Rifapentine

Generic name: Pronounced as (rif'' a pen' teen)
Brand names
  • Priftin®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 04/15/2019

Rifapentine is used with other medications to treat active tuberculosis (TB; a serious infection that affects the lungs and sometimes other parts of the body) in adults and children 12 years of age and older. Rifapentine is also used with isoniazid (Laniazid) to treat adults and children 2 years of age and older with latent (resting or nongrowing) TB, including those in close contact with people who have active TB, a positive tuberculin skin test, human immunodeficiency virus (HIV), or those with pulmonary fibrosis (scarring of the lungs with an unknown cause). Rifapentine is in a class of medications called antimycobacterials. It works by killing the bacteria that cause infection.

Antibiotics such as rifapentine will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Rifapentine comes as a tablet to take by mouth. When rifapentine is used to treat active TB, it is usually taken with food twice weekly, with doses at least 3 days apart, for the first 2 months and then once weekly for 4 months. When rifapentine is used to treat latent TB infection, it should be with food taken once every week. Take rifapentine at around the same time every scheduled day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take rifapentine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are unable to swallow the tablets, you can crush them and mix the medication in a small amount of semisolid food such as pudding or applesauce. Swallow the mixture right away; do not store it for later use.

Continue to take rifapentine until you finish the prescription even if you feel better, and be careful not to miss doses. If you stop taking rifapentine too soon, your infection may not be completely treated and the bacteria may become resistant to antibiotics. If you miss doses of rifapentine, you may develop uncomfortable or serious symptoms when you begin to take the medication again.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking rifapentine,

  • tell your doctor and pharmacist if you are allergic to rifapentine, rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), rifaximin (Xifaxan), any other medications, or any of the ingredients in rifapentine tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antibiotics medications such as chloramphenicol, ciprofloxacin (Cipro), clarithromycin (Biaxin, in Prevpac), dapsone, and doxycycline (Doryx, Monodox, Vibramycin, others); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), and ketoconazole; calcium channel blockers such as diltiazem (Cardizem, Taztia, Tiazac, others), nifedipine (Adalat, Afeditab, Procardia), and verapamil (Calan, Covera, Verelan); clofibrate (Atromid-S; no longer available in U.S.); cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); digoxin (Lanoxin); disopyramide (Norpace); glyburide (Diabeta, Glynase); glipizide (Glucotrol); haloperidol (Haldol); HIV medications; levothyroxine (Levoxyl, Synthroid, Tirosint); methadone (Dolophine, Methadose); mexiletine, phenobarbital; phenytoin (Dilantin, Phenytek); prednisone (Rayos); propranolol (Hemangeol, Inderal, InnoPran); quinidine (in Nuedexta), quinine (Qualaquin); sildenafil (Revatio, Viagra); tacrolimus (Astagraf, Envarsus, Prograf); theophylline (Elixophyllin, Theochron, Uniphyl); tocainide (Tonocard; no longer available in U.S.); and tricyclic antidepressants such as amitriptyline and nortriptyline (Pamelor). Many other medications may interact with rifapentine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you are taking or using hormonal contraceptives (birth control pills, patches, rings, implants, and injections). Rifapentine can decrease the effectiveness of hormonal contraceptives. You should use another method of birth control while taking this medication. Talk to your doctor about birth control while taking rifapentine.

  • tell your doctor if you have active TB or if you were unresponsive to other TB medications or if you have or have ever had porphyria (condition in which certain natural substances build up in the body and may cause stomach pain, changes in thinking and behavior, or other symptoms), HIV infection, or liver disease.

  • tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking rifapentine, call your doctor.

  • do not breastfeed while taking rifapentine. Rifapentine may cause breast milk to turn reddish-orange.

  • tell your doctor if you wear soft contact lenses or dentures. Rifapentine may cause permanent red stains on your contact lenses or dentures.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Rifapentine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • temporary discoloration (yellow, reddish-orange, or brown color) of your skin, teeth, saliva, urine, stool, sweat, and tears

    • dizziness

    • fainting

    • increased sweating

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • diarrhea (up to 2 months after your treatment)

    • rash

    • itching

    • hives

    • cough with wheezing

    • difficulty breathing

    • red, itchy, or irritated eyes

    • fever

    • blisters

    • changes in thinking and behavior

    • swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs

    • fast or irregular heartbeat

    • nausea

    • vomiting

    • chest pain

    • flu-like symptoms such as fever, chills, muscle aches, muscle pain, tiredness, and headache

    • stomach pain

    • loss of appetite

    • dark urine

    • joint pain or swelling

    • yellowing of the skin or eyes

  • Rifapentine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • blood in urine

  • itching

  • body pain or stiffness

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to rifapentine.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking rifapentine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be increased when combined with Rifapentine.
Montelukast Montelukast The metabolism of Montelukast can be increased when combined with Rifapentine.
Nevirapine Nevirapine The metabolism of Nevirapine can be increased when combined with Rifapentine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be increased when combined with Rifapentine.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Rifapentine.
Clopidogrel Clopidogrel The therapeutic efficacy of Clopidogrel can be increased when used in combination with Rifapentine.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be increased when combined with Rifapentine.
Mycophenolate Mycophenolate The serum concentration of Mycophenolic acid can be decreased when it is combined with Rifapentine.
Paregoric Paregoric The metabolism of Morphine can be increased when combined with Rifapentine.
Penbutolol Penbutolol The metabolism of Acebutolol can be increased when combined with Rifapentine.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be increased when combined with Rifapentine.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Rifapentine.
Morphine Injection Morphine Injection The metabolism of Morphine can be increased when combined with Rifapentine.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be increased when combined with Rifapentine.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be increased when combined with Rifapentine.
Torsemide Torsemide The metabolism of Torasemide can be increased when combined with Rifapentine.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Rifapentine.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be increased when combined with Rifapentine.
Pantoprazole Pantoprazole The metabolism of Pantoprazole can be increased when combined with Rifapentine.
Trimipramine Trimipramine The metabolism of Trimipramine can be increased when combined with Rifapentine.
Tenofovir Tenofovir The metabolism of Tenofovir can be increased when combined with Rifapentine.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Rifapentine.
Escitalopram Escitalopram The metabolism of Escitalopram can be increased when combined with Rifapentine.
Zonisamide Zonisamide The metabolism of Zonisamide can be increased when combined with Rifapentine.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Rifapentine.
Atazanavir Atazanavir The metabolism of Atazanavir can be increased when combined with Rifapentine.
Almotriptan Almotriptan The metabolism of Almotriptan can be increased when combined with Rifapentine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Rifapentine.
Progesterone Progesterone The metabolism of Progesterone can be increased when combined with Rifapentine.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be increased when combined with Rifapentine.
Duloxetine Duloxetine The metabolism of Duloxetine can be increased when combined with Rifapentine.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Rifapentine.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Rifapentine.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Rifapentine.
Voriconazole Voriconazole The metabolism of Voriconazole can be increased when combined with Rifapentine.
Ramelteon Ramelteon The metabolism of Ramelteon can be increased when combined with Rifapentine.
Ranolazine Ranolazine The metabolism of Ranolazine can be increased when combined with Rifapentine.
Imatinib Imatinib The metabolism of Imatinib can be increased when combined with Rifapentine.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be increased when combined with Rifapentine.
Bortezomib Bortezomib The metabolism of Bortezomib can be increased when combined with Rifapentine.
Retapamulin Retapamulin The metabolism of Retapamulin can be increased when combined with Rifapentine.
Sorafenib Sorafenib The metabolism of Sorafenib can be increased when combined with Rifapentine.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Rifapentine.
Lapatinib Lapatinib The metabolism of Lapatinib can be increased when combined with Rifapentine.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Rifapentine.
Mexiletine Mexiletine The metabolism of Mexiletine can be increased when combined with Rifapentine.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Rifapentine.
Nilotinib Nilotinib The metabolism of Nilotinib can be increased when combined with Rifapentine.
Etravirine Etravirine The metabolism of Etravirine can be increased when combined with Rifapentine.
Nebivolol Nebivolol The metabolism of Nebivolol can be increased when combined with Rifapentine.
Tretinoin Tretinoin The metabolism of Tretinoin can be increased when combined with Rifapentine.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Rifapentine.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Rifapentine.
Praziquantel Praziquantel The metabolism of Praziquantel can be increased when combined with Rifapentine.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Rifapentine.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be increased when combined with Rifapentine.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Rifapentine.
Dexlansoprazole Dexlansoprazole The metabolism of Dexlansoprazole can be increased when combined with Rifapentine.
Betaxolol Betaxolol The metabolism of Betaxolol can be increased when combined with Rifapentine.
Prasugrel Prasugrel The metabolism of Prasugrel can be increased when combined with Rifapentine.
Lacosamide Lacosamide The metabolism of Lacosamide can be increased when combined with Rifapentine.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Rifapentine.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be increased when combined with Rifapentine.
Dronedarone Dronedarone The metabolism of Dronedarone can be increased when combined with Rifapentine.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Rifapentine.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Rifapentine.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be increased when combined with Rifapentine.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Rifapentine.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Rifapentine.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Rifapentine.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Rifapentine.
Vilazodone Vilazodone The metabolism of Vilazodone can be increased when combined with Rifapentine.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Rifapentine.
Roflumilast Roflumilast The metabolism of Roflumilast can be increased when combined with Rifapentine.
Linagliptin Linagliptin The metabolism of Linagliptin can be increased when combined with Rifapentine.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Rifapentine.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Rifapentine.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Rifapentine.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Rifapentine.
Clobazam Clobazam The metabolism of Clobazam can be increased when combined with Rifapentine.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be increased when combined with Rifapentine.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Rifapentine.
Crizotinib Crizotinib The metabolism of Crizotinib can be increased when combined with Rifapentine.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Rifapentine.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be increased when combined with Rifapentine.
Regorafenib Regorafenib The metabolism of Regorafenib can be increased when combined with Rifapentine.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Rifapentine.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be increased when combined with Rifapentine.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Rifapentine.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Rifapentine.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Rifapentine.
Apixaban Apixaban The metabolism of Apixaban can be increased when combined with Rifapentine.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Rifapentine.
Ospemifene Ospemifene The metabolism of Ospemifene can be increased when combined with Rifapentine.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Rifapentine.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be increased when combined with Rifapentine.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Rifapentine.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Rifapentine.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be increased when combined with Rifapentine.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Rifapentine.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Rifapentine.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be increased when combined with Rifapentine.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Rifapentine.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be increased when combined with Rifapentine.
Suvorexant Suvorexant The metabolism of Suvorexant can be increased when combined with Rifapentine.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Rifapentine.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Rifapentine.
Riociguat Riociguat The metabolism of Riociguat can be increased when combined with Rifapentine.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Rifapentine.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Rifapentine.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Rifapentine.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Rifapentine.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Rifapentine.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Rifapentine.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Rifapentine.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Rifapentine.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Rifapentine.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Rifapentine.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Rifapentine.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be increased when combined with Rifapentine.
Venetoclax Venetoclax The metabolism of Venetoclax can be increased when combined with Rifapentine.
Selexipag Selexipag The metabolism of Selexipag can be increased when combined with Rifapentine.
Ribociclib Ribociclib The metabolism of Ribociclib can be increased when combined with Rifapentine.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Rifapentine.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be increased when combined with Rifapentine.
Midostaurin Midostaurin The metabolism of Midostaurin can be increased when combined with Rifapentine.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Rifapentine.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Rifapentine.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Rifapentine.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Rifapentine.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Rifapentine.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Rifapentine.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be increased when combined with Rifapentine.
Apalutamide Apalutamide The metabolism of Apalutamide can be increased when combined with Rifapentine.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Rifapentine.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Rifapentine.
Elagolix Elagolix The metabolism of Elagolix can be increased when combined with Rifapentine.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be increased when combined with Rifapentine.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Rifapentine.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be increased when combined with Rifapentine.
Glasdegib Glasdegib The metabolism of Glasdegib can be increased when combined with Rifapentine.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be increased when combined with Rifapentine.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Rifapentine.
Prucalopride Prucalopride The metabolism of Prucalopride can be increased when combined with Rifapentine.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Rifapentine.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Rifapentine.
Esomeprazole Injection Esomeprazole Injection The metabolism of Esomeprazole can be increased when combined with Rifapentine.
Alpelisib Alpelisib The metabolism of Alpelisib can be increased when combined with Rifapentine.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be increased when combined with Rifapentine.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Rifapentine.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Rifapentine.
Istradefylline Istradefylline The metabolism of Istradefylline can be increased when combined with Rifapentine.
Pitolisant Pitolisant The serum concentration of Rifapentine can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Fedratinib can be increased when combined with Rifapentine.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Rifapentine.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be increased when combined with Rifapentine.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Rifapentine.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Rifapentine.
Voxelotor Voxelotor The metabolism of Voxelotor can be increased when combined with Rifapentine.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Rifapentine.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Rifapentine.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Rifapentine.
Ozanimod Ozanimod The metabolism of Ozanimod can be increased when combined with Rifapentine.
Selumetinib Selumetinib The metabolism of Selumetinib can be increased when combined with Rifapentine.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Rifapentine.
Tucatinib Tucatinib The metabolism of Tucatinib can be increased when combined with Rifapentine.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Rifapentine.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Rifapentine.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Rifapentine.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be decreased when it is combined with Rifapentine.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Rifapentine can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be decreased when it is combined with Rifapentine.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Rifapentine.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Rifapentine.
Naproxen Naproxen The metabolism of Naproxen can be increased when combined with Rifapentine.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be increased when combined with Rifapentine.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be increased when combined with Rifapentine.
Primidone Primidone The metabolism of Primidone can be increased when combined with Rifapentine.
Methsuximide Methsuximide The metabolism of Methsuximide can be increased when combined with Rifapentine.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Rifapentine.
Diazepam Diazepam The metabolism of Diazepam can be increased when combined with Rifapentine.
Lorazepam Lorazepam The metabolism of Lorazepam can be increased when combined with Rifapentine.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Rifapentine.
Thioridazine Thioridazine The metabolism of Thioridazine can be increased when combined with Rifapentine.
Dapsone Dapsone The metabolism of Dapsone can be increased when combined with Rifapentine.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be increased when combined with Rifapentine.
Methadone Methadone The metabolism of Methadone can be increased when combined with Rifapentine.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be increased when combined with Rifapentine.
Phentermine Phentermine The metabolism of Phentermine can be increased when combined with Rifapentine.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be increased when combined with Rifapentine.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Rifapentine.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Rifapentine.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Rifapentine.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Rifapentine.
Loperamide Loperamide The metabolism of Loperamide can be increased when combined with Rifapentine.
Promethazine Promethazine The metabolism of Promethazine can be increased when combined with Rifapentine.
Chloroquine Chloroquine The metabolism of Chloroquine can be increased when combined with Rifapentine.
Quinine Quinine The metabolism of Quinine can be increased when combined with Rifapentine.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Rifapentine.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Rifapentine.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Rifapentine.
Desipramine Desipramine The metabolism of Desipramine can be increased when combined with Rifapentine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be increased when combined with Rifapentine.
Imipramine Imipramine The metabolism of Imipramine can be increased when combined with Rifapentine.
Quinidine Quinidine The metabolism of Quinidine can be increased when combined with Rifapentine.
Isoniazid Isoniazid Rifapentine may increase the hepatotoxic activities of Isoniazid.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be increased when combined with Rifapentine.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Rifapentine.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be increased when combined with Rifapentine.
Brompheniramine Brompheniramine The metabolism of Brompheniramine can be increased when combined with Rifapentine.
Carisoprodol Carisoprodol The metabolism of Carisoprodol can be increased when combined with Rifapentine.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be decreased when it is combined with Rifapentine.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Rifapentine.
Nadolol Nadolol The metabolism of Nadolol can be increased when combined with Rifapentine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be increased when combined with Rifapentine.
Cephalexin Cephalexin The metabolism of Cephalexin can be increased when combined with Rifapentine.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Rifapentine.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Rifapentine.
Vinblastine Vinblastine The metabolism of Vinblastine can be increased when combined with Rifapentine.
Metoprolol Metoprolol The metabolism of Metoprolol can be increased when combined with Rifapentine.
Diltiazem Diltiazem The metabolism of Diltiazem can be increased when combined with Rifapentine.
Timolol Timolol The metabolism of Timolol can be increased when combined with Rifapentine.
Verapamil Verapamil The metabolism of Verapamil can be increased when combined with Rifapentine.
Atenolol Atenolol The metabolism of Atenolol can be increased when combined with Rifapentine.
Pindolol Pindolol The metabolism of Pindolol can be increased when combined with Rifapentine.
Piroxicam Piroxicam The metabolism of Piroxicam can be increased when combined with Rifapentine.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Rifapentine.
Glyburide Glyburide The metabolism of Glyburide can be increased when combined with Rifapentine.
Labetalol Labetalol The metabolism of Labetalol can be increased when combined with Rifapentine.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Rifapentine.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Rifapentine.
Lovastatin Lovastatin The metabolism of Lovastatin can be increased when combined with Rifapentine.
Diclofenac Diclofenac The metabolism of Diclofenac can be increased when combined with Rifapentine.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be increased when combined with Rifapentine.
Simvastatin Simvastatin The metabolism of Simvastatin can be increased when combined with Rifapentine.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Rifapentine.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be increased when combined with Rifapentine.
Sotalol Sotalol The metabolism of Sotalol can be increased when combined with Rifapentine.
Bisoprolol Bisoprolol The metabolism of Bisoprolol can be increased when combined with Rifapentine.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Rifapentine.
Doxazosin Doxazosin The metabolism of Doxazosin can be increased when combined with Rifapentine.
Omeprazole Omeprazole The metabolism of Omeprazole can be increased when combined with Rifapentine.
Cisapride Cisapride The metabolism of Cisapride can be increased when combined with Rifapentine.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be increased when combined with Rifapentine.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Rifapentine.
Tramadol Tramadol The metabolism of Tramadol can be increased when combined with Rifapentine.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Rifapentine.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be increased when combined with Rifapentine.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Rifapentine.
Nicardipine Nicardipine The metabolism of Nicardipine can be increased when combined with Rifapentine.
Bupropion Bupropion The metabolism of Bupropion can be increased when combined with Rifapentine.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be increased when combined with Rifapentine.
Anastrozole Anastrozole The metabolism of Anastrozole can be increased when combined with Rifapentine.
Ritonavir Ritonavir The serum concentration of Rifapentine can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Rifapentine.
Clomipramine Clomipramine The metabolism of Clomipramine can be increased when combined with Rifapentine.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be increased when combined with Rifapentine.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Rifapentine.
Carvedilol Carvedilol The metabolism of Carvedilol can be increased when combined with Rifapentine.
Selegiline Selegiline The metabolism of Selegiline can be increased when combined with Rifapentine.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be increased when combined with Rifapentine.
Sertraline Sertraline The metabolism of Sertraline can be increased when combined with Rifapentine.
Propafenone Propafenone The metabolism of Propafenone can be increased when combined with Rifapentine.
Irbesartan Irbesartan The metabolism of Irbesartan can be increased when combined with Rifapentine.
Paroxetine Paroxetine The metabolism of Paroxetine can be increased when combined with Rifapentine.
Citalopram Citalopram The metabolism of Citalopram can be increased when combined with Rifapentine.
Capecitabine Capecitabine The metabolism of Capecitabine can be increased when combined with Rifapentine.
Efavirenz Efavirenz The metabolism of Efavirenz can be increased when combined with Rifapentine.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be increased when combined with Rifapentine.
Celecoxib Celecoxib The metabolism of Celecoxib can be increased when combined with Rifapentine.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be increased when combined with Rifapentine.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be increased when combined with Rifapentine.
Terbinafine Terbinafine The metabolism of Terbinafine can be increased when combined with Rifapentine.

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