Herb & supplement monograph

Euphorbia Cyparissias Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Euphorbia Cyparissias

0 medications have a known interaction with Euphorbia Cyparissias, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Euphorbia Cyparissias. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Euphorbia Cyparissias combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Euphorbia Cyparissias: Uses, Safety & Side Effects

The bottom line

Euphorbia cyparissias (cypress spurge) is a wild plant with a toxic, irritating milky sap that has been used in folk medicine as a purgative and to treat warts. There is no reliable evidence that it is safe or effective for any condition, and its latex can cause serious skin, eye, and digestive harm. We do not recommend using it; talk to a pharmacist or doctor before considering any spurge product.

Scientific name
Euphorbia cyparissias
Family
Euphorbiaceae
Part used
Whole flowering plant and its milky latex (sap)
Common forms
Dried herb, tincture, homeopathic preparations; topical applications of the fresh latex
People commonly use it for
  • Constipation (as a harsh purgative)
  • Skin warts and corns
  • Folk remedy for swelling or growths
  • Traditional homeopathic use

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

The plant's latex is toxic and irritating, with little evidence of safe medicinal use.

PregnancyUnsafe

When used orally due to toxicity; avoid using.

Read the full pregnancy detail
BreastfeedingUnsafe

When used orally due to toxicity; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Euphorbia cyparissias, often called cypress spurge, is a low-growing wild plant in the spurge family. It has narrow, needle-like leaves and yellow-green flower clusters, which is why it can look a bit like a small cypress shrub. It grows across Europe and has spread to parts of North America, where it is often considered a weed.

Like other spurges, it contains a sticky, milky white sap (called latex) that oozes out when the plant is broken. In traditional folk medicine, this plant and its sap were used as a strong laxative and applied to the skin to remove warts or growths. Today it has no accepted role in modern medicine, and it is mainly of interest as a wild plant rather than a supplement.

How it works

The milky latex of spurge plants contains compounds called diterpene esters (such as those in the phorbol family), along with other irritating substances. These compounds can strongly irritate the skin, eyes, and lining of the gut. This irritation is likely what produced the old "purgative" effect — the plant essentially forced the bowels to empty by irritating them.

Some of these diterpene-type compounds have been studied in the laboratory for their effects on cells, but this research is early and does not show that the plant is useful or safe as a medicine. Importantly, certain compounds in spurge latex are known to be tumor-promoting in lab settings, which is one reason these plants are treated with caution. Most of this information comes from test-tube and animal research, not from studies in people.

Effectiveness

Does Euphorbia Cyparissias work?

Evidence overview · 4 uses evaluated
4 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Euphorbia Cyparissias, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 4 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Constipation
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Euphorbia cyparissias for constipation, there is insufficient reliable information about the clinical effects of Euphorbia cyparissias for this purpose.

Insufficient Reliable Evidence To Rate Corns
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical Euphorbia cyparissias for corns, there is insufficient reliable information about the clinical effects of Euphorbia cyparissias for this purpose.

Insufficient Reliable Evidence To Rate Toothache
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Euphorbia cyparissias for toothache, there is insufficient reliable information about the clinical effects of Euphorbia cyparissias for this purpose.

Insufficient Reliable Evidence To Rate Warts
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical Euphorbia cyparissias for warts, there is insufficient reliable information about the clinical effects of Euphorbia cyparissias for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Euphorbia cyparissias should be considered toxic and not safe for self-treatment. The milky latex is a known skin and eye irritant. Getting the sap on the skin can cause burning, redness, and blistering, and contact with the eyes can cause severe pain and even damage to vision. Swallowing the plant can cause mouth and throat irritation, nausea, vomiting, and diarrhea.

People with sensitive skin, eye conditions, or digestive disorders are at higher risk of harm. Children and pets should be kept away from the plant. Pregnant and breastfeeding people should avoid it entirely because it can irritate and stimulate the gut and may be toxic; its safety has not been established.

If sap gets in the eyes or causes a serious skin reaction, or if any part of the plant is swallowed, seek medical care or contact a poison control center. Always talk to a pharmacist or doctor before using any product containing spurge.

Side effects

Reported and expected problems mostly come from the irritating latex and include:

  • Skin reactions — burning, redness, rash, and blistering where the sap touches the skin.
  • Eye injury — severe pain, swelling, and inflammation if sap reaches the eyes, sometimes lasting for days.
  • Digestive upset — mouth and throat burning, nausea, vomiting, abdominal cramps, and diarrhea if swallowed.

More serious reactions are possible with larger exposures, and eye contact in particular can be a medical emergency. Because of these risks, this plant is not recommended for medicinal use.

Euphorbia Cyparissias: Reported Adverse Effects

Documented safety reports on Euphorbia Cyparissias from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally and topically, the latex from Euphorbia cyparissias causes significant adverse effects.

Most Common Adverse Effects:

Orally: Burning of the mouth, diarrhea, vomiting.

Topically: Blistering, burning, irritation, itching, ulceration.

Reports by condition
Diarrhea Gastrointestinal

Orally, latex from Euphorbia cyparissias causes burning of the mouth, vomiting, and diarrhea.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Pregnancy-related edema Ocular/Otic

A case report describes an 82-year-old female who touched the eye with Euphorbia cyparissias latex while gardening and presented with redness, hyperemia, and excessive watering of the eyes, blurred vision, photophobia, and rhinorrhea. This progressed to keratouveitis with corneal epithelial erosions, corneal edema, elevated intraocular pressure, elevated ocular pH, anterior chamber inflammation, and significantly decreased vision. The patient made a full recovery within several weeks after treatment with eye irrigations and topical antibiotics.

  1. Fleischman D, Meyer JJ, Fowler WC. Keratouveitis from Euphorbia cyparissias exposure is a temporal phenomenon. Clin Ophthalmol 2012;6:851-3. doi: 10.2147/OPTH.S32209.
Pruritus Dermatologic

Topically, the latex from Euphorbia cyparissias causes reddening, itching, burning, and blisters.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established or safe dose for Euphorbia cyparissias. It is not a standardized supplement, and because the plant is toxic, we do not recommend taking it. Homeopathic products are extremely diluted, but their safety and effectiveness are also not well studied.

If you come across any product containing this plant, do not guess at an amount. Follow the product label only after checking with a pharmacist or doctor, and never apply the raw sap to your skin or take the plant by mouth on your own.

Pregnancy & Breastfeeding

Euphorbia Cyparissias & Pregnancy

Unsafe

When used orally due to toxicity; avoid using.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Euphorbia Cyparissias & Breastfeeding

Unsafe

When used orally due to toxicity; avoid using.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Euphorbia Cyparissias monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Fleischman D, Meyer JJ, Fowler WC. Keratouveitis from Euphorbia cyparissias exposure is a temporal phenomenon. Clin Ophthalmol 2012;6:851-3. doi: 10.2147/OPTH.S32209. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Euphorbia Cyparissias: Common Questions

What is Euphorbia Cyparissias used for, and does it work?
People use Euphorbia Cyparissias for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Euphorbia Cyparissias interact with prescription medications?
We do not currently list any known drug interactions for Euphorbia Cyparissias. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Euphorbia Cyparissias interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Euphorbia Cyparissias with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Euphorbia Cyparissias interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Euphorbia Cyparissias used for?
Traditionally it was used as a strong laxative and to remove warts or skin growths, but there is no reliable evidence it works for any of these uses. It is mostly of historical or folk-medicine interest today.
Is cypress spurge safe to use?
No. The plant's milky sap is toxic and can severely irritate the skin, eyes, and digestive tract, so it is not considered safe for self-treatment.
Can I use it during pregnancy or while breastfeeding?
No. It should be avoided during pregnancy and breastfeeding because it can irritate the gut, may be toxic, and its safety has not been studied.
What should I do if the sap gets on my skin or in my eyes?
Rinse the area thoroughly with water and seek medical care, especially for eye contact, which can be a medical emergency. Contact a poison control center if any part of the plant is swallowed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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