Roman Chamomile Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Roman Chamomile interacts with medications. The heart of this page is the interaction list — every drug Roman Chamomile is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Roman Chamomile is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Roman Chamomile against your medication
Add one medicationDrugs that interact with Roman Chamomile
0 medications have a known interaction with Roman Chamomile, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Roman Chamomile. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Roman Chamomile combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Roman Chamomile: Uses, Safety & Side Effects
Roman chamomile is a daisy-family herb used traditionally as a calming tea and as an oil for digestion, mild anxiety, and skin comfort. Solid human evidence is limited for most uses, but it is generally considered safe in food and tea amounts for most adults. People allergic to ragweed and related plants should be cautious, and pregnant or breastfeeding people should check with a doctor first.
- Scientific name
- Chamaemelum nobile
- Family
- Asteraceae
- Part used
- Flowers (and essential oil)
- Common forms
- Tea, capsules, liquid extract, essential oil, topical creams
- Digestive upset
- Anxiety and relaxation
- Sleep support
- Skin irritation
- Menstrual cramps
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally well tolerated in tea or food amounts, but allergic reactions are possible in sensitive people.
When used orally in medicinal amounts. Roman chamomile is believed to be an abortifacient. Some population research has found a possible link between...
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Roman chamomile (Chamaemelum nobile) is a low-growing, daisy-like plant in the Asteraceae family. It is native to western Europe and is now grown in many parts of the world. The small white-and-yellow flowers have a sweet, apple-like smell and are dried to make teas, extracts, and essential oils.
Roman chamomile is closely related to, but different from, German chamomile (Matricaria chamomilla). The two are often used in similar ways. People have used chamomile for hundreds of years as a gentle tea to relax, to settle the stomach, and to soothe the skin.
How it works
Roman chamomile contains several plant compounds, including flavonoids (such as apigenin), terpenes, and the components of its essential oil. These substances are thought to have mild relaxing, anti-inflammatory, and gas-relieving (antispasmodic) effects.
One proposed mechanism is that apigenin may interact with calming receptors in the brain, which could explain the herb's traditional use for relaxation and sleep. However, most of this evidence comes from laboratory and animal studies, and it is not clear how strongly these effects apply when people drink chamomile tea or take it as a supplement.
Does Roman Chamomile work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Roman Chamomile, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 17 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Allergic rhinitis (hay fever)
Although there is interest in using inhaled Roman chamomile for allergic rhinitis, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.
Insufficient Reliable Evidence To Rate Anxiety
Although there is interest in using inhaled Roman chamomile for anxiety, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.
Insufficient Reliable Evidence To Rate Atopic dermatitis (eczema)
Although there is interest in using topical Roman chamomile for atopic dermatitis, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.
Insufficient Reliable Evidence To Rate Burns
Although there is interest in using topical Roman chamomile for burns, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.
Insufficient Reliable Evidence To Rate Diabetes
Although there is interest in using oral Roman chamomile for diabetes, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.
Insufficient Reliable Evidence To Rate Diaper rash
Although there is interest in using topical Roman chamomile for diaper rash, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.
Insufficient Reliable Evidence To Rate Dysmenorrhea
Although there is interest in using oral Roman chamomile for dysmenorrhea, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.
Insufficient Reliable Evidence To Rate Dyspepsia
Although there is interest in using oral Roman chamomile for dyspepsia, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.
Insufficient Reliable Evidence To Rate Hemorrhoids
Although there is interest in using topical Roman chamomile for hemorrhoids, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.
Insufficient Reliable Evidence To Rate Hypertension
Although there is interest in using oral Roman chamomile for hypertension, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.
Insufficient Reliable Evidence To Rate Insomnia
Although there is interest in using oral or inhaled Roman chamomile for insomnia, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.
Insufficient Reliable Evidence To Rate Lichen planus
It is unclear if topical Roman chamomile is beneficial in patients with lichen planus.
Insufficient Reliable Evidence To Rate Nausea and vomiting
Although there is interest in using oral Roman chamomile for nausea and vomiting, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.
Insufficient Reliable Evidence To Rate Pruritus
It is unclear if Roman chamomile is beneficial for pruritis.
Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Although there is interest in using topical Roman chamomile for RA, there is insufficient reliable information about the clinical effects of Roman chamomile for this condition.
Insufficient Reliable Evidence To Rate Stress
It is unclear if Roman chamomile is beneficial for stress.
Insufficient Reliable Evidence To Rate Wound healing
Although there is interest in using topical Roman chamomile for wound healing, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Roman chamomile is generally considered safe for most adults when used in normal tea or food amounts. The main concern is allergy. People who are allergic to ragweed, marigolds, daisies, or other plants in the Asteraceae family may react to chamomile.
Pregnancy: Avoid medicinal or concentrated amounts during pregnancy. Some traditional sources warn it could affect the uterus, and safety has not been well studied. Breastfeeding: There is not enough reliable information, so use caution and talk to your doctor or pharmacist before using it regularly.
Use extra care with the essential oil, which is very concentrated and should never be swallowed unless directed by a qualified professional. Always check with a pharmacist or doctor before starting any new supplement, especially if you have a medical condition or take other medicines.
Side effects
Most people who drink chamomile tea have no problems. When side effects do occur, they are usually mild and may include drowsiness, nausea, or vomiting if large amounts are taken.
The most important risk is an allergic reaction. In rare cases this can be serious, including swelling, trouble breathing, or anaphylaxis, particularly in people allergic to related plants. Applied to the skin, chamomile can occasionally cause a rash or irritation. Stop using it and seek medical care if you notice signs of an allergic reaction.
Roman Chamomile: Reported Adverse Effects
Documented safety reports on Roman Chamomile from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Reports by conditionCough Pulmonary/Respiratory
A case report describes the development of cough and rhinitis in a 20-year-old female after exposure to chamomile-scented toilet paper. Skin prick testing confirmed the presence of allergenicity to the toilet paper product.
Dermatitis Dermatologic
Topically, Roman chamomile can cause contact dermatitis. Allergic skin reactions can occur in up to 20% of individuals exposed to Roman chamomile. Multiple case reports have described the development of topical allergic reactions, including eczema and rash, with the use of cleaning products and cosmetics containing chamomile oil or chamomile extract. In one case report, a 55-year-old man experienced disseminated erythroderma with itchy, scaly lesions after non-contact exposure to an area containing many plant varieties. Patch testing confirmed the presence of allergenicity to Roman chamomile.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8.
- Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Nausea and vomiting Gastrointestinal
Orally, large amounts of Roman chamomile might cause vomiting, although data are conflicting.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no official standardized dose for Roman chamomile. The amount varies widely depending on the product and the form (tea, capsule, or extract).
A common traditional use is one cup of chamomile tea made from the dried flowers, taken up to a few times a day. For capsules or liquid extracts, follow the directions on the product label, since strengths differ between brands. Because reliable dosing information is limited, it is best to start low and check with a pharmacist or doctor, especially if you are taking other medicines or have health concerns.
Roman Chamomile & Pregnancy
Roman Chamomile & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 6 references that drive our Roman Chamomile monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8. PubMed
- Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Roman Chamomile
3 brands in our database make a supplement containing Roman Chamomile.
Supplement products with Roman Chamomile
8 products in our database contain Roman Chamomile. Open any to see its full ingredient list and every drug interaction we check.
Roman Chamomile: Common Questions
What is Roman Chamomile used for, and does it work?
Does Roman Chamomile interact with prescription medications?
How are Roman Chamomile interactions rated?
Is it safe to take Roman Chamomile with my medications?
Where does this Roman Chamomile interaction information come from?
What is Roman Chamomile used for?
Is Roman Chamomile the same as German chamomile?
Can I drink chamomile tea if I'm pregnant?
Who should avoid Roman Chamomile?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Roman Chamomile
A rotating sample of real supplements in our database that list Roman Chamomile — open any to see its full ingredients and every drug interaction we check.
- Roman Chamomile (Chamaemelum nobile) Flower Powder by TerraVita Premium Collection
- Gaslys +BioPerine by Approved Science
- Roman Chamomile (Chamaemelum nobile) Flower Powder by TerraVita Premium Collection
- Chamomile (Roman) Chocolate Flavor by TerraVita
- Chamomile (Roman) by TerraVita
- Chamomile (Roman) Strawberry Flavor by TerraVita
- Chamomile (Roman) Mint Flavor by TerraVita
- Chamomile (Roman) Vanilla Flavor by TerraVita
Have a question about Roman Chamomile?
Our pharmacists answer your medication & supplement questions — free.