Drug & supplement interaction

Rauvolfia Vomitoria + Phendimetrazine

Phendimetrazine brand names: Plegine, Metra, Weightrol.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Rauvolfia Vomitoria and Phendimetrazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Rauvolfia Vomitoria and Phendimetrazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Phendimetrazine and Rauvolfia Vomitoria in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rauvolfia Vomitoria safety at a glance

Rauvolfia Vomitori... overall Use caution It contains potent alkaloids that can cause low blood pressure, depression, and other significant effects.

Pregnancy Possibly Unsafe When used orally. Animal research suggests that Rauvolfia vomitoria has teratogenic effects. Read the full pregnancy detail

Breastfeeding Avoid Avoid while breastfeeding because alkaloids may pass into milk and safety is unknown.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Phendimetrazine and Rauvolfia Vomitoria? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Phendimetrazine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Phendimetrazine is filed under a single classification — oral drugs. Rauvolfia Vomitoria has documented interactions with 11 drug classes — the most serious being antipsychotic drugs (major), levodopa (major) and monoamine oxidase inhibitors (maois) (major) — and none of Phendimetrazine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rauvolfia Vomitoria Does Interact With Other Medications

Rauvolfia Vomitoria has 230 major, 523 moderate, 87 minor known drug interactions in our database — Phendimetrazine isn’t one of them. If you take anything else, check it against the full list below.

Major 230 Moderate 523 Minor 87 No known interaction 1,990 (incl. Phendimetrazine)

Taking anything else?

Check Another of Your Medications Against Rauvolfia Vomitoria

Covers the 2,830 medications we’ve checked against Rauvolfia Vomitoria. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Rauvolfia Vomitoria and Phendimetrazine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

Raised blood pressure Worth acting on Additional detail
Rauvolfia Vomitoria
“Orally, drinking a beverage made by boiling Rauvolfia vomitoria foliage with bitter orange fruit can reduce levels of high-density lipoprotein (HDL) cholesterol in patients with diabetes. The effect of Rauvolfia vomitoria alone is unclear.

Since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might also cause some of the adverse effects associated with these constituents.”

Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in angina.
6 sources cited

35751. Campbell-Tofte, J. I., Molgaard, P., Josefsen, K., Abdallah, Z., Hansen, S. H., Cornett, C., Mu, H., Richter, E. A., Petersen, H. W., Norregaard, J. C., and Winther, K. Randomized and double-blinded pilot clinical study of the safety and anti-diabetic ef

94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.

17645. Chapotin SM, Razanameharizaka JH, Holbrook NM. A biomechanical perspective on the role of large stem volume and high water content in baobab trees (Adansonia spp.; Bombacaceae). Am J Bot 2006;93:1251-64.

86801. Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed

91521. Ruck B, Shih RD, Marcus SM. Hypertensive crisis from herbal treatment of impotence. Am J Emerg Med. 1999;17:317-318. PubMed

3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
Phendimetrazine

Listed in the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed ›
Tremor or shakiness Additional detail
Rauvolfia Vomitoria

“Orally, Rauvolfia vomitoria is possibly unsafe due to the potential for serious adverse effects from its reserpine and yohimbine constituents.

Serious Adverse Effects (Rare):

Orally: Akathisia, dystonia, hypokinesia, and tremor.”

Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in dystonia.
“Orally, Rauvolfia vomitoria has been associated with the development of extrapyramidal symptoms in some patients. In one clinical study, 4 out of 10 patients who were taking Rauvolfia vomitoria dried root 300-800 mg daily developed extrapyramidal symptoms, including tremor, akathisia, hypokinesia, and dystonia.”

Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in cluster headache.
6 sources cited

95991. Obembe A, Sokomba EN, Sijuwola OA, et al. Antipsychotic effects and tolerance of crude Rauvolfia vomitoria in Nigerian psychiatric inpatients. Phytotherapy Research. 1994;8(4):218-23.

15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.

94332. Vakil RJ. A clinical trial of Rauwolfia serpentina in essential hypertension. Br Heart J. 1949 Oct;11(4):350-5. PubMed

11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Phendimetrazine

Listed in the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed ›
Flushing Additional detail
Rauvolfia Vomitoria
“Since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might also cause some of the adverse effects associated with these constituents. Orally, low amounts of reserpine may cause adverse reactions including facial flushing, skin rash, and itching. Yohimbine may cause rash, erythrodermic skin eruption, and exanthema.”

Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in pruritus.
5 sources cited

94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.

3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed

3971. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.

86878. Mann, K., Klingler, T., Noe, S., Roschke, J., Muller, S., and Benkert, O. Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction. Arch.Sex Behav. 1996;25(1):1-16. PubMed

86896. Riley AJ, Goodman R, Kellett JM, and et al. Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual Marital Ther 1989;4(1):17-26. DOI
Phendimetrazine

Listed in the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed ›
Sweating / Dizziness / Headache Additional detail

Rauvolfia Vomitoria

Recorded for Rauvolfia Vomitoria in the same Natural Medicines adverse-effect record shown under Tremor or shakiness above.

Phendimetrazine

Listed in the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed ›
A fast or pounding heartbeat Additional detail

Rauvolfia Vomitoria

Recorded for Rauvolfia Vomitoria in the same Natural Medicines adverse-effect record shown under Raised blood pressure above.

Phendimetrazine

Listed in the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed ›
Anxiety or restlessness Additional detail
Rauvolfia Vomitoria
“In one clinical study, Rauvolfia vomitoria dried root 300-800 mg orally daily for 6 weeks was not associated with reports of depression or thoughts of suicide in patients with psychosis. However, since Rauvolfia vomitoria contains small amounts of reserpine and yohimbine, theoretically it might cause some of the adverse effects associated with these constituents.”

Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in anxiety.
6 sources cited

95991. Obembe A, Sokomba EN, Sijuwola OA, et al. Antipsychotic effects and tolerance of crude Rauvolfia vomitoria in Nigerian psychiatric inpatients. Phytotherapy Research. 1994;8(4):218-23.

3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed

3970. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.

3971. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.

17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed

86786. Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
Phendimetrazine

Listed in the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed ›
Trouble sleeping Additional detail

Rauvolfia Vomitoria

Recorded for Rauvolfia Vomitoria in the same Natural Medicines adverse-effect record shown under Anxiety or restlessness above.

Phendimetrazine

Listed in the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed ›
Diarrhea Additional detail
Rauvolfia Vomitoria
“Since Rauvolfia vomitoria contains small amounts of yohimbine, theoretically it might cause some of the adverse effects associated with this constituent. Yohimbine has been reported to cause nausea, vomiting, increased salivation, diarrhea, and gastrointestinal distress.”

Rauvolfia Vomitoria · Natural Medicines adverse-effect record, reported in diarrhea.
6 sources cited

3970. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.

17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed

86780. Bagheri, H., Schmitt, L., Berlan, M., and Montastruc, J. L. Effect of 3 weeks treatment with yohimbine on salivary secretion in healthy volunteers and in depressed patients treated with tricyclic antidepressants. Br J Clin Pharmacol 1992;34(6):555-558. PubMed

86786. Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed

86804. Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225.

86827. Susset, J. G., Tessier, C. D., Wincze, J., Bansal, S., Malhotra, C., and Schwacha, M. G. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol. 1989;141(6):1360-1363. PubMed
Phendimetrazine

Listed in the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed ›

Showing the 10 most notable of 11 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Rauvolfia Vomitoria but not commonly for Phendimetrazine: stomach upset, fainting, a heart attack and an irregular heartbeat.

Effects for Phendimetrazine come from the ADVERSE REACTIONS section of its FDA label; effects for Rauvolfia Vomitoria come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Rauvolfia Vomitoria in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Animal research suggests that Rauvolfia vomitoria has teratogenic effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Phendimetrazine Is Prescribed For, and What Rauvolfia Vomitoria Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Phendimetrazine is a prescription medicine with approved uses on its FDA label. Rauvolfia Vomitoria is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Phendimetrazine is prescribed for: Phendimetrazine tartrate is used to help manage exogenous obesity (excess body weight from outside causes like diet and lifestyle) as a short-term addition to a calorie-restricted diet. It is intended for adults with a BMI of 30 or higher, or a BMI of 27 or higher when other risk factors — such as high blood pressure, diabetes, or high cholesterol — are also present. It is approved for use as monotherapy only, meaning it must not be combined with other weight-loss drugs or stimulants. Both the tablet form and the extended-release capsule form are approved for this purpose.

Read the rest of what Phendimetrazine is prescribed for

This medication is meant to be used for only a few weeks as part of a broader weight-management plan.

Rauvolfia Vomitoria has been studied for:

Diabetes studied, not established Rauvolfia Vomitoria has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Rauvolfia Vomitoria for diabetes

Oral Rauvolfia vomitoria has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Phendimetrazine on your own; if you are taking Rauvolfia Vomitoria for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Phendimetrazine

This page covers Rauvolfia Vomitoria only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phendimetrazine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Phendimetrazine page

“Of the 17 supplements on file for phendimetrazine, an appetite-suppressant stimulant prescribed short term for weight loss, activated charcoal is the one that demands real caution. Charcoal binds medications in the gut and can sharply cut how much of a drug your body absorbs, leaving you with less appetite control than your prescriptio…”

Reviewed by 2 · Jul 18, 2026

Open the Phendimetrazine interaction page

One more smart check

Taking Rauvolfia Vomitoria as Part of a Dietary Supplement Product? Check It for Interactions

We hold 17 real supplement products containing Rauvolfia Vomitoria, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rauvolfia Vomitoria. Even though Rauvolfia Vomitoria itself has no known interaction with Phendimetrazine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rauvolfia Vomitoria and Phendimetrazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rauvolfia Vomitoria

Steady interest

#793 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Phendimetrazine

Top half

#743 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rauvolfia Vomitoria reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Rauvolfia Vomitoria and Phendimetrazine records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Rauvolfia Vomitoria

What is Rauvolfia Vomitoria?

High blood pressure
Anxiety and agitation
Sleep problems
Mental health symptoms (traditional use)
Fever and general ailments

Rauvolfia vomitoria is an African shrub whose root contains powerful alkaloids, including reserpine, that have historically been used for high blood pressure and agitation. Because these compounds can strongly affect blood pressure, mood, and the nervous system, the plant can cause serious side effects and is not a casual supplement. Always talk to a doctor or pharmacist before using it.

Rauvolfia vomitoria · Apocynaceae · Root and root bark (sometimes leaves and stem bark) · Dried root powder, capsules, tinctures, decoctions (traditional preparations)

An interaction check asks whether these two react with each other — it does not ask whether Rauvolfia Vomitoria is a good idea for someone in your situation. Here is what our Rauvolfia Vomitoria record says about it on its own.

Rauvolfia Vomitoria: dosing

There is no well-established safe supplement dose for Rauvolfia vomitoria. Traditional preparations vary widely, and the amount of active alkaloid in a given product is often unknown.Because the active compounds are powerful and the line between a calming dose and a harmful one can be narrow, you should not guess at a dose on your own. They can help you decide whether it is appropriate and watch for problems.

From our Rauvolfia Vomitoria monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rauvolfia Vomitoria monograph & all interactions

Medication

About Phendimetrazine

What Is Phendimetrazine Used For?

Brand names: Plegine, Metra, Weightrol

Phendimetrazine tartrate is used to help manage exogenous obesity (excess body weight from outside causes like diet and lifestyle) as a short-term addition to a calorie-restricted diet. It is intended for adults with a BMI of 30 or higher, or a BMI of 27 or higher when other risk factors — such as high blood pressure, diabetes, or high cholesterol — are also present.

It is approved for use as monotherapy only, meaning it must not be combined with other weight-loss drugs or stimulants. Both the tablet form and the extended-release capsule form are approved for this purpose. This medication is meant to be used for only a few weeks as part of a broader weight-management plan.

See full Phendimetrazine drug information

Keep checking

Other Drugs & Rauvolfia Vomitoria

Browse every other medication we’ve checked against Rauvolfia Vomitoria — both the ones with a known interaction and the ones without. Select any drug for the full detail.

230Major

523Moderate

87Minor

1,989No known interaction

230 Major 523 Moderate 87 Minor 1,989 No interaction

Major

230 interactions

Showing 60 of 230 major interactions — see all 230 on the Rauvolfia Vomitoria page.

Moderate

523 interactions

Showing 60 of 523 moderate interactions — see all 523 on the Rauvolfia Vomitoria page.

Minor

87 interactions

Showing 60 of 87 minor interactions — see all 87 on the Rauvolfia Vomitoria page.

No interaction 1,989 drugs checked — show the list

We also checked Rauvolfia Vomitoria against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,989 medications checked with no known interaction — see the full Rauvolfia Vomitoria list.

See the full Rauvolfia Vomitoria interactions page

See every supplement checked against Phendimetrazine, ranked by severity

Evidence & sources

Rauvolfia Vomitoria References

The 46 references that drive our Rauvolfia Vomitoria monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed
Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
Chapotin SM, Razanameharizaka JH, Holbrook NM. A biomechanical perspective on the role of large stem volume and high water content in baobab trees (Adansonia spp.; Bombacaceae). Am J Bot 2006;93:1251-64.
VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
Campbell-Tofte, J. I., Molgaard, P., Josefsen, K., Abdallah, Z., Hansen, S. H., Cornett, C., Mu, H., Richter, E. A., Petersen, H. W., Norregaard, J. C., and Winther, K. Randomized and double-blinded pilot clinical study of the safety and anti-diabetic ef
Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.
Bagheri, H., Schmitt, L., Berlan, M., and Montastruc, J. L. Effect of 3 weeks treatment with yohimbine on salivary secretion in healthy volunteers and in depressed patients treated with tricyclic antidepressants. Br J Clin Pharmacol 1992;34(6):555-558. PubMed
Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed
Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225.
Berlin, I., Crespo-Laumonnier, B., Cournot, A., Landault, C., Aubin, F., Legrand, J. C., and Puech, A. J. The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. Clin Pharmacol.Ther. 199
Cimolai, N. and Cimolai, T. Yohimbine use for physical enhancement and its potential toxicity. J Diet.Suppl 2011;8(4):346-354. PubMed
Landis, E. and Shore, E. Yohimbine-induced bronchospasm. Chest 1989;96(6):1424. PubMed
Susset, J. G., Tessier, C. D., Wincze, J., Bansal, S., Malhotra, C., and Schwacha, M. G. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol. 1989;141(6):1360-1363. PubMed
Charney, D. S., Price, L. H., and Heninger, G. R. Desipramine-yohimbine combination treatment of refractory depression. Implications for the beta-adrenergic receptor hypothesis of antidepressant action. Arch.Gen.Psychiatry 1986;43(12):1155-1161. PubMed
Braddock, L., Cowen, P. J., Elliott, J. M., Fraser, S., and Stump, K. Binding of yohimbine and imipramine to platelets in depressive illness. Psychol.Med 1986;16(4):765-773. PubMed
Charney, D. S., Heninger, G. R., and Sternberg, D. E. Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine. Life Sci 6-7-1982;30(23):2033-2041.
Boon, N. A., Elliott, J. M., Grahame-Smith, D. G., John-Green, T., and Stump, K. A comparison of alpha 2-adrenoreceptor binding characteristics of intact human platelets identified by [3H]-yohimbine and [3H]- dihydroergocryptine. J Auton.Pharmacol 1983;3
Morgan, C. A., III, Southwick, S. M., Grillon, C., Davis, M., Krystal, J. H., and Charney, D. S. Yohimbine-facilitated acoustic startle reflex in humans. Psychopharmacology (Berl) 1993;110(3):342-346. PubMed
Mann, K., Klingler, T., Noe, S., Roschke, J., Muller, S., and Benkert, O. Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction. Arch.Sex Behav. 1996;25(1):1-16. PubMed
Rowland, D. L., Kallan, K., and Slob, A. K. Yohimbine, erectile capacity, and sexual response in men. Arch Sex Behav 1997;26(1):49-62.
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Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rauvolfia Vomitoria and Phendimetrazine Together: Common Questions

Is it safe to take Rauvolfia Vomitoria with Phendimetrazine?

We do not list a known interaction between Rauvolfia Vomitoria and Phendimetrazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Rauvolfia Vomitoria and Phendimetrazine have any of the same side effects?

Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Rauvolfia Vomitoria and Phendimetrazine used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Rauvolfia Vomitoria in each. That is a conversation for your prescriber, especially if Phendimetrazine is being adjusted to a target.

How was the Rauvolfia Vomitoria and Phendimetrazine combination checked?

Interactions in our licensed database are recorded against drug classes. Phendimetrazine is filed under 1 classification, and Rauvolfia Vomitoria has documented interactions with 11 drug classes — none of Phendimetrazine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Rauvolfia Vomitoria interact with any other medications?

Yes. Rauvolfia Vomitoria has 840 documented drug interactions in our database — Phendimetrazine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Phendimetrazine interact with any supplements?

Yes. Phendimetrazine has documented interactions with 17 supplements in our database — Rauvolfia Vomitoria is not one of them. The Phendimetrazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Rauvolfia Vomitoria monograph Uses, safety profile, and every drug interaction in one place Phendimetrazine drug information The full plain-English guide to this medication Phendimetrazine supplement interactions Every supplement checked against Phendimetrazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 46 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.