Herb & supplement monograph

Methylstenbolone Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Methylstenbolone

0 medications have a known interaction with Methylstenbolone, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Methylstenbolone. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Methylstenbolone combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Methylstenbolone: Uses, Safety & Side Effects

The bottom line

Methylstenbolone is a synthetic, oral anabolic-androgenic steroid that has been sold in some 'prosteroid' or 'designer supplement' products, not a natural herb. It is not an approved or safe dietary supplement, it carries real risks including serious liver damage, and it is banned in sports and prohibited in many countries. We strongly recommend against using it and urge you to speak with a doctor or pharmacist first.

Part used
Synthetic compound (not derived from a plant)
Common forms
Capsules, tablets
People commonly use it for
  • Muscle building (bodybuilding)
  • Strength gains
  • Body recomposition
  • Athletic performance enhancement

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

It is an unapproved synthetic anabolic steroid linked to serious liver and hormonal harm.

PregnancyPossibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including red...

Read the full pregnancy detail
BreastfeedingPossibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including red...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Methylstenbolone is not an herb or a natural plant extract. It is a man-made (synthetic) anabolic-androgenic steroid, meaning it is a lab-created chemical that acts like the hormone testosterone. It has been sold illegally in some over-the-counter products marketed to bodybuilders as a 'prohormone,' 'designer steroid,' or muscle-building supplement.

Because it has a chemical change (a methyl group) that lets it survive being taken by mouth, it was made into pills. Products containing methylstenbolone have appeared on the supplement market even though it is not an approved drug or a legitimate dietary supplement ingredient. Regulators such as the U.S. FDA have warned against these kinds of products.

People who use it are usually trying to gain muscle and strength quickly. It is important to understand that 'supplement' marketing does not make a substance safe or legal.

How it works

Methylstenbolone is designed to act like testosterone. It binds to androgen receptors in the body, which can signal muscle cells to grow and increase protein building. This is the same general way other anabolic steroids work.

The added 'methyl' part of its structure (it is what is called a 17-alpha-alkylated steroid) lets it survive digestion so it can be taken as a pill. Unfortunately, this same chemical feature is strongly linked to liver toxicity. Much of what is 'known' about this compound comes from its chemical similarity to other steroids rather than from careful human studies.

Effectiveness

Does Methylstenbolone work?

Evidence overview · 7 uses evaluated
7 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Methylstenbolone, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 7 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Age-related testosterone deficiency
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral methylstenbolone for testosterone deficiency, there is insufficient reliable information about the clinical effects of methylstenbolone for this condition.

Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral methylstenbolone for improving athletic performance and recovery, there is insufficient reliable information about the clinical effects of methylstenbolone for this use.

Insufficient Reliable Evidence To Rate Erectile dysfunction (ED)
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral methylstenbolone for ED, there is insufficient reliable information about the clinical effects of methylstenbolone for this condition.

Insufficient Reliable Evidence To Rate Exercise-induced muscle damage
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral methylstenbolone for muscle recovery after exercise, there is insufficient reliable information about the clinical effects of methylstenbolone for this purpose.

Insufficient Reliable Evidence To Rate Muscle strength
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral methylstenbolone for improving muscle mass, there is insufficient reliable information about the clinical effects of methylstenbolone for this use.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral methylstenbolone for weight loss and reducing abdominal obesity, there is insufficient reliable information about the clinical effects of methylstenbolone for these uses.

Insufficient Reliable Evidence To Rate Sexual arousal
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using oral methylstenbolone for increasing sexual arousal, there is insufficient reliable information about the clinical effects of methylstenbolone for this use.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

This compound is considered unsafe and should be avoided. As an oral anabolic steroid, it can cause serious harm, including liver damage, unhealthy cholesterol changes, high blood pressure, and disruption of your body's natural hormones.

Who should especially avoid it: anyone with liver, heart, or kidney problems; people with a history of hormone-sensitive conditions; teenagers and young adults whose bodies are still developing; and anyone who is pregnant or breastfeeding.

Pregnancy: Avoid completely. Anabolic steroids can cause birth defects and harm a developing baby. Breastfeeding: Avoid completely, since the drug could pass to the infant and cause harm. Because methylstenbolone is sold in unregulated products, you also cannot be sure what is actually in the bottle. Always talk to a doctor or pharmacist before using any product like this.

Side effects

Reported and expected side effects of oral anabolic steroids like methylstenbolone include:

  • Liver injury, sometimes severe, including jaundice (yellowing of skin or eyes) and dangerous bile flow problems
  • Unhealthy cholesterol changes (lower 'good' HDL, higher 'bad' LDL)
  • High blood pressure and increased risk of heart problems
  • Acne, oily skin, and hair loss
  • Hormone disruption: in men, shrinking testicles, low natural testosterone, and breast tissue growth; in women, deepening voice, facial hair, and menstrual changes
  • Mood changes, irritability, and aggression

Some of these effects, especially liver and heart harm and masculinizing changes in women, can be serious or long-lasting. Seek medical care right away if you notice yellowing skin, dark urine, severe abdominal pain, or chest symptoms.

Methylstenbolone: Reported Adverse Effects

Documented safety reports on Methylstenbolone from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, methylstenbolone is possibly unsafe. As an anabolic androgenic steroid, there is concern that it might cause serious side effects including heart disease and liver injury.

Reports by condition
Myasthenia gravis Hepatic

There is a case of cholestatic jaundice with elevated liver enzymes, dark urine, clay stools, and pruritus in a 26-year-old male, likely related to the use of a product (Super DMZ Rx 2.0) containing methylstenbolone 10 mg and dymethazine 10 mg per capsule. The product was used at manufacturer-recommended doses of two capsules daily for up to 1 month. Liver enzyme levels gradually decreased after discontinuation. The specific role of methylstenbolone cannot be determined from this report.

  1. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established, safe, or approved dose for methylstenbolone. It is not a recognized medicine or legitimate dietary supplement, so no medical dosing guidance exists.

We will not provide dosing amounts because doing so could encourage harmful use. If you have taken a product that contains methylstenbolone, stop and talk with a healthcare professional. Never assume a product is safe just because it is sold online or in a store.

Pregnancy & Breastfeeding

Methylstenbolone & Pregnancy

Possibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100.

Methylstenbolone & Breastfeeding

Possibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Methylstenbolone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961 PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Methylstenbolone

27 products in our database contain Methylstenbolone. Open any to see its full ingredient list and every drug interaction we check.

Iron Man IV by Platinum Muscle Nutrition Capsule 90 Capsule(s) View ingredients & interactions M-Sten RX by IronMagLabs Capsule 60 Capsule(s) View ingredients & interactions Msten Extreme Mass Builder by Assault Labs Capsule 120 Capsule(s) View ingredients & interactions Raptor by Muscle House Capsule 60 Cap(s) View ingredients & interactions Super-DMZ RX 2.0 by Blackstone Labs Capsule 60 Capsule(s) View ingredients & interactions Tri-Methyl Xtreme by EPG Capsule 60 Capsule(s) View ingredients & interactions Ultra-Sten by Hardcore Formulations Capsule 90 Capsule(s) View ingredients & interactions Barbarian FX Mass by Xcel Sports Nutrition Capsule 60 Capsule(s) Off market View ingredients & interactions Blood Shed by Xcel Sports Nutrition Capsule 90 Capsule(s) Off market View ingredients & interactions Colossus-HX-Pro by Xcel Sports Nutrition Capsule 60 Capsule(s) Off market View ingredients & interactions Cro-Magnon Extreme Anabolic by DNA Anabolics Capsule 60 Capsule(s) Off market View ingredients & interactions eMass by Galaxy Supplements Capsule 60 Capsule(s) Off market View ingredients & interactions Epic Xtreme by Xcel Sports Nutrition Capsule 60 Capsule(s) Off market View ingredients & interactions Full Xcel Rage by Xcel Sports Nutrition Capsule 60 Capsule(s) Off market View ingredients & interactions Mass Plex-X-Pro by Xcel Sports Nutrition Capsule 60 Capsule(s) Off market View ingredients & interactions Methyl-Sten 200 by Genetech Pharma Labs Capsule 90 Capsule(s) Off market View ingredients & interactions Phantom by Xcel Sports Nutrition Capsule 60 Capsule(s) Off market View ingredients & interactions Pro Extreme by Xcel Sports Nutrition Capsule 60 Capsule(s) Off market View ingredients & interactions Pro Fury Mass by Xcel Sports Nutrition Capsule 60 Capsule(s) Off market View ingredients & interactions Retaliation by Xcel Sports Nutrition Capsule 60 Capsule(s) Off market View ingredients & interactions Silverback DNA by Xcel Sports Nutrition Capsule 60 Capsule(s) Off market View ingredients & interactions Storm X-Pro by Xcel Sports Nutrition Capsule 60 Capsule(s) Off market View ingredients & interactions Super Deca Sten by Warrior Labz Capsule 60 Capsule(s) Off market View ingredients & interactions Titan by Warrior Labz Capsule 90 Capsule(s) Off market View ingredients & interactions
Pharmacist Counseling Corner

Methylstenbolone: Common Questions

What is Methylstenbolone used for, and does it work?
People use Methylstenbolone for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Methylstenbolone interact with prescription medications?
We do not currently list any known drug interactions for Methylstenbolone. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Methylstenbolone interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Methylstenbolone with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Methylstenbolone interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Methylstenbolone a natural supplement or an herb?
No. It is a man-made anabolic-androgenic steroid, not a plant or natural product, even though it has been sold in some 'supplement' products.
Is Methylstenbolone safe to take?
No, it is not considered safe. It is an unapproved oral steroid linked to serious liver damage, heart and cholesterol problems, and hormone disruption.
Is Methylstenbolone legal?
It is not an approved drug or a legal dietary supplement ingredient in many countries, and it is banned in sports. Possessing or selling it may also be illegal depending on where you live.
Can I use Methylstenbolone if I'm pregnant or breastfeeding?
No. Anabolic steroids can harm a developing baby or nursing infant, so it must be avoided during pregnancy and breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Methylstenbolone

A rotating sample of real supplements in our database that list Methylstenbolone — open any to see its full ingredients and every drug interaction we check.

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