion may impair the excretion of digoxin. Individualize the digoxin dosage.
  • Dofetilide: Concomitant administration with digoxin was associated with a higher rate of torsades de pointes. Individualize the digoxin dosage.
  • Sotalol: Proarrhythmic events were more common in patients receiving sotalol and digoxin than on either alone; unclear whether this is an interaction or related to CHF. Individualize the digoxin dosage.
  • Sympathomimetics (epinephrine, norepinephrine, dopamine): Can increase the risk of cardiac arrhythmias. Individualize the digoxin dosage.
  • Beta-adrenergic blockers and calcium channel blockers: Additive effects on AV node conduction can result in bradycardia and advanced or complete heart block. Individualize the digoxin dosage.
Read the label’s full interactions text

7 DRUG INTERACTIONS Digoxin has a narrow therapeutic index, increased monitoring of serum digoxin concentrations and for potential signs and symptoms of clinical toxicity is necessary when initiating, adjusting, or discontinuing drugs that may interact with digoxin. Prescribers should consult the prescribing information of any drug which is co-prescribed with digoxin for potential drug interaction information. • PGP Inducers/Inhibitors: Drugs that induce or inhibit PGP have the potential to alter digoxin pharmacokinetics. ( 7.1 ) • The potential for drug-drug interactions must be considered prior to and during drug therapy. See full prescribing information. ( 7.2 , 7.3 , 12.3 ) 7.1 P-Glycoprotein (PGP) Inducers/Inhibitors Digoxin is a substrate of P-glycoprotein, at the level of intestinal absorption, renal tubular section and biliary-intestinal secretion. Therefore, drugs that induce/inhibit P-glycoprotein have the potential to alter digoxin pharmacokinetics. 7.2 Pharmacokinetic Drug Interactions NA = Not available/reported Digoxin concentrations increased greater than 50% Digoxin Serum Concentration Increase Digoxin AUC Increase Recommendations Amiodarone 70% NA Measure serum digoxin concentrations before initiating concomitant drugs. Reduce digoxin concentrations by decreasing dose by approximately 30 to 50% or by modifying the dosing frequency and continue monitoring. Captopril 58% 39% Clarithromycin NA 70% Dronedarone NA 150% Gentamicin 129 to 212% NA Erythromycin 100% NA Itraconazole 80% NA Lapatinib NA 180% Propafenone NA 60 to 270% Quinidine 100% NA Ranolazine 50% NA Ritonavir NA 86% Telaprevir 50% 85% Tetracycline 100% NA Verapamil 50 to 75% NA Digoxin concentrations increased less than 50% Atorvastatin 22% 15% Measure serum digoxin concentrations before initiating concomitant drugs. Reduce digoxin concentrations by decreasing the dose by approximately 15 to 30% or by modifying the dosing frequency and continue monitoring.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿113 supplements and herbs with documented Digoxin interactions, ranked by severity Check Digoxin against a supplement or herb →

Before taking Digoxin

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  • Do not use with ventricular fibrillation or a known allergy to digoxin or other digitalis medicines.
  • Tell your doctor about kidney disease, heart block, sick sinus syndrome, Wolff-Parkinson-White syndrome, thyroid disease or electrolyte problems.
  • Pregnancy: no drug-related risk of birth defects or miscarriage has been identified. Digoxin crosses the placenta, and your dose may need adjusting during and after pregnancy.
  • Breastfeeding: the amount reaching the baby is small and unlikely to matter clinically.
  • Children: newborns, premature and immature infants are especially sensitive and need individualized dosing.
  • Older adults: dosing should account for kidney function, with careful monitoring.
  • Malabsorption conditions, such as chronic diarrhea, can reduce absorption.

Digoxin overdose

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Digoxin overdose can cause nausea, vomiting, poor appetite, fatigue, vision changes and almost any type of heart rhythm problem. Children may show different signs, such as drowsiness, behavior changes or poor growth in infants. Treatment can include stopping digoxin, heart monitoring, correcting potassium and magnesium, and activated charcoal for a large recent ingestion. Digoxin Immune Fab reverses serious toxicity. Dialysis does not remove digoxin effectively. If you suspect an overdose, get emergency help right away.

What Digoxin does in the body

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Digoxin strengthens the heart’s contraction and slows the heart rate. In heart failure it increases cardiac output and ejection fraction and lowers pressures in the lungs’ blood vessels. It can lengthen the PR interval and depress the ST segment on an ECG. This is expected and not a sign of toxicity. Digoxin does not significantly lower heart rate during exercise.

Effects start in 0.5 to 2 hours with tablets and 5 to 30 minutes with injection. They peak in 2 to 6 hours with tablets and 1 to 4 hours with injection.

How your body processes Digoxin

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Tablets are about 60% to 80% absorbed, with blood levels peaking at 1 to 3 hours. Food slows absorption but usually not the total amount. Digoxin spreads widely into tissues and crosses the placenta. Only a small portion is metabolized, and it does not rely on the CYP450 enzyme system.

About 50% to 70% is cleared unchanged by the kidneys. The half-life is 1.5 to 2 days with normal kidney function and 3.5 to 5 days in people who make no urine. Gut bacteria break down digoxin in some people, so certain antibiotics can raise levels.

How to store Digoxin

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Store in a dry place at 20º to 25ºC (68º to 77ºF) and protect from light. Keep out of reach of children. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

113

Supplements & herbs that interact with Digoxin

113 supplements and herbal products have documented interactions with Digoxin in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 18
  • Moderate · 79
  • Minor · 16
ACTIVATED CHARCOAL Major ALOE Major BLUE FLAG Major DANSHEN Major EUROPEAN BUCKTHORN Major FOXGLOVE Major INDIAN SNAKEROOT Major LILY-OF-THE-VALLEY Major +105 more
Every supplement checked against Digoxin — ranked by severity The full interaction hub: 18 major · 79 moderate · 16 minor · every one linked to its full report. Check Digoxin against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Digoxin has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

MAGNESIUM Moderate Depletion
See the full Digoxin nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Digoxin: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Digoxin — the kind of thing our pharmacy team would talk through with you at the counter.

What is digoxin for?

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It treats mild to moderate heart failure in adults and helps control the heart rate in chronic atrial fibrillation. It is also used in children with heart failure. It can ease symptoms and reduce hospital visits, but it does not change survival.

How should I take it?

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Take it exactly as your prescriber directs, at about the same time each day. Tablets can be taken with or after meals, but try to be consistent. Avoid high-bran meals around your dose, since they can lower absorption. Keep your blood test appointments.

What side effects should I watch for?

▾
Nausea, vomiting, loss of appetite, diarrhea, dizziness, headache and tiredness are among the more common ones. Call me or your doctor if you notice vision changes like blurred or yellow-green vision, confusion, or a very slow or irregular heartbeat. These can be signs of too much digoxin.

Can I take it with my other medicines?

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Many medicines interact with digoxin. Heart rhythm drugs, some antibiotics and antacids are common examples, and St. John’s Wort can lower digoxin levels. Always check with me before starting anything new, including herbal products.

Is it safe in pregnancy or breastfeeding?

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No drug-related risk of birth defects or miscarriage has been identified, and untreated heart failure or atrial fibrillation also carries risks. Your dose may need adjusting during and after pregnancy. Only a small amount reaches breast milk.

Why do I need blood tests?

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Digoxin has a narrow safety margin, so levels, potassium, magnesium and kidney function are checked. Low potassium or kidney problems can make toxicity more likely even at a usual dose.

Is Digoxin available over the counter?

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No. Digoxin is a prescription medicine: every Digoxin product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Digoxin first available?

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The earliest FDA record we hold for Digoxin is from 1954: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Digoxin was first used.

Who makes Digoxin?

▾
30 companies currently list Digoxin products in the FDA's NDC Directory, including A-S Medication Solutions, Bryant Ranch Prepack, Hikma Pharmaceuticals USA Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Digoxin on HelloPharmacist

📊Digoxin supplement interactions113 checked — ranked by severity 🌿Drug & Supplement CheckerDigoxin vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Digoxin NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Digoxin Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Digoxin forms and strengths (how it comes)

Digoxin is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
Brands Lanoxin
How this form is used
What it may be used for
  • Lanoxin and Digoxin tablets are used for mild to moderate heart failure in adults, heart failure in children, and heart rate control in adults with chronic atrial fibrillation.
Important instructions
  • Lanoxin and Digoxin tablets: dosing may start with a loading dose or go straight to maintenance dosing, as your prescriber decides.
  • Your prescriber may reduce or pause Lanoxin or Digoxin tablets before electrical cardioversion.
  • Digoxin tablets taken after meals are absorbed more slowly, but the total amount is usually unchanged. High-bran meals may reduce absorption.
Available strengths 5 strengths
0.0625 mg 0.125 mg 125 mcg 0.25 mg 250 mcg
88 FDA-listed product records ⓘ

Injection

Into a muscle · Into a vein · Parenteral
Brands Lanoxin
How this form is used
What it may be used for
  • Lanoxin injection is used for mild to moderate heart failure in adults, heart failure in children, and heart rate control in adults with chronic atrial fibrillation.
  • Digoxin injection is used for mild to moderate heart failure in adults and for heart rate control in adults with chronic atrial fibrillation. Most Digoxin injection labels also list heart failure in children.
Important instructions
  • Lanoxin and Digoxin injections: intravenous use is preferred over intramuscular, and bolus (rapid push) administration should be avoided.
  • Digoxin injection by injection is used only when a fast effect is urgent or when the drug cannot be taken by mouth.
  • Digoxin injection given into a muscle can cause severe pain at the site. If this route is needed, it is injected deep into the muscle.
Available strengths 3 strengths
100 mcg/mL 0.25 mg/mL 250 mcg/mL
25 FDA-listed product records ⓘ

Oral solution

By mouth
How this form is used
What it may be used for
  • Digoxin Oral Solution is used for mild to moderate heart failure in adults, heart failure in children, and resting heart rate control in chronic atrial fibrillation.
  • Digoxin Oral Solution should not be used for multifocal atrial tachycardia.
Important instructions
  • Digoxin Oral Solution dosing is based on lean body weight, kidney function, age, other conditions and other medicines.
  • Digoxin solution is the form used to get the right dose in infants, young children or people with very low body weight.
Available strengths 1 strength
0.05 mg/mL
9 FDA-listed product records ⓘ

Digoxin on the U.S. market: products, makers and brands

How Digoxin appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

30 companies list 59 Digoxin product records with the FDA, mostly as tablet, injection, oral solution; the earliest marketing or approval year on record is 1954. Brand names on the directory include Cardoxin, Digitek, Lanoxicaps and 2 more; the rest are generics.

3
Dose forms ⓘ
30
Labelers (makers, repackagers, distributors)
2
Brand names
59
FDA-listed product records ⓘ
1954
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (14) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

A-S Medication Solutions8%
Bryant Ranch Prepack8%
Hikma Pharmaceuticals USA Inc.8%
Covis Pharma US, Inc7%
ANI Pharmaceuticals, Inc.5%
Advanz Pharma (US) Corp.5%
Other makers58%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Digoxin is used (Medicaid data)

A general measure of how commonly Digoxin is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Digoxin is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

109,371
Medicaid prescriptions filled (Q1–Q4 2025)
$2.2M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Digoxin prescribed? Of the 1,601 medications we measure, Digoxin ranks #497 by Medicaid prescriptions — more than 69% of them.

Where Digoxin ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #497 of 1,601
#492 Nystatin and Triamcino... 112,193 Rx #493 Vancomycin Injection 112,053 Rx #494 Atropine 111,807 Rx #495 Lifitegrast Ophthalmic 109,594 Rx #496 Midazolam Nasal Spray 109,459 Rx #497 Digoxin 109,371 Rx #498 Upadacitinib 108,976 Rx #499 Chlordiazepoxide 107,446 Rx #500 Alogliptin 105,424 Rx #501 Buprenorphine Transder... 105,289 Rx #502 Telmisartan 104,917 Rx

Utilization by Digoxin product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 0.125 mg oral tablet is the most-dispensed Digoxin product — about 72% of these Medicaid prescriptions.

digoxin 0.125 MG Oral Tablet Most dispensed

79,094 Medicaid prescriptions (Q1–Q4 2025) 72% of Digoxin prescriptions shown $1.1M gross reimbursement (before rebates) ≈ $14 per prescription (gross)

Summed across the 11 of 80 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197604

digoxin 0.25 MG Oral Tablet

22,172 Medicaid prescriptions (Q1–Q4 2025) 20% of Digoxin prescriptions shown $322,954 gross reimbursement (before rebates) ≈ $15 per prescription (gross)

Summed across the 12 of 63 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197606

digoxin 0.05 MG/ML Oral Solution

7,671 Medicaid prescriptions (Q1–Q4 2025) 7% of Digoxin prescriptions shown $701,358 gross reimbursement (before rebates) ≈ $91 per prescription (gross)

Summed across the 3 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 393245

digoxin 0.0625 MG Oral Tablet

245 Medicaid prescriptions (Q1–Q4 2025) <1% of Digoxin prescriptions shown $68,272 gross reimbursement (before rebates) ≈ $279 per prescription (gross)

Summed across the 2 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 245273

2 ML digoxin 0.25 MG/ML Injection

189 Medicaid prescriptions (Q1–Q4 2025) <1% of Digoxin prescriptions shown $7,959 gross reimbursement (before rebates) ≈ $42 per prescription (gross)

Summed across the 2 of 15 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 104208

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Digoxin, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 30 of 168 listed Digoxin NDCs with Medicaid activity.

Compare Digoxin products

A representative set of FDA-listed product records for Digoxin — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 59 of 59 products — FDA National Drug Code Directory. See every product, package size and price: browse all 59 Digoxin NDCs →

Digoxin recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 2 Digoxin recalls since July 2021. None of them is still listed as ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Class III Mar 25, 2024 · Terminated · Novitium Pharma LLC
Failed Impurities/Degradation Specifications
  • Digoxin Tablets, USP 62.5 mcg (0.0625 mg), 100-count bottles, Rx Only, Manufactured by: Novitium Pharma LLC, 70 Lake Drive, East Windsor, New Jersey 08520, NDC 70954-200-10 Lots: Lot M23011A; Exp. 12/2024 FDA record D-0443-2024 →
Class III Mar 4, 2024 · Terminated · Novitium Pharma LLC
Cross Contamination with Other Products:(mycophenolate mofetil).
  • Digoxin Tablets, USP 125mcg, (0.125 mg), 1000-count bottle, Rx Only, Manufactured by: Novitium Pharma LLC., 70 Lake Drive, East Windsor, New Jersey 08520, NDC 70954-201-20 Lots: Lot #: M23172A, Exp 01/31/2025 FDA record D-0389-2024 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Digoxin RxCUI 3407 4 dose forms · 9 strengths
  2. Dose form (SCDF) Oral Capsule RxCUI 371830 No current FDA listing
    Clinical drug / strength (SCD) 0.05 MG RxCUI 237165 0.1 MG RxCUI 237166 0.2 MG RxCUI 197605
  3. Dose form (SCDF) Oral Solution RxCUI 371833 In current FDA listings
    Clinical drug / strength (SCD) 0.05 MG/ML RxCUI 393245
  4. Dose form (SCDF) Oral Tablet RxCUI 371834 In current FDA listings
    Clinical drug / strength (SCD) 0.0625 MG RxCUI 245273 0.125 MG RxCUI 197604 0.25 MG RxCUI 197606

Look up RxCUI 3407 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Digoxin costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Solution · Oral 0.05 mg/mL $1.15 per mL NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Digoxin brand names

Digoxin is sold under 5 brand names in the FDA directory — Cardoxin, Digitek, Lanoxicaps, Lanoxin and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Cardoxin Digitek Lanoxicaps Lanoxin Digox

Who makes Digoxin: manufacturers and labelers

30 companies list Digoxin products with the FDA. By number of product records, the largest are A-S Medication Solutions, Bryant Ranch Prepack, Hikma Pharmaceuticals USA Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

A-S Medication Solutions 5 Bryant Ranch Prepack 5 Hikma Pharmaceuticals USA Inc. 5 Covis Pharma US, Inc 4 ANI Pharmaceuticals, Inc. 3 Advanz Pharma (US) Corp. 3 Aurobindo Pharma Limited 3 American Health Packaging 2 Amneal Pharmaceuticals NY LLC 2 Amneal Pharmaceuticals of New York LLC 2 Cardinal Health 107, LLC 2 Major Pharmaceuticals 2 Marlex Pharmaceuticals, Inc. 2 Oliva Therapeutics, LLC 2 Remedyrepack Inc. 2 Amici Pharma, Inc 1 Aphena Pharma Solutions - Tennessee, LLC 1 Atlantic Biologicals Corps 1 AvPAK 1 Coupler LLC 1 Golden State Medical Supply, Inc. 1 HF Acquisition Co LLC, DBA HealthFirst 1 Henry Schein, Inc. 1 Medical Purchasing Solutions, LLC 1

…and 6 more on the FDA NDC directory.

Digoxin drug class (RxNorm)

Digoxin belongs to the Cardiac Glycoside class.

Pharmacologic class Cardiac Glycoside
Drug family (ATC) Digitalis glycosides

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Digoxin page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective May 8, 2019
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Digoxin.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Digoxin after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
35
Finished products in the current FDA directory
59
Companies listing them (makers, repackagers, distributors)
30
FDA labeler codes behind them ⓘ
33
Linked representative label ⓘ
Aphena Pharma Solutions - Tennessee, LLC
Linked label effective
May 8, 2019
Composite sections available
23
Linked SPL Set ID
f6c7ca21-1c76-4838-8fb9-e1bec6001d8b
Linked SPL Document ID
1d7755ac-5480-4614-bc20-beb024ab95f2
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Aphena Pharma Solutions - Tennessee, LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →