Herb & supplement monograph

Procaine Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Procaine interacts with medications. The heart of this page is the interaction list — every drug Procaine is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Procaine is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Procaine Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the risk of a clinically significant Procaine drug interaction is meaningful and should be taken seriously, since most of the listed interactions are rated major. The majority of interactions here carry a major severity rating, the rest are moderate, and none are considered minor.

Interactions deserving the most attention

The most serious concerns involve digoxin, succinylcholine, and skeletal muscle relaxants, where intravenous procaine is considered contraindicated, meaning the combination should be avoided in that setting. On the moderate side, a breakdown product of procaine can work against sulfonamide antibiotics such as sulfamethoxazole and sulfasalazine, and against aminosalicylic acid, which could make those medicines less effective. These effects are supported by human or animal data rather than firm controlled trials, but the potential stakes are high enough to warrant caution.

What the rest of the list means

A long interaction list does not mean every combination causes harm, and the strongest warnings here apply specifically to intravenous use of procaine. The moderate concerns rest partly on how the body breaks procaine down, and some of those predicted effects remain theoretical. Still, the overall pattern points toward caution rather than reassurance with this ingredient.

Check your medications against Procaine

Based on HelloPharmacist’s Procaine interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Procaine

56 medications have a known interaction with Procaine, graded by severity. Select any drug for the full evidence-based detail.

37 major interactions. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Procaine.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Procaine using our pharmacist-reviewed interaction data.

AI summaries are generated from our Procaine interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Procaine combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Procaine affects

Every type of medication (drug category) Procaine is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 5 drug categories Procaine interacts with

Digoxin (lanoxin)Skeletal Muscle RelaxantsSuccinylcholineAminosalicylic AcidSulfonamide Antibiotics

Digoxin (Lanoxin)

Intravenous use of procaine hydrochloride is contraindicated.