FDA-filed SPL labeling · retrieved through openFDA

Ciprofloxacin

Ciprofloxacin is a powerful antibiotic used to treat a wide range of serious bacterial infections throughout the body.

Brand names Cipro Oral SuspensionCipro TabletsCipro XR Extended-release TabletsProquin XR Extended-release TabletsCiloxan +5 more
Drug classes ⓘ Quinolone Antimicrobial
Rx Forms 6 Routes Oral · Ophthalmic · Intravenous · Topical +2
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 152 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveMar 2, 2026
Clinical labels in scope ⓘ152
AvailabilityRx
Earliest approval/marketing year ⓘ1987
FDA-listed product records ⓘ601
Boxed warningYes
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 22, 2026 🚨Recall on record · 3
Other forms & routes:
Injection Ophthalmic Otic (ear)
⭐ Ciprofloxacin at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Ciprofloxacin is a broad, effective antibiotic — but it comes with real, serious risks that set it apart from most other antibiotics. Take it exactly as prescribed, don't skip doses, and stop and call your doctor immediately if you notice tendon pain, nerve symptoms, or unusual mental changes. For everyday infections, it's typically a last-resort option — so if you're on it, there's usually a good reason.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Ciprofloxacin carries the FDA's most serious warning. Fluoroquinolone antibiotics like ciprofloxacin have been linked to disabling and sometimes permanent side effects that can affect multiple parts of the body at once — including tendons, nerves, and the brain.

Specifically, this means risks of tendon inflammation or rupture (especially the Achilles tendon in the heel), nerve damage causing pain, tingling, or numbness in the limbs, and central nervous system effects like severe anxiety, confusion, hallucinations, and depression. If you experience any of these, stop taking ciprofloxacin immediately and contact your doctor. People with myasthenia gravis (a condition that causes muscle weakness) should not take ciprofloxacin at all — it can make their muscle weakness significantly worse. For milder conditions like sinus infections, bladder infections, and bronchitis flare-ups, ciprofloxacin should only be used when no safer antibiotic option is available.

Read the full warning on DailyMed →

📖 Ciprofloxacin: Patient Information Guide

A plain-language walkthrough of Ciprofloxacin — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Ciprofloxacin is used to treat bacterial infections in adults, and for select infections in children. Here are the main conditions it's approved for:

  • Urinary tract infections (UTIs), including complicated UTIs, simple bladder infections (cystitis), and kidney infections in children
  • Skin and skin structure infections
  • Bone and joint infections
  • Lung infections, including flare-ups of chronic bronchitis (only when no other option is available)
  • Infectious diarrhea caused by certain bacteria
  • Typhoid fever (enteric fever)
  • Intra-abdominal infections (serious infections in the abdomen, used with another antibiotic)
  • Gonorrhea (uncomplicated cervical or urethral)
  • Chronic bacterial prostatitis
  • Sinus infections (sinusitis) — only when no other option is available
  • Anthrax (post-exposure prevention and treatment) in adults and children
  • Plague in adults and children
⚙️How it works▾

Ciprofloxacin kills bacteria by blocking two enzymes — DNA gyrase and topoisomerase IV — that bacteria rely on to copy, repair, and maintain their DNA. Shut those enzymes down and the bacteria can't survive or multiply, so the infection clears.

It's bactericidal, meaning it actively kills bacteria rather than just slowing their growth. To help protect this antibiotic's effectiveness over time, it should only be used when a bacterial infection is confirmed or strongly suspected — not for viral illnesses like colds or the flu.

💊How it's taken▾

Ciprofloxacin tablets are taken by mouth, usually twice a day (roughly every 12 hours), though the exact timing and length of treatment depend on the type and severity of the infection. Food won't significantly affect how much of the drug your body absorbs, so you can take it with or without a meal.

  • Avoid taking it at the same time as dairy products (milk, yogurt) or calcium-fortified drinks — these can reduce absorption
  • People with reduced kidney function may need a lower dose or less frequent dosing — your prescriber will adjust accordingly
  • Always complete the full prescribed course, even if you feel better before it's done
🤒Side effects — in detail▾

Most people tolerate ciprofloxacin reasonably well. The most common side effects include:

  • Nausea
  • Diarrhea
  • Vomiting
  • Skin rash
  • Abnormal liver enzyme levels (usually caught on lab work)

However, some reactions are serious enough to stop the medication immediately and get medical help: tendon pain or rupture, nerve pain/numbness in the limbs, mental health changes (anxiety, hallucinations, confusion), signs of severe allergic reaction, and watery or bloody diarrhea — which can signal a dangerous gut infection (C. diff) even weeks after finishing the course.

⚠️Warnings & precautions▾
  • Tendon damage: Ciprofloxacin raises your risk of tendon inflammation or rupture — most often the Achilles (heel) tendon, but also the shoulder, hand, biceps, and thumb. This can happen within hours of your first dose or even after you finish. Older adults and people on steroids are at especially high risk.
  • Nerve damage (peripheral neuropathy): Tingling, burning, or numbness in hands or feet can develop and may be permanent. Stop the drug at the first sign.
  • Mental and nervous system effects: Hallucinations, severe anxiety, depression, insomnia, confusion, and headaches have been reported — sometimes beginning quickly after starting the medication.
  • Myasthenia gravis: Ciprofloxacin can severely worsen muscle weakness in people with this condition and should be avoided entirely.
  • Heart rhythm (QT prolongation): Ciprofloxacin can prolong the QT interval (an electrical measurement of heart function), increasing the risk of a dangerous irregular heartbeat, especially when combined with other QT-prolonging drugs or in people with low potassium.
  • Aortic aneurysm/dissection: A rare but potentially fatal risk of weakening or tearing of the aorta (the body's main artery) has been linked to fluoroquinolone use.
  • Liver toxicity: Signs of hepatitis — yellowing of the skin or eyes, dark urine, severe fatigue — require stopping the drug immediately.
  • C. difficile diarrhea: Like all antibiotics, ciprofloxacin can trigger an overgrowth of C. diff bacteria in the gut, causing severe colitis. Seek care for persistent or bloody diarrhea.
🔀What it interacts with▾

Ciprofloxacin interacts with a number of medications and foods — some combinations are dangerous enough to be completely avoided:

  • Tizanidine (Zanaflex): Strictly contraindicated — ciprofloxacin drastically increases tizanidine levels, causing dangerous drops in blood pressure and heavy sedation
  • Theophylline: Ciprofloxacin raises theophylline levels, increasing the risk of serious nervous system side effects; avoid combining or monitor very closely
  • QT-prolonging drugs (certain heart medications, tricyclic antidepressants, antipsychotics, macrolide antibiotics): Can further extend the QT interval and increase heart rhythm risk
  • Oral diabetes medications (especially sulfonylureas like glyburide or glimepiride): Blood sugar can drop dangerously low; deaths have been reported — monitor closely
  • Phenytoin (Dilantin): Ciprofloxacin can unpredictably raise or lower phenytoin levels, increasing seizure or toxicity risk
  • Cyclosporine: May cause temporary increases in cyclosporine blood levels
  • Dairy products or calcium-fortified juices: Taking these at the same time as ciprofloxacin can reduce how much is absorbed — take the antibiotic separately
  • Antacids (containing magnesium, aluminum, or calcium): Can bind to ciprofloxacin and reduce absorption; separate doses by several hours

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Do not take ciprofloxacin if you have ever had an allergic reaction to it or any quinolone antibiotic
  • Do not take it if you are also taking tizanidine — this combination is contraindicated
  • Tell your prescriber if you have myasthenia gravis — ciprofloxacin should be avoided entirely in this condition
  • Tell your prescriber about any heart rhythm disorders or if you take medications that affect the heart's electrical activity
  • Tell your prescriber if you have kidney problems — dose adjustments are needed for reduced kidney function, including for people on dialysis
  • Pregnancy: Studies over several decades have not shown clear evidence of harm, but discuss risks and benefits with your doctor before use
  • Breastfeeding: Breastfeeding is generally not recommended during treatment; if you must breastfeed (for example, during anthrax treatment), discuss the risks with your provider. You can pump and discard milk during treatment and for 2 days after the last dose
  • Children: Generally approved for adults; limited pediatric use is approved for specific conditions (complicated UTIs, anthrax, plague) under medical supervision — not for general use in kids
  • Older adults: Have a higher risk of tendon rupture, especially if also taking corticosteroid medications
🚑If you take too much▾

Taking too much ciprofloxacin can cause reversible kidney damage in some cases. If an overdose is suspected, getting medical help right away is important — treatment may include emptying the stomach and providing supportive care, along with monitoring kidney function.

Staying well hydrated is important. Note that dialysis removes very little ciprofloxacin from the body (less than 10%), so it is not an effective way to clear the drug after an overdose.

📡Pharmacodynamics — effects in the body▾

Ciprofloxacin works by blocking bacterial enzymes (DNA gyrase and topoisomerase IV) that are essential for bacteria to copy and repair their DNA. Without these enzymes, bacteria cannot function or reproduce, and they are killed off. This bactericidal (bacteria-killing) action is what resolves the infection.

🔬Pharmacokinetics — how your body processes it▾

When taken as a tablet, about 70% of ciprofloxacin is absorbed into the bloodstream — and this happens fairly quickly, with peak levels in the blood typically reached within 1 to 2 hours of swallowing the dose. Food can push that peak slightly later (closer to 2 hours), but the total amount absorbed stays essentially the same.

The drug has a half-life (the time it takes for the body to clear half the drug) of about 4 hours in people with normal kidney function — which is why it's typically dosed twice a day. It is cleared primarily through the kidneys, so people with reduced kidney function need adjusted doses to prevent the drug from building up to harmful levels.

📦How to store it▾

Store at 20°C to 25°C (68° to 77°F) .

📄 Written from Ciprofloxacin’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

163

Supplements & herbs that interact with Ciprofloxacin

163 supplements and herbal products have documented interactions with Ciprofloxacin in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 8
  • Moderate · 133
  • Minor · 22
ACTIVATED CHARCOAL Major APPLE Major ASARABACCA Major BEER Major GRAPEFRUIT Major SIBERIAN COCKLEBUR Major SWEET ORANGE Major WINE Major +155 more
Every supplement checked against Ciprofloxacin — ranked by severity The full interaction hub: 8 major · 133 moderate · 22 minor · every one linked to its full report. Check Ciprofloxacin against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

11

Nutrient depletion considerations

Ciprofloxacin has been associated with lower levels of 11 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 10
  • Moderate · 1
BIOTIN Insignificant Depletion CALCIUM Insignificant Depletion FOLIC ACID Insignificant Depletion IRON Insignificant Depletion MAGNESIUM Insignificant Depletion RIBOFLAVIN Insignificant Depletion THIAMINE Insignificant Depletion VITAMIN B12 Insignificant Depletion +3 more
See the full Ciprofloxacin nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Ciprofloxacin — the kind of thing our pharmacy team would talk through with you at the counter.

What kinds of infections does ciprofloxacin actually treat? ▾
Ciprofloxacin treats a wide range of bacterial infections — things like urinary tract infections, skin infections, bone and joint infections, infectious diarrhea, typhoid fever, and certain lung infections. It's also used to protect against anthrax or plague after a known exposure. That said, for milder conditions like sinus infections or simple bladder infections, your doctor should only prescribe it if other antibiotics aren't an option — because it carries some serious risks that simpler antibiotics don't.
Can I take it with food or milk? ▾
You can take ciprofloxacin with or without food — that part's flexible. But avoid taking it at the same time as milk, yogurt, or calcium-fortified juices, because dairy and calcium can actually block some of the drug from being absorbed properly. Take it a couple of hours apart from those, and you'll be fine. Also give any antacids (like Tums, Maalox, or similar) a wide berth — separate them by a few hours as well.
What side effects should I watch out for — and which ones mean I should stop taking it? ▾
The most common side effects are nausea, diarrhea, and vomiting — uncomfortable, but usually manageable. The ones that mean stop-and-call-your-doctor-now are tendon pain (especially in your heel, shoulder, or hand), tingling or numbness in your arms or legs, and any unusual mental changes like severe anxiety, confusion, or hallucinations. A severe allergic reaction — trouble breathing, facial swelling — is a 911 situation. If you get bad or bloody diarrhea, even after finishing the course, call your doctor, as it could be a serious gut infection.
I heard ciprofloxacin can rupture tendons — how worried should I be? ▾
It's a real risk, so it's worth knowing about, but it doesn't happen to most people. The concern is mainly with the Achilles tendon in your heel, though other tendons can be affected too. The risk is higher if you're older, if you're on corticosteroid medications (like prednisone), or if you've had tendon problems before. Pain, swelling, or a snapping feeling in any tendon is your signal to stop the medication immediately and contact your doctor — don't try to walk it off.
Are there any medications I absolutely cannot take with ciprofloxacin? ▾
Yes — tizanidine (a muscle relaxer) is completely off-limits while you're taking ciprofloxacin. The combination causes dangerously high tizanidine levels, leading to severe drops in blood pressure and heavy sedation. Theophylline (used for asthma or COPD) should also be avoided or very closely monitored. And if you take any heart rhythm medications, antidepressants, or antipsychotics, make sure your prescriber and pharmacist know — some of those can combine with ciprofloxacin to cause a dangerous heart rhythm problem. Always give your pharmacist a full medication list.
Is it safe to take if I'm pregnant or breastfeeding? ▾
Studies over many years haven't found clear evidence that ciprofloxacin causes birth defects, but the data isn't perfect and pregnancy always warrants extra caution — talk to your doctor about whether the benefit outweighs any risk for your specific situation. For breastfeeding, it's generally recommended to avoid it while nursing. If you have to take it, you can pump and discard your breast milk during treatment and for 2 days after your last dose, then resume breastfeeding. Your doctor can help you figure out the best plan.
Is Ciprofloxacin available over the counter? ▾
Ciprofloxacin is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Ciprofloxacin first available? ▾
Ciprofloxacin has been available in the United States since at least 1987, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Ciprofloxacin? ▾
Ciprofloxacin is supplied by 97 manufacturers listed in the FDA NDC Directory, including A-S Medication Solutions, Bryant Ranch Prepack, NuCare Pharmaceuticals,Inc..

💬 Answers drafted from Ciprofloxacin’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Ciprofloxacin supplement interactions163 checked — ranked by severity 🌿Drug & Supplement CheckerCiprofloxacin vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Ciprofloxacin NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Ciprofloxacin comes

Ciprofloxacin is available in 6 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
Brands Cipro
Available strengths 4 strengths
100 mg 250 mg 500 mg 750 mg
480 FDA-listed product records ⓘ

Eye drops

In the eye · On the skin
Brands Ciloxan
Available strengths 1 strength
3 mg/mL
61 FDA-listed product records ⓘ

Topical solution

On the skin
Available strengths 1 strength
3.5 mg/mL
6 FDA-listed product records ⓘ

Ear drops

In the ear
Brands Cetraxal Ciprofloxacin Otic
Available strengths 1 strength
0.5 mg/0.25 mL
3 FDA-listed product records ⓘ

Eye ointment

In the eye
Brands Ciloxan
Available strengths 1 strength
3 mg/g
3 FDA-listed product records ⓘ

📊 Ciprofloxacin across the U.S. market

How Ciprofloxacin appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

6
Dose forms ⓘ
97
Manufacturers
9
Brand names
601
FDA-listed product records ⓘ
1987
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (18) · Kit (10) · Crystal (1) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

A-S Medication Solutions10%
Bryant Ranch Prepack10%
NuCare Pharmaceuticals,Inc.9%
PD-Rx Pharmaceuticals, Inc.9%
Remedyrepack Inc.6%
Aurobindo Pharma Limited4%
Other makers53%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Ciprofloxacin is used

A general measure of how commonly Ciprofloxacin is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Ciprofloxacin is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

959,810
Medicaid prescriptions filled (Q1–Q4 2025)
$11.7M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Ciprofloxacin prescribed? Of the 1,596 medications we measure, Ciprofloxacin ranks #183 by Medicaid prescriptions — more than 89% of them.

Where Ciprofloxacin ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #183 of 1,596
#178 Lisinopril and Hydroch... 999,534 Rx #179 Naloxone 980,072 Rx #180 Oxybutynin 974,653 Rx #181 Naloxone Nasal Spray 970,105 Rx #182 Budesonide 967,284 Rx #183 Ciprofloxacin 959,810 Rx #184 Erythromycin 942,102 Rx #185 Linaclotide 914,996 Rx #186 Iron Sucrose Injection 913,265 Rx #187 Allopurinol 901,974 Rx #188 Ondansetron Injection 901,061 Rx

Utilization by Ciprofloxacin product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 500 mg oral tablet is the most-dispensed Ciprofloxacin product — about 69% of these Medicaid prescriptions.

ciprofloxacin 500 MG Oral Tablet Most dispensed

665,185 Medicaid prescriptions (Q1–Q4 2025) 69% of Ciprofloxacin prescriptions shown $6.2M gross reimbursement (before rebates) ≈ $9.33 per prescription (gross)

Summed across the 23 of 758 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309309

ciprofloxacin 3 MG/ML Ophthalmic Solution

187,006 Medicaid prescriptions (Q1–Q4 2025) 19% of Ciprofloxacin prescriptions shown $3M gross reimbursement (before rebates) ≈ $16 per prescription (gross)

Summed across the 6 of 79 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309307

ciprofloxacin 250 MG Oral Tablet

79,173 Medicaid prescriptions (Q1–Q4 2025) 8% of Ciprofloxacin prescriptions shown $657,610 gross reimbursement (before rebates) ≈ $8.31 per prescription (gross)

Summed across the 8 of 397 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197511

ciprofloxacin 750 MG Oral Tablet

16,420 Medicaid prescriptions (Q1–Q4 2025) 2% of Ciprofloxacin prescriptions shown $203,369 gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 8 of 100 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197512

200 ML ciprofloxacin 2 MG/ML Injection

4,771 Medicaid prescriptions (Q1–Q4 2025) <1% of Ciprofloxacin prescriptions shown $341,036 gross reimbursement (before rebates) ≈ $71 per prescription (gross)

Summed across the 3 of 12 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1665212

ciprofloxacin 50 MG/ML Oral Suspension

3,364 Medicaid prescriptions (Q1–Q4 2025) <1% of Ciprofloxacin prescriptions shown $552,709 gross reimbursement (before rebates) ≈ $164 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309308

ciprofloxacin 100 MG/ML Oral Suspension

3,198 Medicaid prescriptions (Q1–Q4 2025) <1% of Ciprofloxacin prescriptions shown $531,042 gross reimbursement (before rebates) ≈ $166 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309310

ciprofloxacin 0.003 MG/MG Ophthalmic Ointment

367 Medicaid prescriptions (Q2–Q4 2025) <1% of Ciprofloxacin prescriptions shown $107,609 gross reimbursement (before rebates) ≈ $293 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309306

ciprofloxacin 2 MG/ML Otic Solution

225 Medicaid prescriptions (Q3–Q4 2025) <1% of Ciprofloxacin prescriptions shown $22,789 gross reimbursement (before rebates) ≈ $101 per prescription (gross)

Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 848956

100 ML ciprofloxacin 2 MG/ML Injection

101 Medicaid prescriptions (Q1–Q4 2025) <1% of Ciprofloxacin prescriptions shown $10,098 gross reimbursement (before rebates) ≈ $100 per prescription (gross)

Summed across the 3 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1665210

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Ciprofloxacin, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 55 of 1,366 listed Ciprofloxacin NDCs with Medicaid activity.

🔍 Compare Ciprofloxacin products

A representative set of FDA-listed product records for Ciprofloxacin — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 601 products — FDA National Drug Code Directory. See every product, package size and price: browse all 601 Ciprofloxacin NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Ciprofloxacin RxCUI 2551 7 dose forms · 14 strengths
  1. Dose form (SCDF) Extended Release Oral Tablet RxCUI 597445 No current FDA listing
    Clinical drug / strength (SCD) 24 HR ciprofloxacin 1000 MG RxCUI 403921 24 HR ciprofloxacin 500 MG RxCUI 359383
  3. Dose form (SCDF) Ophthalmic Ointment RxCUI 376483 In current FDA listings
    Clinical drug / strength (SCD) 0.003 MG/MG RxCUI 309306
  4. Dose form (SCDF) Ophthalmic Solution RxCUI 376202 In current FDA listings
    Clinical drug / strength (SCD) 3 MG/ML RxCUI 309307
  5. Dose form (SCDF) Oral Suspension RxCUI 371524 No current FDA listing
    Clinical drug / strength (SCD) 50 MG/ML RxCUI 309308 100 MG/ML RxCUI 309310
  6. Dose form (SCDF) Oral Tablet RxCUI 371525 In current FDA listings
    Clinical drug / strength (SCD) 100 MG RxCUI 199370 250 MG RxCUI 197511 500 MG RxCUI 309309 750 MG RxCUI 197512
  7. Dose form (SCDF) Otic Solution RxCUI 848955 In current FDA listings
    Clinical drug / strength (SCD) 2 MG/ML RxCUI 848956

Look up RxCUI 2551 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Cipro Oral Suspension Cipro Tablets Cipro XR Extended-release Tablets Proquin XR Extended-release Tablets Ciloxan Cipro Proquin Cetraxal Ciprofloxacin in Dextrose Ciprofloxacin Otic

🏭 Manufacturers & labelers

A-S Medication Solutions 48 Bryant Ranch Prepack 48 NuCare Pharmaceuticals,Inc. 46 PD-Rx Pharmaceuticals, Inc. 42 Remedyrepack Inc. 29 Aurobindo Pharma Limited 19 RPK Pharmaceuticals, Inc. 17 Proficient Rx LP 16 Preferred Pharmaceuticals Inc. 14 Preferred Pharmaceuticals, Inc. 12 Bayer HealthCare Pharmaceuticals Inc. 12 RedPharm Drug, Inc. 11 Denton Pharma, Inc. DBA Northwind Pharmaceuticals 10 Chartwell RX, LLC. 10 Direct Rx 9 Hikma Pharmaceuticals USA Inc. 9 Golden State Medical Supply, Inc. 8 Direct_Rx 8 Baxter Healthcare Corporation 8 QPharma Inc 7 Dr. Reddy's Laboratories Limited 7 Carlsbad Technology, Inc. 7 Asclemed USA, Inc. 7 Yiling Pharmaceutical, Inc. 6

…and 16 more on the FDA NDC directory.

RxNorm drug class

Ciprofloxacin belongs to the Fluoroquinolone Antibacterial class.

Pharmacologic class Fluoroquinolone Antibacterial
Drug family (ATC) Fluoroquinolones, Fluoroquinolones, Antiinfectives
How it works Cytochrome P450 1A2 Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Mar 2, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Ciprofloxacin.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Ciprofloxacin after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
152
NDC products indexed
601
Distinct labelers/manufacturers represented
97
Linked representative label ⓘ
Bayer HealthCare Pharmaceuticals Inc.
Linked label effective
Mar 2, 2026
Composite sections available
25
Linked SPL Set ID
888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0
Linked SPL Document ID
1b112839-6cf0-466a-9188-86fc5b1549f9
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 152 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Bayer HealthCare Pharmaceuticals Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.