Euphorbia Cyparissias Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Euphorbia Cyparissias interacts with medications. The heart of this page is the interaction list — every drug Euphorbia Cyparissias is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Euphorbia Cyparissias is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Euphorbia Cyparissias against your medication
Add one medicationDrugs that interact with Euphorbia Cyparissias
0 medications have a known interaction with Euphorbia Cyparissias, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Euphorbia Cyparissias. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Euphorbia Cyparissias combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Euphorbia Cyparissias: Uses, Safety & Side Effects
Euphorbia cyparissias (cypress spurge) is a wild plant with a toxic, irritating milky sap that has been used in folk medicine as a purgative and to treat warts. There is no reliable evidence that it is safe or effective for any condition, and its latex can cause serious skin, eye, and digestive harm. We do not recommend using it; talk to a pharmacist or doctor before considering any spurge product.
- Scientific name
- Euphorbia cyparissias
- Family
- Euphorbiaceae
- Part used
- Whole flowering plant and its milky latex (sap)
- Common forms
- Dried herb, tincture, homeopathic preparations; topical applications of the fresh latex
- Constipation (as a harsh purgative)
- Skin warts and corns
- Folk remedy for swelling or growths
- Traditional homeopathic use
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
The plant's latex is toxic and irritating, with little evidence of safe medicinal use.
When used orally due to toxicity; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Euphorbia cyparissias, often called cypress spurge, is a low-growing wild plant in the spurge family. It has narrow, needle-like leaves and yellow-green flower clusters, which is why it can look a bit like a small cypress shrub. It grows across Europe and has spread to parts of North America, where it is often considered a weed.
Like other spurges, it contains a sticky, milky white sap (called latex) that oozes out when the plant is broken. In traditional folk medicine, this plant and its sap were used as a strong laxative and applied to the skin to remove warts or growths. Today it has no accepted role in modern medicine, and it is mainly of interest as a wild plant rather than a supplement.
How it works
The milky latex of spurge plants contains compounds called diterpene esters (such as those in the phorbol family), along with other irritating substances. These compounds can strongly irritate the skin, eyes, and lining of the gut. This irritation is likely what produced the old "purgative" effect — the plant essentially forced the bowels to empty by irritating them.
Some of these diterpene-type compounds have been studied in the laboratory for their effects on cells, but this research is early and does not show that the plant is useful or safe as a medicine. Importantly, certain compounds in spurge latex are known to be tumor-promoting in lab settings, which is one reason these plants are treated with caution. Most of this information comes from test-tube and animal research, not from studies in people.
Does Euphorbia Cyparissias work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Euphorbia Cyparissias, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 4 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Constipation
Although there is interest in using oral Euphorbia cyparissias for constipation, there is insufficient reliable information about the clinical effects of Euphorbia cyparissias for this purpose.
Insufficient Reliable Evidence To Rate Corns
Although there is interest in using topical Euphorbia cyparissias for corns, there is insufficient reliable information about the clinical effects of Euphorbia cyparissias for this purpose.
Insufficient Reliable Evidence To Rate Toothache
Although there is interest in using oral Euphorbia cyparissias for toothache, there is insufficient reliable information about the clinical effects of Euphorbia cyparissias for this purpose.
Insufficient Reliable Evidence To Rate Warts
Although there is interest in using topical Euphorbia cyparissias for warts, there is insufficient reliable information about the clinical effects of Euphorbia cyparissias for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Euphorbia cyparissias should be considered toxic and not safe for self-treatment. The milky latex is a known skin and eye irritant. Getting the sap on the skin can cause burning, redness, and blistering, and contact with the eyes can cause severe pain and even damage to vision. Swallowing the plant can cause mouth and throat irritation, nausea, vomiting, and diarrhea.
People with sensitive skin, eye conditions, or digestive disorders are at higher risk of harm. Children and pets should be kept away from the plant. Pregnant and breastfeeding people should avoid it entirely because it can irritate and stimulate the gut and may be toxic; its safety has not been established.
If sap gets in the eyes or causes a serious skin reaction, or if any part of the plant is swallowed, seek medical care or contact a poison control center. Always talk to a pharmacist or doctor before using any product containing spurge.
Side effects
Reported and expected problems mostly come from the irritating latex and include:
- Skin reactions — burning, redness, rash, and blistering where the sap touches the skin.
- Eye injury — severe pain, swelling, and inflammation if sap reaches the eyes, sometimes lasting for days.
- Digestive upset — mouth and throat burning, nausea, vomiting, abdominal cramps, and diarrhea if swallowed.
More serious reactions are possible with larger exposures, and eye contact in particular can be a medical emergency. Because of these risks, this plant is not recommended for medicinal use.
Euphorbia Cyparissias: Reported Adverse Effects
Documented safety reports on Euphorbia Cyparissias from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally and topically, the latex from Euphorbia cyparissias causes significant adverse effects.
Most Common Adverse Effects:
Orally: Burning of the mouth, diarrhea, vomiting.
Topically: Blistering, burning, irritation, itching, ulceration.
Diarrhea Gastrointestinal
Orally, latex from Euphorbia cyparissias causes burning of the mouth, vomiting, and diarrhea.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Pregnancy-related edema Ocular/Otic
A case report describes an 82-year-old female who touched the eye with Euphorbia cyparissias latex while gardening and presented with redness, hyperemia, and excessive watering of the eyes, blurred vision, photophobia, and rhinorrhea. This progressed to keratouveitis with corneal epithelial erosions, corneal edema, elevated intraocular pressure, elevated ocular pH, anterior chamber inflammation, and significantly decreased vision. The patient made a full recovery within several weeks after treatment with eye irrigations and topical antibiotics.
Pruritus Dermatologic
Topically, the latex from Euphorbia cyparissias causes reddening, itching, burning, and blisters.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established or safe dose for Euphorbia cyparissias. It is not a standardized supplement, and because the plant is toxic, we do not recommend taking it. Homeopathic products are extremely diluted, but their safety and effectiveness are also not well studied.
If you come across any product containing this plant, do not guess at an amount. Follow the product label only after checking with a pharmacist or doctor, and never apply the raw sap to your skin or take the plant by mouth on your own.
Euphorbia Cyparissias & Pregnancy
Euphorbia Cyparissias & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 references that drive our Euphorbia Cyparissias monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Fleischman D, Meyer JJ, Fowler WC. Keratouveitis from Euphorbia cyparissias exposure is a temporal phenomenon. Clin Ophthalmol 2012;6:851-3. doi: 10.2147/OPTH.S32209. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Euphorbia Cyparissias: Common Questions
What is Euphorbia Cyparissias used for, and does it work?
Does Euphorbia Cyparissias interact with prescription medications?
How are Euphorbia Cyparissias interactions rated?
Is it safe to take Euphorbia Cyparissias with my medications?
Where does this Euphorbia Cyparissias interaction information come from?
What is Euphorbia Cyparissias used for?
Is cypress spurge safe to use?
Can I use it during pregnancy or while breastfeeding?
What should I do if the sap gets on my skin or in my eyes?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Have a question about Euphorbia Cyparissias?
Our pharmacists answer your medication & supplement questions — free.