Cannabinol (cbn) + Interferon Alfa-2b
Interferon Alfa-2b brand names: Rebetron, Intron A, Viraferon.
We found no known interaction between Cannabinol (cbn) and Interferon Alfa-2b in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Cannabinol (cbn) and Interferon Alfa-2b
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Interferon Alfa-2b and Cannabinol (cbn) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Cannabinol (cbn) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Interferon Alfa-2b
Interactions in our licensed database are recorded against drug classes, not just single drug names. Interferon Alfa-2b is filed under 2 classifications — photosensitizing drugs, hepatotoxic drugs. Cannabinol (cbn) has documented interactions with 5 drug classes — the most serious being cytochrome p450 2b6 (cyp2b6) substrates (moderate), cytochrome p450 2c9 (cyp2c9) inhibitors (moderate) and cytochrome p450 2c9 (cyp2c9) substrates (moderate) — and none of Interferon Alfa-2b’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Cannabinol (cbn) Does Interact With Other Medications
Cannabinol (cbn) has 389 moderate known drug interactions in our database — Interferon Alfa-2b isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Cannabinol (cbn)
We haven’t checked that one against Cannabinol (cbn) yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Cannabinol (cbn). Pick one to open its full report.
See Every Supplement That Interacts With Interferon Alfa-2b
This page covers Cannabinol (cbn) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Interferon Alfa-2b page lists 57 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Alfalfa (moderate) and Angelica Archangelica (moderate).
By severity: 3 major · 53 moderate · 1 minor.
From our pharmacist’s overview on the Interferon Alfa-2b page
“People taking interferon alfa-2b (Intron A, Rebetron) are usually treating hepatitis or a cancer, so the liver may already be under strain, and that is exactly where most of this list points. Of the 57 supplements on file, 38 can add to liver stress, and all three major-rated interactions sit in that group: Siberian cocklebur, which ha…”
Reviewed by 2 · Jul 18, 2026
Where Cannabinol (cbn) and Interferon Alfa-2b Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#538 of 1,452 supplements looked up here in the last 7 days
#1,898 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cannabinol (cbn) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cannabinol (cbn) and Interferon Alfa-2b records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Cannabinol (cbn)
What is Cannabinol (cbn)?
- Sleep support
- Relaxation
- Pain or discomfort
- Appetite-related concerns
Cannabinol (CBN) is a minor cannabinoid found in the cannabis plant, often marketed as a 'sleep' aid, but solid human research is very limited. Because it comes from cannabis and product quality varies widely, talk with your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.
Cannabaceae · Aged cannabis flower and resin (where THC degrades into CBN) · Oils and tinctures, gummies, capsules, vape products, topicals
An interaction check asks whether these two react with each other — it does not ask whether Cannabinol (cbn) is a good idea for someone in your situation. Here is what our Cannabinol (cbn) record says about it on its own.
Cannabinol (cbn): dosing
There is no established, standardized dose for CBN. Research is too limited to recommend a specific milligram amount, and products vary widely in strength and quality.If you choose to try a CBN product, follow the directions on the label and start with the lowest amount.
From our Cannabinol (cbn) monograph — the full record covers uses, side effects and every documented interaction.
About Interferon Alfa-2b Injection
What Is Interferon Alfa-2b Injection Used For?
Brand names: Rebetron, Intron A, Viraferon
-
Interferon alfa-2b injection is used to treat a number of conditions.
-
Interferon alfa-2b injection is used
-
alone or in combination with ribavirin (Copegus, Rebetol, Ribasphere) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in people who show signs of liver damage,
-
to treat chronic hepatitis B infection (swelling of the liver caused by a virus) in people who show signs of liver damage,
-
to treat hairy cell leukemia (a white blood cell cancer),
-
to treat genital warts,
-
to treat Kaposi's sarcoma (a type of cancer that causes abnormal tissue to grow on different parts of the body) related to acquired immunodeficiency syndrome (AIDS),
-
to treat malignant melanoma (a cancer that begins in certain skin cells) in certain people who have had surgery to remove the cancer,
-
along with another medication to treat follicular non-Hodgkin's lymphoma (NHL; a slow-growing blood cancer).
-
-
Interferon alfa-2b is in a class of medications called immunomodulators. Interferon alfa-2b works to treat hepatitis C virus (HCV) and hepatitis B virus (HBV) by decreasing the amount virus in the body. Interferon alfa-2b may not cure hepatitis B or hepatitis C or prevent you from developing complications from these infections such as cirrhosis (scarring) of the liver, liver failure, or liver cancer. It also may not prevent the spread of hepatitis B or C to other people. It is not known exactly how interferon alfa-2b works to treat cancer or genital warts.
Other Drugs & Cannabinol (cbn)
Browse every other medication we’ve checked against Cannabinol (cbn) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
389 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Norethindrone ›
- Verapamil ›
- Fenofibrate ›
- Prednisone ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Bupropion ›
- Ciprofloxacin ›
- Flurbiprofen ›
- Orphenadrine ›
- Phenytoin ›
- Diclofenac Potassium ›
- Formoterol ›
- Indomethacin ›
- Miconazole ›
- Trimipramine ›
- Acetaminophen ›
- Diazepam ›
- Everolimus ›
- Meloxicam ›
- Chloramphenicol ›
- Cimetidine ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Isoniazid ›
- Itraconazole ›
- Modafinil ›
- Nicardipine ›
- Omeprazole ›
- Paroxetine ›
- Phenobarbital ›
- Warfarin Sodium ›
- Amiodarone ›
- Aprepitant ›
- Carvedilol ›
- Celecoxib ›
- Clarithromycin ›
- Clomipramine ›
- Danazol ›
- Diclofenac Epolamine ›
- Dronabinol ›
- Fluconazole ›
- Fluoxetine ›
- Fluvastatin ›
- Fosamprenavir ›
- Fosaprepitant ›
- Glipizide ›
- Imipramine ›
- Irbesartan ›
- Lacosamide ›
- Lovastatin ›
Showing 60 of 389 moderate interactions — see all 389 on the Cannabinol (cbn) page.
No interaction 2,440 drugs checked — show the list
We also checked Cannabinol (cbn) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Semaglutide ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Amphetamine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
- Bisoprolol ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Dapsone ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Cephalexin ›
- Cyclopentolate ›
- Atorvastatin Calcium ›
- Mannitol ›
- Ezetimibe ›
- Acetylsalicylic Acid ›
- Levetiracetam ›
- Carbidopa, Levodopa ›
- Phentermine, Topiramate ›
Showing the 60 most looked-up of 2,440 medications checked with no known interaction — see the full Cannabinol (cbn) list.
Cannabinol (cbn) References
The 3 references that drive our Cannabinol (cbn) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Watanabe K, Yamaori S, Funahashi T, Kimura T, Yamamoto I. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sci. 2007;80(15):1415-9. PubMed
- Nasrin S, Watson CJW, Perez-Paramo YX, Lazarus P. Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions. Drug Metab Dispos 2021;49(12):1070-1080. PubMed
- Bonn-Miller MO, Feldner MT, Bynion TM, Eglit GML, Brunstetter M, Kalaba M, Zvorsky I, Peters EN, Hennesy M. A double-blind, randomized, placebo-controlled study of the safety and effects of CBN with and without CBD on sleep quality. Exp Clin Psychopharmac PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Cannabinol (cbn) and Interferon Alfa-2b Together: Common Questions
Is it safe to take Cannabinol (cbn) with Interferon Alfa-2b?
How was the Cannabinol (cbn) and Interferon Alfa-2b combination checked?
Does Cannabinol (cbn) interact with any other medications?
Does Interferon Alfa-2b interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Interferon Alfa-2b and Cannabinol (cbn)?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.