Herb & supplement monograph

American Pawpaw Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how American Pawpaw interacts with medications. The heart of this page is the interaction list — every drug American Pawpaw is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what American Pawpaw is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

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American Pawpaw Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant American Pawpaw drug interaction appears low for most people. Every interaction on record is rated minor, and none reaches moderate or major severity.

Interactions deserving the most attention

Nothing in this profile is backed by strong human evidence. The one area worth knowing about involves cancer medications (antineoplastics), because American pawpaw contains a natural compound called annonacin that has shown anticancer activity in laboratory studies, raising a theoretical question of overlap with these drugs. Even here, the effect has only appeared in lab research and has not been shown to occur in people, so it remains a precaution rather than a proven problem.

What the rest of the list means

A list covering a couple dozen medications can look worrying, but here it mostly reflects a single theoretical concern spread across a group of related drugs, not evidence that each combination causes harm. These predictions come from laboratory findings rather than human studies, and no meaningful change has been documented in people taking these medicines with American pawpaw.

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Based on HelloPharmacist’s American Pawpaw interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with American Pawpaw

25 medications have a known interaction with American Pawpaw, graded by severity. Select any drug for the full evidence-based detail.

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AI summaries are generated from our American Pawpaw interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

AtezolizumabTecentriq

Minor Antineoplastics