Herb & supplement monograph

Self-heal Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Self-heal

0 medications have a known interaction with Self-heal, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Self-heal. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Self-heal combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Self-heal: Uses, Safety & Side Effects

The bottom line

Self-heal (Prunella vulgaris) is a traditional herb used for sore throats, skin issues, and inflammation, mainly in folk and traditional Chinese medicine. Human evidence for its benefits is very limited, so it should be viewed as an unproven remedy. If you want to try it, talk with your pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Scientific name
Prunella vulgaris
Family
Lamiaceae
Part used
Aerial parts (flowering spikes, leaves, and stems)
Common forms
Tea, tincture, capsules, dried herb, topical preparations
People commonly use it for
  • Sore throat and mouth infections
  • Cold sores and skin irritation
  • Inflammation
  • General immune support
  • Minor wounds (topical)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally used in foods and teas, but human safety data are limited.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Self-heal is a small flowering plant in the mint family. Its scientific name is Prunella vulgaris, and it is sometimes called "heal-all" because of its long history of use as a folk remedy. It grows widely across Europe, Asia, and North America, often in fields, lawns, and along roadsides.

The flowering tops and leaves have been used for centuries in traditional European herbal medicine and in traditional Chinese medicine, where the dried flower spike is known as "xia ku cao." People have used it as a tea, a tincture, and in topical preparations placed on the skin.

How it works

Self-heal contains a range of natural compounds, including rosmarinic acid, ursolic acid, flavonoids, tannins, and polysaccharides. In test-tube studies, some of these compounds appear to have antioxidant, anti-inflammatory, and antimicrobial activity.

Researchers have also studied certain sugar-based compounds (polysaccharides) in the plant for possible effects on viruses and the immune system. However, these findings come mostly from cells and animals. The way these compounds behave in the human body, and whether they reach high enough levels to matter, is not well understood.

Effectiveness

Does Self-heal work?

Evidence overview · 1 use evaluated
1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Self-heal, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

Clinical research shows that taking a combination of self-heal, Clematis mandshurica, and Chinese cucumber 200 mg three times daily for 6 weeks is as effective as celecoxib 200 mg twice daily for reducing pain and disease activity associated with RA. There was no difference between groups in the use of rescue medication or the response rate. It is unclear whether these effects are due to self-heal, the other ingredients, or the combination.

Sources Ref 101041

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Self-heal has a long history of use in teas and foods, and it is generally thought to be well tolerated in small, food-like amounts. Still, high-quality human safety studies are lacking, especially for concentrated extracts taken over a long time.

People with allergies to plants in the mint family may react to it. Anyone with a chronic health condition, or who is taking prescription medicines, should check with a pharmacist or doctor before using it.

Pregnancy and breastfeeding: Because there is not enough reliable safety information, self-heal should be avoided during pregnancy and while breastfeeding. When safety is unknown, the cautious choice is to not use it.

Side effects

Reported side effects are uncommon, partly because the herb has not been studied much in people. Possible effects include mild stomach upset or allergic reactions such as a skin rash, especially in people sensitive to mint-family plants.

Topical use could cause skin irritation in some people. Stop using it and seek medical care if you notice signs of a serious allergic reaction, such as swelling of the face or throat or trouble breathing.

Self-heal: Reported Adverse Effects

Documented safety reports on Self-heal from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, self-heal has been reported to cause nausea, vomiting, and diarrhea. Orally and topically, self-heal has been reported to cause allergic reactions in sensitive individuals.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Reports by condition
Diarrhea Gastrointestinal

Orally, self-heal has been reported to cause nausea, vomiting, and diarrhea. A combination product containing self-heal, Clematis mandshurica, and Chinese cucumber has been reported to cause epigastric pain, abdominal discomfort, nausea, reduced appetite, and dyspepsia. It is not clear if these effects are due to self-heal, the other ingredients, or the combination.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Song YW, Lee EY, Koh EM, et al. Assessment of comparative pain relief and tolerability of SKI306X compared with celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, double-dummy, phase III, noninferiority clini
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established, standardized dose for self-heal. Traditional use as a tea involves steeping the dried herb in hot water, but commercial products vary widely in strength and form.

If you choose to use a product, follow the directions on the label and do not exceed the recommended amount. Because product quality and concentration differ between brands, it is a good idea to ask your pharmacist for help choosing a reputable product and a sensible amount.

Pregnancy & Breastfeeding

Self-heal & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Self-heal & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Self-heal monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Song YW, Lee EY, Koh EM, et al. Assessment of comparative pain relief and tolerability of SKI306X compared with celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, double-dummy, phase III, noninferiority clini
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Self-heal

2 brands in our database make a supplement containing Self-heal.

Pharmacist Counseling Corner

Self-heal: Common Questions

What is Self-heal used for, and does it work?
People use Self-heal for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Self-heal interact with prescription medications?
We do not currently list any known drug interactions for Self-heal. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Self-heal interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Self-heal with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Self-heal interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Self-heal used for?
Traditionally it has been used for sore throats, mouth and skin problems, minor wounds, and inflammation. These are popular and traditional uses, not proven medical treatments.
Does Self-heal actually work?
Most evidence comes from lab and animal studies, not solid human trials. There is not enough reliable evidence to confirm it works for any specific condition.
Is Self-heal safe to take?
It is generally considered well tolerated in small, tea-like amounts, but human safety data are limited, especially for strong extracts. Check with your pharmacist or doctor before using it.
Can I use Self-heal if I am pregnant or breastfeeding?
No reliable safety information is available, so it is best to avoid Self-heal during pregnancy and while breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Self-heal

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