Marsh Blazing Star Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Marsh Blazing Star interacts with medications. The heart of this page is the interaction list — every drug Marsh Blazing Star is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Marsh Blazing Star is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Marsh Blazing Star against your medication
Add one medicationDrugs that interact with Marsh Blazing Star
0 medications have a known interaction with Marsh Blazing Star, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Marsh Blazing Star. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Marsh Blazing Star combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Marsh Blazing Star: Uses, Safety & Side Effects
Marsh blazing star (Liatris spicata) is a North American prairie plant whose root has a long history in folk medicine for urinary, menstrual, and digestive complaints. There is very little modern scientific evidence to confirm that it works or to define a safe dose, so it should be used cautiously and avoided in pregnancy and breastfeeding.

- Scientific name
- Liatris spicata
- Family
- Asteraceae
- Part used
- Root
- Common forms
- Dried root, tea, tincture, capsules
- Kidney and urinary complaints
- Menstrual cramps (dysmenorrhea)
- As a diuretic
- Colic and digestive upset
- Sore throat (traditional gargle)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
There is not enough reliable human research to judge its safety.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Marsh blazing star (Liatris spicata) is a tall, upright perennial plant in the aster family (Asteraceae). It is native to eastern and central North America, where it grows in moist prairies, meadows, and marshy areas. In summer it produces striking spikes of fluffy, deep purple flower heads, which is why it is often called "blazing star" or "gay-feather." It is also widely grown as an ornamental garden plant.
In traditional and folk medicine, the part used is the root. It has been used by various groups for urinary and kidney complaints, menstrual cramps, sore throats, and digestive problems. Today it is sometimes sold as a dried root, tea, tincture, or capsule, though it is far more common as a garden flower than as a supplement.
Uses & effectiveness
People have traditionally used marsh blazing star root for kidney and bladder problems, as a diuretic (to increase urine flow), for painful menstrual periods, for colic and digestive upset, and as a gargle for sore throat. Historically it was also used for conditions such as gonorrhea before modern medicine existed.
The evidence for these uses is very weak. There are essentially no good-quality human clinical trials showing that marsh blazing star treats any condition. Most of what is known comes from traditional use and a small amount of laboratory study of its chemical makeup. Because of this, it is not possible to say that it is effective for any health problem. If you are dealing with a urinary infection, kidney issue, or severe menstrual pain, you should see a healthcare provider rather than rely on this herb.
How it works
The root contains coumarin and other plant compounds. Coumarins are naturally occurring substances found in many plants. Some plant coumarins have been studied for effects on blood vessels and fluid balance, which may explain the traditional use as a diuretic, but this has not been confirmed for marsh blazing star specifically.
Like many members of the aster family, the plant also contains a mix of other natural compounds that may have mild antioxidant or antimicrobial activity in the laboratory. It is important to understand that these are mostly test-tube observations. They do not prove that the herb produces meaningful effects in the human body or that it is safe at any particular dose.
Safety & precautions
There is very little modern safety information on marsh blazing star, so its overall safety is considered unknown. Because the root contains coumarin and other active compounds, it is best treated with caution.
People who should be especially careful include those with kidney disease, those who are allergic to plants in the aster/daisy family (such as ragweed, marigolds, and chrysanthemums), and anyone with a bleeding disorder. Pregnant and breastfeeding people should avoid it because of its traditional use related to menstruation and the complete lack of safety data. Always talk with a pharmacist or doctor before trying this or any new herbal product, and do not give it to children.
Side effects
Because marsh blazing star has not been well studied in people, its side effect profile is not well defined. Based on its diuretic reputation, it could in theory increase urination. Plants in the aster family can cause allergic reactions, especially in people sensitive to ragweed and related plants.
As with many herbal products, possible effects include stomach upset, nausea, or skin reactions. Stop using it and seek medical care if you notice signs of an allergic reaction such as rash, itching, swelling, or trouble breathing.
Marsh Blazing Star: Reported Adverse Effects
Documented safety reports on Marsh Blazing Star from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, marsh blazing star, which contains coumarin, can be associated with nausea and vomiting, diarrhea, dizziness, insomnia, asymptomatic SGOT elevations, and liver toxicity.
Topically, handling the plant can cause contact dermatitis.
Marsh blazing star can cause an allergic reaction in individuals sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many other herbs.
- Mohler JL, Gomella LG, Crawford ED, et al. Phase II evaluation of coumarin (1,2-benzopyrone) in metastatic prostatic carcinoma. Prostate 1992;20:123-31.
- Marshall ME, Butler K, Fried A. Phase I evaluation of coumarin (1,2 benzopyrone) and cimetidine in patients with advanced malignancies. Mol Biother 1991;3:170-8.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Goerz G, Wirth G, Maas B, et al. [Allergic contact dermatitis due to Asteraceae (Compositae). Cross reaction with Liatris spicata]. Derm Beruf Umwelt 1985;33:95-8.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established or standardized dose for marsh blazing star. Traditional preparations used the dried root as a tea or tincture, but no reliable amount has been confirmed as safe or effective in modern research.
If you choose to use a commercial product, follow the directions on the label and do not exceed them. Because the quality and strength of herbal supplements can vary widely, talk with a pharmacist or doctor first, especially if you take other medicines or have a health condition.
Marsh Blazing Star & Pregnancy
Marsh Blazing Star & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 5 references that drive our Marsh Blazing Star monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Mohler JL, Gomella LG, Crawford ED, et al. Phase II evaluation of coumarin (1,2-benzopyrone) in metastatic prostatic carcinoma. Prostate 1992;20:123-31. PubMed
- Marshall ME, Butler K, Fried A. Phase I evaluation of coumarin (1,2 benzopyrone) and cimetidine in patients with advanced malignancies. Mol Biother 1991;3:170-8.
- Goerz G, Wirth G, Maas B, et al. [Allergic contact dermatitis due to Asteraceae (Compositae). Cross reaction with Liatris spicata]. Derm Beruf Umwelt 1985;33:95-8.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Marsh Blazing Star: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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