Peru Balsam Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Peru Balsam interacts with medications. The heart of this page is the interaction list — every drug Peru Balsam is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Peru Balsam is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Peru Balsam against your medication
Add one medicationDrugs that interact with Peru Balsam
0 medications have a known interaction with Peru Balsam, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Peru Balsam. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Peru Balsam combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Peru Balsam: Uses, Safety & Side Effects
Peru Balsam is a fragrant tree resin used mainly in topical products for wounds, hemorrhoids, and skin care, and sometimes in cough and throat remedies. Evidence for most uses is limited and largely traditional, and it is a well-known cause of allergic skin reactions, so use it cautiously and check with your pharmacist or doctor first.
- Scientific name
- Myroxylon balsamum var. pereirae
- Family
- Fabaceae
- Part used
- Balsam (resin) obtained from the tree bark
- Common forms
- Topical ointments, creams, suppositories, lozenges, and as a fragrance ingredient
- Wound and skin healing
- Hemorrhoids
- Coughs and sore throat
- Antimicrobial and antiseptic
- Diaper rash and minor skin irritation
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally used topically but is a common cause of allergic and contact skin reactions.
When used orally in medicinal amounts; avoid using. There is insufficient reliable information available about the safety of Peru balsam when used top...
Read the full pregnancy detailWhen used topically because systemic toxicity to babies can occur following application of Peru balsam to the nipples of nursing mothers.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Peru Balsam is a thick, fragrant resin that comes from a tropical tree called Myroxylon balsamum, in the bean family. Despite its name, the tree grows mainly in Central America, especially El Salvador, not Peru. The resin is collected by wounding the bark and letting the dark, sticky balsam ooze out.
Peru Balsam has a warm, vanilla-like scent. It has long been used in folk medicine and is still found today in skin ointments, hemorrhoid creams, suppositories, cough syrups, and lozenges. It is also widely used as a fragrance and flavoring agent in cosmetics, perfumes, and some foods.
Uses & effectiveness
People most often use Peru Balsam on the skin. It is an ingredient in some products for minor wounds, ulcers, bedsores, hemorrhoids, and diaper rash, where it is thought to help protect the skin and fight germs. It is also taken in lozenges or syrups for coughs and sore throats.
The evidence behind these uses is limited and mostly traditional. Some older topical products combine Peru Balsam with other ingredients (such as castor oil) for wound and hemorrhoid care, but high-quality studies that clearly prove it works on its own are lacking. Laboratory studies suggest it may have some germ-fighting activity, but this does not guarantee a benefit in people.
Overall, Peru Balsam should be seen as a traditional remedy with modest supporting evidence rather than a proven treatment.
How it works
Peru Balsam contains a mix of natural compounds, including substances often grouped as "balsamic esters" such as benzyl benzoate and benzyl cinnamate, along with cinnamic and benzoic acids and aromatic oils.
These compounds are thought to have mild antiseptic (germ-killing) and skin-soothing properties, and they may help promote the growth of new skin tissue in wounds. Much of this understanding comes from laboratory research and traditional use rather than large human trials, so the exact way it helps people is not fully proven.
Safety & precautions
When used on the skin in small amounts, Peru Balsam is often tolerated, but it is one of the most common causes of allergic contact dermatitis (an itchy, red skin rash). It is so frequently linked to allergies that it is used in standard skin patch-testing kits. People who are sensitive to fragrances or to related balsams may react to it.
Some people are sensitive to "balsam of Peru" in foods and may be advised by an allergy specialist to limit certain spices and flavorings. Avoid applying it to large areas of broken skin, and stop using it if a rash develops.
Pregnancy and breastfeeding: There is not enough reliable safety information, so it is best to avoid Peru Balsam during pregnancy and while breastfeeding. In particular, do not apply it to the breast or nipple area where a nursing infant could ingest it.
Always talk with a pharmacist or doctor before using Peru Balsam, especially if you have allergies, sensitive skin, or a chronic wound.
Side effects
The most common side effect is a skin reaction: redness, itching, burning, or a rash where the product was applied. Some people develop a true allergy with repeated use.
Less commonly, it can cause more widespread allergic responses in sensitive individuals. Taking large amounts internally is not recommended and could cause kidney irritation or other problems. If you have trouble breathing, swelling, or a spreading rash, stop using it and seek medical care.
Peru Balsam: Reported Adverse Effects
Documented safety reports on Peru Balsam from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Peru balsam can cause kidney damage when taken orally or applied topically in large amounts. Topical use is associated with allergic contact dermatitis and other skin reactions.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
Dermatitis Dermatologic
There are numerous reports of Peru balsam and its extracts causing allergic contact dermatitis, particularly when present in fragrances, cosmetics, and topical medicines. Among people who undergo patch testing for allergic contact dermatitis, reactions to Peru balsam occur in 4% to 8.4%, of whom 70% are women. Peru balsam can also cause contact urticaria, phototoxic reactions, and non-immunological contact reactions.
Two case reports describe cheilitis and perioral dermatitis associated with use of Lucas Papaw ointment (Lucas Papaw Remedies, Australia) containing Peru balsam, as a lip balm.
- Turic P, Lipozencic J, Milavec-Puretic V, Kulisic SM. Contact allergy caused by fragrance mix and Myroxylon pereirae (balsam of Peru) - a retrospective study. Coll Antropol 2011;35(1):83-7.
- Thyssen JP, Carlsen BC, Menné T, Johansen JD. Trends of contact allergy to fragrance mix I and Myroxylon pereirae among Danish eczema patients tested between 1985 and 2007. Contact Dermatitis 2008;59(4):238-44. doi: 10.1111/j.1600-0536.2008.01418.x.
- Avalos-Peralta P, García-Bravo B, Camacho FM. Sensitivity to Myroxylon pereirae resin (balsam of Peru). A study of 50 cases. Contact Dermatitis 2005;52(6):304-6.
- Tan S, Tam MM, Nixon RL. Allergic contact dermatitis to Myroxylon pereirae (Balsam of Peru) in papaw ointment causing cheilitis. Australas J Dermatol 2011;52(3):222-3. doi: 10.1111/j.1440-0960.2011.00772.x.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no well-established standardized dose for Peru Balsam. It is usually found as one ingredient in finished topical products, lozenges, or syrups rather than as a stand-alone supplement.
Follow the directions on the specific product label, and use the smallest amount needed. Because strength varies between products and allergic reactions are common, check with your pharmacist or doctor before starting, and do a small skin-area test if you have sensitive skin.
Peru Balsam & Pregnancy
Peru Balsam & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 7 references that drive our Peru Balsam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Turic P, Lipozencic J, Milavec-Puretic V, Kulisic SM. Contact allergy caused by fragrance mix and Myroxylon pereirae (balsam of Peru) - a retrospective study. Coll Antropol 2011;35(1):83-7.
- Tan S, Tam MM, Nixon RL. Allergic contact dermatitis to Myroxylon pereirae (Balsam of Peru) in papaw ointment causing cheilitis. Australas J Dermatol 2011;52(3):222-3. doi: 10.1111/j.1440-0960.2011.00772.x. PubMed
- Thyssen JP, Carlsen BC, Menné T, Johansen JD. Trends of contact allergy to fragrance mix I and Myroxylon pereirae among Danish eczema patients tested between 1985 and 2007. Contact Dermatitis 2008;59(4):238-44. doi: 10.1111/j.1600-0536.2008.01418.x.
- Avalos-Peralta P, García-Bravo B, Camacho FM. Sensitivity to Myroxylon pereirae resin (balsam of Peru). A study of 50 cases. Contact Dermatitis 2005;52(6):304-6.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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