Herb & supplement monograph

Rauvolfia Vomitoria Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Rauvolfia Vomitoria interacts with medications. The heart of this page is the interaction list — every drug Rauvolfia Vomitoria is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Rauvolfia Vomitoria is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

Check Rauvolfia Vomitoria against your medication

Add one medication

✓ Supplement

Rauvolfia Vomitoria

1 Your medication

Start typing any prescription or over-the-counter drug name.

Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Interaction report

Drugs that interact with Rauvolfia Vomitoria

840 medications have a known interaction with Rauvolfia Vomitoria, graded by severity. Select any drug for the full evidence-based detail.

230 major interactions. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Rauvolfia Vomitoria.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Rauvolfia Vomitoria using our pharmacist-reviewed interaction data.

AI summaries are generated from our Rauvolfia Vomitoria interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Rauvolfia Vomitoria combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Rauvolfia Vomitoria affects

Every type of medication (drug category) Rauvolfia Vomitoria is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 11 drug categories Rauvolfia Vomitoria interacts with

Antipsychotic DrugsLevodopaMonoamine Oxidase Inhibitors (maois)Stimulant DrugsAntidiabetes DrugsAntihypertensive DrugsCns DepressantsCytochrome P450 2d6 (cyp2d6) SubstratesEphedrineTricyclic Antidepressants (tcas)Anticoagulant/antiplatelet Drugs

Antipsychotic Drugs

Theoretically, concomitant use might increase the risk of adverse effects.
Concomitant use of neuroleptics with Rauvolfia vomitoria may potentiate the effects of these drugs and the rauwolfia alkaloids.

Likelihood Probable Evidence D

Levodopa

Theoretically, Rauvolfia vomitoria might reduce the effects of levodopa.
Avoid using Rauvolfia vomitoria with levodopa; concomitant use may reduce drug effectiveness and increase extrapyramidal motor symptoms.

Likelihood Probable Evidence D

Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might cause additive effects.
Yohimbine, a constituent of Rauvolfia vomitoria, has MAO inhibitory effects. At high doses, yohimbine is a non-selective inhibitor of MAO.

Likelihood Probable Evidence D

Stimulant Drugs

Theoretically, concomitant use might cause additive effects.
Yohimbine, a constituent of Rauvolfia vomitoria, has sympathomimetic effects and increases blood pressure in a dose-dependent manner. Theoretically, taking Rauvolfia vomitoria with stimulant drugs can have additive stimulant and hypertensive effects.

Likelihood Probable Evidence D

Antidiabetes Drugs

Theoretically, taking Rauvolfia vomitoria with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that drinking a beverage containing Rauvolfia vomitoria foliage and bitter orange fruit lowers blood glucose levels. Hypoglycemic effects of Rauvolfia vomitoria have also been demonstrated in an animal diabetic model.

Likelihood Possible Evidence D

Antihypertensive Drugs

Theoretically, Rauvolfia vomitoria might increase the risk of hypotension.
Rauvolfia vomitoria contains a very small amount of the drug reserpine. Reserpine can reduce both systolic and diastolic blood pressure.

Likelihood Possible Evidence D

Cns Depressants

Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.
Rauvolfia vomitoria has sedative effects in animal research.

Likelihood Possible Evidence D

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Rauvolfia vomitoria might increase the levels and clinical effects of CYP2D6 substrates.
Rauvolfia vomitoria contains small amounts of the drug yohimbine. In vitro research shows that yohimbine inhibits CYP2D6 enzyme activity.

Likelihood Possible Evidence D

Ephedrine

Theoretically, Rauvolfia vomitoria might alter the effects and side effects of ephedrine.
Rauvolfia vomitoria contains resperine, which might reduce indirect-sympathomimetic drug activity. However, another constituent of Rauvolfia vomitoria, yohimbine, has stimulant activity and may increase the risk of adverse effects with ephedrine.

Likelihood Probable Evidence D

Tricyclic Antidepressants (Tcas)

Theoretically, concomitant use might alter the effects of Rauvolfia vomitoria and increase the risk for adverse effects.
A small clinical study in patients taking TCAs for at least 4 weeks shows that receiving doses of intravenous yohimbine, a constituent of Rauvolfia vomitoria, 2.5-20 mg daily for up to 7 days precipitates severe anxiety, agitation, and tremor. Also, concomitant use of TCAs with Rauvolfia vomitoria may decrease the effects of rauwolfia alkaloids.

Likelihood Probable Evidence D

Anticoagulant/Antiplatelet Drugs

Theoretically, combining Rauvolfia vomitoria with antiplatelet or anticoagulant drugs might have additive effects.
Rauvolfia vomitoria contains small amounts of yohimbine. Research in healthy adults shows that taking yohimbine in doses of 8 mg or more seems to inhibit platelet aggregation in vitro by binding to the alpha-2 adrenoceptor. The effects of Rauvolfia vomitoria itself are unclear.

Likelihood Possible Evidence D

Monograph

Rauvolfia Vomitoria: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Rauvolfia vomitoria is an African shrub whose root contains powerful alkaloids, including reserpine, that have historically been used for high blood pressure and agitation. Because these compounds can strongly affect blood pressure, mood, and the nervous system, the plant can cause serious side effects and is not a casual supplement. Always talk to a doctor or pharmacist before using it.

Scientific name: Rauvolfia vomitoria
Family: Apocynaceae
Part used: Root and root bark (sometimes leaves and stem bark)
Common forms: Dried root powder, capsules, tinctures, decoctions (traditional preparations)

People commonly use it for

High blood pressure
Anxiety and agitation
Sleep problems
Mental health symptoms (traditional use)
Fever and general ailments

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

It contains potent alkaloids that can cause low blood pressure, depression, and other significant effects.

PregnancyPossibly Unsafe

When used orally. Animal research suggests that Rauvolfia vomitoria has teratogenic effects.

Read the full pregnancy detail

BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Rauvolfia vomitoria is a shrub or small tree that grows in tropical Africa. It is closely related to Rauvolfia serpentina, the Indian snakeroot plant that is famous as a source of the blood-pressure drug reserpine.

The root and root bark are the parts most often used. In traditional African medicine, preparations of the root have been used for many purposes, including calming agitation, lowering blood pressure, and treating fevers. Today the plant is also a commercial source of medicinal alkaloids.

Because Rauvolfia contains strong, drug-like compounds, it is very different from a mild kitchen herb. People should treat it with the same caution they would give a prescription medicine.

How it works

The root contains a group of compounds called indole alkaloids. The best known is reserpine, along with others such as ajmaline, ajmalicine, and yohimbine-related compounds.

Reserpine works by reducing the amount of certain chemical messengers (neurotransmitters like norepinephrine, dopamine, and serotonin) stored in nerve cells. This can lower blood pressure and have a calming or sedating effect. Some of the other alkaloids can affect the heart's rhythm and blood vessels.

Much of what we know comes from research on purified reserpine and from laboratory or animal studies of the plant. The exact effects of any given Rauvolfia supplement depend on how much active alkaloid it contains, which can vary a lot.

Effectiveness

Does Rauvolfia Vomitoria work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 3 uses evaluated

3 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Rauvolfia Vomitoria, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 3 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Athletic performance

Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral Rauvolfia vomitoria to improve athletic performance, there is insufficient reliable information about the clinical effects of Rauvolfia vomitoria for this purpose.

Insufficient Reliable Evidence To Rate Diabetes

Rating & evidence shown verbatim from Natural Medicines

Oral Rauvolfia vomitoria has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Psychosis

Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral Rauvolfia vomitoria is beneficial for improving symptoms of psychosis caused by various psychiatric disorders.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Rauvolfia vomitoria is not a gentle herb. Its alkaloids can lower blood pressure too much, slow the heart, and affect mood. Reserpine, in particular, has been linked to depression, sometimes severe.

People with low blood pressure, depression or other mood disorders, Parkinson's disease, stomach ulcers, heart rhythm problems, or kidney disease should avoid it unless a doctor advises otherwise. Older adults may be especially sensitive to its effects.

Pregnancy and breastfeeding: Avoid Rauvolfia vomitoria. Its potent alkaloids and the lack of safety data make it unsafe for the developing baby and possibly for a nursing infant. Do not use it if you are pregnant, trying to become pregnant, or breastfeeding.

Because the strength of products varies and quality control may be poor, always check with a pharmacist or doctor before using any Rauvolfia product.

Side effects

Possible side effects relate to the plant's strong alkaloids and may include:

Low blood pressure, dizziness, or fainting
Slow heart rate
Drowsiness or sedation
Stuffy nose
Stomach upset, nausea, or increased stomach acid
Depression or worsening mood, which can be serious

Larger amounts can cause more serious problems with heart rhythm and blood pressure. Seek medical help if you feel faint, have a very slow or irregular heartbeat, or notice new or worsening depression while using it.

Rauvolfia Vomitoria: Reported Adverse Effects

Documented safety reports on Rauvolfia Vomitoria from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, Rauvolfia vomitoria is possibly unsafe due to the potential for serious adverse effects from its reserpine and yohimbine constituents.

Serious Adverse Effects (Rare):

Orally: Akathisia, dystonia, hypokinesia, and tremor.

Reports by condition

Angina Cardiovascular

Orally, drinking a beverage made by boiling Rauvolfia vomitoria foliage with bitter orange fruit can reduce levels of high-density lipoprotein (HDL) cholesterol in patients with diabetes. The effect of Rauvolfia vomitoria alone is unclear.

Since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might also cause some of the adverse effects associated with these constituents. Adverse reactions to reserpine have included angina-like symptoms. At high doses, adverse effects related to yohimbine have included hypertension, tachycardia or palpitations, and myocardial infarction or atrial fibrillation.

Anxiety Psychiatric

In one clinical study, Rauvolfia vomitoria dried root 300-800 mg orally daily for 6 weeks was not associated with reports of depression or thoughts of suicide in patients with psychosis. However, since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might cause some of the adverse effects associated with these constituents. Orally, low amounts of reserpine may cause nightmares, drowsiness, fatigue, lethargy, and slowed reflexes. In larger amounts, depression may develop. After discontinuation of reserpine, mental depression may persist for several months. Doses of reserpine of greater than 0.5 mg daily appear to increase the risk of these side effects. Orally, yohimbine may increase malaise, fatigue, insomnia, restlessness, agitation, and anxiety.

Asthma Pulmonary/Respiratory

Since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might cause some of the adverse effects associated with these constituents. Orally, reserpine may cause nasal congestion or bronchospasm. Allergic reactions may also occur; while these events are rare, they may precipitate asthma. Orally, yohimbine may cause bronchospasm, tachypnea, cough, sinusitis, and rhinorrhea. Excessive doses of yohimbine can cause respiratory depression.

Breast cancer Oncologic

Since Rauvolfia vomitoria contains small amounts of reserpine, theoretically it might increase the risk of adverse effects associated with this constituent. Some preliminary research suggested a possible relationship between reserpine products and an increased risk of breast cancer; however, further analysis found that use of reserpine products is not associated with an increased risk of breast cancer.

Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.

Cluster headache Neurologic/CNS

Orally, Rauvolfia vomitoria has been associated with the development of extrapyramidal symptoms in some patients. In one clinical study, 4 out of 10 patients who were taking Rauvolfia vomitoria dried root 300-800 mg daily developed extrapyramidal symptoms, including tremor, akathisia, hypokinesia, and dystonia. Two cases were severe enough to warrant treatment with antiparkinsonian medications.

Since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might also increase the risk of adverse effects associated with these constituents. Doses of reserpine of greater than 0.5 mg daily appear to increase the risk of side effects. In extremely large amounts, Parkinson-like symptoms, extrapyramidal reactions, and convulsions may occur. Orally, yohimbine has been associated with reports of tremulousness, head twitching, seizures, loss of consciousness, enhanced brain norepinephrine release, decreased energy, dizziness, vertigo, headache, feeling cold, flushing, diaphoresis, and paralysis.

Obembe A, Sokomba EN, Sijuwola OA, et al. Antipsychotic effects and tolerance of crude Rauvolfia vomitoria in Nigerian psychiatric inpatients. Phytotherapy Research. 1994;8(4):218-23.
McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.
Vakil RJ. A clinical trial of Rauwolfia serpentina in essential hypertension. Br Heart J. 1949 Oct;11(4):350-5.
Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4.
Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9.
Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407.
Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829.
Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225.
Susset, J. G., Tessier, C. D., Wincze, J., Bansal, S., Malhotra, C., and Schwacha, M. G. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol. 1989;141(6):1360-1363.
Riley AJ, Goodman R, Kellett JM, and et al. Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual Marital Ther 1989;4(1):17-26.

Diarrhea Gastrointestinal

Since Rauvolfia vomitoria contains small amounts of yohimbine, theoretically it might cause some of the adverse effects associated with this constituent. Yohimbine has been reported to cause nausea, vomiting, increased salivation, diarrhea, and gastrointestinal distress.

Kidney failure Renal

Since Rauvolfia vomitoria contains small amounts of yohimbine, theoretically it might cause some of the adverse effects associated with this constituent. A case of acute kidney failure related to yohimbine-induced systemic lupus erythematosus has been reported.

Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5.

Kidney failure Immunologic

Since Rauvolfia vomitoria contains small amounts of yohimbine, theoretically it might cause some of the adverse effects associated with this constituent. There is one report of a hypersensitivity reaction including fever; chills; malaise; itchy, scaly skin; progressive renal failure; and lupus-like syndrome associated with ingestion of a one-day dose of yohimbine.

Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5.

Pregnancy-related edema Musculoskeletal

Pruritus Dermatologic

Since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might also cause some of the adverse effects associated with these constituents. Orally, low amounts of reserpine may cause adverse reactions including facial flushing, skin rash, and itching. Yohimbine may cause rash, erythrodermic skin eruption, and exanthema.

Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.
Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4.
Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
Mann, K., Klingler, T., Noe, S., Roschke, J., Muller, S., and Benkert, O. Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction. Arch.Sex Behav. 1996;25(1):1-16.
Riley AJ, Goodman R, Kellett JM, and et al. Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual Marital Ther 1989;4(1):17-26.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established safe supplement dose for Rauvolfia vomitoria. Traditional preparations vary widely, and the amount of active alkaloid in a given product is often unknown.

Because the active compounds are powerful and the line between a calming dose and a harmful one can be narrow, you should not guess at a dose on your own. If you are considering this herb, follow the product label and, more importantly, talk with a pharmacist or doctor first. They can help you decide whether it is appropriate and watch for problems.

Pregnancy & Breastfeeding

Rauvolfia Vomitoria & Pregnancy

Possibly Unsafe

When used orally. Animal research suggests that Rauvolfia vomitoria has teratogenic effects.

Eluwa MA, Udoaffah MT, Vulley MB, et al. Comparative study of teratogenic potentials of crude ethanolic root bark and leaf extract of Rauwolfia vomitoria (apocynaceae) on the fetal heart. N Am J Med Sci 2010;2:592-5.
Eluwa MA, Ekanem TB, Udoh PB, et al. Teratogenic effect of crude ethanolic root bark and leaf extracts of Rauwolfia vomitoria (Apocynaceae) on nissl substances of albino wistar rat fetuses. Neurosci J 2013;2013:906731.
Eluwa MA, Ekanem TB, Udoh PB, et al. Teratogenic effect of crude ethanolic root bark and leaf extracts of Rauwolfia vomitoria (Apocynaceae) on the femur of albino wistar rat fetuses. J. Histol 2013;1-5.

Rauvolfia Vomitoria & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 46 references that drive our Rauvolfia Vomitoria monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed
Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
Chapotin SM, Razanameharizaka JH, Holbrook NM. A biomechanical perspective on the role of large stem volume and high water content in baobab trees (Adansonia spp.; Bombacaceae). Am J Bot 2006;93:1251-64.
VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
Campbell-Tofte, J. I., Molgaard, P., Josefsen, K., Abdallah, Z., Hansen, S. H., Cornett, C., Mu, H., Richter, E. A., Petersen, H. W., Norregaard, J. C., and Winther, K. Randomized and double-blinded pilot clinical study of the safety and anti-diabetic ef
Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.
Bagheri, H., Schmitt, L., Berlan, M., and Montastruc, J. L. Effect of 3 weeks treatment with yohimbine on salivary secretion in healthy volunteers and in depressed patients treated with tricyclic antidepressants. Br J Clin Pharmacol 1992;34(6):555-558. PubMed
Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed
Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225.
Berlin, I., Crespo-Laumonnier, B., Cournot, A., Landault, C., Aubin, F., Legrand, J. C., and Puech, A. J. The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. Clin Pharmacol.Ther. 199
Cimolai, N. and Cimolai, T. Yohimbine use for physical enhancement and its potential toxicity. J Diet.Suppl 2011;8(4):346-354. PubMed
Landis, E. and Shore, E. Yohimbine-induced bronchospasm. Chest 1989;96(6):1424. PubMed
Susset, J. G., Tessier, C. D., Wincze, J., Bansal, S., Malhotra, C., and Schwacha, M. G. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol. 1989;141(6):1360-1363. PubMed
Charney, D. S., Price, L. H., and Heninger, G. R. Desipramine-yohimbine combination treatment of refractory depression. Implications for the beta-adrenergic receptor hypothesis of antidepressant action. Arch.Gen.Psychiatry 1986;43(12):1155-1161. PubMed
Braddock, L., Cowen, P. J., Elliott, J. M., Fraser, S., and Stump, K. Binding of yohimbine and imipramine to platelets in depressive illness. Psychol.Med 1986;16(4):765-773. PubMed
Charney, D. S., Heninger, G. R., and Sternberg, D. E. Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine. Life Sci 6-7-1982;30(23):2033-2041.
Boon, N. A., Elliott, J. M., Grahame-Smith, D. G., John-Green, T., and Stump, K. A comparison of alpha 2-adrenoreceptor binding characteristics of intact human platelets identified by [3H]-yohimbine and [3H]- dihydroergocryptine. J Auton.Pharmacol 1983;3
Morgan, C. A., III, Southwick, S. M., Grillon, C., Davis, M., Krystal, J. H., and Charney, D. S. Yohimbine-facilitated acoustic startle reflex in humans. Psychopharmacology (Berl) 1993;110(3):342-346. PubMed
Mann, K., Klingler, T., Noe, S., Roschke, J., Muller, S., and Benkert, O. Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction. Arch.Sex Behav. 1996;25(1):1-16. PubMed
Rowland, D. L., Kallan, K., and Slob, A. K. Yohimbine, erectile capacity, and sexual response in men. Arch Sex Behav 1997;26(1):49-62.
Riley AJ, Goodman R, Kellett JM, and et al. Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual Marital Ther 1989;4(1):17-26. DOI
Ruck B, Shih RD, Marcus SM. Hypertensive crisis from herbal treatment of impotence. Am J Emerg Med. 1999;17:317-318. PubMed
Eluwa MA, Udoaffah MT, Vulley MB, et al. Comparative study of teratogenic potentials of crude ethanolic root bark and leaf extract of Rauwolfia vomitoria (apocynaceae) on the fetal heart. N Am J Med Sci 2010;2:592-5. PubMed
Eluwa MA, Ekanem TB, Udoh PB, et al. Teratogenic effect of crude ethanolic root bark and leaf extracts of Rauwolfia vomitoria (Apocynaceae) on nissl substances of albino wistar rat fetuses. Neurosci J 2013;2013:906731.
Eluwa MA, Ekanem TB, Udoh PB, et al. Teratogenic effect of crude ethanolic root bark and leaf extracts of Rauwolfia vomitoria (Apocynaceae) on the femur of albino wistar rat fetuses. J. Histol 2013;1-5.
Ekong MB, Peter AI, Edagha IA, et al. Rauwolfia vomitoria inhibits olfaction and modifies olfactory bulb cells. Brain Res Bull 2016;124:206-13. PubMed
Amole OO, Yemitan OK, Oshikoya KA. Anticonvulsant activity of Rauvol?a Vomitoria (Afzel). Afr J Pharmacy Pharmacol 2009;3:319-322.
Campbell JI, Mortensen A, Mølgaard P. Tissue lipid lowering-effect of a traditional Nigerian anti-diabetic infusion of Rauwolfia vomitoria foilage and Citrus aurantium fruit. J Ethnopharmacol 2006;104:379-86. PubMed
Wylie KR. Yohimbine and sinusitis. Br J Psychiatry. 1996;169(3):384-5. PubMed
Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.
Sheldon MB, Kotte JH. Effect of Rauwolfia serpentina and reserpine on the blood pressure in essential hypertension; a long-term double-blind study. Circulation. 1957 Aug;16(2):200-6.
Vakil RJ. A clinical trial of Rauwolfia serpentina in essential hypertension. Br Heart J. 1949 Oct;11(4):350-5. PubMed
Obembe A, Sokomba EN, Sijuwola OA, et al. Antipsychotic effects and tolerance of crude Rauvolfia vomitoria in Nigerian psychiatric inpatients. Phytotherapy Research. 1994;8(4):218-23.
Bharucha AE, Skaar T, Andrews CN, et al Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects. Neurogastroenterol Motil. 2008;20(8):891-9. PubMed
Schmauss M, Laakmann G, Dieterle D. Effects of alpha 2-receptor blockade in addition to tricyclic antidepressants in therapy-resistant depression. J Clin Psychopharmacol. 1988;8(2):108-11.
Wang N, Xie YW, Li MY, et al. Simultaneous determination of five alkaloids from Rauvolfia vomitoria in rat plasma by LC-MS/MS: Application to a comparative pharmacokinetic study in normal and type 2 diabetic rats. J Sep Sci 2021;44(7):1391-1403.

Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

Brand directory

Brands that make products with Rauvolfia Vomitoria

10 brands in our database make a supplement containing Rauvolfia Vomitoria.

American Metabolix 7 products Colossal Labs 11 products Dark Metal 1 product Goliath Labs 33 products Insane Labz 96 products Kali Muscle 1 product Mythical Nutrition 5 products Nutrex Research 160 products Performax Labs 2 products T6 Team Six 2 products

Product directory

Supplement products with Rauvolfia Vomitoria

17 products in our database contain Rauvolfia Vomitoria. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Rauvolfia Vomitoria: Common Questions

What is Rauvolfia Vomitoria used for, and does it work?

People use Rauvolfia Vomitoria for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.

Does Rauvolfia Vomitoria interact with prescription medications?

Yes. We list 840 medications with a known interaction with Rauvolfia Vomitoria, including 230 rated major. Use the checker above to see how Rauvolfia Vomitoria interacts with a specific drug.

How are Rauvolfia Vomitoria interactions rated?

Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.

Is it safe to take Rauvolfia Vomitoria with my medications?

It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.

Where does this Rauvolfia Vomitoria interaction information come from?

Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.

What is Rauvolfia Vomitoria used for?

It has traditionally been used for high blood pressure, anxiety, agitation, and sleep problems, mainly in African folk medicine. Strong scientific proof for these uses as a supplement is limited.

Is Rauvolfia Vomitoria safe to take?

It is not a mild herb. It contains potent alkaloids like reserpine that can dangerously lower blood pressure and cause depression, so it should only be used under medical supervision.

Can I take it during pregnancy or while breastfeeding?

No. You should avoid it during pregnancy and breastfeeding because its powerful alkaloids could harm the baby and safety has not been established.

How is Rauvolfia Vomitoria related to reserpine?

The plant's root naturally contains reserpine, a compound once widely used as a prescription drug for high blood pressure and certain mental health conditions. This is why the herb can have such strong effects.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Rauvolfia Vomitoria

A rotating sample of real supplements in our database that list Rauvolfia Vomitoria — open any to see its full ingredients and every drug interaction we check.

See all 17 products with Rauvolfia Vomitoria →

Where next

Supplement interaction checkerCheck any supplement or product against your medications Drug–drug interactionsCheck two or more of your medications against each other Browse medications A–ZEvery drug we’ve checked against herbs & supplements NDC & pricing lookupFind a drug’s NDCs, packaging and costs Ask a pharmacistFree, personal answer from our licensed team

Have a question about Rauvolfia Vomitoria?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Rauvolfia Vomitoria Drug Interactions, Uses, Effectiveness, Safety & More

Your Choice:

Drugs that interact with Rauvolfia Vomitoria

Don’t want to scroll the list? Just ask.

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Likelihood — How Well It’s Documented

Where This Data Comes From

The kinds of drugs Rauvolfia Vomitoria affects

Rauvolfia Vomitoria: Uses, Safety & Side Effects

Overview

How it works

Does Rauvolfia Vomitoria work?

Safety & precautions

Side effects

Rauvolfia Vomitoria: Reported Adverse Effects

Dosing

Rauvolfia Vomitoria & Pregnancy

Rauvolfia Vomitoria & Breastfeeding

References & further reading

Brands that make products with Rauvolfia Vomitoria

Supplement products with Rauvolfia Vomitoria

Rauvolfia Vomitoria: Common Questions

Related supplements & herbs

Products that contain Rauvolfia Vomitoria

Have a question about Rauvolfia Vomitoria?