Herb & supplement monograph

Urine Therapy Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated June 2026
What is this page for?

First and foremost: how Urine Therapy interacts with medications. The heart of this page is the interaction list — every drug Urine Therapy is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Urine Therapy is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

Check Urine Therapy against your medication

Add one medication
Urine Therapy
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
On this page
Interaction report

Drugs that interact with Urine Therapy

0 medications have a known interaction with Urine Therapy, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Urine Therapy. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Urine Therapy combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Urine Therapy: Uses, Safety & Side Effects

Medically reviewed by · Reviewed June 2026 ·
The bottom line

Urine therapy is a practice of drinking or applying one's own urine, promoted in some traditional and alternative health circles. There is no reliable scientific evidence that it treats or prevents any disease, and drinking urine can cause harm. We do not recommend it.

Part used
Human urine (one's own)
Common forms
Drinking fresh urine, skin application, gargling, eye or ear drops
People commonly use it for
  • General wellness and detox beliefs
  • Skin conditions
  • Wound or rash care
  • Allergies
  • Cancer (alternative use)
  • Infections

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

No proven benefit and a real risk of infection, dehydration, and toxicity.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Urine therapy is an alternative practice where a person drinks their own urine or applies it to the skin, eyes, ears, or mouth. It is sometimes called "urotherapy" or "auto-urine therapy." It is not an herb or a plant product — the "source" is the person's own body.

The practice appears in some traditional healing systems and in modern alternative-health books. Supporters claim it helps with many problems, from skin issues to serious diseases. These claims are based on belief and personal stories, not on solid medical research.

Urine is mostly water, along with waste products your kidneys are removing from your body, such as urea, salts, and small amounts of other compounds. It is a waste fluid, not a nutrient source.

Uses & effectiveness

People use urine therapy for a wide range of conditions, including general "detox," skin rashes, acne, allergies, infections, wound care, and even cancer. None of these uses are supported by reliable scientific evidence.

There are no high-quality human studies showing that drinking or applying urine treats or cures any disease. The idea that urine "detoxifies" the body is backwards — urine is how your body gets rid of waste, so putting it back in does not help and may not be safe.

For serious conditions like cancer or infection, relying on urine therapy instead of proven medical treatment can be dangerous and delay needed care.

How it works

Supporters propose that urine contains hormones, antibodies, and other compounds that the body can "reuse." In reality, urine is the fluid your kidneys produce to remove waste, excess salts, and substances your body does not need.

Any useful compounds are present in tiny amounts, and the body already decided to get rid of them. There is no sound scientific mechanism showing that drinking or applying urine provides a health benefit. Most claims rest on theory and personal belief rather than laboratory or clinical proof.

Safety & precautions

We do not recommend urine therapy. Drinking urine adds salt and waste products back into your body. In hot weather or when you are sick, this can make dehydration worse, not better, and can stress your kidneys.

If urine is not sterile — for example, during a urinary tract infection — drinking or reapplying it may spread bacteria. Applying urine to broken skin, wounds, eyes, or ears can introduce germs and cause infection.

Pregnancy and breastfeeding: Avoid. There is no proven benefit and a real chance of harm to you or your baby. People with kidney disease, heart disease, infections, or anyone taking medications that pass into urine should especially avoid this practice. Always talk with a pharmacist or doctor before trying any alternative therapy.

Side effects

Possible problems include nausea, vomiting, and stomach upset from the salts and waste in urine. Drinking urine may worsen dehydration and upset your body's salt and fluid balance.

More serious risks include infection from bacteria in non-sterile urine, especially when applied to wounds, eyes, ears, or the mouth. People can also be harmed by delaying real medical treatment while relying on urine therapy.

Dosing

There is no established or safe dose for urine therapy because it is not a recognized medical treatment. We do not provide a dose because we do not recommend the practice.

If you are considering urine therapy for a health concern, please speak with a pharmacist or doctor first. There are safer, evidence-based options for nearly every condition people use it for.

Pregnancy & Breastfeeding

Urine Therapy & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Urine Therapy & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 sources that drive our Urine Therapy monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Urine and urination — MedlinePlus (NIH) Source
  2. Urinary Tract Infections — Cleveland Clinic Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Pharmacist Counseling Corner

Urine Therapy: Common Questions

Does Urine Therapy interact with prescription medications?
We do not currently list any known drug interactions for Urine Therapy. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Urine Therapy interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Urine Therapy with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Urine Therapy interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is drinking urine good for you?
No. There is no reliable evidence that drinking urine improves health, and it can add waste and salt back into your body, worsen dehydration, and spread bacteria if the urine is not sterile.
Can Urine Therapy cure or treat diseases?
There is no scientific proof that Urine Therapy treats or cures any disease, including cancer or infections. Relying on it instead of proven medical care can be dangerous.
Is it safe to put urine on my skin or in my eyes?
We advise against it. Applying urine to skin, wounds, eyes, or ears can introduce bacteria and cause infection, with no proven benefit.
Is Urine Therapy safe during pregnancy or breastfeeding?
No. It should be avoided during pregnancy and breastfeeding because there is no proven benefit and a real risk of harm.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next
Supplement interaction checkerCheck any supplement or product against your medications Drug–drug interactionsCheck two or more of your medications against each other Browse medications A–ZEvery drug we’ve checked against herbs & supplements NDC & pricing lookupFind a drug’s NDCs, packaging and costs Ask a pharmacistFree, personal answer from our licensed team

Have a question about Urine Therapy?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist