Temozolomide

Generic name: Pronounced as (te moe zoe' loe mide)
Brand names
  • Temodar®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2016

Temozolomide is used to treat certain types of brain tumors. Temozolomide is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.

Temozolomide comes as a capsule to take by mouth. It is usually taken once a day in the evening at bedtime. Take temozolomide capsules on an empty stomach with a glass of water. Take temozolomide at around the same time every day. For some types of brain tumors, temozolomide is taken daily for 42–49 days. Then, after a 28-day break, it may be taken once a day for 5 days in a row, followed by a 23-day break before repeating the next dosage cycle. For treatment of other types of brain tumors, temozolomide is taken once a day for 5 days in a row, followed by a 23-day break before repeating the next dosage cycle. Your doctor will decide how many times you should repeat the treatment cycles. The length of treatment depends on the how well your body responds to it and the type of cancer that you have. Take temozolomide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your full dose may contain more than one type and color of capsules and may be contained in more than one prescription bottle. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Temozolomide capsules come in several different strengths. Your doctor may want you to take a combination of capsules to make up your full dose. Be sure that you know what each type of capsule looks like and how many you are to take of each. Ask your doctor or pharmacist if you have any questions.

If any of the capsules are broken or leaking, do not touch them with your bare hands and be careful not to breathe in the powder from the capsules. You should wear rubber or latex gloves when you handle broken or opened capsules so that your skin does not come into contact with the powder. If the capsule contents do touch your skin, wash the area well with water right away.

Swallow the capsules whole; do not empty, chew, or crush them.

You may vomit after you take the medication. If this happens, let your doctor know right away. Do not take another dose of temozolomide on the same day.

Your doctor may need to delay your treatment or adjust your dose of temozolomide depending on your response to treatment and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment. Do not stop taking temozolomide without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking temozolomide,

  • tell your doctor and pharmacist if you are allergic to temozolomide, dacarbazine (DTIC-Dome) any other medications, or any of the ingredients in temozolomide capsules. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Carbatrol, Epitol, Tegretol); co-trimoxazole (Bactrim, Septra); phenytoin (Dilantin, Phenytek); steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); and valproic acid (Stavzor, Depakene).

  • tell your doctor if you have or have ever had kidney or liver disease.

  • you should know that temozolomide may interfere with sperm production in men. However, you should not assume that you cannot get someone else pregnant. Tell your doctor if you are pregnant or plan to become pregnant, or if you plan to father a child. You or your partner should not become pregnant while you are taking temozolomide. Use a reliable method of birth control to prevent pregnancy. If you become pregnant while taking temozolomide, call your doctor. Temozolomide may harm the fetus.

  • tell your doctor if you are breast-feeding. You should not breastfeed while you are taking temozolomide.

Unless your doctor tells you otherwise, continue your normal diet.

Talk to your doctor about what to do if you miss a dose of temozolomide. Do not take a double dose to make up for a missed one.

  • Temozolomide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • diarrhea

    • constipation

    • loss of appetite

    • sores in the mouth and throat

    • headache

    • pale skin

    • lack of energy

    • loss of balance or coordination

    • fainting

    • dizziness

    • hair loss

    • insomnia

    • memory problems

    • changes in vision

  • Some side effects can be serious. If you experience any of these symptoms, stop taking temozolomide and call your doctor immediately or get emergency medical treatment:

    • unusual bleeding or bruising

    • red or black, tarry stools

    • pink, red, or dark brown urine

    • coughing up or vomiting blood or material that looks like coffee grounds

    • fever, sore throat, ongoing cough and congestion, or other signs of infection

    • unusual tiredness or weakness

    • rash

    • unable to move one side of the body

    • shortness of breath

    • seizures

    • yellowing of the skin or eyes

    • pain in the upper right part of the stomach

    • decreased urination

  • Temozolomide may increase the risk that you will develop other cancers. Talk to your doctor about the risks of taking temozolomide.

  • Temozolomide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • unusual bleeding or bruising

  • red or black, tarry stools

  • pink, red, or dark brown urine

  • coughing up or vomiting blood or material that looks like coffee grounds

  • fever, sore throat, ongoing cough and congestion, or other signs of infection

Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests before, during, and after your treatment to check your body's response to temozolomide and to see if your blood cells are affected by this drug.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Leflunomide Leflunomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Leflunomide.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Temozolomide.
Cilostazol Cilostazol Temozolomide may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Clopidogrel is combined with Temozolomide.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Fenofibrate Fenofibrate Temozolomide may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine Temozolomide may decrease the excretion rate of Guanfacine which could result in a higher serum level.
Magnesium Hydroxide Magnesium Hydroxide Temozolomide may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Temozolomide is combined with Mycophenolic acid.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Potassium Potassium Potassium may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Temozolomide.
Ranitidine Ranitidine Temozolomide may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine Reserpine Reserpine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Rizatriptan Rizatriptan Temozolomide may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan Sumatriptan may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Tacrolimus Tacrolimus Tacrolimus may increase the immunosuppressive activities of Temozolomide.
Triamcinolone Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Temozolomide.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Fluconazole may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Temozolomide.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Temozolomide.
Levofloxacin Injection Levofloxacin Injection Temozolomide may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection Meperidine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection Temozolomide may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Temozolomide may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Temozolomide.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Cyclosporine Cyclosporine Temozolomide may increase the immunosuppressive activities of Cyclosporine.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Temozolomide.
Torsemide Torsemide Torasemide may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Hydroxychloroquine Hydroxychloroquine The risk or severity of adverse effects can be increased when Temozolomide is combined with Hydroxychloroquine.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Temozolomide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Anakinra Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Temozolomide.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Temozolomide.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Temozolomide.
Etanercept Injection Etanercept Injection The risk or severity of adverse effects can be increased when Etanercept is combined with Temozolomide.
Perindopril Perindopril Perindopril may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Sirolimus Sirolimus The risk or severity of adverse effects can be increased when Temozolomide is combined with Sirolimus.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Temozolomide.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Zonisamide Zonisamide Temozolomide may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Adalimumab Injection Adalimumab Injection The risk or severity of adverse effects can be increased when Adalimumab is combined with Temozolomide.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Glatiramer.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Almotriptan Almotriptan Temozolomide may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Emtricitabine Emtricitabine Temozolomide may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Temozolomide may decrease the excretion rate of Memantine which could result in a higher serum level.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Temozolomide.
Infliximab Injection Infliximab Injection The risk or severity of adverse effects can be increased when Infliximab is combined with Temozolomide.
Duloxetine Duloxetine Duloxetine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Tinidazole Tinidazole Temozolomide may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Natalizumab.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Eszopiclone Eszopiclone Eszopiclone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Ganciclovir Ganciclovir Temozolomide may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Palifermin Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Temozolomide.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Valganciclovir Valganciclovir Temozolomide may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Temozolomide.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Temozolomide.
Ramelteon Ramelteon Temozolomide may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Fentanyl may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Pregabalin Pregabalin Pregabalin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Abatacept Injection Abatacept Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Abatacept.
Rasagiline Rasagiline Temozolomide may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Imatinib Imatinib The risk or severity of adverse effects can be increased when Imatinib is combined with Temozolomide.
Sitagliptin Sitagliptin Temozolomide may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Temozolomide may decrease the excretion rate of Varenicline which could result in a higher serum level.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Temozolomide.
Albuterol Albuterol Temozolomide may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone Temozolomide may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Bortezomib Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Temozolomide.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Temozolomide.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Temozolomide.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Temozolomide.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Temozolomide.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Temozolomide.
Lubiprostone Lubiprostone Temozolomide may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Temozolomide.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Temozolomide.
Pemetrexed Injection Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Temozolomide.
Vorinostat Vorinostat The risk or severity of adverse effects can be increased when Temozolomide is combined with Vorinostat.
Sorafenib Sorafenib The risk or severity of adverse effects can be increased when Sorafenib is combined with Temozolomide.
Sunitinib Sunitinib The risk or severity of adverse effects can be increased when Temozolomide is combined with Sunitinib.
Levocetirizine Levocetirizine Temozolomide may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Temozolomide may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The risk or severity of adverse effects can be increased when Temozolomide is combined with Dasatinib.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Azacitidine.
Temsirolimus Temsirolimus The risk or severity of adverse effects can be increased when Temozolomide is combined with Temsirolimus.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Nelarabine.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Temozolomide.
Nilotinib Nilotinib The risk or severity of adverse effects can be increased when Temozolomide is combined with Nilotinib.
Bexarotene Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Temozolomide.
Budesonide Budesonide The risk or severity of adverse effects can be increased when Temozolomide is combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Temozolomide.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Decitabine.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Doripenem Injection Doripenem Injection Temozolomide may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine Temozolomide may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Temozolomide.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Bendamustine.
Certolizumab Injection Certolizumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Ixabepilone.
Irinotecan Injection Irinotecan Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Temozolomide.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Temozolomide is combined with Estramustine.
Methylnaltrexone Injection Methylnaltrexone Injection Temozolomide may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Temozolomide.
Midazolam Midazolam Midazolam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Temozolomide.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Temozolomide.
Milnacipran Milnacipran Temozolomide may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Plerixafor Injection Plerixafor Injection Temozolomide may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Temozolomide may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Prasugrel Prasugrel Temozolomide may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Everolimus Everolimus The risk or severity of adverse effects can be increased when Temozolomide is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Pralatrexate.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Saxagliptin Saxagliptin Temozolomide may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Temozolomide may decrease the excretion rate of Telavancin which could result in a higher serum level.
Topotecan Topotecan The risk or severity of adverse effects can be increased when Temozolomide is combined with Topotecan.
Golimumab Injection Golimumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Golimumab.
Pazopanib Pazopanib The risk or severity of adverse effects can be increased when Temozolomide is combined with Pazopanib.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Temozolomide.
Dabigatran Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Temozolomide.
Tocilizumab Injection Tocilizumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Tocilizumab.
Dalfampridine Dalfampridine Temozolomide may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Fingolimod Fingolimod Temozolomide may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Cabazitaxel.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Temozolomide may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Temozolomide.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Temozolomide.
Terbutaline Injection Terbutaline Injection Temozolomide may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Belimumab.
Busulfan Injection Busulfan Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Busulfan.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Temozolomide.
Cyclophosphamide Injection Cyclophosphamide Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Temozolomide.
Rivaroxaban Rivaroxaban Rivaroxaban may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Ticagrelor Ticagrelor The risk or severity of bleeding can be increased when Ticagrelor is combined with Temozolomide.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The risk or severity of adverse effects can be increased when Temozolomide is combined with Ruxolitinib.
Clobazam Clobazam Clobazam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Belatacept.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Temozolomide.
Deferiprone Deferiprone Temozolomide may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Melphalan.
Naloxone Injection Naloxone Injection Temozolomide may decrease the excretion rate of Naloxone which could result in a higher serum level.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Eculizumab.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Carfilzomib Injection Carfilzomib Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Carfilzomib.
Iloprost Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Temozolomide.
Enzalutamide Enzalutamide Temozolomide may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Temozolomide may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Bosutinib Bosutinib The risk or severity of adverse effects can be increased when Temozolomide is combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Corticotropin.
Teriflunomide Teriflunomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Teriflunomide.
Teduglutide Injection Teduglutide Injection Temozolomide may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Temozolomide.
Tofacitinib Tofacitinib Temozolomide may increase the immunosuppressive activities of Tofacitinib.
Alogliptin Alogliptin Temozolomide may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Temozolomide is combined with Dimethyl fumarate.
Ponatinib Ponatinib The risk or severity of adverse effects can be increased when Temozolomide is combined with Ponatinib.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Trastuzumab emtansine.
Apixaban Apixaban The risk or severity of bleeding can be increased when Apixaban is combined with Temozolomide.
Canagliflozin Canagliflozin Temozolomide may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Trametinib Trametinib Temozolomide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran Temozolomide may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Vortioxetine Vortioxetine Temozolomide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ibrutinib Ibrutinib The risk or severity of adverse effects can be increased when Temozolomide is combined with Ibrutinib.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Obinutuzumab.
Sofosbuvir Sofosbuvir Temozolomide may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast The risk or severity of adverse effects can be increased when Temozolomide is combined with Apremilast.
Droxidopa Droxidopa Temozolomide may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Siltuximab Injection Siltuximab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Siltuximab.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Vedolizumab.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Belinostat.
Idelalisib Idelalisib The risk or severity of adverse effects can be increased when Temozolomide is combined with Idelalisib.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Vorapaxar Vorapaxar The risk or severity of bleeding can be increased when Vorapaxar is combined with Temozolomide.
Edoxaban Edoxaban Temozolomide may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Peginterferon beta-1a.
Olaparib Olaparib The risk or severity of adverse effects can be increased when Temozolomide is combined with Olaparib.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Blinatumomab.
Methamphetamine Methamphetamine Temozolomide may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Temozolomide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Temozolomide is combined with Pirfenidone.
Secukinumab Injection Secukinumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Secukinumab.
Palbociclib Palbociclib The risk or severity of adverse effects can be increased when Temozolomide is combined with Palbociclib.
Panobinostat Panobinostat The risk or severity of adverse effects can be increased when Temozolomide is combined with Panobinostat.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection Haloperidol may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Amiloride Amiloride Amiloride may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Temozolomide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Prednisolone Prednisolone The risk or severity of adverse effects can be increased when Temozolomide is combined with Prednisolone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Temozolomide may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Mepolizumab.
Trabectedin Injection Trabectedin Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Trabectedin.
Ixazomib Ixazomib Temozolomide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Temozolomide may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Temozolomide.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Ixekizumab.
Brivaracetam Injection Brivaracetam Injection Temozolomide may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Lixisenatide Injection Lixisenatide Injection Temozolomide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Brodalumab.
Doxepin (Insomnia) Doxepin (Insomnia) Temozolomide may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Temozolomide may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Temozolomide may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of adverse effects can be increased when Temozolomide is combined with Deflazacort.
Ocrelizumab Injection Ocrelizumab Injection Ocrelizumab may increase the immunosuppressive activities of Temozolomide.
Naldemedine Naldemedine Temozolomide may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection Sarilumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Sarilumab.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Guselkumab.
Benznidazole Benznidazole Temozolomide may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Temozolomide may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Temozolomide.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Temozolomide.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Apalutamide Apalutamide Temozolomide may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Temozolomide is combined with Penicillamine.
Baricitinib Baricitinib The risk or severity of adverse effects can be increased when Temozolomide is combined with Baricitinib.
Lofexidine Lofexidine Temozolomide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Temozolomide may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Stiripentol Stiripentol Temozolomide may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Temozolomide.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Paclitaxel.
Prucalopride Prucalopride Temozolomide may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Ravulizumab.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Emapalumab.
Siponimod Siponimod The risk or severity of adverse effects can be increased when Temozolomide is combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Temozolomide.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Risankizumab.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Temozolomide.
Solriamfetol Solriamfetol Temozolomide may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Pitolisant Pitolisant Temozolomide may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Ozanimod Ozanimod The risk or severity of adverse effects can be increased when Temozolomide is combined with Ozanimod.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Temozolomide.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Temozolomide.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Temozolomide.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Temozolomide.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Temozolomide may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Temozolomide.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Isotretinoin Isotretinoin Temozolomide may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Hydroxyurea Hydroxyurea The risk or severity of adverse effects can be increased when Temozolomide is combined with Hydroxyurea.
Floxuridine Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Temozolomide.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Temozolomide.
Chlorpromazine Chlorpromazine Chlorpromazine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Diazepam Diazepam Diazepam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Flurazepam Flurazepam Flurazepam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Clorazepate Clorazepate Clorazepic acid may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Lorazepam Lorazepam Lorazepam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Carmustine Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Temozolomide.
Amantadine Amantadine Temozolomide may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine Codeine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Phenelzine Phenelzine Phenelzine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Temozolomide is combined with Procarbazine.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Temozolomide.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Temozolomide.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Methadone Methadone Methadone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Maprotiline Maprotiline Temozolomide may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Temozolomide is combined with Azathioprine.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Temozolomide.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Temozolomide is combined with Lomustine.
Doxorubicin Doxorubicin The risk or severity of adverse effects can be increased when Temozolomide is combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Temozolomide is combined with Cytarabine.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Temozolomide is combined with Mechlorethamine.
Dactinomycin Dactinomycin The risk or severity of adverse effects can be increased when Temozolomide is combined with Dactinomycin.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Carbamazepine Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Temozolomide.
Methyldopa Methyldopa Temozolomide may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Hydralazine Hydralazine Temozolomide may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Warfarin Warfarin Warfarin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Clonazepam Clonazepam Temozolomide may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Promethazine Promethazine Temozolomide may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Daunorubicin Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Temozolomide.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Digoxin Digoxin Temozolomide may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Chloroquine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Triamterene Triamterene Triamterene may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Sulfinpyrazone is combined with Temozolomide.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Temozolomide.
Secobarbital Secobarbital Secobarbital may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Desipramine Desipramine Temozolomide may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline Amitriptyline may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Imipramine Imipramine Imipramine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Probenecid Probenecid Temozolomide may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine Quinidine Temozolomide may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Temozolomide may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Temozolomide may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Disopyramide Disopyramide Disopyramide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Temozolomide.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Temozolomide.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Methimazole Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Temozolomide.
Propylthiouracil Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Temozolomide.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Tolbutamide Tolbutamide Temozolomide may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Baclofen Baclofen Baclofen may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Temozolomide is combined with Mercaptopurine.
Phytonadione Phytonadione Temozolomide may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Nadolol Nadolol Temozolomide may decrease the excretion rate of Nadolol which could result in a higher serum level.
Allopurinol Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Temozolomide.
Flavoxate Flavoxate Temozolomide may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The risk or severity of adverse effects can be increased when Fluorouracil is combined with Temozolomide.
Colchicine Colchicine The risk or severity of adverse effects can be increased when Temozolomide is combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Dacarbazine Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Temozolomide.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Temozolomide.
Pyrantel Pyrantel Temozolomide may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Thiotepa.
Vincristine Injection Vincristine Injection The risk or severity of adverse effects can be increased when Vincristine is combined with Temozolomide.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Temozolomide.
Vinblastine Vinblastine The risk or severity of adverse effects can be increased when Vinblastine is combined with Temozolomide.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Metoprolol Metoprolol Metoprolol may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Temozolomide.
Alprazolam Alprazolam Alprazolam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Triazolam Triazolam Temozolomide may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Nifedipine Nifedipine Temozolomide may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol Timolol may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Verapamil Verapamil Verapamil may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Pindolol Pindolol Temozolomide may decrease the excretion rate of Pindolol which could result in a higher serum level.
Cisplatin Injection Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Temozolomide.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Bumetanide Bumetanide Temozolomide may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Temozolomide.
Etoposide Etoposide The risk or severity of adverse effects can be increased when Etoposide is combined with Temozolomide.
Glipizide Glipizide Temozolomide may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Indapamide may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Temozolomide may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Labetalol Labetalol Labetalol may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Auranofin Auranofin Temozolomide may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Gemfibrozil Gemfibrozil Temozolomide may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin Ciprofloxacin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Temozolomide.
Clozapine Clozapine The risk or severity of neutropenia can be increased when Temozolomide is combined with Clozapine.
Estazolam Estazolam Temozolomide may decrease the excretion rate of Estazolam which could result in a higher serum level.
Idarubicin Idarubicin The risk or severity of adverse effects can be increased when Temozolomide is combined with Idarubicin.
Didanosine Didanosine Temozolomide may decrease the excretion rate of Didanosine which could result in a higher serum level.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Fludarabine.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Temozolomide.
Etodolac Etodolac Etodolac may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Temozolomide.
Teniposide Injection Teniposide Injection The risk or severity of adverse effects can be increased when Teniposide is combined with Temozolomide.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Isradipine Isradipine Isradipine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Venlafaxine Venlafaxine Venlafaxine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Fluvoxamine Fluvoxamine Fluvoxamine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Nefazodone Nefazodone Temozolomide may decrease the excretion rate of Nefazodone which could result in a higher serum level.
Lamotrigine Lamotrigine Lamotrigine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Vinorelbine Injection Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Temozolomide.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Carboplatin.
Ifosfamide Injection Ifosfamide Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Ifosfamide.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Temozolomide.
Bupropion Bupropion Temozolomide may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Metformin Metformin Metformin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Temozolomide.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Acarbose Acarbose Acarbose may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Temozolomide.
Docetaxel Injection Docetaxel Injection The risk or severity of adverse effects can be increased when Temozolomide is combined with Docetaxel.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Clomipramine Clomipramine Temozolomide may decrease the excretion rate of Clomipramine which could result in a higher serum level.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Topiramate Topiramate Topiramate may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Pramipexole Pramipexole Pramipexole may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Flutamide Flutamide Flutamide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Quetiapine Quetiapine Temozolomide may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Capecitabine Capecitabine The risk or severity of adverse effects can be increased when Temozolomide is combined with Capecitabine.
Abacavir Abacavir Temozolomide may decrease the excretion rate of Abacavir which could result in a higher serum level.
Trastuzumab Injection Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Temozolomide.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Rosiglitazone Rosiglitazone Rosiglitazone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Tolterodine Tolterodine Temozolomide may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Nateglinide Nateglinide Nateglinide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Rabeprazole Rabeprazole Temozolomide may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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