Herb & supplement monograph

Roman Chamomile Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Roman Chamomile

0 medications have a known interaction with Roman Chamomile, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Roman Chamomile. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Roman Chamomile combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Roman Chamomile: Uses, Safety & Side Effects

The bottom line

Roman chamomile is a daisy-family herb used traditionally as a calming tea and as an oil for digestion, mild anxiety, and skin comfort. Solid human evidence is limited for most uses, but it is generally considered safe in food and tea amounts for most adults. People allergic to ragweed and related plants should be cautious, and pregnant or breastfeeding people should check with a doctor first.

Scientific name
Chamaemelum nobile
Family
Asteraceae
Part used
Flowers (and essential oil)
Common forms
Tea, capsules, liquid extract, essential oil, topical creams
People commonly use it for
  • Digestive upset
  • Anxiety and relaxation
  • Sleep support
  • Skin irritation
  • Menstrual cramps

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated in tea or food amounts, but allergic reactions are possible in sensitive people.

PregnancyLikely Unsafe

When used orally in medicinal amounts. Roman chamomile is believed to be an abortifacient. Some population research has found a possible link between...

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Roman chamomile (Chamaemelum nobile) is a low-growing, daisy-like plant in the Asteraceae family. It is native to western Europe and is now grown in many parts of the world. The small white-and-yellow flowers have a sweet, apple-like smell and are dried to make teas, extracts, and essential oils.

Roman chamomile is closely related to, but different from, German chamomile (Matricaria chamomilla). The two are often used in similar ways. People have used chamomile for hundreds of years as a gentle tea to relax, to settle the stomach, and to soothe the skin.

How it works

Roman chamomile contains several plant compounds, including flavonoids (such as apigenin), terpenes, and the components of its essential oil. These substances are thought to have mild relaxing, anti-inflammatory, and gas-relieving (antispasmodic) effects.

One proposed mechanism is that apigenin may interact with calming receptors in the brain, which could explain the herb's traditional use for relaxation and sleep. However, most of this evidence comes from laboratory and animal studies, and it is not clear how strongly these effects apply when people drink chamomile tea or take it as a supplement.

Effectiveness

Does Roman Chamomile work?

Evidence overview · 17 uses evaluated
17 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Roman Chamomile, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 17 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Allergic rhinitis (hay fever)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using inhaled Roman chamomile for allergic rhinitis, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.

Insufficient Reliable Evidence To Rate Anxiety
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using inhaled Roman chamomile for anxiety, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.

Insufficient Reliable Evidence To Rate Atopic dermatitis (eczema)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical Roman chamomile for atopic dermatitis, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.

Insufficient Reliable Evidence To Rate Burns
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical Roman chamomile for burns, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Roman chamomile for diabetes, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.

Insufficient Reliable Evidence To Rate Diaper rash
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical Roman chamomile for diaper rash, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.

Insufficient Reliable Evidence To Rate Dysmenorrhea
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Roman chamomile for dysmenorrhea, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.

Insufficient Reliable Evidence To Rate Dyspepsia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Roman chamomile for dyspepsia, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.

Insufficient Reliable Evidence To Rate Hemorrhoids
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical Roman chamomile for hemorrhoids, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Roman chamomile for hypertension, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.

Insufficient Reliable Evidence To Rate Insomnia
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral or inhaled Roman chamomile for insomnia, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.

Insufficient Reliable Evidence To Rate Lichen planus
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical Roman chamomile is beneficial in patients with lichen planus.

Insufficient Reliable Evidence To Rate Nausea and vomiting
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Roman chamomile for nausea and vomiting, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.

Insufficient Reliable Evidence To Rate Pruritus
Rating & evidence shown verbatim from Natural Medicines

It is unclear if Roman chamomile is beneficial for pruritis.

Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical Roman chamomile for RA, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.

Insufficient Reliable Evidence To Rate Stress
Rating & evidence shown verbatim from Natural Medicines

It is unclear if Roman chamomile is beneficial for stress.

Insufficient Reliable Evidence To Rate Wound healing
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using topical Roman chamomile for wound healing, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Roman chamomile is generally considered safe for most adults when used in normal tea or food amounts. The main concern is allergy. People who are allergic to ragweed, marigolds, daisies, or other plants in the Asteraceae family may react to chamomile.

Pregnancy: Avoid medicinal or concentrated amounts during pregnancy. Some traditional sources warn it could affect the uterus, and safety has not been well studied. Breastfeeding: There is not enough reliable information, so use caution and talk to your doctor or pharmacist before using it regularly.

Use extra care with the essential oil, which is very concentrated and should never be swallowed unless directed by a qualified professional. Always check with a pharmacist or doctor before starting any new supplement, especially if you have a medical condition or take other medicines.

Side effects

Most people who drink chamomile tea have no problems. When side effects do occur, they are usually mild and may include drowsiness, nausea, or vomiting if large amounts are taken.

The most important risk is an allergic reaction. In rare cases this can be serious, including swelling, trouble breathing, or anaphylaxis, particularly in people allergic to related plants. Applied to the skin, chamomile can occasionally cause a rash or irritation. Stop using it and seek medical care if you notice signs of an allergic reaction.

Roman Chamomile: Reported Adverse Effects

Documented safety reports on Roman Chamomile from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Cough Pulmonary/Respiratory

A case report describes the development of cough and rhinitis in a 20-year-old female after exposure to chamomile-scented toilet paper. Skin prick testing confirmed the presence of allergenicity to the toilet paper product.

  1. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248.
Dermatitis Dermatologic

Topically, Roman chamomile can cause contact dermatitis. Allergic skin reactions can occur in up to 20% of individuals exposed to Roman chamomile. Multiple case reports have described the development of topical allergic reactions, including eczema and rash, with the use of cleaning products and cosmetics containing chamomile oil or chamomile extract. In one case report, a 55-year-old man experienced disseminated erythroderma with itchy, scaly lesions after non-contact exposure to an area containing many plant varieties. Patch testing confirmed the presence of allergenicity to Roman chamomile.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8.
  3. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Nausea and vomiting Gastrointestinal

Orally, large amounts of Roman chamomile might cause vomiting, although data are conflicting.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official standardized dose for Roman chamomile. The amount varies widely depending on the product and the form (tea, capsule, or extract).

A common traditional use is one cup of chamomile tea made from the dried flowers, taken up to a few times a day. For capsules or liquid extracts, follow the directions on the product label, since strengths differ between brands. Because reliable dosing information is limited, it is best to start low and check with a pharmacist or doctor, especially if you are taking other medicines or have health concerns.

Pregnancy & Breastfeeding

Roman Chamomile & Pregnancy

Likely Unsafe

When used orally in medicinal amounts. Roman chamomile is believed to be an abortifacient. Some population research has found a possible link between the use of Roman chamomile and an increased incidence of reduced birth weight, threatened miscarriage, and preterm labor. There is insufficient reliable information available about the safety of the topical use of Roman chamomile during pregnancy; avoid using.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248.

Roman Chamomile & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 6 references that drive our Roman Chamomile monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8. PubMed
  6. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Roman Chamomile

3 brands in our database make a supplement containing Roman Chamomile.

Pharmacist Counseling Corner

Roman Chamomile: Common Questions

What is Roman Chamomile used for, and does it work?
People use Roman Chamomile for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Roman Chamomile interact with prescription medications?
We do not currently list any known drug interactions for Roman Chamomile. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Roman Chamomile interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Roman Chamomile with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Roman Chamomile interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Roman Chamomile used for?
People most often use it as a calming tea for relaxation and sleep, and as a traditional remedy for upset stomach, gas, menstrual cramps, and minor skin irritation. Strong scientific proof is limited for most of these uses.
Is Roman Chamomile the same as German chamomile?
No. They are related plants used in similar ways, but they are different species. Most research is done on German chamomile, so results do not always apply to the Roman type.
Can I drink chamomile tea if I'm pregnant?
It is safest to avoid medicinal or large amounts during pregnancy because safety hasn't been well studied. Talk to your doctor or pharmacist before using it.
Who should avoid Roman Chamomile?
People allergic to ragweed, daisies, marigolds, or other plants in the Asteraceae family should be cautious, as allergic reactions can occur. Anyone with a medical condition or taking medication should check with a healthcare provider first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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