Medium Chain Triglycerides (mcts) Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Medium Chain Triglycerides (mcts) interacts with medications. The heart of this page is the interaction list — every drug Medium Chain Triglycerides (mcts) is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Medium Chain Triglycerides (mcts) is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Medium Chain Triglycerides (mcts) against your medication
Add one medicationDrugs that interact with Medium Chain Triglycerides (mcts)
0 medications have a known interaction with Medium Chain Triglycerides (mcts), graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Medium Chain Triglycerides (mcts). This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Medium Chain Triglycerides (mcts) combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Medium Chain Triglycerides (mcts): Uses, Safety & Side Effects
Medium chain triglycerides (MCTs) are fats from coconut or palm oil that the body absorbs and uses for energy quickly. They are widely used as an energy source, in ketogenic diets, and in some medical nutrition, but evidence for big benefits like weight loss is modest. They are generally well tolerated when taken in small, gradually increased amounts, but can cause stomach upset.
- Part used
- Fatty acids extracted from coconut or palm kernel oil
- Common forms
- Oil, liquid, powder, capsules
- Energy and sports nutrition
- Weight management
- Ketogenic diets
- Brain and cognitive support
- Nutrition support in medical conditions
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally well tolerated in moderate amounts but can cause digestive upset, especially at higher doses.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Medium chain triglycerides (MCTs) are a type of fat made up of fatty acids of medium length. They are usually made from coconut oil or palm kernel oil, which naturally contain these fats. Manufacturers separate and concentrate the MCTs to make a clear oil, powder, or capsule.
Unlike most fats in food, which are long chain triglycerides, MCTs are absorbed and processed by the body more quickly. Because of this, they are often used as a fast source of energy.
People use MCTs in coffee, smoothies, and cooking, and they are popular with athletes and people following low-carb or ketogenic diets. MCTs are also used in hospitals and special medical foods to help people who have trouble digesting normal fats.
How it works
Most dietary fats are long chain triglycerides, which need bile and several steps to be digested and absorbed. MCTs are different. Because their fatty acids are shorter, they are absorbed more directly from the gut and travel to the liver, where the body can quickly turn them into energy.
In the liver, MCTs can be converted into compounds called ketones, which the body and brain can use as an alternate fuel when carbohydrate intake is low. This is why MCTs are popular with ketogenic diets.
Some researchers believe MCTs may slightly boost calorie burning and reduce hunger, but these effects are modest and not fully understood. Much of the detailed science is based on small human studies and laboratory work.
Does Medium Chain Triglycerides (mcts) work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
Possibly Effective Cachexia
Intravenous MCTs can provide calories in critically ill patients and patients with refractory cachexia, but do not seem to offer any advantages over long chain triglycerides.
Possibly Ineffective HIV/AIDS-related wasting
Oral MCTs do not seem to promote weight gain or prevent weight loss in patients with HIV infection.
Also studied for 18 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Age-related cognitive decline
It is unclear if oral MCTs are beneficial in patients with age-related cognitive decline.
Insufficient Reliable Evidence To Rate Alzheimer disease
Small clinical studies suggest that oral MCTs do not improve cognition in patients with Alzheimer disease or mild cognitive impairment.
Insufficient Reliable Evidence To Rate Athletic performance
It is unclear if oral MCTs are beneficial for endurance athletic performance.
Insufficient Reliable Evidence To Rate Celiac disease
Although there has been interest in using oral MCTs for celiac disease, there is insufficient reliable information about the clinical effects of MCTs for this purpose.
Insufficient Reliable Evidence To Rate Chylothorax
It is unclear if oral MCTs improve time to resolution of spontaneous congenital chylothorax in neonates.
Insufficient Reliable Evidence To Rate Chyluria
Although there has been interest in using oral MCTs for chyluria, there is insufficient reliable information about the clinical effects of MCTs for this purpose.
Insufficient Reliable Evidence To Rate Cystic fibrosis
Although there has been interest in using oral MCTs for cystic fibrosis, there is insufficient reliable information about the clinical effects of MCTs for this purpose.
Insufficient Reliable Evidence To Rate Diabetes
Although there has been interest in using oral MCTs for diabetes, there is insufficient reliable information about the clinical effects of MCTs for this purpose.
Insufficient Reliable Evidence To Rate Epilepsy
It is unclear if oral MCTs are beneficial in adults and adolescents aged 12 years or older with drug-resistant epilepsy.
Insufficient Reliable Evidence To Rate Gallbladder disease
Although there has been interest in using oral MCTs for gallbladder disease, there is insufficient reliable information about the clinical effects of MCTs for this purpose.
Insufficient Reliable Evidence To Rate Hypertriglyceridemia
Oral MCTs might improve triglyceride levels and body weight in some patients with overweight and hypertriglyceridemia, but its effect in other populations is unclear.
Insufficient Reliable Evidence To Rate Obesity
Small clinical studies suggest that oral MCTs modestly improves weight loss; however, any effects may not be clinically relevant.
Insufficient Reliable Evidence To Rate Physical performance
It is unclear if oral MCTs are beneficial for physical performance in nursing home residents.
Insufficient Reliable Evidence To Rate Prematurity
It is unclear if oral or topical MCTs are beneficial in preterm infants.
Insufficient Reliable Evidence To Rate Primary intestinal lymphangiectasia
It is unclear if oral MCTs are beneficial for the management of primary intestinal lymphangiectasia.
Insufficient Reliable Evidence To Rate Quality of life
It is unclear if oral MCTs are beneficial for improving quality of life.
Insufficient Reliable Evidence To Rate Sarcopenia
It is unclear if oral MCTs are beneficial in frail older adults.
Insufficient Reliable Evidence To Rate Short bowel syndrome
Although there has been interest in using oral MCTs for short bowel syndrome, there is insufficient reliable information about the clinical effects of MCTs for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
MCTs are generally considered safe for most healthy adults when used in moderate amounts. The most common problem is digestive discomfort, especially when starting at a high dose.
People with liver disease should be cautious, because MCTs are processed heavily by the liver. Those with diabetes or other metabolic conditions should talk to a healthcare provider before using large amounts. People prone to gallbladder issues or other digestive problems may also want medical guidance.
Pregnancy: MCTs found naturally in foods are fine, but concentrated supplement doses have not been well studied in pregnancy. It is best to use caution and check with your doctor.
Breastfeeding: MCTs occur naturally in breast milk, but the safety of added supplement doses is not well established. Talk to your healthcare provider before using MCT supplements while breastfeeding.
As with any supplement, it is wise to check with a pharmacist or doctor before starting, especially if you have a health condition.
Side effects
The most common side effects of MCTs involve the digestive system, especially at higher doses or when first starting. These can include:
- Nausea or stomach upset
- Cramping
- Bloating or gas
- Diarrhea or loose stools
These effects often improve if you start with a small amount and increase slowly, and take MCTs with food. In rare cases, very large amounts may strain the liver, which is more of a concern for people with existing liver problems. If you have severe or lasting symptoms, stop using MCTs and talk to your healthcare provider.
Medium Chain Triglycerides (mcts): Reported Adverse Effects
Documented safety reports on Medium Chain Triglycerides (mcts) from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, MCTs can cause significant gastrointestinal upset, especially with higher doses.
Most Common Adverse Effects:
Abdominal discomfort, diarrhea, essential fatty acid deficiency, intestinal gas noises, irritability, nausea, reflux, vomiting. Gastrointestinal disturbances are thought to be associated with higher doses of MCT. Since MCTs are fats, excessive consumption can result in weight gain.
Diarrhea Gastrointestinal
Orally, MCTs can cause significant gastrointestinal upset. Diarrhea is the most commonly reported side effect. Other reported side effects include vomiting, irritability, nausea, reflux, abdominal discomfort, intestinal gas noises, and essential fatty acid deficiency. Taking MCTs with food can reduce these adverse effects. Gastrointestinal disturbances are thought to be associated with higher doses of MCT, such as 85 grams.
- Ruppin DC, Middleton WR. Clinical use of medium chain triglycerides. Drugs 1980;20:216-24.
- Brighenti F. Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials. J Nutr. 2007 Nov;137(11 Suppl):2552S-2556S. doi: 10.1093/jn/137.11.2552S.
- St-Onge MP, Mayrsohn B, O'Keeffe M, Kissileff HR, Choudhury AR, Laferrère B. Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. Eur J Clin Nutr. 2014 Oct;68(10):1134-40.
- Borges K, Kaul N, Germaine J, Kwan P, O'Brien TJ. Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy. Epilepsia Open. 2019;4(1):153-163.
- Clegg ME. Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance. Int J Food Sci Nutr. 2010 Nov;61(7):653-79.
Hypertriglyceridemia Cardiovascular
There is some concern that MCTs may further increase the risk for hypertriglyceridemia in some preterm infants due to immature lipoprotein lipase activity in these infants. A case of extremely elevated triglyceride levels of 4,736 mg/dL and associated lipemia retinalis has been reported at 43 weeks post-menstrual age (PMA) for a preterm infant born at 30 weeks' gestational age. It was discovered that the baby had been receiving MCT supplements in addition to breast milk starting at 42 weeks' PMA. MCT supplements were discontinued. One month later triglycerides were reduced to 287 mg/dL, and the retinal vasculature had a normal hue. However, at 2-month follow-up, triglyceride levels were elevated to levels higher than normal for age despite MCT discontinuation. Investigators speculated that a genetic disorder of lipid metabolism may also have contributed to the elevated triglyceride levels in addition to use of MCTs.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no single standardized dose of MCTs that fits everyone, and the right amount depends on why you are using it and how well you tolerate it.
A practical approach is to start low and go slow: begin with a small amount, such as a teaspoon, and gradually increase over days or weeks to reduce stomach upset. Taking MCTs with food can also help.
Always follow the directions on your specific product label, since concentrations vary between oils, powders, and capsules. If you are using MCTs as part of a medical diet, follow your doctor's or dietitian's instructions. Check with a pharmacist or doctor if you are unsure how much is right for you.
Medium Chain Triglycerides (mcts) & Pregnancy
Medium Chain Triglycerides (mcts) & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 6 references that drive our Medium Chain Triglycerides (mcts) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Ruppin DC, Middleton WR. Clinical use of medium chain triglycerides. Drugs 1980;20:216-24. DOI
- Clegg ME. Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance. Int J Food Sci Nutr. 2010 Nov;61(7):653-79. PubMed
- Brighenti F. Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials. J Nutr. 2007 Nov;137(11 Suppl):2552S-2556S. doi: 10.1093/jn/137.11.2552S. PubMed
- St-Onge MP, Mayrsohn B, O'Keeffe M, Kissileff HR, Choudhury AR, Laferrère B. Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. Eur J Clin Nutr. 2014 Oct;68(10):1134-40. PubMed
- Jain A, Mochi TB, Braganza SD, Agrawal S, Shetty BK, Pachiyappan B. Lipemia retinalis in an infant treated for retinopathy of prematurity. J AAPOS 2017;21(3):254-57. PubMed
- Borges K, Kaul N, Germaine J, Kwan P, O'Brien TJ. Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy. Epilepsia Open. 2019;4(1):153-163. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Medium Chain Triglycerides (mcts): Common Questions
What is Medium Chain Triglycerides (mcts) used for, and does it work?
Does Medium Chain Triglycerides (mcts) interact with prescription medications?
How are Medium Chain Triglycerides (mcts) interactions rated?
Is it safe to take Medium Chain Triglycerides (mcts) with my medications?
Where does this Medium Chain Triglycerides (mcts) interaction information come from?
What are MCTs used for?
Will MCT oil help me lose weight?
Why does MCT oil sometimes cause stomach upset?
Is MCT oil the same as coconut oil?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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