Herb & supplement monograph

Cannabinol (cbn) Drug Interactions, Uses, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Cannabinol (cbn) interacts with medications. The heart of this page is the interaction list — every drug Cannabinol (cbn) is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Cannabinol (cbn) is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Cannabinol (cbn) Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Cannabinol (cbn) drug interaction appears low for most people. None of the listed interactions are rated major, and every one rests on lab findings that have so far not been confirmed in humans.

Interactions deserving the most attention

No interaction with cannabinol has solid human evidence behind it, so nothing is firmly established. Even so, lab studies show cannabinol strongly blocks several liver enzymes the body uses to clear medications, so we watch most closely for medications processed by these enzymes, especially CYP2C9 substrates and CYP2B6 substrates, where higher drug levels could matter if a medicine needs to stay in a steady range. Other drugs, such as CYP3A4 inhibitors, could work in the opposite direction and raise cannabinol levels instead.

What the rest of the list means

A long list like this does not mean every combination is risky. Nearly all of these interactions are theoretical, predicted from how cannabinol behaves in laboratory tests with enzymes that handle many common medications. So far, none of these predicted effects has actually been reported in people taking cannabinol.

Check your medications against Cannabinol (cbn)

Based on HelloPharmacist’s Cannabinol (cbn) interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Cannabinol (cbn)

389 medications have a known interaction with Cannabinol (cbn), graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Cannabinol (cbn) using our pharmacist-reviewed interaction data.

AI summaries are generated from our Cannabinol (cbn) interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Cannabinol (cbn) combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Cannabinol (cbn) affects

Every type of medication (drug category) Cannabinol (cbn) is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 5 drug categories Cannabinol (cbn) interacts with

Cytochrome P450 2b6 (cyp2b6) SubstratesCytochrome P450 2c9 (cyp2c9) InhibitorsCytochrome P450 2c9 (cyp2c9) SubstratesCytochrome P450 2e1 (cyp2e1) SubstratesCytochrome P450 3a4 (cyp3a4) Inhibitors

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, cannabinol might increase the levels and clinical effects of CYP2B6 substrates.
In vitro research shows that cannabinol potently inhibits CYP2B6 enzymes. So far, this interaction has not been reported in humans.